KEGG   PATHWAY: opi05169
Entry
opi05169                    Pathway                                
Name
Epstein-Barr virus infection - Ochotona princeps (American pika)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
opi05169  Epstein-Barr virus infection
opi05169

Organism
Ochotona princeps (American pika) [GN:opi]
Gene
101528116  CR2; LOW QUALITY PROTEIN: complement receptor type 2 [KO:K04012]
101531818  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
101532154  mamu class II histocompatibility antigen, DR alpha chain [KO:K06752]
101533349  RLA class II histocompatibility antigen, DP alpha-1 chain [KO:K06752]
101534001  HLA class II histocompatibility antigen, DR beta 3 chain-like [KO:K06752]
101534727  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
101536192  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
101536688  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
101516124  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
101516365  HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
101533755  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DRB1 beta chain-like [KO:K06752]
101535219  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
101532394  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
101534971  SLA class II histocompatibility antigen, DQ haplotype D alpha chain [KO:K06752]
101536435  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
101533271  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
101523730  TLR2; toll-like receptor 2 [KO:K10159]
101524248  MYD88; myeloid differentiation primary response protein MyD88 isoform X2 [KO:K04729]
101526929  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
101523491  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
101518298  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101519619  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
101517735  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
101533713  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101536073  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101517015  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101535976  IKBKG; NF-kappa-B essential modulator [KO:K07210]
101536420  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101531611  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
101530066  RELA; transcription factor p65 [KO:K04735]
101525561  TNF; tumor necrosis factor isoform X2 [KO:K03156]
101531329  IL6; interleukin-6 precursor [KO:K05405]
101524783  DDX58; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
101533668  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
101522714  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
101524697  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101529588  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
101519172  IRF7; interferon regulatory factor 7 [KO:K09447]
101528748  IRF3; interferon regulatory factor 3 [KO:K05411]
101532843  LOW QUALITY PROTEIN: interferon alpha-6-like [KO:K05414]
101533081  interferon alpha-1/13-like [KO:K05414]
101533318  IFNB1; interferon beta [KO:K05415]
101524335  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
101535293  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
101521104  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
101525476  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101536685  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
101535928  IRF9; interferon regulatory factor 9 [KO:K04693]
105941681  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
101528904  2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
101532327  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
101527189  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
101528938  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
101521668  FADD; FAS-associated death domain protein [KO:K02373]
101521762  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
101530204  BID; LOW QUALITY PROTEIN: BH3-interacting domain death agonist [KO:K04726]
101529966  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
101517543  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101517703  BAX; apoptosis regulator BAX [KO:K02159]
101516199  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
101519014  cytochrome c, somatic [KO:K08738]
105941493  cytochrome c, testis-specific [KO:K08738]
105941968  cytochrome c-like [KO:K08738]
101526617  cytochrome c, somatic-like [KO:K08738]
101527226  cytochrome c, somatic-like [KO:K08738]
101517311  APAF1; LOW QUALITY PROTEIN: apoptotic protease-activating factor 1 [KO:K02084]
101526499  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
101531640  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101521312  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
101521553  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
101529860  CD3D; T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
101528647  CD247; T-cell surface glycoprotein CD3 zeta chain [KO:K06453]
101516583  PSMC1; 26S proteasome regulatory subunit 4 isoform X1 [KO:K03062]
101517447  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
101535756  26S proteasome regulatory subunit 6B-like [KO:K03063]
101530445  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
101524950  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
101530966  PSMC5; 26S proteasome regulatory subunit 8 [KO:K03066]
101526204  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 isoform X3 [KO:K03028]
101520787  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
101530323  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 1-like [KO:K03032]
101530301  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
101524737  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 isoform X1 [KO:K03035]
101530720  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
101534207  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
101533164  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
101523268  26S proteasome non-ATPase regulatory subunit 7-like [KO:K03038]
101530419  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
101529788  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
101524760  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
101518333  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
101527302  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
101536570  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
101522128  LOW QUALITY PROTEIN: 26S proteasome complex subunit SEM1-like [KO:K10881]
101527416  26S proteasome complex subunit SEM1-like [KO:K10881]
101535942  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
101535473  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
101517580  tapasin [KO:K08058]
101520793  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
101523445  calreticulin-like [KO:K08057]
101518973  CALR; calreticulin [KO:K08057]
101531661  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
101525155  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like isoform X2 [KO:K06751]
101533457  RLA class I histocompatibility antigen, alpha chain 11/11-like [KO:K06751]
101533688  HLA class I histocompatibility antigen, B alpha chain-like [KO:K06751]
101520712  putative HLA class I histocompatibility antigen, alpha chain H [KO:K06751]
101520958  patr class I histocompatibility antigen, B-2 alpha chain-like [KO:K06751]
101518025  RLA class I histocompatibility antigen, alpha chain 11/11-like [KO:K06751]
101523650  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
101535416  HLA class I histocompatibility antigen, B alpha chain-like [KO:K06751]
101534182  HLA class I histocompatibility antigen, B alpha chain-like isoform X1 [KO:K06751]
101534674  HLA class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
101519729  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
101519974  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
101527525  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
101523895  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like isoform X1 [KO:K06751]
101520226  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
101524843  HLA class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101519479  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
101525080  HLA class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101520475  LOW QUALITY PROTEIN: putative HLA class I histocompatibility antigen, alpha chain H [KO:K06751]
101519332  B2M; beta-2-microglobulin [KO:K08055]
101520815  SNW1; SNW domain-containing protein 1 isoform X1 [KO:K06063]
101532410  SIN3A; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644]
101518320  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
101529108  LOW QUALITY PROTEIN: histone deacetylase 2-like [KO:K06067] [EC:3.5.1.98]
101518852  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
101523557  NCOR2; nuclear receptor corepressor 2 isoform X1 [KO:K06065]
101526215  histone deacetylase complex subunit SAP30L-like [KO:K19202]
101517216  SAP30; histone deacetylase complex subunit SAP30 isoform X1 [KO:K19202]
101533572  SAP30L; histone deacetylase complex subunit SAP30L [KO:K19202]
101533543  CIR1; corepressor interacting with RBPJ 1 [KO:K06066]
101533298  corepressor interacting with RBPJ 1 [KO:K06066]
101519518  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
101525242  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
101517364  HES1; transcription factor HES-1 [KO:K06054]
101520289  FCER2; low affinity immunoglobulin epsilon Fc receptor [KO:K06468]
101523545  RUNX3; runt-related transcription factor 3 isoform X1 [KO:K09279]
101522285  MYC; myc proto-oncogene protein [KO:K04377]
101517653  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
101519018  MDM2; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
101533416  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
101528346  TP53; cellular tumor antigen p53 [KO:K04451]
101522490  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
101516300  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
101519285  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
101521693  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
101527969  DDB2; DNA damage-binding protein 2 [KO:K10140]
101528874  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
101524603  TRAF5; TNF receptor-associated factor 5 isoform X2 [KO:K09849]
101519449  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101533851  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922] [EC:2.7.1.153]
101533024  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101532354  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101517982  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101528030  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101533296  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101519021  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101525801  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101516061  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
101523567  RELB; transcription factor RelB isoform X1 [KO:K09253]
101533623  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
101518461  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
101522585  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
101533905  NFKBIE; NF-kappa-B inhibitor epsilon [KO:K05872]
101517343  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
101518825  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101531453  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101524844  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101518695  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
101527835  TRAF2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
101525469  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
101517788  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
101519949  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
101525120  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101525684  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101524339  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101524571  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
101521685  JUN; transcription factor AP-1 [KO:K04448]
101524654  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
101523344  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
101528455  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
101522956  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
101533097  CD44; CD44 antigen isoform X1 [KO:K06256]
101536679  ITGAL; integrin alpha-L [KO:K05718]
101533287  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
101524063  VIM; vimentin [KO:K07606]
101530617  TNFAIP3; LOW QUALITY PROTEIN: tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
101527090  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
101528287  STAT3; signal transducer and activator of transcription 3 isoform X2 [KO:K04692]
101531240  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
101521299  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
101529654  NEDD4; E3 ubiquitin-protein ligase NEDD4 [KO:K10591] [EC:2.3.2.26]
101532428  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101527518  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
101516844  BTK; tyrosine-protein kinase BTK isoform X1 [KO:K07370] [EC:2.7.10.2]
101518447  BLNK; B-cell linker protein [KO:K07371]
101526399  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101531086  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
101522654  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
101531631  CCND1; G1/S-specific cyclin-D1 isoform X2 [KO:K04503]
101528096  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101535218  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
101530437  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
101530682  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
101527767  CCNA1; cyclin-A1 [KO:K06627]
101531289  CCNA2; cyclin-A2 isoform X1 [KO:K06627]
101524825  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
101522364  G1/S-specific cyclin-E2-like [KO:K06626]
101520975  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
101516195  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
101517612  RB1; retinoblastoma-associated protein [KO:K06618]
101529862  E2F1; transcription factor E2F1 [KO:K17454]
101528728  E2F2; transcription factor E2F2 [KO:K09389]
101536117  E2F3; transcription factor E2F3 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
  Journal
F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
Reference
PMID:12740915
  Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
  Journal
Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
  Journal
MBio 6:e00441-15 (2015)
DOI:10.1128/mBio.00441-15
Reference
PMID:11905817
  Authors
Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
  Journal
Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
  Journal
Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
  Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
  Journal
J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
Reference
PMID:25403939
  Authors
Kang H, Kiess A, Chung CH
  Title
Emerging biomarkers in head and neck cancer in the era of genomics.
  Journal
Nat Rev Clin Oncol 12:11-26 (2015)
DOI:10.1038/nrclinonc.2014.192
Reference
PMID:29932446
  Authors
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
  Title
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
  Journal
Cancers (Basel) 10:E213 (2018)
DOI:10.3390/cancers10070213
Reference
PMID:19649319
  Authors
Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
  Title
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
  Journal
PLoS Pathog 5:e1000530 (2009)
DOI:10.1371/journal.ppat.1000530
Reference
PMID:19244339
  Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
  Journal
J Virol 83:4652-69 (2009)
DOI:10.1128/JVI.02408-08
Reference
PMID:19394062
  Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
  Journal
Virology 388:236-47 (2009)
DOI:10.1016/j.virol.2009.03.027
Reference
PMID:25635182
  Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
  Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
  Journal
Future Virol 4:79-91 (2009)
DOI:10.2217/17460794.4.1.79
Reference
PMID:10818681
  Authors
Longnecker R
  Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
  Journal
Adv Cancer Res 79:175-200 (2000)
DOI:10.1016/s0065-230x(00)79006-3
Reference
PMID:30116721
  Authors
El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
  Journal
Front Oncol 8:265 (2018)
DOI:10.3389/fonc.2018.00265
Reference
PMID:12811813
  Authors
Dolcetti R, Masucci MG
  Title
Epstein-Barr virus: induction and control of cell transformation.
  Journal
J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
Reference
PMID:21347341
  Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
  Journal
PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Related
pathway
opi03050  Proteasome
opi04010  MAPK signaling pathway
opi04020  Calcium signaling pathway
opi04064  NF-kappa B signaling pathway
opi04110  Cell cycle
opi04115  p53 signaling pathway
opi04210  Apoptosis
opi04612  Antigen processing and presentation
opi04620  Toll-like receptor signaling pathway
opi04622  RIG-I-like receptor signaling pathway
opi04630  JAK-STAT signaling pathway
opi04662  B cell receptor signaling pathway
KO pathway
ko05169   
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