KEGG   PATHWAY: shab04820
Entry
shab04820                   Pathway                                
Name
Cytoskeleton in muscle cells - Strigops habroptila (Kakapo)
Class
Cellular Processes; Cell motility
Pathway map
shab04820  Cytoskeleton in muscle cells
shab04820

Organism
Strigops habroptila (Kakapo) [GN:shab]
Gene
115605860  COL1A2; collagen alpha-2(I) chain [KO:K06236]
115617800  COL1A1; collagen alpha-1(I) chain [KO:K06236]
115608047  COL3A1; collagen alpha-1(III) chain [KO:K19720]
115617090  COL5A1; collagen alpha-1(V) chain isoform X1 [KO:K19721]
115617202  collagen alpha-1(I) chain-like isoform X1 [KO:K19721]
115617228  collagen alpha-1(XXVII) chain-like [KO:K19721]
115611599  COL11A1; collagen alpha-1(XI) chain [KO:K19721]
115611797  COL24A1; collagen alpha-1(XXIV) chain isoform X1 [KO:K19721]
115608048  COL5A2; collagen alpha-2(V) chain isoform X1 [KO:K19721]
115603384  COL5A3; LOW QUALITY PROTEIN: collagen alpha-3(V) chain [KO:K19721]
115603546  COL11A2; collagen alpha-2(XI) chain [KO:K19721]
115615047  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
115609769  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
115616117  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
115605117  DCN; decorin [KO:K04660]
115619663  VCAN; versican core protein isoform X1 [KO:K06793]
115603120  ELN; elastin isoform X1 [KO:K14211]
115608569  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
115608887  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
115608903  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
115607044  THBS1; thrombospondin-1 [KO:K16857]
115618290  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
115613877  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
115619530  THBS4; thrombospondin-4 [KO:K04659]
115602540  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
115612828  FBN1; fibrillin-1 [KO:K06825]
115618248  fibrillin-2-like [KO:K23342]
115601359  FBN2; fibrillin-2 [KO:K23342]
115604602  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
115604603  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
115611755  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
115611756  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
115612742  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
115613256  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
115605469  FBLN1; fibulin-1 isoform X1 [KO:K17307]
115614637  FBLN2; fibulin-2 [KO:K17307]
115617448  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X1 [KO:K06255]
115607498  NID2; nidogen-2 isoform X1 [KO:K06826]
115614033  NID1; nidogen-1 isoform X1 [KO:K06826]
115608501  FN1; fibronectin isoform X1 [KO:K05717]
115609841  SDC1; syndecan-1 [KO:K06257]
115612684  SDC2; syndecan-2 [KO:K16336]
115615471  SDC3; syndecan-3 [KO:K16337]
115614980  SDC4; syndecan-4 [KO:K16338]
115617376  AGRN; agrin isoform X1 [KO:K06254]
115609468  LOW QUALITY PROTEIN: desmocollin-2-like [KO:K07601]
115609713  DSG2; desmoglein-2 [KO:K07597]
115605424  PKP2; plakophilin-2 [KO:K12642]
115617580  JUP; junction plakoglobin [KO:K10056]
115616367  DSP; desmoplakin isoform X1 [KO:K10381]
115606781  VIM; vimentin [KO:K07606]
115608291  DES; desmin [KO:K07610]
115609253  LAMA2; LOW QUALITY PROTEIN: laminin subunit alpha-2 [KO:K05637]
115604330  LAMA1; laminin subunit alpha-1 [KO:K05637]
115619479  integrin alpha-1-like isoform X1 [KO:K06480]
115619480  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
115617950  ITGA2B; integrin alpha-IIb [KO:K06476]
115617630  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
115608332  ITGA4; integrin alpha-4 [KO:K06483]
115609033  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
115618639  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
115612001  ITGA8; LOW QUALITY PROTEIN: integrin alpha-8 [KO:K06584]
115613436  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
115613024  ITGA11; integrin alpha-11 [KO:K06587]
115607829  ITGAV; integrin alpha-V [KO:K06487]
115615651  ITGB1; integrin beta-1 [KO:K05719]
115617744  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
115616545  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
115608838  ITGB5; integrin beta-5 [KO:K06588]
115608879  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
115606719  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
115612879  TLN2; talin-2 isoform X1 [KO:K06271]
115619815  TLN1; talin-1 [KO:K06271]
115609134  VCL; vinculin isoform X1 [KO:K05700]
115613851  ACTN2; alpha-actinin-2 isoform X1 [KO:K21073]
115616751  ACTG1; actin, cytoplasmic 2 [KO:K05692]
115612443  actin, cytoplasmic type 5 [KO:K05692]
115606888  ACTB; actin, cytoplasmic 1 [KO:K05692]
115618475  ACTG2; actin, gamma-enteric smooth muscle [KO:K12315]
115614216  DAG1; dystroglycan [KO:K06265]
115617803  SGCA; alpha-sarcoglycan isoform X1 [KO:K12565]
115618929  SGCE; epsilon-sarcoglycan isoform X1 [KO:K27061]
115611067  SGCB; beta-sarcoglycan isoform X1 [KO:K12566]
115615975  SGCD; delta-sarcoglycan isoform X1 [KO:K12563]
115603768  SGCG; gamma-sarcoglycan isoform X1 [KO:K12564]
115610717  SGCZ; zeta-sarcoglycan isoform X1 [KO:K27062]
115605244  SSPN; sarcospan isoform X1 [KO:K22194]
115603653  DMD; dystrophin isoform X1 [KO:K10366]
115615353  SNTA1; alpha-1-syntrophin isoform X1 [KO:K24063]
115619125  SNTB2; LOW QUALITY PROTEIN: beta-2-syntrophin [KO:K24064]
115608457  SNTB1; beta-1-syntrophin [KO:K24064]
115606597  DTNA; dystrobrevin alpha isoform X1 [KO:K26998]
115601457  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
115612045  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
115613345  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
115602931  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 isoform X1 [KO:K01540]
115603878  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
115609119  ANK3; ankyrin-3 isoform X1 [KO:K09259]
115617063  SPTAN1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
115606920  SPTBN5; LOW QUALITY PROTEIN: spectrin beta chain, non-erythrocytic 5 [KO:K06115]
115603331  SPTBN4; spectrin beta chain, non-erythrocytic 4 isoform X1 [KO:K06115]
115609276  SPTBN1; spectrin beta chain, non-erythrocytic 1 isoform X1 [KO:K06115]
115614663  SPTBN2; spectrin beta chain, non-erythrocytic 2 [KO:K23932]
115604808  CSRP2; cysteine and glycine-rich protein 2 [KO:K09377]
115607415  CSRP3; cysteine and glycine-rich protein 3 [KO:K09377]
115602427  CSRP1; cysteine and glycine-rich protein 1 [KO:K09377]
115616510  myosin-3-like [KO:K24220]
115616511  myosin heavy chain, skeletal muscle, adult-like isoform X1 [KO:K24220]
115616512  myosin heavy chain, skeletal muscle, adult isoform X1 [KO:K24220]
115616513  myosin-1B-like isoform X1 [KO:K24220]
115616514  myosin-1B isoform X1 [KO:K24220]
115616516  myosin heavy chain, skeletal muscle, adult-like isoform X1 [KO:K24220]
115616517  myosin heavy chain, skeletal muscle, adult-like isoform X1 [KO:K24220]
115616521  myosin heavy chain, skeletal muscle, adult-like [KO:K24220]
115601506  MYH15; myosin-15 [KO:K24220]
115615367  MYH7B; myosin-7B [KO:K24220]
115602616  myosin-6 [KO:K17751]
115616479  MYH10; myosin-10 isoform X1 [KO:K10352]
115604913  MYH9; myosin-9 [KO:K10352]
115606818  MYH11; myosin-11 isoform X1 [KO:K10352]
115608239  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
115608520  MYL3; myosin light chain 3 [KO:K12749]
115617910  MYL4; myosin light chain 4 [KO:K12750]
115614657  MYL2; LOW QUALITY PROTEIN: myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
115615234  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
115603061  myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
115604747  MYBPC1; LOW QUALITY PROTEIN: myosin-binding protein C, slow-type [KO:K12557]
115606591  MYBPC3; myosin-binding protein C, cardiac-type [KO:K12568]
115602329  MYBPH; myosin-binding protein H [KO:K24494]
115613788  ACTA1; actin, alpha skeletal muscle [KO:K10354]
115606000  actin, alpha skeletal muscle B-like [KO:K12314]
115606898  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
115614732  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
115602429  TNNI1; troponin I, slow skeletal muscle [KO:K10371]
115615010  TNNC2; troponin C, skeletal muscle [KO:K12042]
115607565  TNNI2; troponin I, fast skeletal muscle isoform X1 [KO:K12043]
115606395  TNNT3; troponin T, fast skeletal muscle [KO:K12046]
115602432  TNNT2; troponin T, cardiac muscle isoform X1 [KO:K12045]
115612575  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
115619814  TPM2; tropomyosin beta chain isoform X1 [KO:K09290]
115609501  LOW QUALITY PROTEIN: tropomyosin beta chain-like [KO:K09290]
115602715  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
115618351  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
115607849  TTN; titin [KO:K12567] [EC:2.7.11.1]
115615658  MYOT; myotilin isoform X1 [KO:K19875]
115617710  TCAP; telethonin [KO:K19879]
115605932  SYNPO2; synaptopodin-2 [KO:K24066]
115608760  NEB; nebulin [KO:K18267]
115612008  NEBL; nebulette isoform X1 [KO:K25865]
115605933  MYOZ2; myozenin-2 [KO:K26050]
115608030  MYOZ1; myozenin-1 isoform X1 [KO:K26050]
115616047  MYOZ3; LOW QUALITY PROTEIN: myozenin-3 [KO:K26050]
115610920  PDLIM3; PDZ and LIM domain protein 3 isoform X1 [KO:K23353]
115618547  PDLIM2; PDZ and LIM domain protein 2 [KO:K23353]
115608528  PDLIM1; PDZ and LIM domain protein 1 isoform X1 [KO:K23353]
115615539  PDLIM4; PDZ and LIM domain protein 4 isoform X1 [KO:K23353]
115604872  CAPZA2; F-actin-capping protein subunit alpha-2 isoform X1 [KO:K10364]
115605317  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
115602239  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
115617297  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
115619862  XIRP1; xin actin-binding repeat-containing protein 1 [KO:K27381]
115608816  NRAP; nebulin-related-anchoring protein [KO:K24421]
115608359  MYPN; myopalladin [KO:K22028]
115609107  LDB3; LIM domain-binding protein 3 isoform X1 [KO:K19867]
115610287  PDLIM5; PDZ and LIM domain protein 5 isoform X1 [KO:K19867]
115616058  PDLIM7; PDZ and LIM domain protein 7 [KO:K19867]
115612531  tropomodulin-2 [KO:K10370]
115612533  tropomodulin-3 isoform X1 [KO:K10370]
115601340  TMOD1; tropomodulin-1 [KO:K10370]
115602666  TMOD4; tropomodulin-4 [KO:K10370]
115601474  ZYX; zyxin isoform X1 [KO:K06273]
115612568  FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365]
115603851  FHL2; four and a half LIM domains protein 2 [KO:K14380]
115616152  FHL3; four and a half LIM domains protein 3 [KO:K24414]
115605775  LMOD2; leiomodin-2 isoform X1 [KO:K22030]
115602395  LMOD1; leiomodin-1 [KO:K22030]
115614816  LMOD3; leiomodin-3 [KO:K22030]
115608589  ANKRD1; ankyrin repeat domain-containing protein 1 [KO:K21433]
115608255  ANKRD2; ankyrin repeat domain-containing protein 2 isoform X1 [KO:K21434]
115617820  FMNL1; formin-like protein 1 isoform X1 [KO:K23957]
115618667  FMNL3; formin-like protein 3 isoform X1 [KO:K23957]
115608056  FMNL2; formin-like protein 2 isoform X1 [KO:K23957]
115606816  inverted formin-2-like isoform X1 [KO:K23958]
115606535  DAAM1; disheveled-associated activator of morphogenesis 1 isoform X1 [KO:K04512]
115613557  DAAM2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512]
115613132  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
115604208  DIAPH3; LOW QUALITY PROTEIN: protein diaphanous homolog 3 [KO:K05745]
115613751  FMN2; formin-2 isoform X1 [KO:K02184]
115609485  MYOM2; myomesin-2 [KO:K24495]
115604217  MYOM1; myomesin-1 [KO:K24495]
115617425  ENO1; alpha-enolase [KO:K01689] [EC:4.2.1.11]
115601654  ENO2; gamma-enolase isoform X1 [KO:K01689] [EC:4.2.1.11]
115605490  ANK2; ankyrin-2 isoform X1 [KO:K09255]
115609301  TRIM54; tripartite motif-containing protein 54 [KO:K10653]
115617314  TRIM55; tripartite motif-containing protein 55 [KO:K10654]
115615980  TRIM63; E3 ubiquitin-protein ligase TRIM63 [KO:K10655] [EC:2.3.2.27]
115607131  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
115602189  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
115602281  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
115606602  OBSCN; LOW QUALITY PROTEIN: obscurin [KO:K17531] [EC:2.7.11.1]
115606495  CAPN3; calpain-3 isoform X1 [KO:K08573] [EC:3.4.22.54]
115608247  PLEC; plectin isoform X4 [KO:K10388]
115607567  SYNE3; nesprin-3 isoform X1 [KO:K21761]
115613472  SYNE1; nesprin-1 isoform X1 [KO:K19326]
115606612  SYNE2; nesprin-2 isoform X1 [KO:K19346]
115604783  SUN2; SUN domain-containing protein 2 isoform X1 [KO:K19347]
115606514  SUN domain-containing protein 1-like isoform X1 [KO:K19347]
115606426  SUN domain-containing protein 1-like [KO:K19347]
115614169  TMEM43; LOW QUALITY PROTEIN: transmembrane protein 43 [KO:K27488]
115602861  EMD; emerin [KO:K12569]
115613612  LBR; delta(14)-sterol reductase LBR isoform X1 [KO:K19532] [EC:1.3.1.70]
115602596  LMNA; lamin [KO:K12641]
115618203  LMNB2; lamin-B2 [KO:K07611]
115600732  LMNB1; lamin-B1 isoform X1 [KO:K07611]
115613169  lamin-L(III)-like isoform X1 [KO:K07611]
Reference
PMID:12142273
  Authors
Clark KA, McElhinny AS, Beckerle MC, Gregorio CC
  Title
Striated muscle cytoarchitecture: an intricate web of form and function.
  Journal
Annu Rev Cell Dev Biol 18:637-706 (2002)
DOI:10.1146/annurev.cellbio.18.012502.105840
Reference
PMID:31407867
  Authors
Mukund K, Subramaniam S
  Title
Skeletal muscle: A review of molecular structure and function, in health and disease.
  Journal
Wiley Interdiscip Rev Syst Biol Med 12:e1462 (2020)
DOI:10.1002/wsbm.1462
Reference
PMID:24481844
  Authors
Stroud MJ, Banerjee I, Veevers J, Chen J
  Title
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
  Journal
Circ Res 114:538-48 (2014)
DOI:10.1161/CIRCRESAHA.114.301236
Reference
PMID:28640448
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
PMID:32265741
  Authors
Csapo R, Gumpenberger M, Wessner B
  Title
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review.
  Journal
Front Physiol 11:253 (2020)
DOI:10.3389/fphys.2020.00253
Reference
PMID:27114860
  Authors
Pinch M, Guth R, Samanta MP, Chaidez A, Unguez GA
  Title
The myogenic electric organ of Sternopygus macrurus: a non-contractile tissue with a skeletal muscle transcriptome.
  Journal
PeerJ 4:e1828 (2016)
DOI:10.7717/peerj.1828
Reference
PMID:23860255
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
PMID:36960155
  Authors
Zhang B, Powers JD, McCulloch AD, Chi NC
  Title
Nuclear mechanosignaling in striated muscle diseases.
  Journal
Front Physiol 14:1126111 (2023)
DOI:10.3389/fphys.2023.1126111
Reference
PMID:21464301
  Authors
Al-Amoudi A, Castano-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS
  Title
The three-dimensional molecular structure of the desmosomal plaque.
  Journal
Proc Natl Acad Sci U S A 108:6480-5 (2011)
DOI:10.1073/pnas.1019469108
Reference
PMID:33067392
  Authors
Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS
  Title
Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography.
  Journal
Proc Natl Acad Sci U S A 117:27132-27140 (2020)
DOI:10.1073/pnas.2004563117
Reference
PMID:26910421
  Authors
Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
  Title
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human alpha(IIb)beta(3) Integrin Complexes.
  Journal
Biophys J 110:798-809 (2016)
DOI:10.1016/j.bpj.2016.01.016
Reference
PMID:22945352
  Authors
Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z
  Title
Structural insights into SUN-KASH complexes across the nuclear envelope.
  Journal
Cell Res 22:1440-52 (2012)
DOI:10.1038/cr.2012.126
Reference
PMID:23597672
  Authors
Sosa BA, Kutay U, Schwartz TU
  Title
Structural insights into LINC complexes.
  Journal
Curr Opin Struct Biol 23:285-91 (2013)
DOI:10.1016/j.sbi.2013.03.005
Reference
PMID:33058875
  Authors
Cruz VE, Esra Demircioglu F, Schwartz TU
  Title
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  Journal
J Mol Biol 432:6028-6041 (2020)
DOI:10.1016/j.jmb.2020.09.019
Reference
PMID:36523505
  Authors
Schuler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF
  Title
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
  Journal
Front Cell Dev Biol 10:1056523 (2022)
DOI:10.3389/fcell.2022.1056523
Reference
PMID:30425656
  Authors
Brull A, Morales Rodriguez B, Bonne G, Muchir A, Bertrand AT
  Title
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
  Journal
Front Physiol 9:1533 (2018)
DOI:10.3389/fphys.2018.01533
Reference
PMID:36552829
  Authors
Storey EC, Fuller HR
  Title
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
  Journal
Cells 11:cells11244065 (2022)
DOI:10.3390/cells11244065
Related
pathway
shab04512  ECM-receptor interaction
shab04814  Motor proteins
KO pathway
ko04820   
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