KEGG   PATHWAY: phas05415
Entry
phas05415                   Pathway                                
Name
Diabetic cardiomyopathy - Phyllostomus hastatus (greater spear-nosed bat)
Description
Diabetic cardiomyopathy has been defined as left ventricular dysfunction that occurs among patients with diabetes mellitus independent of a recognized cause such as coronary artery disease or hypertension. The pathogenesis of diabetic cardiomyopathy broadly involves hyperglycemia, increased circulating fatty acids, and insulin resistance contributing to reactive oxygen species (ROS) generation, mitochondrial dysfunction, impaired calcium metabolism, Renin-Angiotensin System (RAS) activation, and altered substrate metabolism. These effects result in cardiac fibrosis, hypertrophy, cardiomyocyte death, contractile dysfunction, endothelial cell damage and eventually heart failure. In the process of cardiac fibrosis, cardiac fibroblasts are the final effector cell.
Class
Human Diseases; Cardiovascular disease
Pathway map
phas05415  Diabetic cardiomyopathy
phas05415

Organism
Phyllostomus hastatus (greater spear-nosed bat) [GN:phas]
Gene
123832054  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
123809243  SLC2A4; solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
123811607  GFPT1; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 [KO:K00820] [EC:2.6.1.16]
123808602  GFPT2; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 [KO:K00820] [EC:2.6.1.16]
123811379  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
123813723  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
123821027  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
123806400  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
123813365  TNNI3; troponin I, cardiac muscle [KO:K12044]
123832904  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
123821438  PLN; cardiac phospholamban [KO:K05852]
123822544  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
123809456  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
123825463  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
123812402  SP1; transcription factor Sp1 [KO:K04684]
123804835  AGT; angiotensinogen [KO:K09821]
123820662  REN; renin isoform X1 [KO:K01380] [EC:3.4.23.15]
123820465  chymase-like isoform X1 [KO:K01329] [EC:3.4.21.39]
123820484  mast cell protease 4-like [KO:K01329] [EC:3.4.21.39]
123825494  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
123810501  AGER; advanced glycosylation end product-specific receptor [KO:K19722]
123832753  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
123806369  NCF1; neutrophil cytosol factor 1 [KO:K08011]
123806190  cytochrome b-245 light chain [KO:K08009]
123818495  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
123816131  NCF4; neutrophil cytosol factor 4 [KO:K08012]
123810462  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
123816243  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
123827516  AGTR1; type-1 angiotensin II receptor [KO:K04166]
123806785  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
123829518  RELA; transcription factor p65 [KO:K04735]
123822258  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
123822259  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
123816206  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
123816247  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
123820887  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
123806902  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
123807193  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
123806069  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
123815340  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
123811431  COL1A2; collagen alpha-2(I) chain [KO:K06236]
123817007  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
123823454  COL3A1; collagen alpha-1(III) chain [KO:K19720]
123823713  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
123804941  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
123808879  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
123811382  CD36; platelet glycoprotein 4 [KO:K06259]
123816169  PPARA; peroxisome proliferator-activated receptor alpha isoform X1 [KO:K07294]
123816102  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
123811362  PDK4; pyruvate dehydrogenase kinase, isozyme 4 [KO:K00898] [EC:2.7.11.2]
123830007  PDK3; pyruvate dehydrogenase kinase, isozyme 3 isoform X1 [KO:K00898] [EC:2.7.11.2]
123817251  PDK2; pyruvate dehydrogenase kinase, isozyme 2 [KO:K00898] [EC:2.7.11.2]
123817558  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
123814537  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
123823438  PTPA; serine/threonine-protein phosphatase 2A activator [KO:K17605]
123821109  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
123829523  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
123822478  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
123807349  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
123831995  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
123830877  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial isoform X1 [KO:K08766] [EC:2.3.1.21]
123807354  INS; insulin isoform X1 [KO:K04526]
123811181  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
123828676  IRS1; insulin receptor substrate 1 [KO:K16172]
123826750  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
123830565  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123831922  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123828291  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
123824527  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
123832298  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
123829008  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
123808608  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123823743  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123832297  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123831556  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
123827255  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
123812688  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
123830251  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
123818766  TBC1D4; TBC1 domain family member 4 isoform X1 [KO:K17902]
123821780  MPC1; mitochondrial pyruvate carrier 1 isoform X1 [KO:K22138]
123832821  MPC1L; mitochondrial pyruvate carrier 1-like protein [KO:K22138]
123818395  MPC2; mitochondrial pyruvate carrier 2 [KO:K22139]
123806900  PDHA2; pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial isoform X1 [KO:K00161] [EC:1.2.4.1]
123830010  PDHA1; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial [KO:K00161] [EC:1.2.4.1]
123814286  PDHB; pyruvate dehydrogenase E1 component subunit beta, mitochondrial [KO:K00162] [EC:1.2.4.1]
123829375  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
123826178  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
123828050  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
123805221  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
123812472  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
123833351  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
123824163  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
123812021  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
123812535  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
123812941  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
123820504  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
123826900  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
123829019  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
123814503  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
123822907  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
123824647  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
123816179  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
123826555  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
123819642  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
123813492  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
123823171  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
123825565  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
123813983  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
123810668  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
123828390  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
123814093  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
123808962  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 isoform X1 [KO:K03957]
123829673  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial isoform X1 [KO:K03958]
123824497  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
123825798  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
123827131  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
123826773  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
123819739  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
123828268  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
123829684  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7-like [KO:K03963]
123829129  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
123833083  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
123806305  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9-like [KO:K03965]
123807255  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
123832760  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
123828735  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
123818338  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
123809989  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
123819553  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
123831898  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 isoform X1 [KO:K03938]
123824685  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
123813923  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
123829201  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
123813841  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
123805583  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
123824609  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
123832053  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
123818415  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
123807164  LOW QUALITY PROTEIN: succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
123807584  LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like [KO:K00237]
123818009  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
123806199  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
123832975  cytochrome c1, heme protein, mitochondrial [KO:K00413]
123830829  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
123825550  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
123831735  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
123832773  cytochrome b-c1 complex subunit 6, mitochondrial-like [KO:K00416]
123833068  cytochrome b-c1 complex subunit 7 [KO:K00417]
123806279  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit 7-like [KO:K00417]
123811889  cytochrome b-c1 complex subunit 8 isoform X1 [KO:K00418]
123810973  cytochrome b-c1 complex subunit 9 [KO:K00419]
123813621  cytochrome b-c1 complex subunit 10 [KO:K00420]
123806008  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
123815170  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
123825217  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
123811145  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
123821799  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
123825588  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
123833236  cytochrome c oxidase subunit 6B1-like [KO:K02267]
123813397  cytochrome c oxidase subunit 6B2 [KO:K02267]
123822567  cytochrome c oxidase subunit 6B1-like [KO:K02267]
123823826  cytochrome c oxidase subunit 6B1 [KO:K02267]
123824360  cytochrome c oxidase subunit 6B1-like [KO:K02267]
123824558  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 6B1-like [KO:K02267]
123825289  cytochrome c oxidase subunit 6B1-like [KO:K02267]
123811244  cytochrome c oxidase subunit 6C [KO:K02268]
123811371  cytochrome c oxidase subunit 6C [KO:K02268]
123811375  cytochrome c oxidase subunit 6C [KO:K02268]
123833100  cytochrome c oxidase subunit 6C [KO:K02268]
123808926  cytochrome c oxidase subunit 6C-like [KO:K02268]
123811641  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
123822051  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
123823748  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
123815903  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
123824316  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
123817363  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
123818042  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
123808025  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
123809182  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
123824839  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
123808735  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
123810432  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
123829465  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
123826185  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
123812902  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
123831098  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
123813700  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
123815079  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
123804392  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
123812687  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
123814039  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
123817223  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial isoform X1 [KO:K02128]
123816769  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
123828113  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
123826271  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
123826830  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
123819767  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
123806839  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
123820947  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
123807653  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
123811817  ADP/ATP translocase 3-like [KO:K05863]
123805109  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
123814072  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
123807679  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
123830028  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
123821079  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
123824140  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
123817951  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
123821125  LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
123806402  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
123829225  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
123810686  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
123804554  PARP1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
123823080  G6PD; glucose-6-phosphate 1-dehydrogenase isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
123807738  GSR; glutathione reductase, mitochondrial [KO:K00383] [EC:1.8.1.7]
123819748  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
123830471  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
123826060  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
123808094  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
123829335  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
123814755  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
123814917  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
123808665  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
123817563  ACE; angiotensin-converting enzyme isoform X1 [KO:K01283] [EC:3.4.15.1]
Compound
C00001  H2O
C00002  ATP
C00005  NADPH
C00006  NADP+
C00022  Pyruvate
C00024  Acetyl-CoA
C00027  Hydrogen peroxide
C00031  D-Glucose
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00051  Glutathione
C00076  Calcium cation
C00085  D-Fructose 6-phosphate
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00118  D-Glyceraldehyde 3-phosphate
C00127  Glutathione disulfide
C00162  Fatty acid
C00165  Diacylglycerol
C00195  N-Acylsphingosine
C00236  3-Phospho-D-glyceroyl phosphate
C00318  L-Carnitine
C00352  D-Glucosamine 6-phosphate
C00369  Starch
C00533  Nitric oxide
C00546  Methylglyoxal
C00704  Superoxide
C00794  D-Sorbitol
C00873  Angiotensin I
C02135  Angiotensin II
C02843  Long-chain acyl-CoA
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06156  alpha-D-Glucosamine 1-phosphate
C16844  Hydroxyl radical
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
C22310  Fructose 3-phosphate
C22311  3-Deoxyglucosone
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Related
pathway
phas00010  Glycolysis / Gluconeogenesis
phas00020  Citrate cycle (TCA cycle)
phas00190  Oxidative phosphorylation
phas00520  Amino sugar and nucleotide sugar metabolism
phas03320  PPAR signaling pathway
phas04071  Sphingolipid signaling pathway
phas04150  mTOR signaling pathway
phas04210  Apoptosis
phas04260  Cardiac muscle contraction
phas04350  TGF-beta signaling pathway
phas04614  Renin-angiotensin system
phas04910  Insulin signaling pathway
phas04930  Type II diabetes mellitus
phas04931  Insulin resistance
phas04933  AGE-RAGE signaling pathway in diabetic complications
phas04940  Type I diabetes mellitus
KO pathway
ko05415   
LinkDB

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