KEGG   PATHWAY: pgig05166
Entry
pgig05166                   Pathway                                
Name
Human T-cell leukemia virus 1 infection - Pteropus giganteus (Indian flying fox)
Description
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, and SRF.
Class
Human Diseases; Infectious disease: viral
Pathway map
pgig05166  Human T-cell leukemia virus 1 infection
pgig05166

Organism
Pteropus giganteus (Indian flying fox) [GN:pgig]
Gene
120607180  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 isoform X1 [KO:K07299]
120584127  NRP1; neuropilin-1 isoform X1 [KO:K06724]
120595433  MYC; myc proto-oncogene protein [KO:K04377]
120616661  transformation/transcription domain-associated protein [KO:K08874]
120584836  KAT5; histone acetyltransferase KAT5 isoform X1 [KO:K11304] [EC:2.3.1.48]
120607308  CCND2; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
120620083  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
120584403  ITGB2; integrin beta-2 [KO:K06464]
120610878  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
120584662  HRAS; GTPase HRas isoform X1 [KO:K02833]
120618351  KRAS; GTPase KRas isoform X1 [KO:K07827]
120585069  NRAS; GTPase NRas isoform X1 [KO:K07828]
120604492  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
120615382  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
120606851  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
120620121  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
120611664  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
120604562  TLN2; talin-2 isoform X1 [KO:K06271]
120612860  TLN1; talin-1 [KO:K06271]
120615431  RANBP3; ran-binding protein 3 isoform X1 [KO:K15304]
120615984  RAN; GTP-binding nuclear protein Ran [KO:K07936]
120621607  XPO1; exportin-1 isoform X1 [KO:K14290]
120618527  CALR; calreticulin [KO:K08057]
120616625  CANX; calnexin [KO:K08054]
120591098  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
120606631  PPP3CC; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
120609542  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
120594548  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
120596960  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
120583821  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
120603824  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
120593904  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
120608533  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
120614851  IL2RB; LOW QUALITY PROTEIN: interleukin-2 receptor subunit beta [KO:K05069]
120585387  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
120583126  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
120606540  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
120611099  signal transducer and activator of transcription 5A [KO:K11223]
120611100  signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
120616276  IL2; interleukin-2 [KO:K05429]
120613145  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
120592308  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
120592320  saoe class I histocompatibility antigen, C alpha chain-like [KO:K06751]
120592626  patr class I histocompatibility antigen, B-2 alpha chain-like isoform X1 [KO:K06751]
120615897  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
120616337  HLA class I histocompatibility antigen, B alpha chain-like isoform X1 [KO:K06751]
120616593  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
120606422  class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X1 [KO:K06751]
120618951  HLA class I histocompatibility antigen, B alpha chain-like [KO:K06751]
120599497  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
120589178  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
120589505  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
120622700  B2M; beta-2-microglobulin [KO:K08055]
120592220  FDPS; farnesyl pyrophosphate synthase [KO:K00787] [EC:2.5.1.1 2.5.1.10]
120581285  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
120591624  ADP/ATP translocase 3-like [KO:K05863]
120616243  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
120618453  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
120586046  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
120589516  ADP/ATP translocase 3 [KO:K05863]
120609565  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
120595502  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
120602910  TSPO; translocator protein [KO:K05770]
120596175  TSPO2; translocator protein 2 isoform X1 [KO:K05770]
120593963  VAC14; protein VAC14 homolog [KO:K15305]
120610501  RANBP1; ran-specific GTPase-activating protein isoform X1 [KO:K15306]
120616197  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
120616206  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
120587191  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
120608842  BUB3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
120610278  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
120599741  ANAPC2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
120589270  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
120582770  ANAPC4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
120616081  ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
120615604  CDC16; cell division cycle protein 16 homolog [KO:K03353]
120616089  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
120581345  CDC23; cell division cycle protein 23 homolog [KO:K03355]
120613334  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
120592428  anaphase-promoting complex subunit 10-like isoform X1 [KO:K03357]
120609714  LOW QUALITY PROTEIN: anaphase-promoting complex subunit 10-like [KO:K03357]
120600212  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
120605826  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
120582104  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
120590295  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
120609514  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
120619216  CDC20; cell division cycle protein 20 homolog [KO:K03363]
120614331  PTTG1; securin [KO:K06635]
120602112  ESPL1; separin isoform X1 [KO:K02365] [EC:3.4.22.49]
120604578  CCNB2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
120617116  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
120617114  cyclin-dependent kinase inhibitor 2A-like isoform X1 [KO:K06621]
120604974  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
120584714  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
120596338  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
120597553  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
120616219  CCNA2; cyclin-A2 isoform X1 [KO:K06627]
120610618  CCNA1; cyclin-A1 [KO:K06627]
120605475  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
120617212  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
120604889  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
120583848  RB1; retinoblastoma-associated protein [KO:K06618]
120603555  E2F1; transcription factor E2F1 isoform X1 [KO:K17454]
120596256  E2F2; LOW QUALITY PROTEIN: transcription factor E2F2 [KO:K09389]
120596257  transcription factor E2F2-like [KO:K09389]
120605571  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
120619030  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
120613812  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
120610459  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
120601945  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
120589680  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
120606549  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
120608247  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
120620206  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
120582132  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
120596984  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
120585845  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
120613959  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
120595669  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
120619079  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
120592931  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
120609356  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
120618944  TNF; tumor necrosis factor [KO:K03156]
120611633  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
120608191  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
120589749  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
120616614  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
120609636  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
120588349  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
120621837  JUN; transcription factor AP-1 [KO:K04448]
120618081  MMP7; matrilysin isoform X1 [KO:K01397] [EC:3.4.24.23]
120584449  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
120584447  IL1R2; interleukin-1 receptor type 2 isoform X1 [KO:K04387]
120589132  uncharacterized protein LOC120589132 [KO:K10785]
120622049  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
120622048  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
120622052  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
120600282  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
120609204  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
120595665  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
120605919  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
120620765  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
120591230  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
120584840  RELA; transcription factor p65 [KO:K04735]
120589648  GPS2; G protein pathway suppressor 2 [KO:K15307]
120611634  LTBR; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159]
120603392  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
120602944  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C isoform X1 [KO:K05151]
120589252  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
120605283  RELB; transcription factor RelB isoform X1 [KO:K09253]
120609155  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
120596088  ZFP36; mRNA decay activator protein ZFP36 [KO:K15308]
120609005  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
120609702  IL15RA; interleukin-15 receptor subunit alpha [KO:K05074]
120602335  IL6; interleukin-6 isoform X1 [KO:K05405]
120616524  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
120618947  LTA; lymphotoxin-alpha isoform X1 [KO:K05468]
120603516  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
120612220  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
120586591  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
120619172  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
120619522  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
120597204  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
120586804  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
120585764  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
120604483  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
120585140  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
120589581  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
120586284  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
120621545  ADCY3; LOW QUALITY PROTEIN: adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
120608523  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
120586714  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
120618216  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
120617254  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
120588721  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
120620331  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
120583269  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
120618485  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
120614941  NFYB; nuclear transcription factor Y subunit beta isoform X1 [KO:K08065]
120597570  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
120597603  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
120597605  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
120597654  HLA class II histocompatibility antigen, DO alpha chain isoform X1 [KO:K06752]
120597655  HLA class II histocompatibility antigen, DQ beta 1 chain-like isoform X1 [KO:K06752]
120597657  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
120597658  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
120597659  boLa class II histocompatibility antigen, DQB*0101 beta chain-like isoform X1 [KO:K06752]
120597661  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
120597662  HLA class II histocompatibility antigen, DO beta chain-like [KO:K06752]
120597678  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
120597680  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
120596153  SRF; serum response factor [KO:K04378]
120617947  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
120605522  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
120607313  SPI1; transcription factor PU.1 [KO:K09438]
120610430  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
120598560  ETS2; protein C-ets-2 [KO:K21932]
120615800  TBPL1; TATA box-binding protein-like 1 [KO:K03120]
120605605  TBPL2; TATA box-binding protein-like 2 isoform X1 [KO:K03120]
120618243  TATA-box-binding protein [KO:K03120]
120619517  FOS; proto-oncogene c-Fos [KO:K04379]
120581359  EGR1; early growth response protein 1 [KO:K09203]
120584830  FOSL1; fos-related antigen 1 isoform X1 [KO:K04502]
120609416  EGR2; E3 SUMO-protein ligase EGR2 [KO:K12496]
120587583  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
120592160  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
120615385  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
120606645  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
120601151  CREB3L2; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
120612863  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
120597156  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
120602997  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
120602391  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
120618891  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
120606570  CRTC1; LOW QUALITY PROTEIN: CREB-regulated transcription coactivator 1 [KO:K15309]
120592226  CRTC2; CREB-regulated transcription coactivator 2 [KO:K16333]
120599269  CRTC3; CREB-regulated transcription coactivator 3 isoform X1 [KO:K16334]
120602971  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
120620322  LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
120581660  KAT2B; histone acetyltransferase KAT2B [KO:K06062] [EC:2.3.1.48]
120611106  KAT2A; histone acetyltransferase KAT2A isoform X1 [KO:K06062] [EC:2.3.1.48]
120583708  TCF3; transcription factor E2-alpha isoform X1 [KO:K09063]
120595666  POLB; DNA polymerase beta [KO:K02330] [EC:2.7.7.7 4.2.99.-]
120581990  LCK; tyrosine-protein kinase Lck isoform X1 [KO:K05856] [EC:2.7.10.2]
120606950  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
120620809  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
120586142  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
120615178  MSX2; homeobox protein MSX-2 [KO:K09341]
120582857  MSX1; homeobox protein MSX-1 [KO:K09341]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17384582
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
PMID:16155604
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
PMID:18702816
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
PMID:21994754
  Authors
Jones KS, Lambert S, Bouttier M, Benit L, Ruscetti FW, Hermine O, Pique C
  Title
Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
  Journal
Viruses 3:794-810 (2011)
DOI:10.3390/v3060794
Reference
PMID:21114861
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
DOI:10.1186/1742-4690-7-99
Reference
  Authors
Sinet F.
  Title
Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: a number of proteins play a key role in the establishment and maintenance of viral infection.
  Journal
BioSciences Master Reviews, July 2013
Reference
PMID:18923409
  Authors
Sattentau Q
  Title
Avoiding the void: cell-to-cell spread of human viruses.
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Nat Rev Microbiol 6:815-26 (2008)
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Vicente-Manzanares M, Sanchez-Madrid F
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Role of the cytoskeleton during leukocyte responses.
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Nat Rev Immunol 4:110-22 (2004)
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Dutartre H, Claviere M, Journo C, Mahieux R
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Cell-Free versus Cell-to-Cell Infection by Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Type 1: Exploring the Link among Viral Source, Viral Trafficking, and Viral Replication.
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J Virol 90:7607-17 (2016)
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Awasthi S, Sharma A, Wong K, Zhang J, Matlock EF, Rogers L, Motloch P, Takemoto S, Taguchi H, Cole MD, Luscher B, Dittrich O, Tagami H, Nakatani Y, McGee M, Girard AM, Gaughan L, Robson CN, Monnat RJ Jr, Harrod R
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A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions.
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Mol Cell Biol 25:6178-98 (2005)
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PMID:21994758
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Edwards D, Fenizia C, Gold H, de Castro-Amarante MF, Buchmann C, Pise-Masison CA, Franchini G
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Orf-I and orf-II-encoded proteins in HTLV-1 infection and persistence.
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Viruses 3:861-85 (2011)
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HTLV-1 Rex Tunes the Cellular Environment Favorable for Viral Replication.
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Viruses 8:58 (2016)
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PMID:22783232
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Shida H
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Role of Nucleocytoplasmic RNA Transport during the Life Cycle of Retroviruses.
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Front Microbiol 3:179 (2012)
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PMID:23248621
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Overview on HTLV-1 p12, p8, p30, p13: accomplices in persistent infection and viral pathogenesis.
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Front Microbiol 3:400 (2012)
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PMID:18421579
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HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches.
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Apoptosis 13:733-47 (2008)
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The human T-cell leukemia virus type 1 p13II protein: effects on mitochondrial function and cell growth.
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Cell Death Differ 12 Suppl 1:905-15 (2005)
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Silic-Benussi M, Biasiotto R, Andresen V, Franchini G, D'Agostino DM, Ciminale V
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HTLV-1 p13, a small protein with a busy agenda.
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Mol Aspects Med 31:350-8 (2010)
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PMID:23741982
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Fuentes-Gonzalez AM, Contreras-Paredes A, Manzo-Merino J, Lizano M
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The modulation of apoptosis by oncogenic viruses.
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Virol J 10:182 (2013)
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Human T-cell lymphotropic virus: a model of NF-kappaB-associated tumorigenesis.
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Viruses 3:714-49 (2011)
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Anti-apoptotic effect of Tax: an NF-kappaB path or a CREB way?
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Viruses 3:1001-14 (2011)
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Mechanisms of persistent NF-kappaB activation by HTLV-I tax.
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IUBMB Life 57:83-91 (2005)
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Oncogene 24:5952-64 (2005)
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Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.
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Nakachi S, Nakazato T, Ishikawa C, Kimura R, Mann DA, Senba M, Masuzaki H, Mori N
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Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling.
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Biochim Biophys Acta 1813:731-41 (2011)
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James CD, Roberts S
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Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
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Pathogens 5:E8 (2016)
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Cherian MA, Baydoun HH, Al-Saleem J, Shkriabai N, Kvaratskhelia M, Green P, Ratner L
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Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein.
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J Biol Chem 290:26270-81 (2015)
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Mori N, Morishita M, Tsukazaki T, Giam CZ, Kumatori A, Tanaka Y, Yamamoto N
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Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.
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Blood 97:2137-44 (2001)
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PMID:15310405
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Azran I, Schavinsky-Khrapunsky Y, Aboud M
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Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.
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Retrovirology 1:20 (2004)
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PMID:11244044
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Yoshida M
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Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
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Annu Rev Immunol 19:475-96 (2001)
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PMID:12802280
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Gabet AS, Mortreux F, Charneau P, Riou P, Duc-Dodon M, Wu Y, Jeang KT, Wattel E
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Inactivation of hTERT transcription by Tax.
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Oncogene 22:3734-41 (2003)
DOI:10.1038/sj.onc.1206468
Related
pathway
pgig03013  Nucleocytoplasmic transport
pgig04010  MAPK signaling pathway
pgig04064  NF-kappa B signaling pathway
pgig04110  Cell cycle
pgig04115  p53 signaling pathway
pgig04151  PI3K-Akt signaling pathway
pgig04210  Apoptosis
pgig04350  TGF-beta signaling pathway
pgig04612  Antigen processing and presentation
pgig04660  T cell receptor signaling pathway
pgig04668  TNF signaling pathway
KO pathway
ko05166   
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