KEGG   PATHWAY: phas05166
Entry
phas05166                   Pathway                                
Name
Human T-cell leukemia virus 1 infection - Phyllostomus hastatus (greater spear-nosed bat)
Description
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, and SRF.
Class
Human Diseases; Infectious disease: viral
Pathway map
phas05166  Human T-cell leukemia virus 1 infection
phas05166

Organism
Phyllostomus hastatus (greater spear-nosed bat) [GN:phas]
Gene
123832054  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
123806779  NRP1; neuropilin-1 isoform X1 [KO:K06724]
123833339  MYC; myc proto-oncogene protein [KO:K04377]
123811525  transformation/transcription domain-associated protein isoform X1 [KO:K08874]
123829511  KAT5; histone acetyltransferase KAT5 isoform X1 [KO:K11304] [EC:2.3.1.48]
123813418  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
123825537  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
123828067  ITGB2; integrin beta-2 [KO:K06464]
123828517  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
123807317  HRAS; GTPase HRas isoform X1 [KO:K02833]
123812406  KRAS; GTPase KRas isoform X1 [KO:K07827]
123804414  NRAS; GTPase NRas [KO:K07828]
123808110  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
123813640  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
123806569  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
123825523  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
123810628  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
123819664  TLN1; talin-1 isoform X1 [KO:K06271]
123807969  TLN2; talin-2 isoform X1 [KO:K06271]
123814002  RANBP3; ran-binding protein 3 isoform X1 [KO:K15304]
123823414  RAN; GTP-binding nuclear protein Ran [KO:K07936]
123811635  XPO1; exportin-1 [KO:K14290]
123828193  CALR; calreticulin isoform X1 [KO:K08057]
123810236  CANX; calnexin [KO:K08054]
123828197  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123820880  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123806766  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123811378  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
123820198  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
123826011  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
123815210  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
123805975  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
123820485  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
123816246  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
123824325  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
123816436  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
123828481  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
123817091  LOW QUALITY PROTEIN: signal transducer and activator of transcription 5A-like [KO:K11223]
123816875  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
123814106  IL2; interleukin-2 [KO:K05429]
123827873  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X1 [KO:K06751]
123827876  HLA class I histocompatibility antigen, alpha chain F-like isoform X1 [KO:K06751]
123827879  HLA class I histocompatibility antigen, alpha chain F-like [KO:K06751]
123827882  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
123827889  class I histocompatibility antigen, Gogo-C*0203 alpha chain-like [KO:K06751]
123813010  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
123828142  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
123828143  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
123828144  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
123828146  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
123828149  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X1 [KO:K06751]
123828150  class I histocompatibility antigen, B alpha chain-like [KO:K06751]
123828151  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
123828154  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
123813377  class I histocompatibility antigen, Gogo-C*0203 alpha chain-like isoform X1 [KO:K06751]
123813380  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
123813381  class I histocompatibility antigen, B alpha chain-like [KO:K06751]
123813382  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X1 [KO:K06751]
123813383  class I histocompatibility antigen, Gogo-C*0202 alpha chain-like [KO:K06751]
123813384  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
123813606  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
123821898  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
123815167  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
123822856  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
123822859  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
123822862  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
123816372  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
123816992  HLA class I histocompatibility antigen, alpha chain F-like [KO:K06751]
123810292  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
123825277  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
123825288  HLA class I histocompatibility antigen, B alpha chain-like isoform X1 [KO:K06751]
123825316  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
123825325  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
123825342  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
123818210  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
123818211  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X1 [KO:K06751]
123818213  class I histocompatibility antigen, Gogo-C*0202 alpha chain-like isoform X1 [KO:K06751]
123818217  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like isoform X1 [KO:K06751]
123825908  class I histocompatibility antigen, Gogo-B*0201 alpha chain-like isoform X1 [KO:K06751]
123825918  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
123825922  class I histocompatibility antigen, B alpha chain-like isoform X1 [KO:K06751]
123825923  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
123808707  B2M; beta-2-microglobulin [KO:K08055]
123833514  FDPS; farnesyl pyrophosphate synthase isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
123806839  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
123811817  ADP/ATP translocase 3-like [KO:K05863]
123805109  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
123814072  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
123807679  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
123830028  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
123820947  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
123807653  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
123816166  TSPO; translocator protein [KO:K05770]
123822158  TSPO2; translocator protein 2 [KO:K05770]
123806062  VAC14; protein VAC14 homolog isoform X1 [KO:K15305]
123806605  RANBP1; ran-specific GTPase-activating protein [KO:K15306]
123809412  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
123813867  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
123808254  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform X1 [KO:K06637] [EC:2.7.11.1]
123828891  BUB3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
123811515  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
123823439  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
123817244  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
123815883  ANAPC4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
123823167  ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
123807652  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
123822094  ANAPC7; anaphase-promoting complex subunit 7 [KO:K03354]
123811089  CDC23; cell division cycle protein 23 homolog isoform X1 [KO:K03355]
123814196  ANAPC10; anaphase-promoting complex subunit 10 [KO:K03357]
123816919  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
123819979  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
123813913  anaphase-promoting complex subunit 13-like [KO:K12456]
123830479  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
123805403  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
123820904  ANAPC16; anaphase-promoting complex subunit 16 isoform X1 [KO:K25229]
123831879  CDC20; cell division cycle protein 20 homolog [KO:K03363]
123810685  PTTG1; securin isoform X1 [KO:K06635]
123813111  ESPL1; separin [KO:K02365] [EC:3.4.22.49]
123808416  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
123819579  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
123820004  cyclin-dependent kinase inhibitor 2A-like isoform X1 [KO:K06621]
123812897  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
123829562  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
123821479  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
123822234  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
123818843  CCNA1; cyclin-A1 [KO:K06627]
123813988  CCNA2; cyclin-A2 [KO:K06627]
123833091  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
123805874  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
123813020  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
123818741  RB1; retinoblastoma-associated protein [KO:K06618]
123815031  E2F1; transcription factor E2F1 [KO:K17454]
123832315  E2F2; transcription factor E2F2 [KO:K09389]
123824076  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
123818096  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
123827058  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
123832554  CHEK1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
123810780  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
123809443  TP53; cellular tumor antigen p53 [KO:K04451]
123828291  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
123824527  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
123832298  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
123826750  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
123830565  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123831922  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123808608  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123823743  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123832297  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123826784  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
123829008  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
123810433  TNF; tumor necrosis factor isoform X1 [KO:K03156]
123810612  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
123819501  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
123809359  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
123820887  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
123806902  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
123807193  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
123831409  JUN; transcription factor AP-1 [KO:K04448]
123805486  MMP7; matrilysin [KO:K01397] [EC:3.4.24.23]
123811594  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
123811723  IL1R2; interleukin-1 receptor type 2 isoform X1 [KO:K04387]
123816833  uncharacterized protein LOC123816833 [KO:K10784]
123819998  CD3D; T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
123818673  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
123818852  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
123816809  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
123828668  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
123807522  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
123823081  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
123825207  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
123806785  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
123829518  RELA; transcription factor p65 [KO:K04735]
123809331  GPS2; G protein pathway suppressor 2 isoform X1 [KO:K15307]
123810603  LTBR; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159]
123814884  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
123816244  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C isoform X1 [KO:K05151]
123817083  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
123822966  RELB; transcription factor RelB [KO:K09253]
123828689  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
123823777  ZFP36; mRNA decay activator protein ZFP36 [KO:K15308]
123831329  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
123813840  IL15; interleukin-15 [KO:K05433]
123831204  IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
123811876  IL6; interleukin-6 isoform X1 [KO:K05405]
123811909  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
123810385  LTA; lymphotoxin-alpha isoform X1 [KO:K05468]
123814855  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
123827723  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
123823713  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
123804941  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
123808879  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
123819748  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
123830471  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
123826060  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
123808094  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
123825966  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
123811468  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
123824963  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
123822448  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
123820487  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
123826843  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
123812947  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
123805699  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
123833093  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
123807136  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
123828245  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
123816440  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
123810732  NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
123815923  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
123816020  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
123816129  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
123816250  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
123816448  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
123810280  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
123810358  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
123821969  SRF; serum response factor [KO:K04378]
123820551  ELK4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
123832645  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
123810220  SPI1; transcription factor PU.1 isoform X1 [KO:K09438]
123832500  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
123828039  ETS2; protein C-ets-2 [KO:K21932]
123821521  TATA-box-binding protein [KO:K03120]
123821542  TBPL1; TATA box-binding protein-like 1 [KO:K03120]
123808750  TBPL2; TATA box-binding protein-like 2 [KO:K03120]
123808226  FOS; proto-oncogene c-Fos [KO:K04379]
123813207  EGR1; early growth response protein 1 isoform X1 [KO:K09203]
123829606  FOSL1; fos-related antigen 1 [KO:K04502]
123820941  EGR2; E3 SUMO-protein ligase EGR2 [KO:K12496]
123828120  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
123804840  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
123819667  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
123813639  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
123829665  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
123810038  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
123808666  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
123816126  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
123811809  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
123810486  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
123828563  CRTC1; CREB-regulated transcription coactivator 1 isoform X1 [KO:K15309]
123804750  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
123809621  CRTC3; CREB-regulated transcription coactivator 3 isoform X1 [KO:K16334]
123807079  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
123816025  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
123830582  KAT2B; histone acetyltransferase KAT2B [KO:K06062] [EC:2.3.1.48]
123816776  KAT2A; histone acetyltransferase KAT2A isoform X1 [KO:K06062] [EC:2.3.1.48]
123813765  TCF3; transcription factor E2-alpha isoform X1 [KO:K09063]
123807739  POLB; DNA polymerase beta isoform X1 [KO:K02330] [EC:2.7.7.7 4.2.99.-]
123832115  LCK; tyrosine-protein kinase Lck isoform X1 [KO:K05856] [EC:2.7.10.2]
123830279  BAX; apoptosis regulator BAX [KO:K02159]
123830717  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
123824722  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
123828658  VENTX; homeobox protein VENTX [KO:K09341]
123815791  MSX1; homeobox protein MSX-1 [KO:K09341]
123810914  MSX2; homeobox protein MSX-2 [KO:K09341]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17384582
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
PMID:16155604
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
PMID:18702816
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
PMID:21994754
  Authors
Jones KS, Lambert S, Bouttier M, Benit L, Ruscetti FW, Hermine O, Pique C
  Title
Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
  Journal
Viruses 3:794-810 (2011)
DOI:10.3390/v3060794
Reference
PMID:21114861
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
DOI:10.1186/1742-4690-7-99
Reference
  Authors
Sinet F.
  Title
Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: a number of proteins play a key role in the establishment and maintenance of viral infection.
  Journal
BioSciences Master Reviews, July 2013
Reference
PMID:18923409
  Authors
Sattentau Q
  Title
Avoiding the void: cell-to-cell spread of human viruses.
  Journal
Nat Rev Microbiol 6:815-26 (2008)
DOI:10.1038/nrmicro1972
Reference
PMID:15040584
  Authors
Vicente-Manzanares M, Sanchez-Madrid F
  Title
Role of the cytoskeleton during leukocyte responses.
  Journal
Nat Rev Immunol 4:110-22 (2004)
DOI:10.1038/nri1268
Reference
PMID:27334587
  Authors
Dutartre H, Claviere M, Journo C, Mahieux R
  Title
Cell-Free versus Cell-to-Cell Infection by Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Type 1: Exploring the Link among Viral Source, Viral Trafficking, and Viral Replication.
  Journal
J Virol 90:7607-17 (2016)
DOI:10.1128/JVI.00407-16
Reference
PMID:15988028
  Authors
Awasthi S, Sharma A, Wong K, Zhang J, Matlock EF, Rogers L, Motloch P, Takemoto S, Taguchi H, Cole MD, Luscher B, Dittrich O, Tagami H, Nakatani Y, McGee M, Girard AM, Gaughan L, Robson CN, Monnat RJ Jr, Harrod R
  Title
A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions.
  Journal
Mol Cell Biol 25:6178-98 (2005)
DOI:10.1128/MCB.25.14.6178-6198.2005
Reference
PMID:21994758
  Authors
Edwards D, Fenizia C, Gold H, de Castro-Amarante MF, Buchmann C, Pise-Masison CA, Franchini G
  Title
Orf-I and orf-II-encoded proteins in HTLV-1 infection and persistence.
  Journal
Viruses 3:861-85 (2011)
DOI:10.3390/v3060861
Reference
PMID:26927155
  Authors
Nakano K, Watanabe T
  Title
HTLV-1 Rex Tunes the Cellular Environment Favorable for Viral Replication.
  Journal
Viruses 8:58 (2016)
DOI:10.3390/v8030058
Reference
PMID:22783232
  Authors
Shida H
  Title
Role of Nucleocytoplasmic RNA Transport during the Life Cycle of Retroviruses.
  Journal
Front Microbiol 3:179 (2012)
DOI:10.3389/fmicb.2012.00179
Reference
PMID:23248621
  Authors
Bai XT, Nicot C
  Title
Overview on HTLV-1 p12, p8, p30, p13: accomplices in persistent infection and viral pathogenesis.
  Journal
Front Microbiol 3:400 (2012)
DOI:10.3389/fmicb.2012.00400
Reference
PMID:18421579
  Authors
Taylor JM, Nicot C
  Title
HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches.
  Journal
Apoptosis 13:733-47 (2008)
DOI:10.1007/s10495-008-0208-7
Reference
PMID:15761473
  Authors
D'Agostino DM, Silic-Benussi M, Hiraragi H, Lairmore MD, Ciminale V
  Title
The human T-cell leukemia virus type 1 p13II protein: effects on mitochondrial function and cell growth.
  Journal
Cell Death Differ 12 Suppl 1:905-15 (2005)
DOI:10.1038/sj.cdd.4401576
Reference
PMID:20332002
  Authors
Silic-Benussi M, Biasiotto R, Andresen V, Franchini G, D'Agostino DM, Ciminale V
  Title
HTLV-1 p13, a small protein with a busy agenda.
  Journal
Mol Aspects Med 31:350-8 (2010)
DOI:10.1016/j.mam.2010.03.001
Reference
PMID:23741982
  Authors
Fuentes-Gonzalez AM, Contreras-Paredes A, Manzo-Merino J, Lizano M
  Title
The modulation of apoptosis by oncogenic viruses.
  Journal
Virol J 10:182 (2013)
DOI:10.1186/1743-422X-10-182
Reference
PMID:21743832
  Authors
Qu Z, Xiao G
  Title
Human T-cell lymphotropic virus: a model of NF-kappaB-associated tumorigenesis.
  Journal
Viruses 3:714-49 (2011)
DOI:10.3390/v3060714
Reference
PMID:21994767
  Authors
Saggioro D
  Title
Anti-apoptotic effect of Tax: an NF-kappaB path or a CREB way?
  Journal
Viruses 3:1001-14 (2011)
DOI:10.3390/v3071001
Reference
PMID:16036567
  Authors
Harhaj EW, Harhaj NS
  Title
Mechanisms of persistent NF-kappaB activation by HTLV-I tax.
  Journal
IUBMB Life 57:83-91 (2005)
DOI:10.1080/15216540500078715
Reference
PMID:16155602
  Authors
Sun SC, Yamaoka S
  Title
Activation of NF-kappaB by HTLV-I and implications for cell transformation.
  Journal
Oncogene 24:5952-64 (2005)
DOI:10.1038/sj.onc.1208969
Reference
PMID:9710600
  Authors
Geleziunas R, Ferrell S, Lin X, Mu Y, Cunningham ET Jr, Grant M, Connelly MA, Hambor JE, Marcu KB, Greene WC
  Title
Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.
  Journal
Mol Cell Biol 18:5157-65 (1998)
DOI:10.1128/MCB.18.9.5157
Reference
PMID:21315773
  Authors
Nakachi S, Nakazato T, Ishikawa C, Kimura R, Mann DA, Senba M, Masuzaki H, Mori N
  Title
Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling.
  Journal
Biochim Biophys Acta 1813:731-41 (2011)
DOI:10.1016/j.bbamcr.2011.02.002
Reference
PMID:26797638
  Authors
James CD, Roberts S
  Title
Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
  Journal
Pathogens 5:E8 (2016)
DOI:10.3390/pathogens5010008
Reference
PMID:26324707
  Authors
Cherian MA, Baydoun HH, Al-Saleem J, Shkriabai N, Kvaratskhelia M, Green P, Ratner L
  Title
Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein.
  Journal
J Biol Chem 290:26270-81 (2015)
DOI:10.1074/jbc.M115.684746
Reference
PMID:11264182
  Authors
Mori N, Morishita M, Tsukazaki T, Giam CZ, Kumatori A, Tanaka Y, Yamamoto N
  Title
Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.
  Journal
Blood 97:2137-44 (2001)
DOI:10.1182/blood.v97.7.2137
Reference
PMID:15310405
  Authors
Azran I, Schavinsky-Khrapunsky Y, Aboud M
  Title
Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.
  Journal
Retrovirology 1:20 (2004)
DOI:10.1186/1742-4690-1-20
Reference
PMID:11244044
  Authors
Yoshida M
  Title
Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
  Journal
Annu Rev Immunol 19:475-96 (2001)
DOI:10.1146/annurev.immunol.19.1.475
Reference
PMID:12802280
  Authors
Gabet AS, Mortreux F, Charneau P, Riou P, Duc-Dodon M, Wu Y, Jeang KT, Wattel E
  Title
Inactivation of hTERT transcription by Tax.
  Journal
Oncogene 22:3734-41 (2003)
DOI:10.1038/sj.onc.1206468
Related
pathway
phas03013  Nucleocytoplasmic transport
phas04010  MAPK signaling pathway
phas04064  NF-kappa B signaling pathway
phas04110  Cell cycle
phas04115  p53 signaling pathway
phas04151  PI3K-Akt signaling pathway
phas04210  Apoptosis
phas04350  TGF-beta signaling pathway
phas04612  Antigen processing and presentation
phas04660  T cell receptor signaling pathway
phas04668  TNF signaling pathway
KO pathway
ko05166   
LinkDB

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