KEGG   PATHWAY: pteh04062
Entry
pteh04062                   Pathway                                
Name
Chemokine signaling pathway - Piliocolobus tephrosceles (Ugandan red Colobus)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
pteh04062  Chemokine signaling pathway
pteh04062

Other DBs
GO: 0070098
Organism
Piliocolobus tephrosceles (Ugandan red Colobus) [GN:pteh]
Gene
111528185  growth-regulated alpha protein-like isoform X2 [KO:K05505]
111531279  growth-regulated protein homolog gamma-like [KO:K05505]
111531286  CXCL1; growth-regulated alpha protein [KO:K05505]
111524574  growth-regulated alpha protein-like [KO:K05505]
111531293  CXCL6; C-X-C motif chemokine 6 [KO:K05506]
111532251  C-X-C motif chemokine 5-like [KO:K05506]
111532227  C-X-C motif chemokine 5-like [KO:K05506]
111531282  PPBP; platelet basic protein [KO:K10029]
111531283  CXCL8; interleukin-8 [KO:K10030]
111549408  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
111549386  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
111549385  CXCL11; C-X-C motif chemokine 11 isoform X1 [KO:K12672]
111531323  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
111549402  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
111521302  CXCL16; C-X-C motif chemokine 16 [KO:K10035]
111531288  PF4V1; platelet factor 4 variant [KO:K05407]
111531294  platelet factor 4 isoform X1 [KO:K05407]
111528882  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
113222923  lymphotactin-like [KO:K05507]
111539246  lymphotactin [KO:K05507]
111539307  lymphotactin [KO:K05507]
111541283  CX3CL1; fractalkine isoform X1 [KO:K05508]
111526860  CCL1; C-C motif chemokine 1 [KO:K05514]
111526876  C-C motif chemokine 2 isoform X1 [KO:K14624]
111529368  C-C motif chemokine 3 [KO:K05408]
111520807  C-C motif chemokine 3-like 1 [KO:K05408]
113221818  C-C motif chemokine 3 [KO:K05408]
111529365  C-C motif chemokine 4-like [KO:K12964]
111520266  C-C motif chemokine 4-like [KO:K12964]
113221820  C-C motif chemokine 4-like [KO:K12964]
111525412  CCL5; C-C motif chemokine 5 [KO:K12499]
111526875  CCL7; C-C motif chemokine 7 [KO:K05509]
111526878  CCL8; C-C motif chemokine 8 [KO:K16596]
111526881  CCL13; C-C motif chemokine 13 [KO:K16595]
111529360  C-C motif chemokine 14 [KO:K21092]
113221816  C-C motif chemokine 14-like [KO:K21092]
111529362  C-C motif chemokine 23 [KO:K05511]
111529364  C-C motif chemokine 15-like [KO:K05511]
113221817  C-C motif chemokine 23 isoform X2 [KO:K05511]
113222033  C-C motif chemokine 15-like [KO:K05511]
111529361  LOW QUALITY PROTEIN: C-C motif chemokine 16 [KO:K21093]
111541235  CCL17; C-C motif chemokine 17 [KO:K21083]
111529366  C-C motif chemokine 18 [KO:K21094]
113222035  C-C motif chemokine 18 [KO:K21094]
111535219  CCL19; C-C motif chemokine 19 [KO:K05512]
111527543  CCL20; C-C motif chemokine 20 isoform X1 [KO:K14625]
111535207  CCL21; C-C motif chemokine 21 isoform X1 [KO:K16062]
111541202  CCL22; C-C motif chemokine 22 [KO:K21095]
111546999  CCL24; C-C motif chemokine 24 [KO:K21097]
111522607  CCL25; C-C motif chemokine 25 isoform X1 [KO:K13072]
111547023  CCL26; C-C motif chemokine 26 [KO:K21096]
111536785  CCL27; C-C motif chemokine 27 [KO:K16598]
111545592  CCL28; C-C motif chemokine 28 isoform X1 [KO:K05513]
111548370  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
111548396  CXCR1; C-X-C chemokine receptor type 1 [KO:K04175]
111535674  CXCR3; C-X-C chemokine receptor type 3 isoform X1 [KO:K04188]
111527474  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
111540221  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
111555611  CXCR6; C-X-C chemokine receptor type 6 isoform X1 [KO:K04191]
111555595  XCR1; chemokine XC receptor 1 [KO:K04193]
111555341  CX3CR1; CX3C chemokine receptor 1 isoform X1 [KO:K04192]
111555573  CCR8; C-C chemokine receptor type 8 isoform X1 [KO:K04183]
111550269  CCR6; C-C chemokine receptor type 6 [KO:K04181]
111555606  CCR9; C-C chemokine receptor type 9 isoform X1 [KO:K04184]
111544240  CCR4; C-C chemokine receptor type 4 [KO:K04179]
111537445  CCR7; C-C chemokine receptor type 7 [KO:K04182]
111555460  CCR2; C-C chemokine receptor type 2 [KO:K04177]
111555364  CCR5; C-C chemokine receptor type 5 [KO:K04180]
111555471  CCR1; C-C chemokine receptor type 1 [KO:K04176]
111555470  CCR3; C-C chemokine receptor type 3 isoform X1 [KO:K04178]
111537352  CCR10; C-C chemokine receptor type 10 [KO:K04185]
111543300  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
111554242  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
111546340  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
111541846  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
111537369  signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
111537374  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
111552452  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
111555442  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
111556065  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
111546755  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
111554419  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
111552878  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
111544335  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
111542054  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
111541238  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
111549769  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
111551667  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
111523821  PRKACA; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
111543418  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma isoform X1 [KO:K04345] [EC:2.7.11.11]
111540404  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
111524867  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
111548133  HCK; tyrosine-protein kinase HCK [KO:K08893] [EC:2.7.10.2]
111547623  FGR; tyrosine-protein kinase Fgr isoform X1 [KO:K08891] [EC:2.7.10.2]
111553268  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
111543732  SHC1; LOW QUALITY PROTEIN: SHC-transforming protein 1 [KO:K06279]
111528883  SHC2; SHC-transforming protein 2 [KO:K17447]
111527961  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
111552722  SHC4; SHC-transforming protein 4 [KO:K17449]
111542428  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
111545353  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
111549528  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
111540622  KRAS; GTPase KRas isoform X1 [KO:K07827]
111549619  NRAS; GTPase NRas [KO:K07828]
111546904  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111521522  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
111548354  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111530673  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111525729  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
111521403  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111544647  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
111523340  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
111554247  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
111539891  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111548774  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
111520385  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
111525462  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
111525465  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
111544572  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
111554120  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111545216  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111538340  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111538546  FOXO3; forkhead box protein O3 [KO:K09408]
111538794  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
111544093  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
111524454  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
111554041  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
111547971  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
111522422  RELA; transcription factor p65 isoform X1 [KO:K04735]
111522294  BAD; bcl2-associated agonist of cell death [KO:K02158]
111553981  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
111543871  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
111547160  ITK; tyrosine-protein kinase ITK/TSK [KO:K07363] [EC:2.7.10.2]
111530126  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
111523994  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
111522605  VAV1; proto-oncogene vav [KO:K05730]
111530500  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
111549042  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
111527658  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X2 [KO:K07861]
111540806  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
111547718  CDC42; cell division control protein 42 homolog [KO:K04393]
111535699  WAS; wiskott-Aldrich syndrome protein [KO:K05747]
111555593  RHOA; transforming protein RhoA [KO:K04513]
111553507  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
111532006  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
111544570  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
111530203  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
111555925  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
111521415  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
111552767  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
111549428  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
111522414  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
113224997  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
111540329  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
111534550  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
111535694  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
111551379  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
111552373  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
111541090  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
111524122  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
111537549  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
111530220  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1 [KO:K12365]
111520360  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
111547206  DOCK2; dedicator of cytokinesis protein 2 isoform X1 [KO:K12367]
111553372  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
111537633  paxillin isoform X1 [KO:K05760]
111536154  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
111530661  CRKL; crk-like protein [KO:K04438]
111530638  CRK; adapter molecule crk isoform X1 [KO:K04438]
111545732  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
111543374  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
111546451  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
111522292  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
111524236  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
111546452  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
111553217  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
111552578  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
111522280  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
111556041  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
111528626  RAP1B; ras-related protein Rap-1b [KO:K07836]
111532119  ras-related protein Rap-1b [KO:K07836]
111546665  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
111524998  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
111524197  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
111524359  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
111547038  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
111546381  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
111526431  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
111525328  GRK3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
111522233  GRK2; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
111550779  GRK5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
111521617  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
111539096  GRK4; G protein-coupled receptor kinase 4 isoform X2 [KO:K08291] [EC:2.7.11.16]
111540828  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
111521236  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
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Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
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PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
pteh04010  MAPK signaling pathway
pteh04060  Cytokine-cytokine receptor interaction
pteh04120  Ubiquitin mediated proteolysis
pteh04630  JAK-STAT signaling pathway
pteh04670  Leukocyte transendothelial migration
pteh04810  Regulation of actin cytoskeleton
KO pathway
ko04062   
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