KEGG   PATHWAY: var04144
Entry
var04144                    Pathway                                
Name
Endocytosis - Vigna angularis (adzuki bean)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
var04144  Endocytosis
var04144

Other DBs
GO: 0006897
Organism
Vigna angularis (adzuki bean) [GN:var]
Gene
108332116  phosphatidylinositol 4-phosphate 5-kinase 2-like [KO:K00889] [EC:2.7.1.68]
108322466  phosphatidylinositol 4-phosphate 5-kinase 9-like [KO:K00889] [EC:2.7.1.68]
108325783  phosphatidylinositol 4-phosphate 5-kinase 4-like [KO:K00889] [EC:2.7.1.68]
108326010  phosphatidylinositol 4-phosphate 5-kinase 9 [KO:K00889] [EC:2.7.1.68]
108328402  phosphatidylinositol 4-phosphate 5-kinase 5-like [KO:K00889] [EC:2.7.1.68]
108318719  phosphatidylinositol 4-phosphate 5-kinase 7-like [KO:K00889] [EC:2.7.1.68]
108343441  phosphatidylinositol 4-phosphate 5-kinase 7 [KO:K00889] [EC:2.7.1.68]
108333557  phosphatidylinositol 4-phosphate 5-kinase 6-like [KO:K00889] [EC:2.7.1.68]
108339698  phosphatidylinositol 4-phosphate 5-kinase 6-like [KO:K00889] [EC:2.7.1.68]
108320970  phosphatidylinositol 4-phosphate 5-kinase 1-like [KO:K00889] [EC:2.7.1.68]
108320997  phosphatidylinositol 4-phosphate 5-kinase 1-like [KO:K00889] [EC:2.7.1.68]
108331901  phosphatidylinositol 4-phosphate 5-kinase 2 [KO:K00889] [EC:2.7.1.68]
108333372  phospholipase D alpha 4-like [KO:K01115] [EC:3.1.4.4]
108334641  phospholipase D beta 1-like [KO:K01115] [EC:3.1.4.4]
108338311  phospholipase D gamma 1-like [KO:K01115] [EC:3.1.4.4]
108321294  phospholipase D delta [KO:K01115] [EC:3.1.4.4]
108331050  phospholipase D alpha 1-like [KO:K01115] [EC:3.1.4.4]
108324250  phospholipase D zeta 1-like [KO:K01115] [EC:3.1.4.4]
108333925  phospholipase D alpha 1 [KO:K01115] [EC:3.1.4.4]
108322306  phospholipase D zeta 1-like [KO:K01115] [EC:3.1.4.4]
108330787  phospholipase D alpha 1-like [KO:K01115] [EC:3.1.4.4]
108323330  phospholipase D alpha 4-like [KO:K01115] [EC:3.1.4.4]
108323478  phospholipase D delta-like [KO:K01115] [EC:3.1.4.4]
108347502  phospholipase D gamma 1-like [KO:K01115] [EC:3.1.4.4]
108320624  phospholipase D alpha 1 [KO:K01115] [EC:3.1.4.4]
108343560  phospholipase D delta-like [KO:K01115] [EC:3.1.4.4]
108346498  dynamin-2A [KO:K01528] [EC:3.6.5.5]
108340293  dynamin-2B-like [KO:K01528] [EC:3.6.5.5]
108328915  clathrin heavy chain 1 [KO:K04646]
108337923  clathrin heavy chain 2 [KO:K04646]
108342812  clathrin heavy chain 2-like [KO:K04646]
108333992  AP-2 complex subunit alpha-1-like [KO:K11824]
108334611  AP-2 complex subunit mu-like [KO:K11826]
108323764  AP-2 complex subunit mu [KO:K11826]
108338209  AP-2 complex subunit sigma [KO:K11827]
108326165  clathrin interactor EPSIN 2 [KO:K12471]
108333456  epsin-3-like [KO:K12471]
108321668  clathrin interactor EPSIN 2-like [KO:K12471]
108321685  clathrin interactor EPSIN 2-like [KO:K12471]
108324704  epsin-3 [KO:K12471]
108319598  epsin-3-like [KO:K12471]
108338414  clathrin interactor EPSIN 1 [KO:K12471]
108342858  epidermal growth factor receptor substrate 15 [KO:K12472]
108320169  actin cytoskeleton-regulatory complex protein PAN1-like [KO:K12472]
108321292  spartin [KO:K19366]
108340661  spartin [KO:K19366]
108340701  uncharacterized LOC108340701 [KO:K19366]
108329310  actin-related protein 2 [KO:K17260]
108331133  actin-related protein 3 [KO:K18584]
108331144  actin-related protein 3-like [KO:K18584]
108334189  actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
108343237  actin-related protein 2/3 complex subunit 1B-like [KO:K05757]
108326615  actin-related protein 2/3 complex subunit 2B [KO:K05758]
108323897  actin-related protein 2/3 complex subunit 2A [KO:K05758]
108333514  actin-related protein 2/3 complex subunit 3 [KO:K05756]
108343574  actin-related protein 2/3 complex subunit 3-like [KO:K05756]
108347705  actin-related protein 2/3 complex subunit 4 [KO:K05755]
108346994  actin-related protein 2/3 complex subunit 5A-like [KO:K05754]
108347070  actin-related protein 2/3 complex subunit 5A-like [KO:K05754]
108335814  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
108338197  heat shock cognate 70 kDa protein 2 [KO:K03283]
108321613  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
108321630  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
108321631  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
108321632  heat shock cognate 70 kDa protein 2-like [KO:K03283]
108319632  heat shock cognate 70 kDa protein 2 [KO:K03283]
108325995  heat shock cognate 70 kDa protein 2-like [KO:K03283]
108330741  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
108338419  heat shock cognate 70 kDa protein 2-like [KO:K03283]
108320180  heat shock 70 kDa protein [KO:K03283]
108321720  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
108321721  heat shock cognate 70 kDa protein-like [KO:K03283]
108320666  heat shock 70 kDa protein-like [KO:K03283]
108323002  heat shock cognate 70 kDa protein 2-like [KO:K03283]
108342648  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
108343473  heat shock 70 kDa protein-like [KO:K03283]
108343597  heat shock 70 kDa protein-like [KO:K03283]
108341795  F-actin-capping protein subunit alpha [KO:K10364]
108324929  probable F-actin-capping protein subunit beta [KO:K10365]
108338447  vacuolar protein sorting-associated protein 29 [KO:K18467]
108334259  vacuolar protein sorting-associated protein 26A [KO:K18466]
108321295  vacuolar protein sorting-associated protein 35A-like [KO:K18468]
108338454  vacuolar protein sorting-associated protein 35B-like [KO:K18468]
108346069  AMSH-like ubiquitin thioesterase 1 [KO:K11866] [EC:3.4.19.12]
108322257  AMSH-like ubiquitin thioesterase 3 [KO:K11866] [EC:3.4.19.12]
108335198  AMSH-like ubiquitin thioesterase 2 [KO:K11866] [EC:3.4.19.12]
108323140  AMSH-like ubiquitin thioesterase 1 [KO:K11866] [EC:3.4.19.12]
108340619  ras-related protein Rab7 [KO:K07897]
108326450  ras-related protein Rab7 [KO:K07897]
108336646  ras-related protein Rab7 [KO:K07897]
108320410  ras-related protein Rab7 [KO:K07897]
108340790  protein ELC-like [KO:K12183]
108334527  vacuolar protein sorting-associated protein 28 homolog 2 [KO:K12184]
108322465  vacuolar protein-sorting-associated protein 37 homolog 1 [KO:K12185]
108325412  vacuolar protein-sorting-associated protein 37 homolog 1-like [KO:K12185]
108341954  vacuolar protein sorting-associated protein 22 homolog 1 [KO:K12188]
108321753  vacuolar protein sorting-associated protein 36-like [KO:K12190]
108321764  vacuolar protein sorting-associated protein 36-like [KO:K12190]
108334732  vacuolar protein sorting-associated protein 25 [KO:K12189]
108331581  vacuolar protein sorting-associated protein 20 homolog 2-like [KO:K12195]
108347597  vacuolar protein sorting-associated protein 32 homolog 2-like [KO:K12194]
108345560  vacuolar protein sorting-associated protein 32 homolog 2-like [KO:K12194]
108345561  vacuolar protein sorting-associated protein 32 homolog 2 [KO:K12194]
108338919  vacuolar protein sorting-associated protein 24 homolog 1 [KO:K12193]
108319321  vacuolar protein sorting-associated protein 2 homolog 1-like [KO:K12191]
108337834  vacuolar protein sorting-associated protein 2 homolog 1-like [KO:K12191]
108319458  vacuolar protein sorting-associated protein 2 homolog 2 [KO:K12191]
108331940  vacuolar protein sorting-associated protein 2 homolog 1 [KO:K12191]
108323232  vacuolar protein sorting-associated protein 2 homolog 3 [KO:K12192]
108326790  charged multivesicular body protein 7 [KO:K15053]
108340364  protein SUPPRESSOR OF K(+) TRANSPORT GROWTH DEFECT 1-like [KO:K12196]
108334156  protein SUPPRESSOR OF K(+) TRANSPORT GROWTH DEFECT 1 [KO:K12196]
108338700  protein HOMOLOG OF MAMMALIAN LYST-INTERACTING PROTEIN 5 [KO:K12199]
108332311  ESCRT-related protein CHMP1B [KO:K12197]
108343168  charged multivesicular body protein 5-like [KO:K12198]
108322072  ALG-2 interacting protein X [KO:K12200]
108323899  maspardin [KO:K19367]
108324146  sorting nexin 1 [KO:K17917]
108332346  ras-related protein RABF2b-like [KO:K07889]
108347154  ras-related protein RHN1-like [KO:K07889]
108343377  ras-related protein RHN1 [KO:K07889]
108338183  EH domain-containing protein 1-like [KO:K12483]
108338182  EH domain-containing protein 1-like [KO:K12483]
108332607  EH domain-containing protein 1-like [KO:K12483]
108325743  EH domain-containing protein 1-like [KO:K12483]
108325746  EH domain-containing protein 1-like [KO:K12483]
108342053  EH domain-containing protein 2-like [KO:K12483]
108331849  vacuolar protein sorting-associated protein 45 homolog [KO:K12479]
108334245  ras-related protein RABE1c-like [KO:K07901]
108323464  ras-related protein RABE1c [KO:K07901]
108326452  ras-related protein RABE1c-like [KO:K07901]
108338403  ras-related protein RABE1c-like [KO:K07901]
108326421  ras-related protein RABE1c [KO:K07901]
108334139  ras-related protein RABA1b [KO:K07904]
108326646  ras-related protein RABA4d [KO:K07904]
108327923  ras-related protein RABA4d-like [KO:K07904]
108329411  ras-related protein Rab11A-like [KO:K07904]
108333947  ras-related protein Rab11D [KO:K07904]
108319629  ras-related protein Rab11C [KO:K07904]
108318800  ras-related protein Rab11C-like [KO:K07904]
108319225  ras-related protein Rab11E-like [KO:K07904]
108319238  ras-related protein RABA3-like [KO:K07904]
108321639  ras-related protein RABA5d-like [KO:K07904]
108322760  ras-related protein RABA4d-like [KO:K07904]
108322798  ras-related protein RABA5a [KO:K07904]
108328116  ras-related protein Rab2BV-like [KO:K07904]
108343547  ras-related protein RABA2a [KO:K07904]
108343570  ras-related protein RABA3 [KO:K07904]
108342142  ras-related protein Rab11A [KO:K07904]
108340587  ras-related protein RABA1f [KO:K07904]
108345164  probable ADP-ribosylation factor GTPase-activating protein AGD15 [KO:K12486]
108343366  ADP-ribosylation factor GTPase-activating protein AGD12-like [KO:K12486]
108334324  probable ADP-ribosylation factor GTPase-activating protein AGD5 [KO:K12486]
108333612  probable ADP-ribosylation factor GTPase-activating protein AGD15 [KO:K12486]
108340696  probable ADP-ribosylation factor GTPase-activating protein AGD5 [KO:K12486]
108338539  ADP-ribosylation factor GTPase-activating protein AGD12-like [KO:K12486]
108332554  probable ADP-ribosylation factor GTPase-activating protein AGD11 [KO:K12486]
108339872  probable ADP-ribosylation factor GTPase-activating protein AGD11 [KO:K12486]
108330399  ADP-ribosylation factor GTPase-activating protein AGD1-like [KO:K12489]
108328961  ADP-ribosylation factor GTPase-activating protein AGD3 [KO:K12489]
108340449  ADP-ribosylation factor GTPase-activating protein AGD2-like [KO:K12489]
108323855  ADP-ribosylation factor GTPase-activating protein AGD3-like [KO:K12489]
108326241  ADP-ribosylation factor GTPase-activating protein AGD7 [KO:K12492]
108323012  probable ADP-ribosylation factor GTPase-activating protein AGD6 [KO:K12492]
108336728  probable ADP-ribosylation factor GTPase-activating protein AGD8 [KO:K12493]
108320450  probable ADP-ribosylation factor GTPase-activating protein AGD8 [KO:K12493]
108320168  brefeldin A-inhibited guanine nucleotide-exchange protein 1 [KO:K18442]
108338102  brefeldin A-inhibited guanine nucleotide-exchange protein 2 [KO:K18442]
108327690  brefeldin A-inhibited guanine nucleotide-exchange protein 2 [KO:K18442]
108345258  ARF guanine-nucleotide exchange factor GNL2 [KO:K18443]
108329296  ARF guanine-nucleotide exchange factor GNOM-like [KO:K18443]
108329051  ARF guanine-nucleotide exchange factor GNOM-like [KO:K18443]
108338084  ARF guanine-nucleotide exchange factor GNOM-like [KO:K18443]
108326226  ADP-ribosylation factor [KO:K07937]
108335919  ADP-ribosylation factor 2-like [KO:K07937]
108335223  ADP-ribosylation factor 2-like [KO:K07937]
108347840  ADP-ribosylation factor 2 [KO:K07937]
108326330  ADP-ribosylation factor [KO:K07937]
108329636  ADP-ribosylation factor [KO:K07937]
108344604  ADP-ribosylation factor-like [KO:K07937]
108342038  ADP-ribosylation factor 1-like [KO:K07937]
108340679  ADP-ribosylation factor-like [KO:K07937]
108320935  ADP-ribosylation factor-like [KO:K07937]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
var04070  Phosphatidylinositol signaling system
var04130  SNARE interactions in vesicular transport
KO pathway
ko04144   
LinkDB

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