KEGG   PATHWAY: ssc05169
Entry
ssc05169                    Pathway                                
Name
Epstein-Barr virus infection - Sus scrofa (pig)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
ssc05169  Epstein-Barr virus infection
ssc05169

Organism
Sus scrofa (pig) [GN:ssc]
Gene
397669  CD19; B-lymphocyte antigen CD19 precursor [KO:K06465]
445528  SLA-DMA; SLA-DM alpha chain precursor [KO:K06752]
100135040  SLA-DRA; MHC class II DR-alpha precursor [KO:K06752]
100135049  SLA-DOB; MHC class II, DO beta precursor [KO:K06752]
100135050  SLA-DMB; MHC class II, DM beta precursor [KO:K06752]
100037921  SLA-DQB1; SLA class II histocompatibility antigen, DQ haplotype C beta chain precursor [KO:K06752]
100153387  SLA-DQA1; SLA class II histocompatibility antigen, DQ haplotype D alpha chain precursor [KO:K06752]
100153386  SLA-DRB1; MHC class II histocompatibility antigen SLA-DRB1 precursor [KO:K06752]
100157996  SLA-DOA; SLA class II histocompatibility antigen, DO alpha chain precursor [KO:K06752]
106504372  DLA class II histocompatibility antigen, DR-1 beta chain-like precursor [KO:K06752]
396623  TLR2; toll-like receptor 2 precursor [KO:K10159]
396646  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
100127166  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
396606  IRAK1; LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
396629  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100153785  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
100156182  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
100135663  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
100135662  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
100101471  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100127355  IKBKG; NF-kappa-B essential modulator [KO:K07210]
406188  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
751869  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
100135665  RELA; transcription factor p65 [KO:K04735]
397086  TNF; tumor necrosis factor [KO:K03156]
399500  IL6; interleukin-6 precursor [KO:K05405]
396723  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
100037290  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
100156979  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
100125828  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
100519508  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
100037289  IRF7; interferon regulatory factor 7 [KO:K09447]
396656  IRF3; interferon regulatory factor 3 [KO:K05411]
397686  IFNA1; interferon alpha-1 precursor [KO:K05414]
100153724  IFN-ALPHA-8; uncharacterized protein LOC100153724 precursor [KO:K05414]
100153661  interferon alpha-14 precursor [KO:K05414]
100157766  IFN-ALPHA-9; uncharacterized protein LOC100157766 precursor [KO:K05414]
100152100  IFN-ALPHA-13; uncharacterized protein LOC100152100 precursor [KO:K05414]
100152504  IFN-ALPHA-15; uncharacterized protein LOC100152504 precursor [KO:K05414]
100310806  IFN-ALPHAOMEGA; interferon-alphaomega precursor [KO:K05414]
100303758  IFN-ALPHA-5; interferon, alpha 5 precursor [KO:K05414]
100157735  IFN-ALPHA-16; uncharacterized protein LOC100157735 precursor [KO:K05414]
100153325  interferon alpha-2 precursor [KO:K05414]
100737904  interferon alpha-1-like [KO:K05414]
100154938  IFN-ALPHA-17; uncharacterized protein LOC100154938 precursor [KO:K05414]
100156561  IFN-ALPHA-10; interferon-alpha-10 precursor [KO:K05414]
100156936  interferon alpha-11 precursor [KO:K05414]
100157352  IFN-ALPHA-1; interferon-alpha-1 precursor [KO:K05414]
445459  IFNB1; interferon beta precursor [KO:K05415]
396658  IFNAR1; interferon alpha/beta receptor 1 precursor [KO:K05130]
100533555  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
397202  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
397363  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
396655  STAT1; signal transducer and activator of transcription 1 [KO:K11220]
396923  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
780415  IRF9; interferon regulatory factor 9 [KO:K04693]
397588  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
397570  OAS1; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
595128  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
494019  CXCL10; C-X-C motif chemokine 10 precursor [KO:K12671]
100145895  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
396826  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
595129  FADD; FAS-associated death domain protein [KO:K02373]
595105  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
594852  BID; BH3-interacting domain death agonist [KO:K04726]
396632  BCL2L11; bcl-2-like protein 11 isoform 2 [KO:K16341]
100049703  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
396633  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
397543  BAK1; bcl-2 homologous antagonist/killer isoform X2 [KO:K14021]
100170131  CYCS; cytochrome c [KO:K08738]
100522842  cytochrome c [KO:K08738]
100519295  cytochrome c-like [KO:K08738]
100621347  cytochrome c-like [KO:K08738]
100513283  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
100518913  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
397244  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
110261595  uncharacterized protein LOC110261595 [KO:K10784]
100620407  uncharacterized protein LOC100620407 [KO:K10784]
100626606  uncharacterized protein LOC100626606 [KO:K10784]
110255290  LOW QUALITY PROTEIN: uncharacterized protein LOC110255290 [KO:K10784]
100621559  T-cell receptor beta-1 chain C region [KO:K10785]
110257615  uncharacterized protein LOC110257615 [KO:K10785]
397455  CD3E; T-cell surface glycoprotein CD3 epsilon chain precursor [KO:K06451]
494013  CD3G; T-cell surface glycoprotein CD3 gamma chain precursor [KO:K06452]
396661  CD3D; T-cell surface glycoprotein CD3 delta chain precursor [KO:K06450]
397302  CD247; T-cell surface glycoprotein CD3 zeta chain precursor [KO:K06453]
100514865  PSMC2; 26S protease regulatory subunit 7 [KO:K03061]
100155274  PSMC1; 26S protease regulatory subunit 4 [KO:K03062]
110260986  PSMC4; 26S protease regulatory subunit 6B [KO:K03063]
100154148  PSMC6; 26S protease regulatory subunit 10B [KO:K03064]
100512454  PSMC3; 26S protease regulatory subunit 6A isoform X1 [KO:K03065]
397043  PSMC5; 26S protease regulatory subunit 8 [KO:K03066]
100627568  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
100153828  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
100512253  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
100524394  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
100523278  PSMD11; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
100519870  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
100626274  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
100517815  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
733583  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 [KO:K03029]
100156327  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
100515483  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
102157770  proteasomal ubiquitin receptor ADRM1 [KO:K06691]
110257483  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
100155621  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
733649  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
733650  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
100155428  TAPBP; tapasin [KO:K08058]
100156204  PDIA3; protein disulfide-isomerase A3 precursor [KO:K08056] [EC:5.3.4.1]
100381266  CALR; calreticulin precursor [KO:K08057]
396650  SLA-7; MHC class I antigen 7 precursor [KO:K06751]
100135031  SLA-2; MHC class I antigen 2 precursor [KO:K06751]
100037288  SLA-3; MHC class I antigen 3 precursor [KO:K06751]
100037293  SLA-1; MHC class I antigen 1 isoform X2 [KO:K06751]
100135029  SLA-5; MHC class I antigen 5 precursor [KO:K06751]
100135036  SLA-8; MHC class I antigen 8 precursor [KO:K06751]
100135037  SLA-6; MHC class I antigen 6 precursor [KO:K06751]
397033  B2M; beta-2-microglobulin precursor [KO:K08055]
110255236  B2M; beta-2-microglobulin [KO:K08055]
100623576  SNW1; SNW domain-containing protein 1 [KO:K06063]
100621221  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
100156170  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
100622482  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
733643  NCOR2; nuclear receptor corepressor 2 [KO:K06065]
100525720  SAP30L; histone deacetylase complex subunit SAP30L [KO:K19202]
100620430  SAP30; histone deacetylase complex subunit SAP30 isoform X1 [KO:K19202]
100511415  CIR1; corepressor interacting with RBPJ 1 [KO:K06066]
100518262  RBPJ; recombining binding protein suppressor of hairless isoform X4 [KO:K06053]
102163140  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
100499567  HES1; transcription factor HES-1 [KO:K06054]
100037942  FCER2; low affinity immunoglobulin epsilon Fc receptor [KO:K06468]
100622884  RUNX3; runt-related transcription factor 3 isoform X1 [KO:K09279]
448810  MYC; myc proto-oncogene protein [KO:K04377]
100190899  USP7; ubiquitin carboxyl-terminal hydrolase 7 [KO:K11838] [EC:3.4.19.12]
100125959  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
397276  TP53; cellular tumor antigen p53 [KO:K04451]
100152215  CDKN1A; LOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 1 [KO:K06625]
100152997  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
733669  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
100621090  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
100513197  DDB2; DNA damage-binding protein 2 isoform X2 [KO:K10140]
100518650  POLK; LOW QUALITY PROTEIN: DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
396616  TRAF5; TNF receptor-associated factor 5 isoform X2 [KO:K09849]
100518131  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100621789  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100622559  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100511937  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100739510  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100623707  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
100126861  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100513811  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100127478  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100520402  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
100622609  RELB; transcription factor RelB isoform X1 [KO:K09253]
100153829  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
100620340  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
100621111  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
100153486  NFKBIE; LOW QUALITY PROTEIN: NF-kappa-B inhibitor epsilon [KO:K05872]
100520100  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [KO:K04430] [EC:2.7.12.2]
100520418  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X5 [KO:K04431] [EC:2.7.12.2]
396610  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100521736  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
396609  MAPK9; mitogen-activated protein kinase 9 isoform X4 [KO:K04440] [EC:2.7.11.24]
100513840  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
100524751  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
110256149  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
100625946  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
574062  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100156630  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
100155841  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
110260605  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
396913  JUN; transcription factor AP-1 [KO:K04448]
397298  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
100516719  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
100623360  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
397395  CD40; tumor necrosis factor receptor superfamily member 5 precursor [KO:K03160]
100525150  CD44; CD44 antigen isoform X9 [KO:K06256]
733681  ITGAL; integrin alpha-L precursor [KO:K05718]
396702  CD58; lymphocyte function-associated antigen 3 precursor [KO:K06492]
396750  ICAM1; intercellular adhesion molecule 1 precursor [KO:K06490]
100522394  VIM; vimentin isoform X1 [KO:K07606]
100622156  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
100518649  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
733648  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
100152890  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
100125540  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
100514504  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
100627149  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
396781  IgG heavy chain precursor [KO:K06856]
100038328  immunoglobulin heavy variable 3-23 [KO:K06856]
100627308  BTK; tyrosine-protein kinase BTK [KO:K07370] [EC:2.7.10.2]
100152350  BLNK; B-cell linker protein [KO:K07371]
100518663  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
100329128  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
397584  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
100738589  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
397162  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
780426  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
100144492  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100415929  CCNA2; cyclin-A2 [KO:K06627]
100156017  CCNA1; cyclin-A1 [KO:K06627]
100512048  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
100523248  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
100154715  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
100151828  RB1; retinoblastoma-associated protein [KO:K06618]
100153846  E2F1; transcription factor E2F1 [KO:K17454]
110261113  E2F2; transcription factor E2F2 [KO:K09389]
100154407  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
  Journal
F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
Reference
PMID:12740915
  Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
  Journal
Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
  Journal
MBio 6:e00441-15 (2015)
DOI:10.1128/mBio.00441-15
Reference
PMID:11905817
  Authors
Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
  Journal
Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
  Journal
Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
  Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
  Journal
J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
Reference
PMID:25403939
  Authors
Kang H, Kiess A, Chung CH
  Title
Emerging biomarkers in head and neck cancer in the era of genomics.
  Journal
Nat Rev Clin Oncol 12:11-26 (2015)
DOI:10.1038/nrclinonc.2014.192
Reference
PMID:29932446
  Authors
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
  Title
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
  Journal
Cancers (Basel) 10:E213 (2018)
DOI:10.3390/cancers10070213
Reference
PMID:19649319
  Authors
Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
  Title
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
  Journal
PLoS Pathog 5:e1000530 (2009)
DOI:10.1371/journal.ppat.1000530
Reference
PMID:19244339
  Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
  Journal
J Virol 83:4652-69 (2009)
DOI:10.1128/JVI.02408-08
Reference
PMID:19394062
  Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
  Journal
Virology 388:236-47 (2009)
DOI:10.1016/j.virol.2009.03.027
Reference
PMID:25635182
  Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
  Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
  Journal
Future Virol 4:79-91 (2009)
DOI:10.2217/17460794.4.1.79
Reference
PMID:10818681
  Authors
Longnecker R
  Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
  Journal
Adv Cancer Res 79:175-200 (2000)
DOI:10.1016/s0065-230x(00)79006-3
Reference
PMID:30116721
  Authors
El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
  Journal
Front Oncol 8:265 (2018)
DOI:10.3389/fonc.2018.00265
Reference
PMID:12811813
  Authors
Dolcetti R, Masucci MG
  Title
Epstein-Barr virus: induction and control of cell transformation.
  Journal
J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
Reference
PMID:21347341
  Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
  Journal
PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Related
pathway
ssc03050  Proteasome
ssc04010  MAPK signaling pathway
ssc04020  Calcium signaling pathway
ssc04064  NF-kappa B signaling pathway
ssc04110  Cell cycle
ssc04115  p53 signaling pathway
ssc04210  Apoptosis
ssc04612  Antigen processing and presentation
ssc04620  Toll-like receptor signaling pathway
ssc04622  RIG-I-like receptor signaling pathway
ssc04630  JAK-STAT signaling pathway
ssc04662  B cell receptor signaling pathway
KO pathway
ko05169   
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