KEGG   PATHWAY: oro05168
Entry
oro05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Odobenus rosmarus divergens (Pacific walrus)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
oro05168  Herpes simplex virus 1 infection
oro05168

Organism
Odobenus rosmarus divergens (Pacific walrus) [GN:oro]
Gene
101367910  LTA; lymphotoxin-alpha [KO:K05468]
101385561  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
101368733  TNFRSF14; tumor necrosis factor receptor superfamily member 14 [KO:K05152]
101371938  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101373241  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
101375346  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101364103  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101384959  IKBKG; NF-kappa-B essential modulator isoform X2 [KO:K07210]
101384149  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101371488  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101381225  RELA; transcription factor p65 [KO:K04735]
101372845  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
101373139  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
101377584  CCL2; C-C motif chemokine 2 [KO:K14624]
101374642  PVRL1; nectin-1 [KO:K06081]
101362224  PVRL2; nectin-2 [KO:K06531]
101378254  PILRA; paired immunoglobulin-like type 2 receptor alpha [KO:K15411]
101366356  PILRB; paired immunoglobulin-like type 2 receptor beta [KO:K15411]
101368461  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
101374328  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
101380023  ITGA5; integrin alpha-5 [KO:K06484]
101369957  ITGB3; integrin beta-3 [KO:K06493]
101368668  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
101373095  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
101382186  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
101386524  IRF3; interferon regulatory factor 3 [KO:K05411]
101374900  IFNB1; interferon beta [KO:K05415]
101362427  TP53; cellular tumor antigen p53 [KO:K04451]
101385252  C3; complement C3 [KO:K03990]
101364833  C5; complement C5 [KO:K03994]
101369795  CFP; properdin [KO:K15412]
101363280  TLR2; toll-like receptor 2 [KO:K10159]
101367407  uncharacterized protein LOC101367407 [KO:K10159]
101370160  toll-like receptor 9 isoform X2 [KO:K10161]
101363951  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
101374020  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
101378402  TLR3; toll-like receptor 3 [KO:K05401]
101371542  TICAM1; TIR domain-containing adapter molecule 1 isoform X2 [KO:K05842]
101380365  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
101382179  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
101362953  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101376824  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101369401  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
101369627  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
101383005  IL1B; interleukin-1 beta [KO:K04519]
101381338  CCL5; LOW QUALITY PROTEIN: C-C motif chemokine 5 [KO:K12499]
101377851  IL6; interleukin-6 isoform X1 [KO:K05405]
101368209  TNF; tumor necrosis factor [KO:K03156]
101367178  IL12A; interleukin-12 subunit alpha [KO:K05406]
101372789  IL12B; interleukin-12 subunit beta isoform X1 [KO:K05425]
101383901  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
101381886  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
101367736  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
101374855  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
101366827  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
101362394  TBK1; serine/threonine-protein kinase TBK1 isoform X2 [KO:K05410] [EC:2.7.11.10]
101377641  interferon alpha-1/2-like [KO:K05414]
101378214  IFNA5; interferon alpha-5 [KO:K05414]
101374322  interferon alpha-1/2-like [KO:K05414]
101374610  interferon alpha-14-like [KO:K05414]
101379735  interferon beta-like [KO:K05414]
101374743  MB21D1; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
101384140  TMEM173; stimulator of interferon genes protein [KO:K12654]
101382867  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
101372346  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
101386053  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
101380155  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]
101373670  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
101365565  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
101374587  EIF2AK4; eukaryotic translation initiation factor 2-alpha kinase 4 [KO:K16196] [EC:2.7.11.1]
101363609  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
101382103  EIF2B1; translation initiation factor eIF-2B subunit alpha isoform X2 [KO:K03239]
101369416  EIF2B2; translation initiation factor eIF-2B subunit beta [KO:K03754]
101383575  EIF2B3; translation initiation factor eIF-2B subunit gamma isoform X1 [KO:K03241]
101380056  EIF2B4; translation initiation factor eIF-2B subunit delta isoform X2 [KO:K03680]
101381091  EIF2B5; translation initiation factor eIF-2B subunit epsilon isoform X1 [KO:K03240]
101369458  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
101373749  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
101374040  OAS3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
101366276  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
101381881  HCFC1; host cell factor 1 [KO:K14966]
101383636  HCFC2; host cell factor 2 [KO:K27390]
101380999  POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
101375679  POU2F2; POU domain, class 2, transcription factor 2 isoform X2 [KO:K09364]
101373870  POU2F3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
101370046  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
101386107  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
101364487  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
101365648  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
101377296  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
101378785  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101368050  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
101379624  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
101380901  zinc finger protein 256-like [KO:K09228]
101362547  zinc finger protein 418-like [KO:K09228]
101363173  ZFP1; zinc finger protein 1 homolog isoform X1 [KO:K09228]
101374372  ZNF662; zinc finger protein 662 isoform X2 [KO:K09228]
101377621  LOW QUALITY PROTEIN: zinc finger protein 883-like [KO:K09228]
105757047  ZNF10; zinc finger protein 10 isoform X1 [KO:K09228]
101366738  zinc finger protein 84 isoform X2 [KO:K09228]
101367615  zinc finger protein 605 isoform X1 [KO:K09228]
101371762  ZNF268; zinc finger protein 268 [KO:K09228]
101375449  ZNF354B; LOW QUALITY PROTEIN: zinc finger protein 354B [KO:K09228]
101376310  ZNF354A; LOW QUALITY PROTEIN: zinc finger protein 354A [KO:K09228]
105757107  RBAK; RB-associated KRAB zinc finger protein [KO:K09228]
101367804  zinc finger protein 25-like [KO:K09228]
101368104  ZNF853; zinc finger protein 853 [KO:K09228]
105757109  ZNF12; zinc finger protein 12 isoform X1 [KO:K09228]
105757110  zinc finger protein 300-like [KO:K09228]
105757111  ZNF316; zinc finger protein 316 [KO:K09228]
105757954  zinc finger protein 677-like [KO:K09228]
101383987  zinc finger protein 677-like [KO:K09228]
101381399  zinc finger protein 888-like [KO:K09228]
101386024  ZNF677; zinc finger protein 677 [KO:K09228]
101386314  LOW QUALITY PROTEIN: zinc finger protein 160-like [KO:K09228]
105757956  LOW QUALITY PROTEIN: zinc finger protein 107-like [KO:K09228]
105757092  zinc finger protein 850-like [KO:K09228]
101381972  ZNF473; zinc finger protein 473 [KO:K09228]
101382262  zinc finger protein 260 [KO:K09228]
101378210  ZNF23; zinc finger protein 23 isoform X1 [KO:K09228]
101386949  ZKSCAN8; zinc finger protein with KRAB and SCAN domains 8 isoform X1 [KO:K09228]
101386745  zinc finger protein 77 [KO:K09228]
101368010  zinc finger protein 57-like [KO:K09228]
101368588  zinc finger protein 77-like [KO:K09228]
101369187  LOW QUALITY PROTEIN: zinc finger protein 77-like [KO:K09228]
101369488  ZNF556; LOW QUALITY PROTEIN: zinc finger protein 556 [KO:K09228]
105757093  LOW QUALITY PROTEIN: zinc finger protein 419-like [KO:K09228]
101381976  zinc finger protein OZF-like [KO:K09228]
105758014  zinc finger protein 154-like [KO:K09228]
101382566  zinc finger protein 154-like [KO:K09228]
101383418  zinc finger protein OZF-like [KO:K09228]
101384273  ZNF416; LOW QUALITY PROTEIN: zinc finger protein 416 [KO:K09228]
101384833  zinc finger protein 211-like [KO:K09228]
101385130  zinc finger protein OZF-like [KO:K09228]
101386028  zinc finger protein 501-like [KO:K09228]
101386621  LOW QUALITY PROTEIN: zinc finger protein 547 [KO:K09228]
101386912  zinc finger protein 850-like isoform X1 [KO:K09228]
101386318  ZNF548; zinc finger protein 548 [KO:K09228]
101362870  zinc finger protein 883-like [KO:K09228]
105758016  zinc finger protein 772-like [KO:K09228]
105758017  ZNF550; zinc finger protein 550 [KO:K09228]
105758020  zinc finger protein OZF-like isoform X1 [KO:K09228]
101382267  zinc finger protein 551-like [KO:K09228]
101362288  ZNF658; zinc finger protein 658 [KO:K09228]
101362106  ZNF554; zinc finger protein 554 [KO:K09228]
101371720  ZNF777; zinc finger protein 777 [KO:K09228]
101372209  ZNF398; zinc finger protein 398 [KO:K09228]
101372509  ZNF425; zinc finger protein 425 [KO:K09228]
101372802  ZNF212; zinc finger protein 212 [KO:K09228]
101373378  ZNF746; zinc finger protein 746 isoform X2 [KO:K09228]
101371269  ZNF768; zinc finger protein 768 [KO:K09228]
101371556  ZNF785; zinc finger protein 785 [KO:K09228]
101371864  zinc finger protein 689 isoform X2 [KO:K09228]
101384796  ZNF205; zinc finger protein 205 isoform X1 [KO:K09228]
101385693  ZNF200; zinc finger protein 200 [KO:K09228]
101381512  ZNF454; zinc finger protein 454 [KO:K09228]
105758150  zinc finger protein 33B-like [KO:K09228]
101366057  zinc finger protein 33B isoform X1 [KO:K09228]
105758151  ZNF248; zinc finger protein 248 isoform X1 [KO:K09228]
101365149  ZNF25; zinc finger protein 25 [KO:K09228]
101381703  ZNF484; zinc finger protein 484 isoform X2 [KO:K09228]
101371171  zinc finger protein 790 [KO:K09228]
101383475  ZNF74; zinc finger protein 74 [KO:K09228]
101380306  ZNF517; zinc finger protein 517 [KO:K09228]
101373349  ZNF7; zinc finger protein 7 [KO:K09228]
101372057  ZNF26; zinc finger protein 26 [KO:K09228]
101372355  LOW QUALITY PROTEIN: zinc finger protein 84-like [KO:K09228]
101367596  ZNF621; zinc finger protein 621 [KO:K09228]
101369964  ZNF619; zinc finger protein 619 [KO:K09228]
101383985  ZNF275; zinc finger protein 275 [KO:K09228]
101371169  zinc finger protein 624 [KO:K09228]
101379457  zinc finger protein 211 [KO:K09228]
101379020  ZNF30; LOW QUALITY PROTEIN: zinc finger protein 30 [KO:K09228]
101376681  ZNF214; zinc finger protein 214 isoform X1 [KO:K09228]
101368401  ZNF641; zinc finger protein 641 isoform X1 [KO:K09228]
101376953  ZNF311; zinc finger protein 311 [KO:K09228]
101366551  ZNF189; zinc finger protein 189 isoform X1 [KO:K09228]
101380602  ZNF300; LOW QUALITY PROTEIN: zinc finger protein 300 [KO:K09228]
101371514  zinc finger protein 33B-like [KO:K09228]
105757094  zinc finger protein 596-like [KO:K09228]
101382018  ZNF596; zinc finger protein 596 isoform X1 [KO:K09228]
101383841  ZNF684; zinc finger protein 684 [KO:K09228]
101370888  ZNF286A; zinc finger protein 286A isoform X2 [KO:K09228]
101363796  zinc finger protein 260-like [KO:K09228]
101369788  zinc finger protein 555 [KO:K09228]
101376036  ZNF2; zinc finger protein 2 isoform X3 [KO:K09228]
101369506  ZNF699; zinc finger protein 699 [KO:K09228]
101369826  ZNF597; zinc finger protein 597 [KO:K09228]
101371673  zinc finger protein 883-like [KO:K09228]
101366166  ZNF607; zinc finger protein 607 [KO:K09228]
101363706  ZNF180; zinc finger protein 180 [KO:K09228]
101364592  ZNF235; zinc finger protein 235 isoform X1 [KO:K09228]
101364887  ZNF226; zinc finger protein 226 isoform X2 [KO:K09228]
101365195  ZNF404; zinc finger protein 404 [KO:K09228]
101365501  ZNF227; zinc finger protein 227 isoform X3 [KO:K09228]
101368436  ZNF713; zinc finger protein 713 [KO:K09228]
101368402  ZNF891; LOW QUALITY PROTEIN: zinc finger protein 891 [KO:K09228]
101377484  ZNF343; LOW QUALITY PROTEIN: zinc finger protein 343 [KO:K09228]
101374012  zinc finger protein 234 [KO:K09228]
101373441  ZNF229; zinc finger protein 229 [KO:K09228]
101374306  LOW QUALITY PROTEIN: zinc finger protein 208 [KO:K09228]
101373721  ZNF112; zinc finger protein 112 [KO:K09228]
105757454  ZNF285; zinc finger protein 285 [KO:K09228]
101376464  ZNF282; zinc finger protein 282 [KO:K09228]
101376173  ZNF786; LOW QUALITY PROTEIN: zinc finger protein 786 [KO:K09228]
101373091  ZNF783; protein ZNF783 [KO:K09228]
101384265  ZFP92; zinc finger protein 92 homolog [KO:K09228]
101369029  zinc finger protein 28 homolog isoform X2 [KO:K09228]
101369536  ZNF582; zinc finger protein 582 [KO:K09228]
101369834  ZNF583; zinc finger protein 583 isoform X1 [KO:K09228]
101386711  ZNF331; zinc finger protein 331 [KO:K09228]
101380819  ZNF304; zinc finger protein 304 [KO:K09228]
101364384  ZNF559; LOW QUALITY PROTEIN: zinc finger protein 559 [KO:K09228]
101369115  zinc finger protein 709 [KO:K09228]
101369414  ZNF564; LOW QUALITY PROTEIN: zinc finger protein 564 [KO:K09228]
101366671  zinc finger protein 709-like [KO:K09228]
101371777  ZNF333; zinc finger protein 333 [KO:K09228]
101367146  zinc finger protein 709-like isoform X1 [KO:K09228]
101366088  LOW QUALITY PROTEIN: zinc finger protein 709-like [KO:K09228]
101365898  ZNF846; zinc finger protein 846 [KO:K09228]
105757342  ZNF317; zinc finger protein 317 isoform X1 [KO:K09228]
101364984  zinc finger protein 426-like [KO:K09228]
101364677  ZNF177; zinc finger protein 177 [KO:K09228]
105758189  ZNF184; zinc finger protein 184 [KO:K09228]
105758190  LOW QUALITY PROTEIN: zinc finger protein 665-like [KO:K09228]
101368199  zinc finger protein 181 [KO:K09228]
101364178  ZFP69B; zinc finger protein ZFP69B [KO:K09228]
105758284  ZFP69; zinc finger protein ZFP69 isoform X1 [KO:K09228]
101364568  ZNF616; LOW QUALITY PROTEIN: zinc finger protein 616 [KO:K09228]
101364865  zinc finger protein 84-like [KO:K09228]
101365170  LOW QUALITY PROTEIN: zinc finger protein 432-like [KO:K09228]
101366943  zinc finger protein 480-like [KO:K09228]
105758291  zinc finger protein 415-like [KO:K09228]
101366078  ZNF432; zinc finger protein 432 [KO:K09228]
105758292  ZNF614; zinc finger protein 614 [KO:K09228]
101370280  zinc finger protein 717-like [KO:K09228]
101362447  ZSCAN32; LOW QUALITY PROTEIN: zinc finger and SCAN domain-containing protein 32 [KO:K09228]
105757076  ZNF569; zinc finger protein 569 [KO:K09228]
105757218  zinc finger protein 420 [KO:K09228]
101370190  zinc finger protein 345 [KO:K09228]
101371460  zinc finger protein 585A [KO:K09228]
105757219  ZNF793; zinc finger protein 793 [KO:K09228]
105757660  LOW QUALITY PROTEIN: zinc finger protein 92 homolog [KO:K09228]
101369183  ZNF436; zinc finger protein 436 isoform X1 [KO:K09228]
101370334  ZNF667; zinc finger protein 667 [KO:K09228]
101379050  zinc finger protein 883-like [KO:K09228]
101380464  zinc finger protein 883-like [KO:K09228]
101386345  ZNF615; zinc finger protein 615 isoform X1 [KO:K09228]
101386848  ZNF350; zinc finger protein 350 isoform X1 [KO:K09228]
101363397  ZNF175; zinc finger protein 175 [KO:K09228]
101365480  ZNF613; zinc finger protein 613 [KO:K09228]
101362293  LOW QUALITY PROTEIN: zinc finger protein 780A [KO:K09228]
101371263  ZNF630; zinc finger protein 630 [KO:K09228]
101379204  LOW QUALITY PROTEIN: zinc finger protein 420-like [KO:K09228]
105757249  ZFP37; zinc finger protein 37 homolog isoform X1 [KO:K09228]
101386802  zinc finger protein 25-like [KO:K09228]
101370262  ZNF620; zinc finger protein 620 [KO:K09228]
101368379  LOW QUALITY PROTEIN: zinc finger protein 558-like [KO:K09228]
101376571  ZFP57; zinc finger protein 57 homolog [KO:K09228]
101362187  zinc finger protein 37A [KO:K09228]
101366172  zinc finger protein 772-like [KO:K09228]
101376325  ZNF514; zinc finger protein 514 [KO:K09228]
101382641  ZNF782; LOW QUALITY PROTEIN: zinc finger protein 782 [KO:K09228]
101385423  LOW QUALITY PROTEIN: zinc finger protein OZF-like [KO:K09228]
101367577  LOW QUALITY PROTEIN: zinc finger protein 93-like [KO:K09228]
101376183  ZFP90; zinc finger protein 90 homolog [KO:K09228]
101372574  zinc finger protein 252 [KO:K09228]
101372865  ZNF250; zinc finger protein 250 isoform X1 [KO:K09228]
101375936  ZNF623; zinc finger protein 623 [KO:K09228]
101380592  ZNF34; zinc finger protein 34 [KO:K09228]
101383350  ZNF557; zinc finger protein 557 [KO:K09228]
101373135  ZNF41; LOW QUALITY PROTEIN: zinc finger protein 41 [KO:K09228]
101373700  ZNF157; zinc finger protein 157 [KO:K09228]
101373986  ZNF182; zinc finger protein 182 isoform X2 [KO:K09228]
101374471  ZNF81; zinc finger protein 81 [KO:K09228]
101375477  ZNF133; zinc finger protein 133 isoform X2 [KO:K09228]
101374255  ZNF79; zinc finger protein 79 isoform X1 [KO:K09228]
101371568  ZNF674; zinc finger protein 674 [KO:K09228]
101376130  ZNF792; zinc finger protein 792 isoform X1 [KO:K09228]
101376423  ZNF599; zinc finger protein 599 [KO:K09228]
101385070  zinc finger protein 764-like isoform X1 [KO:K09228]
105757081  ZNF688; zinc finger protein 688 [KO:K09228]
101385368  zinc finger protein OZF [KO:K09228]
101386007  zinc finger protein 850-like [KO:K09228]
101386599  zinc finger protein 256-like [KO:K09228]
101386887  zinc finger protein 418-like [KO:K09228]
101364018  ZNF544; zinc finger protein 544 [KO:K09228]
101364314  zinc finger protein 345-like [KO:K09228]
105757710  zinc finger protein 132-like [KO:K09228]
105757711  zinc finger protein 324A-like [KO:K09228]
101385703  zinc finger protein 345-like isoform X1 [KO:K09228]
105757713  ZNF132; zinc finger protein 132 [KO:K09228]
105757714  zinc finger protein 324A-like [KO:K09228]
105757715  ZNF8; zinc finger protein 8 isoform X1 [KO:K09228]
101365521  ZNF584; zinc finger protein 584 [KO:K09228]
101362848  ZNF671; LOW QUALITY PROTEIN: zinc finger protein 671 [KO:K09228]
101373365  zinc finger protein 705F-like [KO:K09228]
101370138  LOW QUALITY PROTEIN: zinc finger protein 705A-like [KO:K09228]
105758133  ZNF354C; zinc finger protein 354C [KO:K09228]
101383521  ZNF879; zinc finger protein 879 isoform X1 [KO:K09228]
101384289  ZNF169; zinc finger protein 169 [KO:K09228]
105757082  ZNF606; zinc finger protein 606 [KO:K09228]
101386539  ZNF19; zinc finger protein 19 isoform X1 [KO:K09228]
101371211  ZNF71; endothelial zinc finger protein induced by tumor necrosis factor alpha [KO:K09228]
101384806  LOW QUALITY PROTEIN: uncharacterized protein LOC101384806 [KO:K09228]
101369593  ZNF573; zinc finger protein 573 [KO:K09228]
101363228  zinc finger protein 239-like [KO:K09228]
101363037  zinc finger protein 501-like [KO:K09228]
105757089  zinc finger protein 85-like [KO:K09228]
101368168  zinc finger protein 345-like [KO:K09228]
105757086  LOW QUALITY PROTEIN: zinc finger protein 43-like [KO:K09228]
105757108  zinc finger protein OZF-like [KO:K09228]
105757953  zinc finger protein 501-like [KO:K09228]
101382560  zinc finger protein 260-like [KO:K09228]
101370352  ZNF485; zinc finger protein 485 [KO:K09228]
101362149  LOW QUALITY PROTEIN: zinc finger and SCAN domain-containing protein 32-like [KO:K09228]
101371402  BST2; bone marrow stromal antigen 2 [KO:K06731]
101382125  IFNG; interferon gamma [KO:K04687]
101375882  IFNGR1; interferon gamma receptor 1 [KO:K05132]
101375007  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
101377893  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
101383358  nuclear body protein SP140-like protein [KO:K15413]
101365827  PML; protein PML [KO:K10054] [EC:2.3.2.-]
101370146  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
101369846  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
101377133  TAPBP; tapasin [KO:K08058]
101375604  PDIA3; protein disulfide-isomerase A3 isoform X1 [KO:K08056] [EC:5.3.4.1]
101374398  CALR; calreticulin [KO:K08057]
101382309  HLA class I histocompatibility antigen, B-41 alpha chain-like [KO:K06751]
101372021  HLA class I histocompatibility antigen, A-36 alpha chain-like [KO:K06751]
101384872  class I histocompatibility antigen, Gogo-C*0201 alpha chain-like [KO:K06751]
101383124  B2M; beta-2-microglobulin isoform X2 [KO:K08055]
101372409  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
101368848  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
101367969  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
101370206  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
101370503  HLA class II histocompatibility antigen, DQ beta 1 chain-like isoform X1 [KO:K06752]
101370728  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
101371503  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
101371809  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
101372107  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
101379071  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
101379947  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
101380246  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
101380534  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
101377021  CD74; HLA class II histocompatibility antigen gamma chain [KO:K06505]
101370689  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101385241  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101385267  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101374787  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
101370100  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101371800  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101383166  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101382320  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101374757  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101363167  TSC1; hamartin isoform X2 [KO:K07206]
101371494  TSC2; tuberin isoform X1 [KO:K07207]
101363732  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
101363844  MTOR; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101386736  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
101366804  SRPK1; LOW QUALITY PROTEIN: SRSF protein kinase 1 [KO:K15409] [EC:2.7.11.1]
101362455  SRSF1; serine/arginine-rich splicing factor 1 [KO:K12890]
101372242  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
101375397  SRSF3; serine/arginine-rich splicing factor 3 isoform X2 [KO:K12892]
101372555  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
101362612  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
101380558  SRSF4; serine/arginine-rich splicing factor 4 [KO:K12893]
101367579  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
101367030  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
101378805  NXF1; nuclear RNA export factor 1 [KO:K14284]
101365073  uncharacterized protein LOC101365073 [KO:K14284]
101385673  NXF3; nuclear RNA export factor 3 [KO:K14284]
101364769  nuclear RNA export factor 2-like [KO:K14284]
101378175  ALYREF; THO complex subunit 4 [KO:K12881]
101381319  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
101369551  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
101386839  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101368290  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
101385048  FADD; FAS-associated death domain protein [KO:K02373]
101365855  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
101371120  BID; BH3-interacting domain death agonist [KO:K04726]
101371652  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
101380231  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
101375422  BAD; bcl2-associated agonist of cell death [KO:K02158]
101372267  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101380440  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
101386882  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]
101386944  cytochrome c [KO:K08738]
101383104  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
101362812  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
101371336  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
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Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
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Cytokine Growth Factor Rev 14:289-96 (2003)
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Reference
PMID:19495760
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Steinberg MW, Shui JW, Ware CF, Kronenberg M
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Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
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Semin Immunopathol 31:207-21 (2009)
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PMID:20221426
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MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
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PLoS One 5:e9560 (2010)
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Reference
PMID:23150579
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Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
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Proc Natl Acad Sci U S A 109:19792-7 (2012)
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Reference
PMID:25375272
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Gianni T, Campadelli-Fiume G
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The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
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PLoS Pathog 10:e1004477 (2014)
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Reference
PMID:15056211
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Spear PG
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Herpes simplex virus: receptors and ligands for cell entry.
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Cell Microbiol 6:401-10 (2004)
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Reference
PMID:12855695
  Authors
Boutell C, Everett RD
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The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
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J Biol Chem 278:36596-602 (2003)
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Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
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J Mol Biol 426:1133-47 (2014)
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Reference
PMID:26952111
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Su C, Zhan G, Zheng C
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Evasion of host antiviral innate immunity by HSV-1, an update.
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Virol J 13:38 (2016)
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Reference
PMID:21994567
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Melchjorsen J, Matikainen S, Paludan SR
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Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
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Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
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Trends Microbiol 12:353-6 (2004)
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Reference
PMID:29298887
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Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
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J Virol 92:e00099-17 (2018)
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Reference
PMID:19344302
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Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
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Design and application of oncolytic HSV vectors for glioblastoma therapy.
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Expert Rev Neurother 9:505-17 (2009)
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Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
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J Virol 87:859-71 (2013)
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Reference
PMID:17229694
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Sanchez R, Mohr I
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Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
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J Virol 81:3455-64 (2007)
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Reference
PMID:12826401
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Wysocka J, Herr W
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The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
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Trends Biochem Sci 28:294-304 (2003)
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Reference
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Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
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Vaccines (Basel) 4:E23 (2016)
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Reference
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Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
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J Virol 78:6282-6 (2004)
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Reference
PMID:23864622
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Gu H, Zheng Y, Roizman B
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Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
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J Virol 87:10244-54 (2013)
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Reference
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Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
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Viruses 1:1240-64 (2009)
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Reference
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Viral evasion of T cell immunity: ancient mechanisms offering new applications.
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Curr Opin Immunol 23:96-103 (2011)
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Reference
PMID:12960333
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Neumann J, Eis-Hubinger AM, Koch N
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Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
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J Immunol 171:3075-83 (2003)
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Reference
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Liu X, Cohen JI
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The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
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Virology 479-480:568-77 (2015)
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Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
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Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
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J Virol 91:e00295-17 (2017)
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Reference
PMID:18508584
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Sandri-Goldin RM
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The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
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Front Biosci 13:5241-56 (2008)
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Reference
PMID:15078920
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Sandri-Goldin RM
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Viral regulation of mRNA export.
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J Virol 78:4389-96 (2004)
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Reference
PMID:27154074
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Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
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Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
oro03040  Spliceosome
oro03050  Proteasome
oro04115  p53 signaling pathway
oro04151  PI3K-Akt signaling pathway
oro04210  Apoptosis
oro04610  Complement and coagulation cascades
oro04612  Antigen processing and presentation
oro04620  Toll-like receptor signaling pathway
oro04622  RIG-I-like receptor signaling pathway
oro04630  JAK-STAT signaling pathway
KO pathway
ko05168   
LinkDB

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