KEGG   PATHWAY: ptr05166
Entry
ptr05166                    Pathway                                
Name
Human T-cell leukemia virus 1 infection - Pan troglodytes (chimpanzee)
Description
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, and SRF.
Class
Human Diseases; Infectious disease: viral
Pathway map
ptr05166  Human T-cell leukemia virus 1 infection
ptr05166

Organism
Pan troglodytes (chimpanzee) [GN:ptr]
Gene
100613619  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
450397  NRP1; neuropilin-1 isoform X1 [KO:K06724]
464393  MYC; myc proto-oncogene protein [KO:K04377]
463564  TRRAP; transformation/transcription domain-associated protein isoform X1 [KO:K08874]
451329  KAT5; histone acetyltransferase KAT5 isoform X3 [KO:K11304] [EC:2.3.1.48]
747123  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
454045  ITGAL; integrin alpha-L [KO:K05718]
458607  ITGB2; integrin beta-2 isoform X2 [KO:K06464]
450196  ICAM1; intercellular adhesion molecule 1 precursor [KO:K06490]
466302  HRAS; GTPase HRas isoform X1 [KO:K02833]
473387  KRAS; GTPase KRas isoform X1 [KO:K07827]
742713  NRAS; GTPase NRas [KO:K07828]
450188  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100611792  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
456390  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
454037  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
458680  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
450124  CD4; T-cell surface glycoprotein CD4 isoform X1 [KO:K06454]
453494  TLN2; talin-2 isoform X1 [KO:K06271]
465082  TLN1; talin-1 [KO:K06271]
739886  RANBP3; ran-binding protein 3 [KO:K15304]
452414  RAN; GTP-binding nuclear protein Ran isoform X1 [KO:K07936]
459534  XPO1; exportin-1 isoform X1 [KO:K14290]
455756  CALR; calreticulin [KO:K08057]
462330  CANX; calnexin isoform X2 [KO:K08054]
742406  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
461403  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
450898  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
736325  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
100613118  PPP3R1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
455485  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X6 [KO:K04446]
469972  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X3 [KO:K17332]
454184  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X6 [KO:K17333]
452821  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X6 [KO:K17334]
470203  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
101059843  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
743373  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
454681  STAT5A; signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
454679  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
461472  IL2; interleukin-2 [KO:K05429]
450202  PATR-B; CHLA class I histocompatibility antigen, B-2 alpha chain isoform X1 [KO:K06751]
471962  PATR-C; patr class I histocompatibility antigen, C alpha chain isoform X4 [KO:K06751]
462540  PATR-E; patr class I histocompatibility antigen, alpha chain E precursor [KO:K06751]
494187  PATR-G; class I histocompatibility antigen, alpha chain G precursor [KO:K06751]
100169977  PATR-F; patr class I histocompatibility antigen, CH28 alpha chain precursor [KO:K06751]
750725  PATR-A; patr class I histocompatibility antigen, A-126 alpha chain precursor [KO:K06751]
471948  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A alpha chain [KO:K06751]
450170  B2M; beta-2-microglobulin precursor [KO:K08055]
457366  FDPS; farnesyl pyrophosphate synthase isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
129135519  farnesyl pyrophosphate synthase-like [KO:K00787] [EC:2.5.1.1 2.5.1.10]
745717  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
742793  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1-like [KO:K05862]
461632  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
742937  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
736938  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
107972834  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
101057286  ADP/ATP translocase 3-like [KO:K05863]
738876  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
737891  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
458887  TSPO; translocator protein [KO:K05770]
454220  VAC14; protein VAC14 homolog isoform X2 [KO:K15305]
458661  RANBP1; ran-specific GTPase-activating protein isoform X1 [KO:K15306]
100608612  ran-specific GTPase-activating protein-like [KO:K15306]
473539  ran-specific GTPase-activating protein-like [KO:K15306]
461661  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
453324  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform X1 [KO:K06637] [EC:2.7.11.1]
450800  BUB3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
459381  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
107973078  LOW QUALITY PROTEIN: anaphase-promoting complex subunit 1-like [KO:K03348]
465174  ANAPC2; anaphase-promoting complex subunit 2 isoform X2 [KO:K03349]
454815  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
461149  ANAPC4; anaphase-promoting complex subunit 4 isoform X2 [KO:K03351]
452321  ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
452688  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
467128  ANAPC7; anaphase-promoting complex subunit 7 isoform X2 [KO:K03354]
462092  CDC23; cell division cycle protein 23 homolog [KO:K03355]
739629  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
129137158  anaphase-promoting complex subunit 10-like [KO:K03357]
454972  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
473026  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
460984  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
101058140  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
101059660  anaphase-promoting complex subunit 15-like [KO:K25228]
736866  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
456819  CDC20; cell division cycle protein 20 homolog [KO:K03363]
737111  cell division cycle protein 20 homolog [KO:K03363]
462238  PTTG1; securin [KO:K06635]
736475  PTTG2; securin-2 [KO:K06635]
451937  ESPL1; separin isoform X1 [KO:K02365] [EC:3.4.22.49]
453478  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
473204  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
465021  CDKN2A; cyclin-dependent kinase inhibitor 2A [KO:K06621]
452025  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
747442  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
462689  CCND3; G1/S-specific cyclin-D3 isoform X2 [KO:K10152]
104001067  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
467260  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
461467  CCNA2; cyclin-A2 [KO:K06627]
464292  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
455914  CCNE1; G1/S-specific cyclin-E1 isoform X2 [KO:K06626]
467032  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
452715  RB1; retinoblastoma-associated protein isoform X2 [KO:K06618]
107969994  E2F1; transcription factor E2F1 [KO:K17454]
469153  E2F2; transcription factor E2F2 isoform X2 [KO:K09389]
471865  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
451530  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
460745  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
739836  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
458733  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
455214  TP53; cellular tumor antigen p53 isoform X2 [KO:K04451]
456565  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
461836  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
460858  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
457922  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
471079  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
456035  AKT2; RAC-beta serine/threonine-protein kinase isoform X6 [KO:K04456] [EC:2.7.11.1]
740898  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100609583  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
460968  DLG1; disks large homolog 1 isoform X26 [KO:K12076]
466142  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
107976636  LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
494186  TNF; tumor necrosis factor [KO:K03156]
466934  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
471543  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
455065  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X4 [KO:K04430] [EC:2.7.12.2]
450445  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
462336  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
461358  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
456893  JUN; transcription factor Jun [KO:K04448]
451509  MMP7; matrilysin [KO:K01397] [EC:3.4.24.23]
459460  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
470455  IL1R2; interleukin-1 receptor type 2 isoform X5 [KO:K04387]
743494  T cell receptor alpha variable 9-2 [KO:K10784]
100615597  BV7-9; T cell receptor beta variable 7-9 [KO:K10785]
743326  BV7-2; LOW QUALITY PROTEIN: T cell receptor beta variable 7-2 [KO:K10785]
472543  BV6-3; T-cell receptor beta chain V region 86T1 [KO:K10785]
451584  CD3D; T-cell surface glycoprotein CD3 delta chain isoform X2 [KO:K06450]
742330  CD3E; T-cell surface glycoprotein CD3 epsilon chain isoform X1 [KO:K06451]
451585  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
468286  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
450673  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
472749  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100610002  NF-kappa-B essential modulator isoform X1 [KO:K07210]
100609537  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
467426  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
461406  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
466665  RELA; transcription factor P65 [KO:K04735]
455229  GPS2; G protein pathway suppressor 2 [KO:K15307]
451778  LTBR; tumor necrosis factor receptor superfamily member 3 precursor [KO:K03159]
100615583  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
104003794  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C isoform X2 [KO:K05151]
454750  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
456119  RELB; transcription factor RelB [KO:K09253]
450697  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
736203  ZFP36; mRNA decay activator protein ZFP36 [KO:K15308]
450884  IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068]
737808  IL15; interleukin-15 isoform X2 [KO:K05433]
738192  IL15RA; interleukin-15 receptor subunit alpha isoform X4 [KO:K05074]
463288  IL6; interleukin-6 isoform X1 [KO:K05405]
471627  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
494185  LTA; lymphotoxin-alpha precursor [KO:K05468]
458156  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
473765  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
456060  TGFB1; transforming growth factor beta-1 proprotein isoform X3 [KO:K13375]
457742  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
453054  TGFB3; transforming growth factor beta-3 proprotein isoform X2 [KO:K13377]
472992  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
460243  TGFBR2; TGF-beta receptor type-2 isoform X2 [KO:K04388] [EC:2.7.11.30]
455407  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
748161  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
468537  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
463392  ADCY1; adenylate cyclase type 1 isoform X2 [KO:K08041] [EC:4.6.1.1]
100608010  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
459070  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
452819  ADCY4; adenylate cyclase type 4 isoform X2 [KO:K08044] [EC:4.6.1.1]
470905  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
451866  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
473278  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
464400  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
453869  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
469367  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X6 [KO:K04345] [EC:2.7.11.11]
472944  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
107966260  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
452191  NFYB; nuclear transcription factor Y subunit beta isoform X1 [KO:K08065]
449592  PATR-DMB; major histocompatibility complex, class II, DM beta precursor [KO:K06752]
471974  PATR-DQA1; HLA class II histocompatibility antigen, DQ alpha 1 chain isoform X2 [KO:K06752]
471976  PATR-DQA2; HLA class II histocompatibility antigen, DQ alpha 2 chain [KO:K06752]
471977  PATR-DOB; patr class II histocompatibility antigen, DO beta chain precursor [KO:K06752]
462591  PATR-DRA; major histocompatibility complex, class II, DR alpha precursor [KO:K06752]
462594  PATR-DQB1; major histocompatibility complex, class II, DQ beta 1 precursor [KO:K06752]
462598  PATR-DPA1; HLA class II histocompatibility antigen, DP alpha 1 chain isoform X1 [KO:K06752]
462599  PATR-DPB1; HLA class II histocompatibility antigen, DP beta 1 chain isoform X1 [KO:K06752]
462592  PATR-DRB5; major histocompatibility complex, class II, DR beta 5 precursor [KO:K06752]
104006793  HLA class II histocompatibility antigen, DR beta 3 chain precursor [KO:K06752]
100616520  HLA class II histocompatibility antigen, DQ beta 1 chain isoform X5 [KO:K06752]
100608816  MAMU-DMA; HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
100610904  HLA class II histocompatibility antigen, DP beta 1 chain-like isoform X3 [KO:K06752]
462709  SRF; serum response factor isoform X1 [KO:K04378]
742304  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
473591  ELK1; ETS domain-containing protein Elk-1 isoform X2 [KO:K04375]
451169  SPI1; transcription factor PU.1 isoform X1 [KO:K09438]
451695  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
473996  ETS2; protein C-ets-2 isoform X1 [KO:K21932]
452923  TBPL2; TATA box-binding protein-like 2 [KO:K03120]
738472  TBP; TATA-box-binding protein [KO:K03120]
463010  TBPL1; TATA box-binding protein-like 1 [KO:K03120]
453047  FOS; protein C-Fos [KO:K04379]
462097  EGR1; early growth response protein 1 [KO:K09203]
745919  FOSL1; fos-related antigen 1 isoform X1 [KO:K04502]
745846  EGR2; E3 SUMO-protein ligase EGR2 isoform X1 [KO:K12496]
459901  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
451704  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X2 [KO:K09048]
468672  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X4 [KO:K09048]
738928  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
457341  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
465081  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101059354  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
744513  ATF4; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374]
463318  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X11 [KO:K09047]
107975108  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X3 [KO:K09049]
735806  CRTC1; CREB-regulated transcription coactivator 1 isoform X1 [KO:K15309]
738694  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
453648  CRTC3; CREB-regulated transcription coactivator 3 isoform X2 [KO:K16334]
467891  CREBBP; CREB-binding protein isoform X6 [KO:K04498] [EC:2.3.1.48]
458862  EP300; histone acetyltransferase P300 [KO:K04498] [EC:2.3.1.48]
460219  KAT2B; histone acetyltransferase KAT2B isoform X1 [KO:K06062] [EC:2.3.1.48]
454677  KAT2A; histone acetyltransferase KAT2A isoform X1 [KO:K06062] [EC:2.3.1.48]
468650  TCF3; transcription factor E2-alpha isoform X1 [KO:K09063]
737210  POLB; DNA polymerase beta isoform X4 [KO:K02330] [EC:2.7.7.7 4.2.99.-]
456715  LCK; tyrosine-protein kinase Lck isoform X1 [KO:K05856] [EC:2.7.10.2]
747093  BAX; apoptosis regulator BAX isoform X4 [KO:K02159]
469319  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
101058547  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
461092  MSX1; homeobox protein MSX-1 [KO:K09341]
744194  MSX2; homeobox protein MSX-2 [KO:K09341]
748658  LOW QUALITY PROTEIN: homeobox protein MSX-2-like [KO:K09341]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17384582
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
PMID:16155604
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
PMID:18702816
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
PMID:21994754
  Authors
Jones KS, Lambert S, Bouttier M, Benit L, Ruscetti FW, Hermine O, Pique C
  Title
Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
  Journal
Viruses 3:794-810 (2011)
DOI:10.3390/v3060794
Reference
PMID:21114861
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
DOI:10.1186/1742-4690-7-99
Reference
  Authors
Sinet F.
  Title
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Retrovirology 1:20 (2004)
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Related
pathway
ptr03013  Nucleocytoplasmic transport
ptr04010  MAPK signaling pathway
ptr04064  NF-kappa B signaling pathway
ptr04110  Cell cycle
ptr04115  p53 signaling pathway
ptr04151  PI3K-Akt signaling pathway
ptr04210  Apoptosis
ptr04350  TGF-beta signaling pathway
ptr04612  Antigen processing and presentation
ptr04660  T cell receptor signaling pathway
ptr04668  TNF signaling pathway
KO pathway
ko05166   
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