KEGG   PATHWAY: pleu05224
Entry
pleu05224                   Pathway                                
Name
Breast cancer - Peromyscus leucopus (white-footed mouse)
Description
Breast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gland. The molecular subtypes of breast cancer, which are based on the presence or absence of hormone receptors (estrogen and progesterone subtypes) and human epidermal growth factor receptor-2 (HER2), include: hormone receptor positive and HER2 negative (luminal A subtype), hormone receptor positive and HER2 positive (luminal B subtype), hormone receptor negative and HER2 positive (HER2 positive), and hormone receptor negative and HER2 negative (basal-like or triple-negative breast cancers (TNBCs)). Hormone receptor positive breast cancers are largely driven by the estrogen/ER pathway. In HER2 positive breast tumours, HER2 activates the PI3K/AKT and the RAS/RAF/MAPK pathways, and stimulate cell growth, survival and differentiation. In patients suffering from TNBC, the deregulation of various signalling pathways (Notch and Wnt/beta-catenin), EGFR protein have been confirmed. In the case of breast cancer only 8% of all cancers are hereditary, a phenomenon linked to genetic changes in BRCA1 or BRCA2. Somatic mutations in only three genes (TP53, PIK3CA and GATA3) occurred at >10% incidence across all breast cancers.
Class
Human Diseases; Cancer: specific types
Pathway map
pleu05224  Breast cancer
pleu05224

Organism
Peromyscus leucopus (white-footed mouse) [GN:pleu]
Gene
114707480  Esr1; estrogen receptor [KO:K08550]
114697733  Esr2; estrogen receptor beta [KO:K08551]
114697171  Ncoa1; nuclear receptor coactivator 1 isoform X1 [KO:K09101] [EC:2.3.1.48]
114692649  Ncoa3; nuclear receptor coactivator 3 isoform X1 [KO:K11256] [EC:2.3.1.48]
114698038  Fos; proto-oncogene c-Fos [KO:K04379]
114693768  Jun; transcription factor AP-1 [KO:K04448]
114696625  Sp1; transcription factor Sp1 isoform X1 [KO:K04684]
114694498  Ccnd1; G1/S-specific cyclin-D1 isoform X2 [KO:K04503]
114701991  Myc; myc proto-oncogene protein [KO:K04377]
114695676  Pgr; progesterone receptor [KO:K08556]
114708572  Wnt1; proto-oncogene Wnt-1 [KO:K03209]
114697207  Wnt4; protein Wnt-4 [KO:K00408]
114699851  Tnfsf11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
114706940  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
114708354  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
114707170  Fgf2; fibroblast growth factor 2 isoform X1 [KO:K18497]
114683479  Fgf18; fibroblast growth factor 18 [KO:K04358]
114684105  Fgf22; fibroblast growth factor 22 isoform X1 [KO:K04358]
114704240  Fgf10; fibroblast growth factor 10 [KO:K04358]
114704897  Fgf16; fibroblast growth factor 16 [KO:K04358]
114698782  Fgf17; fibroblast growth factor 17 [KO:K04358]
114693842  Fgf9; fibroblast growth factor 9 [KO:K04358]
114708136  Fgf8; fibroblast growth factor 8 isoform X2 [KO:K04358]
114701407  Fgf6; fibroblast growth factor 6 [KO:K04358]
114695166  Fgf20; fibroblast growth factor 20 [KO:K04358]
114695227  Fgf3; fibroblast growth factor 3 [KO:K04358]
114695229  Fgf4; fibroblast growth factor 4 [KO:K04358]
114695719  Fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
114709068  Fgf7; fibroblast growth factor 7 [KO:K04358]
114695237  Fgf19; fibroblast growth factor 19 [KO:K22603]
114684727  Fgf21; fibroblast growth factor 21 [KO:K22429]
114701473  Fgf23; fibroblast growth factor 23 [KO:K22428]
114681341  Fgfr1; fibroblast growth factor receptor 1 isoform X4 [KO:K04362] [EC:2.7.10.1]
114700619  Igf1; insulin-like growth factor I isoform X2 [KO:K05459]
114695462  Igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
114682692  Egf; pro-epidermal growth factor [KO:K04357]
114705532  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
114683608  Kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
114707889  Shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
114684102  Shc2; SHC-transforming protein 2 [KO:K17447]
114689488  Shc3; SHC-transforming protein 3 [KO:K17448]
114683897  Shc4; LOW QUALITY PROTEIN: SHC-transforming protein 4 [KO:K17449]
114707024  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
114684224  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
114681621  Sos1; son of sevenless homolog 1 [KO:K03099]
114685127  GTPase HRas-like [KO:K02833]
114688488  GTPase HRas-like [KO:K02833]
114693493  GTPase HRas-like [KO:K02833]
114693595  Hras; GTPase HRas isoform X1 [KO:K02833]
114696553  GTPase HRas-like [KO:K02833]
114708477  Kras; GTPase KRas isoform X2 [KO:K07827]
114698582  Nras; GTPase NRas [KO:K07828]
114703900  Araf; serine/threonine-protein kinase A-Raf isoform X2 [KO:K08845] [EC:2.7.11.1]
114706830  Braf; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
114689636  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
114691497  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
114688121  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
114682732  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114704332  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
114710523  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
114684032  Pik3cd; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
114693559  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
114695335  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
114688966  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
114706924  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
114703850  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
114690660  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114681524  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114703046  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114709670  Mtor; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
114685999  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
114699281  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
114702976  Jag1; protein jagged-1 [KO:K06052]
114703037  Jag2; protein jagged-2 isoform X1 [KO:K21635]
114691330  Dll1; delta-like protein 1 [KO:K06051]
114684632  Dll3; LOW QUALITY PROTEIN: delta-like protein 3 [KO:K06051]
114704625  Dll4; delta-like protein 4 [KO:K06051]
114692821  Notch1; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1 [KO:K02599]
114686260  Notch2; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 2 [KO:K20994]
114686138  Notch3; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 3 [KO:K20995]
114705807  Notch4; neurogenic locus notch homolog protein 4 [KO:K20996]
114707351  Hes1; transcription factor HES-1 [KO:K06054]
114708255  Hes5; transcription factor HES-5 [KO:K06055]
114681158  Heyl; LOW QUALITY PROTEIN: hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091]
114692533  Hey2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
114707632  Hey1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
114681497  Flt4; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
114706157  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
114696755  Nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
114707263  Wnt2b; protein Wnt-2b [KO:K00182]
114694717  Wnt2; protein Wnt-2 [KO:K00182]
114682971  Wnt3a; protein Wnt-3a [KO:K00312]
114702271  Wnt3; proto-oncogene Wnt-3 [KO:K00312]
114700757  Wnt5b; protein Wnt-5b [KO:K00444]
114702120  Wnt5a; protein Wnt-5a isoform X1 [KO:K00444]
114709311  Wnt6; protein Wnt-6 [KO:K00445]
114681319  Wnt7a; protein Wnt-7a [KO:K00572]
114699199  Wnt7b; protein Wnt-7b isoform X1 [KO:K00572]
114705144  Wnt8a; protein Wnt-8a [KO:K00714]
114708149  Wnt8b; protein Wnt-8b [KO:K00714]
114683006  Wnt9a; protein Wnt-9a [KO:K01064]
114702202  Wnt9b; protein Wnt-9b [KO:K01064]
114708546  Wnt10b; protein Wnt-10b [KO:K01357]
114709307  Wnt10a; LOW QUALITY PROTEIN: protein Wnt-10a [KO:K01357]
114698691  Wnt11; protein Wnt-11 isoform X1 [KO:K01384]
114695609  Wnt16; protein Wnt-16 [KO:K01558]
114685753  Fzd7; frizzled-7 [KO:K02432]
114687963  Fzd1; frizzled-1 [KO:K02432]
114702239  Fzd2; frizzled-2 [KO:K02235]
114707293  Fzd3; frizzled-3 isoform X1 [KO:K02329]
114710708  Fzd4; frizzled-4 [KO:K02354]
114705069  Fzd5; frizzled-5 [KO:K02375]
114695763  Fzd8; frizzled-8 [KO:K02375]
114699911  Fzd6; frizzled-6 [KO:K02376]
114686016  Fzd9; frizzled-9 [KO:K02842]
114693690  Fzd10; frizzled-10 [KO:K02842]
114694590  Lrp5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
114710353  Lrp6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
114683308  Dvl3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
114693209  Dvl2; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
114708251  Dvl1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
114706884  proto-oncogene FRAT1 [KO:K03069]
114706894  LOW QUALITY PROTEIN: GSK-3-binding protein FRAT2-like [KO:K03096]
114701479  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
114709466  Axin1; axin-1 isoform X1 [KO:K02157]
114690442  Axin2; axin-2 [KO:K04385]
114684081  Apc2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
114705120  Apc; adenomatous polyposis coli protein isoform X1 [KO:K02085]
114681270  Ctnnb1; catenin beta-1 isoform X1 [KO:K02105]
114707394  Csnk1a1; casein kinase I isoform X2 [KO:K08957] [EC:2.7.11.1]
114683055  Tcf7; transcription factor 7 isoform X2 [KO:K02620]
114681591  Tcf7l1; transcription factor 7-like 1 isoform X1 [KO:K04490]
114697060  Tcf7l2; transcription factor 7-like 2 isoform X1 [KO:K04491]
114682816  Lef1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
114693171  Tp53; cellular tumor antigen p53 [KO:K04451]
114688301  Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
114689482  Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
114700921  Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
114684640  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
114706143  Bak1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
114699687  Ddb2; DNA damage-binding protein 2 [KO:K10140]
114694653  Polk; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
114704814  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
114688249  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
114698792  Rb1; retinoblastoma-associated protein isoform X1 [KO:K06618]
114706553  E2f1; LOW QUALITY PROTEIN: transcription factor E2F1 [KO:K17454]
114697224  E2f2; transcription factor E2F2 isoform X1 [KO:K09389]
114701050  E2f3; transcription factor E2F3 isoform X1 [KO:K06620]
114682837  Brca1; LOW QUALITY PROTEIN: breast cancer type 1 susceptibility protein [KO:K10605] [EC:2.3.2.27]
114699159  Brca2; LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein [KO:K08775]
Compound
C00410  Progesterone
C00951  Estradiol-17beta
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:24649067
  Authors
Zhang MH, Man HT, Zhao XD, Dong N, Ma SL
  Title
Estrogen receptor-positive breast cancer molecular signatures and therapeutic potentials (Review).
  Journal
Biomed Rep 2:41-52 (2014)
DOI:10.3892/br.2013.187
Reference
PMID:27390604
  Authors
Dai X, Xiang L, Li T, Bai Z
  Title
Cancer Hallmarks, Biomarkers and Breast Cancer Molecular Subtypes.
  Journal
J Cancer 7:1281-94 (2016)
DOI:10.7150/jca.13141
Reference
PMID:20436504
  Authors
Schnitt SJ
  Title
Classification and prognosis of invasive breast cancer: from morphology to molecular taxonomy.
  Journal
Mod Pathol 23 Suppl 2:S60-4 (2010)
DOI:10.1038/modpathol.2010.33
Reference
PMID:23000897
  Authors
  Title
Comprehensive molecular portraits of human breast tumours.
  Journal
Nature 490:61-70 (2012)
DOI:10.1038/nature11412
Reference
PMID:22178455
  Authors
Eroles P, Bosch A, Perez-Fidalgo JA, Lluch A
  Title
Molecular biology in breast cancer: intrinsic subtypes and signaling pathways.
  Journal
Cancer Treat Rev 38:698-707 (2012)
DOI:10.1016/j.ctrv.2011.11.005
Reference
  Authors
Karamouzis MV, Papavassiliou KA, Adamopoulos C, Papavassiliou AG.
  Title
Targeting androgen/estrogen receptors crosstalk in cancer
  Journal
Trends Cancer 2:35-48 (2016)
DOI:10.1016/j.trecan.2015.12.001
Reference
  Authors
Sharp A, Harper-Wynne C.
  Title
Treatment of advanced breast cancer (ABC): the expanding landscape of targeted therapies
  Journal
J Cancer Biol Res 2:1036 (2014)
Reference
PMID:24596345
  Authors
Byler S, Goldgar S, Heerboth S, Leary M, Housman G, Moulton K, Sarkar S
  Title
Genetic and epigenetic aspects of breast cancer progression and therapy.
  Journal
Anticancer Res 34:1071-7 (2014)
Reference
PMID:23988612
  Authors
Mohamed A, Krajewski K, Cakar B, Ma CX
  Title
Targeted therapy for breast cancer.
  Journal
Am J Pathol 183:1096-112 (2013)
DOI:10.1016/j.ajpath.2013.07.005
Reference
PMID:22722193
  Authors
Ellis MJ, Ding L, Shen D, Luo J, Suman VJ, Wallis JW, Van Tine BA, Hoog J, Goiffon RJ, Goldstein TC, Ng S, Lin L, Crowder R, Snider J, Ballman K, Weber J, Chen K, Koboldt DC, Kandoth C, Schierding WS, McMichael JF, Miller CA, Lu C, Harris CC, McLellan MD, Wendl MC, DeSchryver K, Allred DC, Esserman L, Unzeitig G, Margenthaler J, Babiera GV, Marcom PK, Guenther JM, Leitch M, Hunt K, Olson J, Tao Y, Maher CA, Fulton LL, Fulton RS, Harrison M, Oberkfell B, Du F, Demeter R, Vickery TL, Elhammali A, Piwnica-Worms H, McDonald S, Watson M, Dooling DJ, Ota D, Chang LW, Bose R, Ley TJ, Piwnica-Worms D, Stuart JM, Wilson RK, Mardis ER
  Title
Whole-genome analysis informs breast cancer response to aromatase inhibition.
  Journal
Nature 486:353-60 (2012)
DOI:10.1038/nature11143
Reference
PMID:25907219
  Authors
Ma CX, Reinert T, Chmielewska I, Ellis MJ
  Title
Mechanisms of aromatase inhibitor resistance.
  Journal
Nat Rev Cancer 15:261-75 (2015)
DOI:10.1038/nrc3920
Reference
PMID:16113099
  Authors
Butt AJ, McNeil CM, Musgrove EA, Sutherland RL
  Title
Downstream targets of growth factor and oestrogen signalling and endocrine resistance: the potential roles of c-Myc, cyclin D1 and cyclin E.
  Journal
Endocr Relat Cancer 12 Suppl 1:S47-59 (2005)
DOI:10.1677/erc.1.00993
Reference
PMID:24111892
  Authors
Dasgupta S, Lonard DM, O'Malley BW
  Title
Nuclear receptor coactivators: master regulators of human health and disease.
  Journal
Annu Rev Med 65:279-92 (2014)
DOI:10.1146/annurev-med-051812-145316
Reference
PMID:23702927
  Authors
Brisken C
  Title
Progesterone signalling in breast cancer: a neglected hormone coming into the limelight.
  Journal
Nat Rev Cancer 13:385-96 (2013)
DOI:10.1038/nrc3518
Reference
PMID:20087430
  Authors
Scarpin KM, Graham JD, Mote PA, Clarke CL
  Title
Progesterone action in human tissues: regulation by progesterone receptor (PR) isoform expression, nuclear positioning and coregulator expression.
  Journal
Nucl Recept Signal 7:e009 (2009)
DOI:10.1621/nrs.07009
Reference
PMID:24291072
  Authors
Knutson TP, Lange CA
  Title
Tracking progesterone receptor-mediated actions in breast cancer.
  Journal
Pharmacol Ther 142:114-25 (2014)
DOI:10.1016/j.pharmthera.2013.11.010
Reference
PMID:25544707
  Authors
Dittrich A, Gautrey H, Browell D, Tyson-Capper A
  Title
The HER2 Signaling Network in Breast Cancer--Like a Spider in its Web.
  Journal
J Mammary Gland Biol Neoplasia 19:253-70 (2014)
DOI:10.1007/s10911-014-9329-5
Reference
PMID:21965336
  Authors
Higgins MJ, Baselga J
  Title
Targeted therapies for breast cancer.
  Journal
J Clin Invest 121:3797-803 (2011)
DOI:10.1172/JCI57152
Reference
PMID:26028978
  Authors
Mukohara T
  Title
PI3K mutations in breast cancer: prognostic and therapeutic implications.
  Journal
Breast Cancer (Dove Med Press) 7:111-23 (2015)
DOI:10.2147/BCTT.S60696
Reference
PMID:19088017
  Authors
Schneider BP, Winer EP, Foulkes WD, Garber J, Perou CM, Richardson A, Sledge GW, Carey LA
  Title
Triple-negative breast cancer: risk factors to potential targets.
  Journal
Clin Cancer Res 14:8010-8 (2008)
DOI:10.1158/1078-0432.CCR-08-1208
Reference
PMID:21898546
  Authors
King TD, Suto MJ, Li Y
  Title
The Wnt/beta-catenin signaling pathway: a potential therapeutic target in the treatment of triple negative breast cancer.
  Journal
J Cell Biochem 113:13-8 (2012)
DOI:10.1002/jcb.23350
Reference
PMID:11737884
  Authors
Brown AM
  Title
Wnt signaling in breast cancer: have we come full circle?
  Journal
Breast Cancer Res 3:351-5 (2001)
DOI:10.1186/bcr321
Reference
PMID:21076461
  Authors
Geyer FC, Lacroix-Triki M, Savage K, Arnedos M, Lambros MB, MacKay A, Natrajan R, Reis-Filho JS
  Title
beta-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation.
  Journal
Mod Pathol 24:209-31 (2011)
DOI:10.1038/modpathol.2010.205
Reference
PMID:20971825
  Authors
Al-Hussaini H, Subramanyam D, Reedijk M, Sridhar SS
  Title
Notch signaling pathway as a therapeutic target in breast cancer.
  Journal
Mol Cancer Ther 10:9-15 (2011)
DOI:10.1158/1535-7163.MCT-10-0677
Reference
PMID:26968398
  Authors
Rangel MC, Bertolette D, Castro NP, Klauzinska M, Cuttitta F, Salomon DS
  Title
Developmental signaling pathways regulating mammary stem cells and contributing to the etiology of triple-negative breast cancer.
  Journal
Breast Cancer Res Treat 156:211-26 (2016)
DOI:10.1007/s10549-016-3746-7
Reference
PMID:26040571
  Authors
Jamdade VS, Sethi N, Mundhe NA, Kumar P, Lahkar M, Sinha N
  Title
Therapeutic targets of triple-negative breast cancer: a review.
  Journal
Br J Pharmacol 172:4228-37 (2015)
DOI:10.1111/bph.13211
Reference
PMID:23196196
  Authors
Karamboulas C, Ailles L
  Title
Developmental signaling pathways in cancer stem cells of solid tumors.
  Journal
Biochim Biophys Acta 1830:2481-95 (2013)
DOI:10.1016/j.bbagen.2012.11.008
Reference
PMID:23881035
  Authors
Ignatiadis M, Sotiriou C
  Title
Luminal breast cancer: from biology to treatment.
  Journal
Nat Rev Clin Oncol 10:494-506 (2013)
DOI:10.1038/nrclinonc.2013.124
Reference
PMID:25013431
  Authors
Shin SJ, Gong G, Lee HJ, Kang J, Bae YK, Lee A, Cho EY, Lee JS, Suh KS, Lee DW, Jung WH
  Title
Positive expression of insulin-like growth factor-1 receptor is associated with a positive hormone receptor status and a favorable prognosis in breast cancer.
  Journal
J Breast Cancer 17:113-20 (2014)
DOI:10.4048/jbc.2014.17.2.113
Reference
PMID:11879567
  Authors
Gasco M, Shami S, Crook T
  Title
The p53 pathway in breast cancer.
  Journal
Breast Cancer Res 4:70-6 (2002)
DOI:10.1186/bcr426
Reference
PMID:15343273
  Authors
Narod SA, Foulkes WD
  Title
BRCA1 and BRCA2: 1994 and beyond.
  Journal
Nat Rev Cancer 4:665-76 (2004)
DOI:10.1038/nrc1431
Related
pathway
pleu03440  Homologous recombination
pleu04010  MAPK signaling pathway
pleu04110  Cell cycle
pleu04115  p53 signaling pathway
pleu04151  PI3K-Akt signaling pathway
pleu04310  Wnt signaling pathway
pleu04330  Notch signaling pathway
pleu04915  Estrogen signaling pathway
KO pathway
ko05224   
LinkDB

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