KEGG   PATHWAY: padl04520
Entry
padl04520                   Pathway                                
Name
Adherens junction - Pygoscelis adeliae (Adelie penguin)
Description
Cell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation. At AJs, E-cadherin serves as an essential cell adhesion molecules (CAMs). The cytoplasmic tail binds beta-catenin, which in turn binds alpha-catenin. Alpha-catenin is associated with F-actin bundles directly and indirectly. The integrity of the cadherin-catenin complex is negatively regulated by phosphorylation of beta-catenin by receptor tyrosine kinases (RTKs) and cytoplasmic tyrosine kinases (Fer, Fyn, Yes, and Src), which leads to dissociation of the cadherin-catenin complex. Integrity of this complex is positively regulated by beta -catenin phosphorylation by casein kinase II, and dephosphorylation by protein tyrosine phosphatases. Changes in the phosphorylation state of beta-catenin affect cell-cell adhesion, cell migration and the level of signaling beta-catenin. Wnt signaling acts as a positive regulator of beta-catenin by inhibiting beta-catenin degradation, which stabilizes beta-catenin, and causes its accumulation. Cadherin may acts as a negative regulator of signaling beta-catenin as it binds beta-catenin at the cell surface and thereby sequesters it from the nucleus. Nectins also function as CAMs at AJs, but are more highly concentrated at AJs than E-cadherin. Nectins transduce signals through Cdc42 and Rac, which reorganize the actin cytoskeleton, regulate the formation of AJs, and strengthen cell-cell adhesion.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
padl04520  Adherens junction
padl04520

Other DBs
GO: 0005912
Organism
Pygoscelis adeliae (Adelie penguin) [GN:padl]
Gene
103922304  PVRL1; nectin-1 [KO:K06081]
103916862  PVRL3; nectin-3 [KO:K06592]
103918266  PARD3; partitioning defective 3 homolog [KO:K04237]
103912412  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
103916226  FARP2; LOW QUALITY PROTEIN: FERM, RhoGEF and pleckstrin domain-containing protein 2 [KO:K06082]
103925407  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
103913498  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103924148  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
103917419  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
103923835  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
103914866  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
103917437  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 [KO:K05627]
103918994  WASF1; wiskott-Aldrich syndrome protein family member 1 [KO:K05753]
103912774  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
103920100  WASF3; wiskott-Aldrich syndrome protein family member 3 [KO:K06083]
103916354  wiskott-Aldrich syndrome protein family member 3-like [KO:K06083]
103921260  MLLT4; afadin [KO:K05702]
103913098  LMO7; LIM domain only protein 7 isoform X1 [KO:K06084]
103925144  SSX2IP; afadin- and alpha-actinin-binding protein [KO:K06085]
103915571  SORBS1; sorbin and SH3 domain-containing protein 1 isoform X1 [KO:K06086]
103918284  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
103915612  VCL; vinculin [KO:K05700]
103914850  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
103914417  CTNND1; LOW QUALITY PROTEIN: catenin delta-1 [KO:K05690]
103914490  CTNNB1; catenin beta-1 [KO:K02105]
103918493  CTNNA3; catenin alpha-3 [KO:K05691]
103923501  CTNNA2; catenin alpha-2 isoform X1 [KO:K05691]
103921956  CTNNA1; catenin alpha-1 [KO:K05691]
103913542  ACTB; actin, cytoplasmic 1 [KO:K05692]
103925495  RHOA; transforming protein RhoA [KO:K04513]
103921346  ACP1; low molecular weight phosphotyrosine protein phosphatase isoform X1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
103924545  receptor-type tyrosine-protein phosphatase mu-like [KO:K05693] [EC:3.1.3.48]
103920034  PTPRB; receptor-type tyrosine-protein phosphatase beta [KO:K05694] [EC:3.1.3.48]
103924074  PTPRF; receptor-type tyrosine-protein phosphatase F [KO:K05695] [EC:3.1.3.48]
103919268  PTPN1; tyrosine-protein phosphatase non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
103920898  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
103920761  PTPRJ; receptor-type tyrosine-protein phosphatase eta [KO:K05698] [EC:3.1.3.48]
103912576  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
103922230  casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
103915850  TCF7; transcription factor 7 [KO:K02620]
103918670  TCF7L2; transcription factor 7-like 2 [KO:K04491]
103919538  LEF1; LOW QUALITY PROTEIN: lymphoid enhancer-binding factor 1 [KO:K04492]
103914830  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103926439  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
103916977  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
103914859  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103912362  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
103920857  FER; tyrosine-protein kinase Fer [KO:K08889] [EC:2.7.10.2]
103918980  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
103925465  YES1; tyrosine-protein kinase Yes [KO:K05705] [EC:2.7.10.2]
103922585  MAPK1; LOW QUALITY PROTEIN: mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103923140  SNAI2; LOW QUALITY PROTEIN: zinc finger protein SNAI2 [KO:K05706]
103919350  SNAI1; zinc finger protein SNAI1 [KO:K05707]
103917369  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
103919595  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
103917105  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
103914749  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
103916117  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
103915110  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
103917529  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
103913621  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
103912520  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
103913716  CDH5; cadherin-5 [KO:K06533]
103919600  protein HEG homolog 1-like [KO:K24472]
103922387  KRIT1; krev interaction trapped protein 1 isoform X1 [KO:K17705]
103916041  CCM2; malcavernin [KO:K26416]
103924948  PDCD10; programmed cell death protein 10 [KO:K18269]
103914169  SMURF1; E3 ubiquitin-protein ligase SMURF1 [KO:K04678] [EC:2.3.2.26]
103916653  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
103923560  RAP1A; LOW QUALITY PROTEIN: ras-related protein Rap-1A [KO:K04353]
103919959  RAP1B; ras-related protein Rap-1b [KO:K07836]
103913577  RADIL; ras-associating and dilute domain-containing protein [KO:K26418]
103925112  ARHGAP29; rho GTPase-activating protein 29 [KO:K20644]
103923171  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
103924034  ROCK2; LOW QUALITY PROTEIN: rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
103914543  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
103921386  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
103912916  MYL10; myosin regulatory light chain 10 [KO:K12756]
103917825  myosin regulatory light chain 2, smooth muscle minor isoform-like [KO:K12757]
103917836  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
Reference
  Authors
Nelson WJ, Nusse R.
  Title
Convergence of Wnt, beta-catenin, and cadherin pathways.
  Journal
Science 303:1483-7 (2004)
DOI:10.1126/science.1094291
Reference
  Authors
Potter E, Bergwitz C, Brabant G.
  Title
The cadherin-catenin system: implications for growth and differentiation of endocrine tissues.
  Journal
Endocr Rev 20:207-39 (1999)
DOI:10.1210/edrv.20.2.0362
Reference
  Authors
Beavon IR.
  Title
The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation.
  Journal
Eur J Cancer 36:1607-20 (2000)
DOI:10.1016/S0959-8049(00)00158-1
Reference
  Authors
Reynolds AB, Roczniak-Ferguson A.
  Title
Emerging roles for p120-catenin in cell adhesion and cancer.
  Journal
Oncogene 23:7947-56 (2004)
DOI:10.1038/sj.onc.1208161
Reference
  Authors
Angst BD, Marcozzi C, Magee AI.
  Title
The cadherin superfamily: diversity in form and function.
  Journal
J Cell Sci 114:629-41 (2001)
Reference
  Authors
Lilien J, Balsamo J, Arregui C, Xu G.
  Title
Turn-off, drop-out: functional state switching of cadherins.
  Journal
Dev Dyn 224:18-29 (2002)
DOI:10.1002/dvdy.10087
Reference
  Authors
Piedra J, Miravet S, Castano J, Palmer HG, Heisterkamp N, Garcia de Herreros A, Dunach M.
  Title
p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction.
  Journal
Mol Cell Biol 23:2287-97 (2003)
DOI:10.1128/MCB.23.7.2287-2297.2003
Reference
  Authors
Conacci-Sorrell M, Simcha I, Ben-Yedidia T, Blechman J, Savagner P, Ben-Ze'ev A.
  Title
Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK.
  Journal
J Cell Biol 163:847-57 (2003)
DOI:10.1083/jcb.200308162
Reference
  Authors
Ciruna B, Rossant J.
  Title
FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak.
  Journal
Dev Cell 1:37-49 (2001)
DOI:10.1016/S1534-5807(01)00017-X
Reference
  Authors
Peinado H, Quintanilla M, Cano A.
  Title
Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions.
  Journal
J Biol Chem 278:21113-23 (2003)
DOI:10.1074/jbc.M211304200
Reference
  Authors
Labbe E, Letamendia A, Attisano L.
  Title
Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways.
  Journal
Proc Natl Acad Sci U S A 97:8358-63 (2000)
DOI:10.1073/pnas.150152697
Reference
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Related
pathway
padl04010  MAPK signaling pathway
padl04060  Cytokine-cytokine receptor interaction
padl04310  Wnt signaling pathway
padl04350  TGF-beta signaling pathway
padl04530  Tight junction
padl04810  Regulation of actin cytoskeleton
KO pathway
ko04520   
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