KEGG   PATHWAY: pcoq05166
Entry
pcoq05166                   Pathway                                
Name
Human T-cell leukemia virus 1 infection - Propithecus coquereli (Coquerel's sifaka)
Description
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, and SRF.
Class
Human Diseases; Infectious disease: viral
Pathway map
pcoq05166  Human T-cell leukemia virus 1 infection
pcoq05166

Organism
Propithecus coquereli (Coquerel's sifaka) [GN:pcoq]
Gene
105812310  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
105808534  NRP1; neuropilin-1 isoform X1 [KO:K06724]
105811323  MYC; myc proto-oncogene protein [KO:K04377]
105805928  TRRAP; transformation/transcription domain-associated protein [KO:K08874]
105827427  KAT5; histone acetyltransferase KAT5 isoform X1 [KO:K11304] [EC:2.3.1.48]
105822622  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
105823192  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
105817083  ITGB2; LOW QUALITY PROTEIN: integrin beta-2 [KO:K06464]
105807825  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
105816561  HRAS; GTPase HRas isoform X1 [KO:K02833]
105807545  KRAS; GTPase KRas [KO:K07827]
105810591  NRAS; GTPase NRas [KO:K07828]
105810783  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105811965  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105823104  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105810199  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105805024  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
105820004  TLN1; talin-1 isoform X1 [KO:K06271]
105810968  TLN2; talin-2 [KO:K06271]
105811955  RANBP3; ran-binding protein 3 isoform X1 [KO:K15304]
105821033  RAN; GTP-binding nuclear protein Ran [KO:K07936]
105823285  LOW QUALITY PROTEIN: GTP-binding nuclear protein Ran-like [KO:K07936]
105806133  XPO1; exportin-1 [KO:K14290]
105806269  calreticulin-like [KO:K08057]
105807890  CALR; calreticulin [KO:K08057]
105823264  CANX; calnexin [KO:K08054]
105825283  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
105825498  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105821611  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
105812112  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
105805391  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
105821171  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
105820432  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
105823351  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
105812762  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
105805206  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
105809985  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
105806352  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
105818130  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
105820251  signal transducer and activator of transcription 5A [KO:K11223]
105820211  signal transducer and activator of transcription 5A-like [KO:K11224]
105815260  IL2; interleukin-2 [KO:K05429]
105817846  HLA class I histocompatibility antigen, B-8 alpha chain-like [KO:K06751]
105817910  HLA class I histocompatibility antigen, B-46 alpha chain-like [KO:K06751]
105817268  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
105817288  HLA class I histocompatibility antigen, B-14 alpha chain-like isoform X1 [KO:K06751]
105817290  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
105817294  HLA class I histocompatibility antigen, B-41 alpha chain-like [KO:K06751]
105814533  B2M; beta-2-microglobulin [KO:K08055]
105821869  FDPS; farnesyl pyrophosphate synthase [KO:K00787] [EC:2.5.1.1 2.5.1.10]
105816029  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
105820356  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
105817755  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
105809466  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
105810108  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
105825488  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
105819681  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
105807496  TSPO2; translocator protein 2 [KO:K05770]
105805293  TSPO; translocator protein [KO:K05770]
105808017  VAC14; protein VAC14 homolog [KO:K15305]
105818854  RANBP1; ran-specific GTPase-activating protein isoform X1 [KO:K15306]
105806053  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
105806410  mitotic spindle assembly checkpoint protein MAD2A-like [KO:K02537]
105811207  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
105814453  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
105808699  BUB3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
105820300  ANAPC1; anaphase-promoting complex subunit 1 [KO:K03348]
105818715  ANAPC2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
105819065  CDC27; cell division cycle protein 27 homolog [KO:K03350]
105826242  ANAPC4; anaphase-promoting complex subunit 4 [KO:K03351]
105825618  ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
105824403  CDC16; cell division cycle protein 16 homolog [KO:K03353]
105823228  LOW QUALITY PROTEIN: cell division cycle protein 16 homolog [KO:K03353]
105825612  ANAPC7; anaphase-promoting complex subunit 7 [KO:K03354]
105811993  CDC23; cell division cycle protein 23 homolog [KO:K03355]
105808981  ANAPC10; anaphase-promoting complex subunit 10 [KO:K03357]
105820024  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
105807742  CDC26; anaphase-promoting complex subunit CDC26 isoform X1 [KO:K03359]
105826452  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
105811495  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
105825483  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
105814100  CDC20; cell division cycle protein 20 homolog [KO:K03363]
105823867  securin-like [KO:K06635]
105810772  PTTG1; securin [KO:K06635]
105817396  ESPL1; separin [KO:K02365] [EC:3.4.22.49]
105821367  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
105826999  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
105827003  CDKN2A; cyclin-dependent kinase inhibitor 2A [KO:K06621]
105816738  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
105827423  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
105807480  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
105812249  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
105815267  CCNA2; cyclin-A2 [KO:K06627]
105810131  CCNA1; cyclin-A1 [KO:K06627]
105812544  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
105809789  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
105817322  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
105813707  RB1; retinoblastoma-associated protein [KO:K06618]
105804948  E2F1; transcription factor E2F1 [KO:K17454]
105815699  E2F2; transcription factor E2F2 [KO:K09389]
105805737  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
105822182  ATM; LOW QUALITY PROTEIN: serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
105812887  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
105821450  CHEK1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
105810166  CHEK2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
105819395  TP53; cellular tumor antigen p53 [KO:K04451]
105826612  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105818191  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105814042  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
105824997  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105826540  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105806240  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105820591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105812606  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105810397  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105807991  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
105822702  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105817905  TNF; tumor necrosis factor isoform X1 [KO:K03156]
105805081  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105819135  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
105818077  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
105823643  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105812700  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105815999  mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
105806347  JUN; transcription factor AP-1 [KO:K04448]
105822224  MMP7; matrilysin [KO:K01397] [EC:3.4.24.23]
105808263  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
105808352  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
105814175  uncharacterized protein LOC105814175 [KO:K10784]
105819245  CD3D; T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
105819243  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
105819211  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
105824000  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
105824261  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
105819687  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
105824538  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
105821530  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
105819191  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105827383  RELA; transcription factor p65 isoform X1 [KO:K04735]
105819452  GPS2; G protein pathway suppressor 2 [KO:K15307]
105805078  LTBR; tumor necrosis factor receptor superfamily member 3 [KO:K03159]
105807125  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
105805260  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151]
105824147  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
105817529  RELB; transcription factor RelB [KO:K09253]
105824302  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
105820542  ZFP36; tristetraprolin [KO:K15308]
105826916  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
105826899  IL15RA; interleukin-15 receptor subunit alpha [KO:K05074]
105822445  IL6; interleukin-6 [KO:K05405]
105821018  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
105817906  LTA; lymphotoxin-alpha [KO:K05468]
105814728  bcl-2-like protein 1 isoform X1 [KO:K04570]
105804942  BCL2L1; bcl-2-like protein 1 [KO:K04570]
105826835  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
105820566  TGFB1; transforming growth factor beta-1 isoform X1 [KO:K13375]
105826908  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
105819930  TGFB3; transforming growth factor beta-3 isoform X1 [KO:K13377]
105805373  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
105810553  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
105808878  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
105821424  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
105816381  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
105812499  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
105821322  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105816960  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
105812764  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
105808688  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
105818188  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
105808848  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
105813348  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
105813177  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
105823839  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105807940  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
105812179  nuclear transcription factor Y subunit beta [KO:K08065]
105815115  NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
105824372  H-2 class II histocompatibility antigen, I-E beta chain-like [KO:K06752]
105824381  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
105824383  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
105824384  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
105824385  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
105824386  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
105824388  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
105824389  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
105817835  HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
105817913  mamu class II histocompatibility antigen, DR alpha chain [KO:K06752]
105810148  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
105807488  SRF; serum response factor [KO:K04378]
105821206  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
105816821  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
105811046  SPI1; transcription factor PU.1 isoform X1 [KO:K09438]
105816291  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
105806890  ETS2; protein C-ets-2 [KO:K21932]
105825838  TBPL2; TATA box-binding protein-like protein 2 [KO:K03120]
105827201  TBPL1; TATA box-binding protein-like protein 1 [KO:K03120]
105822335  TBP; TATA-box-binding protein isoform X1 [KO:K03120]
105819831  FOS; proto-oncogene c-Fos [KO:K04379]
105812037  EGR1; early growth response protein 1 [KO:K09203]
105827345  FOSL1; fos-related antigen 1 [KO:K04502]
105821106  EGR2; E3 SUMO-protein ligase EGR2 [KO:K12496]
105823945  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
105820021  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
105821904  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
105811984  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
105809025  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
105811104  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
105815570  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
105805232  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105807372  cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
105817861  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
105818181  CRTC1; CREB-regulated transcription coactivator 1 [KO:K15309]
105821908  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
105809899  CRTC3; CREB-regulated transcription coactivator 3 [KO:K16334]
105813122  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
105805288  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
105825397  KAT2B; histone acetyltransferase KAT2B [KO:K06062] [EC:2.3.1.48]
105820247  KAT2A; histone acetyltransferase KAT2A [KO:K06062] [EC:2.3.1.48]
105811283  TCF3; transcription factor E2-alpha isoform X1 [KO:K09063]
105819664  POLB; DNA polymerase beta [KO:K02330] [EC:2.7.7.7 4.2.99.-]
105808545  LCK; tyrosine-protein kinase Lck [KO:K05856] [EC:2.7.10.2]
105809316  BAX; apoptosis regulator BAX [KO:K02159]
105806281  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
105825821  TERT; telomerase reverse transcriptase isoform X1 [KO:K11126] [EC:2.7.7.49]
105825153  MSX1; homeobox protein MSX-1 [KO:K09341]
105826045  MSX2; homeobox protein MSX-2 [KO:K09341]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17384582
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
PMID:16155604
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
PMID:18702816
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
PMID:21994754
  Authors
Jones KS, Lambert S, Bouttier M, Benit L, Ruscetti FW, Hermine O, Pique C
  Title
Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
  Journal
Viruses 3:794-810 (2011)
DOI:10.3390/v3060794
Reference
PMID:21114861
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
DOI:10.1186/1742-4690-7-99
Reference
  Authors
Sinet F.
  Title
Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: a number of proteins play a key role in the establishment and maintenance of viral infection.
  Journal
BioSciences Master Reviews, July 2013
Reference
PMID:18923409
  Authors
Sattentau Q
  Title
Avoiding the void: cell-to-cell spread of human viruses.
  Journal
Nat Rev Microbiol 6:815-26 (2008)
DOI:10.1038/nrmicro1972
Reference
PMID:15040584
  Authors
Vicente-Manzanares M, Sanchez-Madrid F
  Title
Role of the cytoskeleton during leukocyte responses.
  Journal
Nat Rev Immunol 4:110-22 (2004)
DOI:10.1038/nri1268
Reference
PMID:27334587
  Authors
Dutartre H, Claviere M, Journo C, Mahieux R
  Title
Cell-Free versus Cell-to-Cell Infection by Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Type 1: Exploring the Link among Viral Source, Viral Trafficking, and Viral Replication.
  Journal
J Virol 90:7607-17 (2016)
DOI:10.1128/JVI.00407-16
Reference
PMID:15988028
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Mol Cell Biol 25:6178-98 (2005)
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Viruses 3:861-85 (2011)
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HTLV-1 Rex Tunes the Cellular Environment Favorable for Viral Replication.
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Viruses 8:58 (2016)
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Role of Nucleocytoplasmic RNA Transport during the Life Cycle of Retroviruses.
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Front Microbiol 3:179 (2012)
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PMID:23248621
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Overview on HTLV-1 p12, p8, p30, p13: accomplices in persistent infection and viral pathogenesis.
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Front Microbiol 3:400 (2012)
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HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches.
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Apoptosis 13:733-47 (2008)
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Mol Aspects Med 31:350-8 (2010)
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Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.
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Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling.
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Biochim Biophys Acta 1813:731-41 (2011)
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Pathogens 5:E8 (2016)
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Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.
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Blood 97:2137-44 (2001)
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Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.
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Retrovirology 1:20 (2004)
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Yoshida M
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Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
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Annu Rev Immunol 19:475-96 (2001)
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PMID:12802280
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Gabet AS, Mortreux F, Charneau P, Riou P, Duc-Dodon M, Wu Y, Jeang KT, Wattel E
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Inactivation of hTERT transcription by Tax.
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Oncogene 22:3734-41 (2003)
DOI:10.1038/sj.onc.1206468
Related
pathway
pcoq03013  Nucleocytoplasmic transport
pcoq04010  MAPK signaling pathway
pcoq04064  NF-kappa B signaling pathway
pcoq04110  Cell cycle
pcoq04115  p53 signaling pathway
pcoq04151  PI3K-Akt signaling pathway
pcoq04210  Apoptosis
pcoq04350  TGF-beta signaling pathway
pcoq04612  Antigen processing and presentation
pcoq04660  T cell receptor signaling pathway
pcoq04668  TNF signaling pathway
KO pathway
ko05166   
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