KEGG   PATHWAY: plop05166
Entry
plop05166                   Pathway                                
Name
Human T-cell leukemia virus 1 infection - Perognathus longimembris pacificus (Pacific pocket mouse)
Description
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, and SRF.
Class
Human Diseases; Infectious disease: viral
Pathway map
plop05166  Human T-cell leukemia virus 1 infection
plop05166

Organism
Perognathus longimembris pacificus (Pacific pocket mouse) [GN:plop]
Gene
125355023  Slc2a1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
125367101  Nrp1; neuropilin-1 isoform X1 [KO:K06724]
125360808  Myc; myc proto-oncogene protein [KO:K04377]
125366930  transformation/transcription domain-associated protein isoform X1 [KO:K08874]
125361156  Kat5; histone acetyltransferase KAT5 isoform X1 [KO:K11304] [EC:2.3.1.48]
125341191  Itgal; integrin alpha-L [KO:K05718]
125351175  LOW QUALITY PROTEIN: integrin beta-2-like [KO:K06464]
125351390  Itgb2; integrin beta-2 isoform X1 [KO:K06464]
125345006  integrin beta-2-like [KO:K06464]
125348743  Icam1; intercellular adhesion molecule 1 [KO:K06490]
125362333  Hras; GTPase HRas isoform X1 [KO:K02833]
125342925  Kras; GTPase KRas isoform X1 [KO:K07827]
125355453  Nras; GTPase NRas [KO:K07828]
125340362  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
125348606  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
125340801  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
125349325  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
125339566  Tln1; talin-1 isoform X1 [KO:K06271]
125340800  Tln2; talin-2 [KO:K06271]
125348569  Ranbp3; ran-binding protein 3 isoform X1 [KO:K15304]
125347875  GTP-binding nuclear protein Ran-like [KO:K07936]
125349228  Ran; GTP-binding nuclear protein Ran [KO:K07936]
125356409  Xpo1; exportin-1 [KO:K14290]
125348828  Calr; calreticulin [KO:K08057]
125355673  calreticulin-like [KO:K08057]
125342170  Canx; calnexin isoform X1 [KO:K08054]
125346456  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125339659  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125341424  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125356276  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
125346113  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
125363835  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
125353892  Nfatc2; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
125358263  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
125345045  nuclear factor of activated T-cells, cytoplasmic 4-like [KO:K17334]
125345056  Nfatc4; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
125353753  Il2rb; interleukin-2 receptor subunit beta [KO:K05069]
125343243  Il2rg; cytokine receptor common subunit gamma [KO:K05070]
125355256  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
125348908  Jak3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
125366352  signal transducer and activator of transcription 5A [KO:K11223]
125365131  Stat5b; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
125341318  Il2; interleukin-2 [KO:K05429]
125352790  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
125352791  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
125352794  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
125352795  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like [KO:K06751]
125352797  HLA class I histocompatibility antigen, B alpha chain-like [KO:K06751]
125340587  B2m; beta-2-microglobulin [KO:K08055]
125351089  beta-2-microglobulin-like [KO:K08055]
125359211  Fdps; farnesyl pyrophosphate synthase isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
125341918  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
125358491  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1-like [KO:K05862]
125339621  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
125341476  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
125343942  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
125346491  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
125342990  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 2-like [KO:K15040]
125359238  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 2-like [KO:K15040]
125339434  Vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
125359898  voltage-dependent anion-selective channel protein 3-like [KO:K15041]
125357376  Tspo; translocator protein [KO:K05770]
125352614  Tspo2; LOW QUALITY PROTEIN: translocator protein 2 [KO:K05770]
125358202  Vac14; protein VAC14 homolog isoform X1 [KO:K15305]
125349397  Ranbp1; ran-specific GTPase-activating protein isoform X1 [KO:K15306]
125339280  Mad1l1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
125341601  Mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
125340885  Bub1b; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
125345969  Bub3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
125356077  Anapc1; anaphase-promoting complex subunit 1 [KO:K03348]
125351669  Anapc2; anaphase-promoting complex subunit 2 [KO:K03349]
125366513  Cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
125364972  Anapc4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
125349147  Anapc5; LOW QUALITY PROTEIN: anaphase-promoting complex subunit 5 [KO:K03352]
125348082  Cdc16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
125349128  Anapc7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
125367839  Cdc23; cell division cycle protein 23 homolog [KO:K03355]
125341718  Anapc10; anaphase-promoting complex subunit 10 [KO:K03357]
125365246  Anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
125346823  Cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
125342307  Anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
125352270  anaphase-promoting complex subunit 13-like [KO:K12456]
125361197  Anapc15; anaphase-promoting complex subunit 15 [KO:K25228]
125346437  Anapc16; anaphase-promoting complex subunit 16 isoform X1 [KO:K25229]
125367467  anaphase-promoting complex subunit 16-like [KO:K25229]
125355022  Cdc20; cell division cycle protein 20 homolog [KO:K03363]
125341864  Pttg1; securin [KO:K06635]
125364055  Espl1; separin isoform X1 [KO:K02365] [EC:3.4.22.49]
125340324  Ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
125360741  cyclin-dependent kinase 4 inhibitor B-like [KO:K04685]
125360604  cyclin-dependent kinase inhibitor 2A-like [KO:K06621]
125362060  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
125362637  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
125352590  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
125352645  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
125339709  LOW QUALITY PROTEIN: cyclin-A2-like [KO:K06627]
125347890  Ccna1; cyclin-A1 [KO:K06627]
125341412  Ccna2; cyclin-A2 [KO:K06627]
125338744  Ccne1; G1/S-specific cyclin-E1 [KO:K06626]
125360962  Ccne2; G1/S-specific cyclin-E2 [KO:K06626]
125363256  Cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
125348277  Rb1; retinoblastoma-associated protein isoform X1 [KO:K06618]
125352360  E2f1; transcription factor E2F1 [KO:K17454]
125354710  E2f2; transcription factor E2F2 [KO:K09389]
125352980  E2f3; transcription factor E2F3 isoform X1 [KO:K06620]
125349550  Atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
125342646  Atr; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
125349506  Chek1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
125348986  Chek2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
125365886  Tp53; cellular tumor antigen p53 [KO:K04451]
125367817  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
125355095  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
125348916  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
125354550  Pik3cd; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
125342393  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
125351954  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
125338979  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125363440  LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
125363452  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125359645  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125351837  Dlg1; disks large homolog 1 isoform X1 [KO:K12076]
125343908  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
125352808  Tnf; tumor necrosis factor [KO:K03156]
125367414  Map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
125366471  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
125346549  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
125341845  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
125364712  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
125355221  Jun; transcription factor Jun [KO:K04448]
125349683  Mmp7; matrilysin [KO:K01397] [EC:3.4.24.23]
125356117  Il1r1; interleukin-1 receptor type 1 [KO:K04386]
125356835  Il1r2; interleukin-1 receptor type 2 [KO:K04387]
125349618  T-cell surface glycoprotein CD3 delta chain [KO:K06450]
125347803  T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
125347804  T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
125365123  Map3k3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
125346167  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
125339226  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
125343265  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
125363243  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
125341680  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
125361933  Rela; transcription factor p65 isoform X1 [KO:K04735]
125366461  Gps2; G protein pathway suppressor 2 isoform X1 [KO:K15307]
125353853  Cd40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
125365518  Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
125368265  Relb; transcription factor RelB [KO:K09253]
125346119  Nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
125367914  Zfp36; mRNA decay activator protein ZFP36 [KO:K15308]
125367340  Il2ra; interleukin-2 receptor subunit alpha [KO:K05068]
125341450  Il15; interleukin-15 [KO:K05433]
125367339  Il15ra; interleukin-15 receptor subunit alpha [KO:K05074]
125342101  Csf2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
125353519  Lta; lymphotoxin-alpha [KO:K05468]
125353354  Bcl2l1; bcl-2-like protein 1 isoform X1 [KO:K04570]
125343374  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
125338685  Tgfb1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
125359114  Tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
125363309  Tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
125345915  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
125353128  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
125364233  Smad2; mothers against decapentaplegic homolog 2 [KO:K04500]
125341157  Smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
125364252  Smad4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
125345732  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
125367715  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
125356676  Adcy3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
125363469  Adcy4; LOW QUALITY PROTEIN: adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
125345042  LOW QUALITY PROTEIN: adenylate cyclase type 4-like [KO:K08044] [EC:4.6.1.1]
125351778  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
125365347  Adcy6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
125358478  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
125360503  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
125340976  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
125348811  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
125355340  Prkacb; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
125359274  Nfyb; nuclear transcription factor Y subunit beta [KO:K08065]
125353511  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
125352188  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
125352379  HLA class II histocompatibility antigen, DR beta 4 chain-like [KO:K06752]
125352715  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
125352717  HLA class II histocompatibility antigen, DP alpha 1 chain isoform X1 [KO:K06752]
125352718  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
125352720  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
125352723  HLA class II histocompatibility antigen, DO beta chain-like isoform X1 [KO:K06752]
125352725  HLA class II histocompatibility antigen, DR beta 3 chain-like isoform X1 [KO:K06752]
125352726  HLA class II histocompatibility antigen, DR beta 4 chain-like isoform X1 [KO:K06752]
125352727  HLA class II histocompatibility antigen, DR beta 4 chain-like [KO:K06752]
125352728  HLA class II histocompatibility antigen, DR beta 5 chain-like [KO:K06752]
125352729  HLA class II histocompatibility antigen, DR beta 5 chain-like [KO:K06752]
125352734  mamu class II histocompatibility antigen, DR alpha chain [KO:K06752]
125352568  Srf; serum response factor [KO:K04378]
125359378  Elk4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
125343348  Elk1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
125362209  Spi1; transcription factor PU.1 isoform X1 [KO:K09438]
125349488  Ets1; protein C-ets-1 isoform X1 [KO:K02678]
125351451  Ets2; protein C-ets-2 [KO:K21932]
125363066  Tbpl2; TATA box-binding protein-like 2 [KO:K03120]
125357302  Tbpl1; TATA box-binding protein-like 1 isoform X1 [KO:K03120]
125357508  TATA-box-binding protein isoform X1 [KO:K03120]
125363230  Fos; protein c-Fos [KO:K04379]
125340054  Egr1; early growth response protein 1 [KO:K09203]
125361856  Fosl1; fos-related antigen 1 [KO:K04502]
125346366  Egr2; E3 SUMO-protein ligase EGR2 [KO:K12496]
125350355  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
125347188  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
125339860  Creb3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
125362185  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
125348600  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
125359105  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
125350538  Atf2; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
125358158  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
125346776  Creb5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
125352747  Atf6b; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
125348934  Crtc1; CREB-regulated transcription coactivator 1 isoform X1 [KO:K15309]
125359104  Crtc2; CREB-regulated transcription coactivator 2 [KO:K16333]
125368068  Crtc3; CREB-regulated transcription coactivator 3 isoform X1 [KO:K16334]
125340965  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
125357982  Ep300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
125358646  Kat2b; histone acetyltransferase KAT2B [KO:K06062] [EC:2.3.1.48]
125365898  Kat2a; histone acetyltransferase KAT2A isoform X1 [KO:K06062] [EC:2.3.1.48]
125348488  Tcf3; transcription factor E2-alpha isoform X1 [KO:K09063]
125339359  Polb; DNA polymerase beta isoform X1 [KO:K02330] [EC:2.7.7.7 4.2.99.-]
125363317  DNA polymerase beta-like [KO:K02330] [EC:2.7.7.7 4.2.99.-]
125354858  Lck; tyrosine-protein kinase Lck [KO:K05856] [EC:2.7.10.2]
125338870  Bax; apoptosis regulator BAX [KO:K02159]
125355142  Cdkn2c; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
125345084  LOW QUALITY PROTEIN: telomerase reverse transcriptase-like [KO:K11126] [EC:2.7.7.49]
125345087  telomerase reverse transcriptase-like [KO:K11126] [EC:2.7.7.49]
125364489  Msx1; homeobox protein MSX-1 [KO:K09341]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17384582
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
PMID:16155604
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
PMID:18702816
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
PMID:21994754
  Authors
Jones KS, Lambert S, Bouttier M, Benit L, Ruscetti FW, Hermine O, Pique C
  Title
Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
  Journal
Viruses 3:794-810 (2011)
DOI:10.3390/v3060794
Reference
PMID:21114861
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
DOI:10.1186/1742-4690-7-99
Reference
  Authors
Sinet F.
  Title
Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: a number of proteins play a key role in the establishment and maintenance of viral infection.
  Journal
BioSciences Master Reviews, July 2013
Reference
PMID:18923409
  Authors
Sattentau Q
  Title
Avoiding the void: cell-to-cell spread of human viruses.
  Journal
Nat Rev Microbiol 6:815-26 (2008)
DOI:10.1038/nrmicro1972
Reference
PMID:15040584
  Authors
Vicente-Manzanares M, Sanchez-Madrid F
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Role of the cytoskeleton during leukocyte responses.
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J Virol 90:7607-17 (2016)
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HTLV-1 Rex Tunes the Cellular Environment Favorable for Viral Replication.
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Front Microbiol 3:179 (2012)
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Blood 97:2137-44 (2001)
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Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.
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Retrovirology 1:20 (2004)
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Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
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Annu Rev Immunol 19:475-96 (2001)
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PMID:12802280
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Gabet AS, Mortreux F, Charneau P, Riou P, Duc-Dodon M, Wu Y, Jeang KT, Wattel E
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Inactivation of hTERT transcription by Tax.
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Oncogene 22:3734-41 (2003)
DOI:10.1038/sj.onc.1206468
Related
pathway
plop03013  Nucleocytoplasmic transport
plop04010  MAPK signaling pathway
plop04064  NF-kappa B signaling pathway
plop04110  Cell cycle
plop04115  p53 signaling pathway
plop04151  PI3K-Akt signaling pathway
plop04210  Apoptosis
plop04350  TGF-beta signaling pathway
plop04612  Antigen processing and presentation
plop04660  T cell receptor signaling pathway
plop04668  TNF signaling pathway
KO pathway
ko05166   
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