KEGG   PATHWAY: scan04530
Entry
scan04530                   Pathway                                
Name
Tight junction - Serinus canaria (common canary)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
scan04530  Tight junction
scan04530

Other DBs
GO: 0005923
Organism
Serinus canaria (common canary) [GN:scan]
Gene
108961966  CLDN34; claudin-34 [KO:K06087]
103815385  CLDN16; claudin-16 isoform X1 [KO:K06087]
103815720  CLDN14; claudin-14 [KO:K06087]
103820042  CLDN3; claudin-3 [KO:K06087]
103820044  claudin-4-like [KO:K06087]
103815288  CLDN11; claudin-11 [KO:K06087]
103815485  CLDN18; claudin-18 isoform X2 [KO:K06087]
103815539  claudin-19-like isoform X2 [KO:K06087]
103824171  CLDN19; claudin-19 isoform X2 [KO:K06087]
103825978  CLDN23; claudin-23 [KO:K06087]
103812283  CLDN10; claudin-10 isoform X1 [KO:K06087]
103824170  claudin-16-like [KO:K06087]
103824241  CLDN2; claudin-2 [KO:K06087]
103818443  claudin-8 [KO:K06087]
103820043  CLDN4; claudin-4 isoform X1 [KO:K06087]
103822787  CLDN25; putative claudin-25 [KO:K06087]
103825750  CLDN22; claudin-22 [KO:K06087]
115483987  CLDN1; claudin-1 [KO:K06087]
115484953  CLDN20; claudin-20 [KO:K06087]
103812808  CLDN12; claudin-12 [KO:K06087]
103824942  uncharacterized protein LOC103824942 [KO:K06089]
103823753  JAM2; junctional adhesion molecule B isoform X2 [KO:K06735]
103823645  JAM3; junctional adhesion molecule C [KO:K06785]
103818873  BVES; blood vessel epicardial substance isoform X1 [KO:K21108]
103824159  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
103816850  PARD6A; partitioning defective 6 homolog alpha [KO:K06093]
103815699  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
103818767  PARD6B; partitioning defective 6 homolog beta isoform X2 [KO:K06093]
103826593  MPP5; MAGUK p55 subfamily member 5 [KO:K06091]
103814726  MPP4; LOW QUALITY PROTEIN: MAGUK p55 subfamily member 4 [KO:K21109]
103821890  TJP3; tight junction protein ZO-3 isoform X1 [KO:K06097]
103815211  PATJ; inaD-like protein isoform X1 [KO:K06092]
103819456  MPDZ; multiple PDZ domain protein isoform X12 [KO:K06095]
103820807  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
103815286  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
103816346  AMOT; angiomotin [KO:K16819]
103812512  AMOTL1; LOW QUALITY PROTEIN: angiomotin-like protein 1 [KO:K06104]
103815675  AMOTL2; angiomotin-like protein 2 isoform X1 [KO:K06104]
103817805  ARHGAP17; rho GTPase-activating protein 17 [KO:K20638]
103817879  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103820087  merlin-like isoform X1 [KO:K16684]
103818220  NF2; merlin isoform X1 [KO:K16684]
103817597  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
103819849  LLGL2; lethal(2) giant larvae protein homolog 2 [KO:K06094]
103815402  DLG1; disks large homolog 1 isoform X14 [KO:K12076]
103814877  SCRIB; LOW QUALITY PROTEIN: protein scribble homolog [KO:K16175]
103817471  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
103823422  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
103817406  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
103824110  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X2 [KO:K04354]
103822705  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
103814089  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
103813075  PARD3; partitioning defective 3 homolog isoform X6 [KO:K04237]
103818444  LOW QUALITY PROTEIN: T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
103815972  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
103817427  TJAP1; tight junction-associated protein 1 [KO:K06105]
103827238  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
103824213  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
103815988  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
103824385  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X9 [KO:K13305] [EC:2.3.2.26]
103824738  CGN; cingulin [KO:K06102]
103815985  CGNL1; cingulin-like protein 1 isoform X1 [KO:K21110]
103824796  ARHGEF2; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 2 [KO:K12791]
103816985  RHOA; transforming protein RhoA [KO:K04513]
103823321  GATA4; transcription factor GATA-4 isoform X3 [KO:K09183]
103815314  MARVEL domain-containing protein 3-like [KO:K21099]
115484050  MARVELD3; LOW QUALITY PROTEIN: MARVEL domain-containing protein 3 [KO:K21099]
103821035  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
103817284  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
103813947  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
103826066  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103815057  JUN; transcription factor AP-1 [KO:K04448]
103816923  T-cell surface glycoprotein CD1b-3-like isoform X1 [KO:K06448]
103817102  antigen-presenting glycoprotein CD1d-like [KO:K06448]
103813684  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
103819683  YBX3; Y-box-binding protein 3 [KO:K06099]
103822675  PCNA; LOW QUALITY PROTEIN: proliferating cell nuclear antigen [KO:K04802]
103822217  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
103821628  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
103815716  runt-related transcription factor 1 isoform X2 [KO:K08367]
108961955  runt-related transcription factor 1-like [KO:K08367]
103817393  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
103819828  SLC9A3R1; LOW QUALITY PROTEIN: Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
103820599  EZR; ezrin isoform X1 [KO:K08007]
103827299  RDX; radixin isoform X1 [KO:K05762]
103816416  MSN; moesin isoform X1 [KO:K05763]
103817167  PRKCE; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
103823197  actin, cytoplasmic type 5 [KO:K05692]
103817621  ACTB; actin, cytoplasmic 1 [KO:K05692]
103816992  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
103818465  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
103818614  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
103822115  CTTN; src substrate cortactin isoform X1 [KO:K06106]
103822460  hematopoietic lineage cell-specific protein-like isoform X1 [KO:K06106]
103821396  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
103812718  ACTR3B; actin-related protein 3B [KO:K18584]
103814631  ACTR3; actin-related protein 3 [KO:K18584]
103817616  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
103817617  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
103814346  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
103818322  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
103817048  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
103814816  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
103819100  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
103816041  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
103814927  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
103821922  ARHGEF18; rho guanine nucleotide exchange factor 18 isoform X2 [KO:K21066]
103826969  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
103820586  ROCK2; rho-associated protein kinase 2 isoform X3 [KO:K17388] [EC:2.7.11.1]
103818146  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
108961262  EPB41L4B; band 4.1-like protein 4B [KO:K21111]
103821949  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
103815205  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
103824837  5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
103821077  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
103818046  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 isoform X1 [KO:K07199]
103824682  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
103814355  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X5 [KO:K07200]
103812715  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
103824624  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
103813216  MYH9; myosin-9 [KO:K10352]
103817704  MYH11; myosin-11 isoform X1 [KO:K10352]
103819902  MYH10; myosin-10 [KO:K10352]
103823660  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
103826830  myosin regulatory light chain 2, smooth muscle minor isoform-like [KO:K12757]
103826849  myosin regulatory light chain 2, smooth muscle minor isoform isoform X1 [KO:K12757]
103815740  IGSF5; immunoglobulin superfamily member 5 [KO:K06786]
103817078  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
103817486  SYNPO; synaptopodin isoform X1 [KO:K21112]
103826606  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
103817866  MICALL2; MICAL-like protein 2 [KO:K21068]
103824119  RAB8A; ras-related protein Rab-8A [KO:K07901]
103815953  RAB8B; ras-related protein Rab-8B isoform X1 [KO:K07902]
103817468  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X12 [KO:K08020]
103823268  RAP1A; ras-related protein Rap-1A [KO:K04353]
103813076  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
103818483  AFDN; afadin isoform X1 [KO:K05702]
103819441  TJP2; tight junction protein ZO-2 isoform X1 [KO:K06098]
103825944  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X4 [KO:K08018]
103816552  RAP2C; ras-related protein Rap-2c [KO:K07839]
103821263  MARVELD2; MARVEL domain-containing protein 2 [KO:K17291]
103815242  tubulin alpha-3 chain isoform X1 [KO:K07374]
103822471  TUBAL3; tubulin alpha chain-like 3 isoform X2 [KO:K07374]
103824613  tubulin alpha-1 chain-like [KO:K07374]
103822357  tubulin alpha-8 chain [KO:K07374]
103820471  TUBA8; tubulin alpha-8 chain [KO:K07374]
103814372  LOW QUALITY PROTEIN: tubulin alpha-5 chain [KO:K07374]
103824612  LOW QUALITY PROTEIN: tubulin alpha-1A chain [KO:K07374]
108963627  tubulin alpha-1C chain-like [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
scan04520  Adherens junction
scan04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
LinkDB

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