KEGG   PATHWAY: shr05170
Entry
shr05170                    Pathway                                
Name
Human immunodeficiency virus 1 infection - Sarcophilus harrisii (Tasmanian devil)
Description
Human immunodeficiency virus type 1 (HIV-1) , the causative agent of AIDS (acquired immunodeficiency syndrome), is a lentivirus belonging to the Retroviridae family. The primary cell surface receptor for HIV-1, the CD4 protein, and the co-receptor for HIV-1, either CCR5 or CXCR4, are found on macrophages and T lymphocytes. At the earliest step, sequential binding of virus envelope (Env) glycoprotein gp120 to CD4 and the co-receptor CCR5 or CXCR4 facilitates HIV-1 entry and has the potential to trigger critical signaling that may favor viral replication. At advanced stages of the disease, HIV-1 infection results in dramatic induction of T-cell (CD4+ T and CD8+ T cell) apoptosis both in infected and uninfected bystander T cells, a hallmark of HIV-1 pathogenesis. On the contrary, macrophages are resistant to the cytopathic effect of HIV-1 and produce virus for longer periods of time.
Class
Human Diseases; Infectious disease: viral
Pathway map
shr05170  Human immunodeficiency virus 1 infection
shr05170

Organism
Sarcophilus harrisii (Tasmanian devil) [GN:shr]
Gene
100923185  CD4; T-cell surface glycoprotein CD4 precursor [KO:K06454]
100923383  FBXW11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
100925642  BTRC; F-box/WD repeat-containing protein 1A isoform X4 [KO:K03362]
100927300  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
100926417  CUL1; cullin-1 [KO:K03347]
100918404  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
100934336  CXCR4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
100913351  C-C chemokine receptor type 5 [KO:K04180]
100913616  C-C chemokine receptor type 5-like [KO:K04180]
100914706  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
100928725  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
100916740  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
100914773  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
100929811  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100932099  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105749979  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100926892  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100924976  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
100935230  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100933019  PTK2; focal adhesion kinase 1 isoform X6 [KO:K05725] [EC:2.7.10.2]
100923387  PTK2B; protein-tyrosine kinase 2-beta isoform X2 [KO:K05871] [EC:2.7.10.2]
100917237  PXN; paxillin [KO:K05760]
100923581  CRKL; crk-like protein [KO:K04438]
116423462  CRK; adapter molecule crk isoform X1 [KO:K04438]
100917987  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100913262  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100925440  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100931480  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
100935081  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
100930707  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X2 [KO:K04688] [EC:2.7.11.1]
100917619  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100932473  RELA; transcription factor p65 [KO:K04735]
100924435  FOS; proto-oncogene c-Fos [KO:K04379]
116423739  JUN; transcription factor AP-1 [KO:K04448]
100923199  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
100929168  ras-like protein [KO:K02833]
116419913  HRAS; GTPase HRas [KO:K02833]
100915526  KRAS; GTPase KRas isoform X1 [KO:K07827]
100927252  ras-related protein Rab-26-like [KO:K07827]
100929426  ras protein let-60-like [KO:K07827]
100928986  NRAS; GTPase NRas [KO:K07828]
100935202  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
100921899  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
100917396  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
100934330  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100913231  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
100916183  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
100920179  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
100923119  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
100919206  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2 [KO:K05859] [EC:3.1.4.11]
100918532  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X7 [KO:K04958]
100921270  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
100916996  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X2 [KO:K04960]
100929017  CALM1; calmodulin-1 isoform X2 [KO:K02183]
100920429  CALM2; calmodulin-2 [KO:K02183]
105750699  calmodulin-A [KO:K02183]
100935134  CALM3; calmodulin-3 isoform X1 [KO:K02183]
100925046  CALML4; calmodulin-like protein 4 [KO:K02183]
116419081  calmodulin [KO:K02183]
116423459  calmodulin-like [KO:K02183]
116423460  calmodulin-like [KO:K02183]
100917281  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100915297  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
100918408  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100918689  PPP3R1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
100926364  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
100920251  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X2 [KO:K17332]
100917473  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
100920502  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
100913337  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100924022  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100935225  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100930507  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
100917513  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
100914745  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
100932612  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
100931703  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
116419987  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
100917856  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
100933735  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
100920700  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
100934873  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
116419978  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
100920799  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 isoform X2 [KO:K04546]
100920266  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
100914479  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
100927581  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
100920537  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
100915783  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
100919657  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100932383  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100924669  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
100928883  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100926699  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
100919323  PAK4; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
100932749  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
100924604  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
100927614  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
100929464  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
100923817  CFL1; cofilin-1 [KO:K05765]
100929451  CFL2; cofilin-2 [KO:K05765]
100921875  TNF; tumor necrosis factor [KO:K03156]
100914374  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141]
100915548  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
100932981  TLR2; toll-like receptor 2 [KO:K10159]
100927125  TLR4; toll-like receptor 4 [KO:K10160]
100927751  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
100934112  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
100923900  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
100922331  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100917609  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
100930713  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
100920997  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
100913624  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100928932  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100926701  IKBKG; NF-kappa-B essential modulator isoform X3 [KO:K07210]
100919027  NFKBIA; LOW QUALITY PROTEIN: NF-kappa-B inhibitor alpha [KO:K04734]
100914965  interferon tau-like [KO:K05414]
100920968  interferon tau-2-like [KO:K05414]
100914703  interferon tau-2-like [KO:K05414]
116420987  interferon omega-1-like [KO:K05414]
116420989  interferon omega-1-like [KO:K05414]
100914443  interferon beta [KO:K05415]
100928729  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
100928990  MAPK11; LOW QUALITY PROTEIN: mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100925013  MAPK14; mitogen-activated protein kinase 14 isoform X2 [KO:K04441] [EC:2.7.11.24]
100925447  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100930815  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100928480  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100924267  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100920386  CGAS; cyclic GMP-AMP synthase isoform X2 [KO:K17834] [EC:2.7.7.86]
100932153  STING1; stimulator of interferon genes protein [KO:K12654]
100915362  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
100933650  interferon regulatory factor 3 [KO:K05411]
100914817  single-stranded DNA cytosine deaminase [KO:K18750] [EC:3.5.4.-]
100933973  SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [KO:K22544] [EC:3.1.5.-]
105749720  BST2; bone marrow stromal antigen 2 [KO:K06731]
100919788  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
100914177  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
116421331  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
100926831  TRAF5; TNF receptor-associated factor 5 isoform X2 [KO:K09849]
100934749  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
100925586  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
100926110  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
100919776  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
105749219  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
100925732  FADD; FAS-associated death domain protein [KO:K02373]
100931580  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100929676  BID; BH3-interacting domain death agonist [KO:K04726]
100916731  BAK1; bcl-2 homologous antagonist/killer isoform X2 [KO:K14021]
100934666  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
100919671  cytochrome c 2 [KO:K08738]
111721251  cytochrome c [KO:K08738]
100931481  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
100922757  caspase-3-like [KO:K02187] [EC:3.4.22.56]
100922500  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100919058  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
100924822  T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
100925080  T-cell surface glycoprotein CD3 delta chain [KO:K06450]
100935395  CD247; T-cell surface glycoprotein CD3 zeta chain [KO:K06453]
116423203  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
100926063  TAP2; antigen peptide transporter 2 isoform X1 [KO:K05654] [EC:7.4.2.14]
100913606  TAPBP; tapasin [KO:K08058]
100920935  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
100926396  calreticulin-like [KO:K08057]
100918092  CALR; calreticulin [KO:K08057]
100919863  SAHAI-12; HLA class I histocompatibility antigen, A-69 alpha chain-like [KO:K06751]
100913535  SAHAI-01; class I histocompatibility antigen, Gogo-OKO alpha chain-like precursor [KO:K06751]
100928906  class I histocompatibility antigen, Gogo-OKO alpha chain [KO:K06751]
100926320  DLA class I histocompatibility antigen, A9/A9 alpha chain [KO:K06751]
105749194  zinc-alpha-2-glycoprotein [KO:K06751]
105749196  class I histocompatibility antigen, F10 alpha chain [KO:K06751]
105749124  zinc-alpha-2-glycoprotein [KO:K06751]
105749195  major histocompatibility complex class I-related gene protein-like [KO:K06751]
105749197  LOW QUALITY PROTEIN: zinc-alpha-2-glycoprotein-like [KO:K06751]
100931105  hereditary hemochromatosis protein-like isoform X1 [KO:K06751]
105749122  major histocompatibility complex class I-related gene protein-like [KO:K06751]
105750614  class I histocompatibility antigen, Gogo-OKO alpha chain isoform X1 [KO:K06751]
100927947  class I histocompatibility antigen, Gogo-OKO alpha chain [KO:K06751]
100927921  AP1B1; AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
100925141  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
100926953  AP1G2; AP-1 complex subunit gamma-like 2 isoform X1 [KO:K12391]
100913483  AP1M1; AP-1 complex subunit mu-1 isoform X1 [KO:K12393]
100926975  AP1M2; AP-1 complex subunit mu-2 isoform X2 [KO:K12393]
100914815  AP1S2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
100916131  AP1S1; AP-1 complex subunit sigma-1A isoform X1 [KO:K12394]
100922303  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
100922420  B2M; beta-2-microglobulin [KO:K08055]
100915663  ELOB; elongin-B [KO:K03873]
100928425  ELOC; elongin-C [KO:K03872]
100927251  CUL5; cullin-5 isoform X1 [KO:K10612]
100931485  RNF7; RING-box protein 2 isoform X1 [KO:K10611]
100934156  DCAF1; DDB1- and CUL4-associated factor 1 isoform X1 [KO:K11789] [EC:2.7.11.1]
100932655  DDB1; DNA damage-binding protein 1 [KO:K10610]
100920722  CUL4A; cullin-4A [KO:K10609]
100933866  CUL4B; cullin-4B isoform X2 [KO:K10609]
100925167  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
100934350  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
100933648  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
100924438  CDC25C; M-phase inducer phosphatase 3 [KO:K05867] [EC:3.1.3.48]
100921012  WEE2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
100917017  WEE1; wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
100925753  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
100931176  CCNB2; G2/mitotic-specific cyclin-B2 isoform X2 [KO:K21770]
100921735  CCNB3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
100924163  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:22749173
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Evans VA, Khoury G, Saleh S, Cameron PU, Lewin SR
  Title
HIV persistence: chemokines and their signalling pathways.
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Cytokine Growth Factor Rev 23:151-7 (2012)
DOI:10.1016/j.cytogfr.2012.05.002
Reference
PMID:23806647
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Abbas W, Herbein G
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Plasma membrane signaling in HIV-1 infection.
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Biochim Biophys Acta 1838:1132-42 (2014)
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Reference
PMID:20041213
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Wu Y, Yoder A
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Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.
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PLoS Pathog 5:e1000520 (2009)
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Reference
PMID:22085380
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Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4).
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J Med Chem 55:977-94 (2012)
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Reference
PMID:21321123
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Vorster PJ, Guo J, Yoder A, Wang W, Zheng Y, Xu X, Yu D, Spear M, Wu Y
  Title
LIM kinase 1 modulates cortical actin and CXCR4 cycling and is activated by HIV-1 to initiate viral infection.
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J Biol Chem 286:12554-64 (2011)
DOI:10.1074/jbc.M110.182238
Reference
PMID:15817946
  Authors
Das SR, Jameel S
  Title
Biology of the HIV Nef protein.
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Indian J Med Res 121:315-32 (2005)
Reference
PMID:24822052
  Authors
Roy N, Pacini G, Berlioz-Torrent C, Janvier K
  Title
Mechanisms underlying HIV-1 Vpu-mediated viral egress.
  Journal
Front Microbiol 5:177 (2014)
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Reference
PMID:22090097
  Authors
Magadan JG, Bonifacino JS
  Title
Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu.
  Journal
J Virol 86:757-72 (2012)
DOI:10.1128/JVI.05933-11
Reference
PMID:26056579
  Authors
Kumar A, Herbein G
  Title
The macrophage: a therapeutic target in HIV-1 infection.
  Journal
Mol Cell Ther 2:10 (2014)
DOI:10.1186/2052-8426-2-10
Reference
PMID:20672047
  Authors
Yokota S, Okabayashi T, Fujii N
  Title
The battle between virus and host: modulation of Toll-like receptor signaling pathways by virus infection.
  Journal
Mediators Inflamm 2010:184328 (2010)
DOI:10.1155/2010/184328
Reference
PMID:26628325
  Authors
Sauter D, Kirchhoff F
  Title
HIV replication: a game of hide and sense.
  Journal
Curr Opin HIV AIDS 11:173-81 (2016)
DOI:10.1097/COH.0000000000000233
Reference
PMID:25988887
  Authors
Altfeld M, Gale M Jr
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Innate immunity against HIV-1 infection.
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J Virol 85:11220-34 (2011)
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Related
pathway
shr03050  Proteasome
shr04010  MAPK signaling pathway
shr04020  Calcium signaling pathway
shr04064  NF-kappa B signaling pathway
shr04110  Cell cycle
shr04141  Protein processing in endoplasmic reticulum
shr04142  Lysosome
shr04150  mTOR signaling pathway
shr04151  PI3K-Akt signaling pathway
shr04210  Apoptosis
shr04612  Antigen processing and presentation
shr04620  Toll-like receptor signaling pathway
shr04623  Cytosolic DNA-sensing pathway
shr04668  TNF signaling pathway
shr04810  Regulation of actin cytoskeleton
KO pathway
ko05170   
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