KEGG   PATHWAY: ray04015
Entry
ray04015                    Pathway                                
Name
Rap1 signaling pathway - Rousettus aegyptiacus (Egyptian rousette)
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
Pathway map
ray04015  Rap1 signaling pathway
ray04015

Other DBs
GO: 0007264
Organism
Rousettus aegyptiacus (Egyptian rousette) [GN:ray]
Gene
107499843  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
107512678  RAP1B; ras-related protein Rap-1b [KO:K07836]
107513955  MRAS; ras-related protein M-Ras [KO:K07831]
107518119  RAPGEF5; rap guanine nucleotide exchange factor 5 [KO:K08019]
107499317  DOCK4; LOW QUALITY PROTEIN: dedicator of cytokinesis protein 4 [KO:K17697]
107503090  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
107514651  GRIN2A; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2A [KO:K05209]
107508606  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
107509556  CALM2; calmodulin [KO:K02183]
107508927  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
107515457  CALM1; calmodulin [KO:K02183]
107516034  CALM3; calmodulin [KO:K02183]
107501627  calmodulin-like protein 5 [KO:K02183]
107501531  F2R; proteinase-activated receptor 1 [KO:K03914]
107517273  F2RL3; proteinase-activated receptor 4 [KO:K04236]
107518093  P2RY1; P2Y purinoceptor 1 [KO:K04270]
107502626  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
107503740  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
107511577  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
107500228  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
107519844  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
107500692  ADORA2A; adenosine receptor A2a [KO:K04266]
107511058  ADORA2B; adenosine receptor A2b [KO:K04267]
107500068  neuroendocrine secretory protein 55-like [KO:K04632]
107500067  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
107512406  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
107502700  ADCY2; LOW QUALITY PROTEIN: adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
107498506  ADCY3; LOW QUALITY PROTEIN: adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
107498014  ADCY4; LOW QUALITY PROTEIN: adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
107518038  ADCY5; LOW QUALITY PROTEIN: adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
107514224  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
107512248  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
107497689  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
107521680  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
107499884  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
107505164  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
107517194  GNAQ; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
107506114  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
107519930  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
107497081  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
107514464  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
107505744  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
107517268  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
107508819  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
107500865  FGF1; fibroblast growth factor 1 [KO:K18496]
107518501  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
107507115  FGF16; fibroblast growth factor 16 [KO:K04358]
107503931  FGF3; fibroblast growth factor 3 [KO:K04358]
107503977  FGF4; LOW QUALITY PROTEIN: fibroblast growth factor 4 [KO:K04358]
107511020  FGF18; fibroblast growth factor 18 [KO:K04358]
107514447  FGF9; fibroblast growth factor 9 [KO:K04358]
107502706  FGF20; fibroblast growth factor 20 [KO:K04358]
107513447  FGF6; fibroblast growth factor 6 [KO:K04358]
107516440  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
107509200  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
107518965  FGF10; fibroblast growth factor 10 [KO:K04358]
107500922  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
107497786  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
107501960  FGF7; LOW QUALITY PROTEIN: fibroblast growth factor 7 [KO:K04358]
107498854  FGF21; fibroblast growth factor 21 [KO:K22429]
107513448  FGF23; fibroblast growth factor 23 [KO:K22428]
107499858  NGF; beta-nerve growth factor [KO:K02582]
107513269  INS; insulin isoform X1 [KO:K04526]
107501166  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
107497394  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
107502078  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
107507553  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
107520204  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
107516132  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
107508690  KITLG; LOW QUALITY PROTEIN: kit ligand [KO:K05461]
107502007  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
107497088  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
107504821  PGF; placenta growth factor isoform X1 [KO:K16859]
107521392  VEGFC; vascular endothelial growth factor C [KO:K05449]
107497293  FIGF; vascular endothelial growth factor D [KO:K05449]
107501285  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
107512193  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
107504264  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
107512910  ANGPT4; angiopoietin-4 [KO:K05467]
107505460  EFNA1; ephrin-A1 [KO:K05462]
107505461  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
107505463  EFNA4; ephrin-A4 [KO:K05462]
107500908  EFNA2; LOW QUALITY PROTEIN: ephrin-A2 [KO:K05462]
107497396  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
107498193  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
107515961  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
107512997  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
107518024  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
107517559  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
107517615  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
107519908  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
107509347  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
107499793  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
107497163  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
107513557  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
107499790  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
107498919  LOW QUALITY PROTEIN: vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
107514322  FLT1; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
107512332  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
107520899  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
107497465  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
107516483  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
107501839  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
107507729  CRK; adapter molecule crk isoform X1 [KO:K04438]
107497859  CRKL; crk-like protein [KO:K04438]
107504562  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
107502656  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
107520648  CDH1; LOW QUALITY PROTEIN: cadherin-1 [KO:K05689]
107519993  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
107513480  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
107511478  MAGI2; LOW QUALITY PROTEIN: membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
107499812  MAGI3; LOW QUALITY PROTEIN: membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 [KO:K06112]
107511410  RAPGEF2; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 2 [KO:K08018]
107497019  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
107516945  uncharacterized protein LOC107516945 [KO:K10785]
107515810  LAT; linker for activation of T-cells family member 1 [KO:K07362]
107512431  FYB; FYN-binding protein [KO:K17698]
107518466  LCP2; lymphocyte cytosolic protein 2 [KO:K07361]
107520636  SKAP1; src kinase-associated phosphoprotein 1 isoform X1 [KO:K17699]
107506741  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
107510307  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
107516091  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
107503061  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
107519634  PRKD3; serine/threonine-protein kinase D3 isoform X1 [KO:K06070] [EC:2.7.11.13]
107516002  PRKD2; serine/threonine-protein kinase D2 isoform X1 [KO:K06070] [EC:2.7.11.13]
107499449  PRKD1; LOW QUALITY PROTEIN: serine/threonine-protein kinase D1 [KO:K06070] [EC:2.7.11.13]
107512952  DRD2; D(2) dopamine receptor [KO:K04145]
107508671  CNR1; cannabinoid receptor 1 [KO:K04277]
107516134  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
107518173  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
107513376  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
107499654  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
107513052  RAP1GAP; rap1 GTPase-activating protein 1 isoform X1 [KO:K17700]
107497136  SIPA1L1; signal-induced proliferation-associated 1-like protein 1 isoform X1 [KO:K17701]
107497521  SIPA1; signal-induced proliferation-associated protein 1 isoform X1 [KO:K08013]
107520013  SIPA1L2; LOW QUALITY PROTEIN: signal-induced proliferation-associated 1-like protein 2 [KO:K17702]
107520951  SIPA1L3; signal-induced proliferation-associated 1-like protein 3 [KO:K17703]
107512890  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
107514453  THBS1; LOW QUALITY PROTEIN: thrombospondin-1 [KO:K16857]
107504584  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
107512715  RALA; ras-related protein Ral-A [KO:K07834]
107501432  RALB; ras-related protein Ral-B [KO:K07835]
107515925  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
107519267  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
107520254  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
107503335  APBB1IP; amyloid beta A4 precursor protein-binding family B member 1-interacting protein [KO:K17704]
107502773  TLN1; talin-1 [KO:K06271]
107508999  TLN2; LOW QUALITY PROTEIN: talin-2 [KO:K06271]
107508144  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
107501647  integrin beta-3 [KO:K06493]
107517535  PFN3; profilin-3 [KO:K05759]
107516596  PFN2; profilin-2 isoform X1 [KO:K05759]
107509489  PFN1; profilin-1 [KO:K05759]
107499322  profilin-1-like [KO:K05759]
107498552  PFN4; profilin-4 isoform X1 [KO:K05759]
107515989  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
107517100  LOW QUALITY PROTEIN: protein enabled homolog [KO:K05746]
107521070  LOW QUALITY PROTEIN: protein enabled homolog [KO:K05746]
107497562  EVL; LOW QUALITY PROTEIN: ena/VASP-like protein [KO:K23487]
107520262  ACTG1; actin, cytoplasmic 2 [KO:K05692]
107515934  ACTB; actin, cytoplasmic 1 [KO:K05692]
107499695  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
107513350  RHOA; transforming protein RhoA [KO:K04513]
107512598  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
107510565  FARP2; FERM, RhoGEF and pleckstrin domain-containing protein 2 isoform X1 [KO:K06082]
107513058  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
107502025  guanine nucleotide exchange factor VAV2-like [KO:K05730]
107511258  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
107518292  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
107519567  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
107520741  PARD3; partitioning defective 3 homolog [KO:K04237]
107510342  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
107520321  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
107500856  PARD6G; LOW QUALITY PROTEIN: partitioning defective 6 homolog gamma [KO:K06093]
107510685  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
107501405  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
107518106  MLLT4; LOW QUALITY PROTEIN: afadin [KO:K05702]
107518391  CTNND1; catenin delta-1 isoform X1 [KO:K05690]
107519057  KRIT1; krev interaction trapped protein 1 [KO:K17705]
107517562  RGS14; regulator of G-protein signaling 14 isoform X1 [KO:K17706]
107502226  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
107515868  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
107506837  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
107510212  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
107499295  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
107504052  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
107519729  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
107508942  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
107510634  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
107515836  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
107497830  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107506757  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
107510279  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
107497883  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
107497895  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
107500264  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
107500274  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
107520152  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
107517828  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
107513958  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
107521668  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
107517899  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
107498704  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
107513978  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107521783  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107498395  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107520393  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
107507127  HRAS; GTPase HRas isoform X1 [KO:K02833]
107497434  KRAS; GTPase KRas isoform X1 [KO:K07827]
107499847  NRAS; LOW QUALITY PROTEIN: GTPase NRas [KO:K07828]
107498824  RRAS; ras-related protein R-Ras [KO:K07829]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:11331911
  Authors
Bos JL, de Rooij J, Reedquist KA
  Title
Rap1 signalling: adhering to new models.
  Journal
Nat Rev Mol Cell Biol 2:369-77 (2001)
DOI:10.1038/35073073
Reference
PMID:17383543
  Authors
Minato N, Kometani K, Hattori M
  Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
  Journal
Adv Immunol 93:229-64 (2007)
DOI:10.1016/S0065-2776(06)93006-5
Reference
PMID:15780587
  Authors
Bos JL
  Title
Linking Rap to cell adhesion.
  Journal
Curr Opin Cell Biol 17:123-8 (2005)
DOI:10.1016/j.ceb.2005.02.009
Reference
PMID:12508104
  Authors
Caron E
  Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
  Journal
J Cell Sci 116:435-40 (2003)
DOI:10.1242/jcs.00238
Reference
PMID:10579920
  Authors
Zwartkruis FJ, Bos JL
  Title
Ras and Rap1: two highly related small GTPases with distinct function.
  Journal
Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695
Reference
PMID:14607972
  Authors
Hattori M, Minato N
  Title
Rap1 GTPase: functions, regulation, and malignancy.
  Journal
J Biochem 134:479-84 (2003)
DOI:10.1093/jb/mvg180
Reference
PMID:19159611
  Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
  Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1788:790-6 (2009)
DOI:10.1016/j.bbamem.2008.12.010
Reference
PMID:19615876
  Authors
Boettner B, Van Aelst L
  Title
Control of cell adhesion dynamics by Rap1 signaling.
  Journal
Curr Opin Cell Biol 21:684-93 (2009)
DOI:10.1016/j.ceb.2009.06.004
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
PMID:17624948
  Authors
Mor A, Dustin ML, Philips MR
  Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
  Journal
Immunol Rev 218:114-25 (2007)
DOI:10.1111/j.1600-065X.2007.00538.x
Reference
PMID:17624944
  Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
  Title
T-cell receptor signaling to integrins.
  Journal
Immunol Rev 218:65-81 (2007)
DOI:10.1111/j.1600-065X.2007.00527.x
Reference
PMID:12765839
  Authors
Stork PJ
  Title
Does Rap1 deserve a bad Rap?
  Journal
Trends Biochem Sci 28:267-75 (2003)
DOI:10.1016/S0968-0004(03)00087-2
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Banihashemi B, Albert PR
  Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
  Journal
Mol Endocrinol 16:2393-404 (2002)
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PMID:18363565
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Banno A, Ginsberg MH
  Title
Integrin activation.
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Biochem Soc Trans 36:229-34 (2008)
DOI:10.1042/BST0360229
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PMID:19710505
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Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
  Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
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Blood 114:4592-600 (2009)
DOI:10.1182/blood-2009-04-217042
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PMID:21402149
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Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
  Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
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Cell Signal 23:1257-66 (2011)
DOI:10.1016/j.cellsig.2011.03.007
Related
pathway
ray04010  MAPK signaling pathway
ray04014  Ras signaling pathway
ray04020  Calcium signaling pathway
ray04151  PI3K-Akt signaling pathway
ray04510  Focal adhesion
ray04520  Adherens junction
ray04660  T cell receptor signaling pathway
ray04810  Regulation of actin cytoskeleton
KO pathway
ko04015   
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