Entry Name JAK-STAT signaling pathway - Odobenus rosmarus divergens (Pacific walrus)
Description The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Odobenus rosmarus divergens (Pacific walrus) [GN:
oro ]
Gene 101365120 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
101383763 IL3RA; LOW QUALITY PROTEIN: interleukin-3 receptor subunit alpha [KO:K04737 ]
101383473 CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066 ]
105757391 granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066 ]
101368221 IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060 ]
101373105 IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056 ]
101371898 IL13RA1; interleukin-13 receptor subunit alpha-1 isoform X2 [KO:K05076 ]
101363367 IL13RA2; interleukin-13 receptor subunit alpha-2 isoform X1 [KO:K05077 ]
101369960 CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
101362999 IL20RB; LOW QUALITY PROTEIN: interleukin-20 receptor subunit beta [KO:K05137 ]
101376489 IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064 ]
101377969 CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061 ]
101377629 EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357 ]
101386160 PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359 ]
101370194 PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386 ]
101378785 STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
101368050 STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221 ]
101373587 STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692 ]
101379077 STAT4; signal transducer and activator of transcription 4 [KO:K11222 ]
101372719 STAT5A; signal transducer and activator of transcription 5A isoform X1 [KO:K11223 ]
101372217 STAT5B; signal transducer and activator of transcription 5B isoform X2 [KO:K11224 ]
101375468 STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225 ]
101373719 SOCS2; LOW QUALITY PROTEIN: suppressor of cytokine signaling 2 [KO:K04695 ]
101368348 MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539 ]
101376217 induced myeloid leukemia cell differentiation protein Mcl-1 homolog [KO:K02539 ]
101374081 STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705 ]
101382859 STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705 ]
101384284 PIAS1; E3 SUMO-protein ligase PIAS1 isoform X2 [KO:K04706 ] [EC:2.3.2.-]
101383602 PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063 ] [EC:2.3.2.-]
101383416 FHL1; four and a half LIM domains protein 1 isoform X2 [KO:K14365 ]
101362094 GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364 ]
101370689 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
101385241 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
101385267 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
101374787 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
101370100 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
101371800 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
Reference Authors Harrison DA
Title The Jak/STAT pathway.
Journal Reference Authors Kiu H, Nicholson SE
Title Biology and significance of the JAK/STAT signalling pathways.
Journal Reference Authors Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
Title Direct effects of type I interferons on cells of the immune system.
Journal Reference Authors Fish EN, Platanias LC
Title Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
Journal Reference Authors Ivanenkov YA, Balakin KV, Lavrovsky Y
Title Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
Journal Reference Authors O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
Title The JAK-STAT pathway: impact on human disease and therapeutic intervention.
Journal Reference Authors Zoranovic T, Grmai L, Bach EA
Title Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
Journal Reference Authors Ungureanu D, Silvennoinen O
Title SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
Journal Reference Authors Richard AJ, Stephens JM
Title The role of JAK-STAT signaling in adipose tissue function.
Journal Reference Authors Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
Title STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
Journal Reference Authors Hirano T, Ishihara K, Hibi M
Title Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
Journal Reference Authors Rane SG, Reddy EP
Title Janus kinases: components of multiple signaling pathways.
Journal Reference Authors Heim MH
Title The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
Journal Reference Authors Morris R, Kershaw NJ, Babon JJ
Title The molecular details of cytokine signaling via the JAK/STAT pathway.
Journal Reference Authors Tzeng HT, Chyuan IT, Lai JH
Title Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
Journal Reference Authors Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
Title JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
Journal Related oro04060 Cytokine-cytokine receptor interaction
KO pathway LinkDB All DBs
