KEGG   PATHWAY: vpc05415
Entry
vpc05415                    Pathway                                
Name
Diabetic cardiomyopathy - Vicugna pacos (alpaca)
Description
Diabetic cardiomyopathy has been defined as left ventricular dysfunction that occurs among patients with diabetes mellitus independent of a recognized cause such as coronary artery disease or hypertension. The pathogenesis of diabetic cardiomyopathy broadly involves hyperglycemia, increased circulating fatty acids, and insulin resistance contributing to reactive oxygen species (ROS) generation, mitochondrial dysfunction, impaired calcium metabolism, Renin-Angiotensin System (RAS) activation, and altered substrate metabolism. These effects result in cardiac fibrosis, hypertrophy, cardiomyocyte death, contractile dysfunction, endothelial cell damage and eventually heart failure. In the process of cardiac fibrosis, cardiac fibroblasts are the final effector cell.
Class
Human Diseases; Cardiovascular disease
Pathway map
vpc05415  Diabetic cardiomyopathy
vpc05415

Organism
Vicugna pacos (alpaca) [GN:vpc]
Gene
102542924  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
102536880  SLC2A4; solute carrier family 2, facilitated glucose transporter member 4 isoform X1 [KO:K07191]
102542674  GFPT1; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 isoform X1 [KO:K00820] [EC:2.6.1.16]
102543179  GFPT2; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 isoform X1 [KO:K00820] [EC:2.6.1.16]
102543778  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X3 [KO:K04515] [EC:2.7.11.17]
102536144  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
102541361  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
102544405  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
102524999  TNNI3; troponin I, cardiac muscle isoform X1 [KO:K12044]
102537530  RYR2; ryanodine receptor 2 [KO:K04962]
102526032  PLN; cardiac phospholamban [KO:K05852]
102537306  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
102528424  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
102532821  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
102540803  SP1; transcription factor Sp1 [KO:K04684]
102543577  AGT; angiotensinogen [KO:K09821]
102527009  REN; renin isoform X1 [KO:K01380] [EC:3.4.23.15]
102529914  LOW QUALITY PROTEIN: chymase-like [KO:K01329] [EC:3.4.21.39]
102526158  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
102531985  AGER; advanced glycosylation end product-specific receptor [KO:K19722]
102540012  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
102539399  NCF1; LOW QUALITY PROTEIN: neutrophil cytosol factor 1 [KO:K08011]
102539436  cytochrome b-245 light chain isoform X3 [KO:K08009]
102537415  NCF2; neutrophil cytosol factor 2 [KO:K08010]
102540241  NCF4; neutrophil cytosol factor 4 [KO:K08012]
102543993  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102541733  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
102531032  AGTR1; type-1 angiotensin II receptor [KO:K04166]
102532161  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102540197  RELA; transcription factor p65 isoform X1 [KO:K04735]
102525219  MAPK12; mitogen-activated protein kinase 12 isoform X7 [KO:K04441] [EC:2.7.11.24]
102531650  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
102540698  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
102541290  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
102528221  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102543430  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102539859  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102524948  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
102528343  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
102529561  COL1A1; LOW QUALITY PROTEIN: collagen alpha-1(I) chain [KO:K06236]
102536258  COL1A2; collagen alpha-2(I) chain [KO:K06236]
102535927  COL3A1; collagen alpha-1(III) chain isoform X1 [KO:K19720]
102539136  TGFB1; transforming growth factor beta-1 proprotein precursor [KO:K13375]
102543548  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
102534848  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
102530127  CD36; platelet glycoprotein 4 isoform X2 [KO:K06259]
102527411  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
102544168  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
102528602  PDK2; pyruvate dehydrogenase kinase, isozyme 2 [KO:K00898] [EC:2.7.11.2]
102533838  PDK4; pyruvate dehydrogenase kinase, isozyme 4 [KO:K00898] [EC:2.7.11.2]
102539849  PDK3; pyruvate dehydrogenase kinase, isozyme 3 isoform X1 [KO:K00898] [EC:2.7.11.2]
102541926  PRKCA; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
102537750  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
102534665  PTPA; serine/threonine-protein phosphatase 2A activator isoform X1 [KO:K17605]
102534257  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X3 [KO:K06269] [EC:3.1.3.16]
102532474  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
102536752  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
102525806  CTSD; cathepsin D isoform X1 [KO:K01379] [EC:3.4.23.5]
102544003  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
102532414  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial isoform X1 [KO:K08766] [EC:2.3.1.21]
116285510  INS; insulin [KO:K04526]
102544508  INSR; insulin receptor isoform X3 [KO:K04527] [EC:2.7.10.1]
102533840  IRS1; insulin receptor substrate 1 [KO:K16172]
102540289  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102524821  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102543068  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102532395  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102536302  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102536225  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102530539  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102526860  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102546009  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102542031  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102529880  MTOR; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
102539918  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
102542710  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
102524906  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
102524883  TBC1D4; TBC1 domain family member 4 isoform X1 [KO:K17902]
102541903  MPC1L; mitochondrial pyruvate carrier 1-like protein [KO:K22138]
102541338  MPC1; mitochondrial pyruvate carrier 1 [KO:K22138]
102525568  MPC2; mitochondrial pyruvate carrier 2 [KO:K22139]
102544377  PDHA1; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial [KO:K00161] [EC:1.2.4.1]
102530901  PDHA2; pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial [KO:K00161] [EC:1.2.4.1]
102526467  PDHB; pyruvate dehydrogenase E1 component subunit beta, mitochondrial [KO:K00162] [EC:1.2.4.1]
809425  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
809424  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
809423  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
809433  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
809422  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
809432  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
809421  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
102525385  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
102532562  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
116277286  NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial-like [KO:K03944]
102533334  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [KO:K03944]
116277276  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
102545551  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 isoform X2 [KO:K03946]
102545369  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
102529038  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
102532337  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
102542319  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
102540724  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
102541381  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X1 [KO:K03952]
102545483  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
102529865  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
102525012  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
102531947  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
102530402  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
102526228  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
116281018  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
102528538  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
102541378  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
102541999  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
102545837  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
102531674  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
102546139  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
102532297  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
102538521  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
102544402  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
102526073  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
102527215  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
102530062  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
102545302  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
102533367  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
102540111  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
102544411  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
102539766  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
102526408  NDUFC1; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
102545496  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
102537928  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
102541082  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
102533226  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
102540794  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
102531964  cytochrome b-c1 complex subunit Rieske, mitochondrial isoform X1 [KO:K00411] [EC:7.1.1.8]
809426  CYTB; cytochrome b [KO:K00412]
102536999  cytochrome c1, heme protein, mitochondrial [KO:K00413]
102527945  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
102543034  cytochrome b-c1 complex subunit 2, mitochondrial isoform X1 [KO:K00415]
102537356  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
102541957  cytochrome b-c1 complex subunit 7 [KO:K00417]
102527563  cytochrome b-c1 complex subunit 7 [KO:K00417]
102540022  cytochrome b-c1 complex subunit 8 [KO:K00418]
102544889  cytochrome b-c1 complex subunit 9 [KO:K00419]
107033710  cytochrome b-c1 complex subunit 10 [KO:K00420]
809427  COX3; cytochrome c oxidase subunit III [KO:K02262]
809429  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
809428  COX2; cytochrome c oxidase subunit II [KO:K02261]
102542090  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
102531685  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X3 [KO:K02263]
102531058  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
102535574  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
102525188  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
102532905  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
102531509  cytochrome c oxidase subunit 6B2 [KO:K02267]
102529630  cytochrome c oxidase subunit 6B1 [KO:K02267]
102535870  cytochrome c oxidase subunit 6B1-like [KO:K02267]
102536543  cytochrome c oxidase subunit 6B1-like [KO:K02267]
116285593  uncharacterized protein LOC116285593 [KO:K02268]
102538808  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
102545108  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
102539271  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
102544618  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
102527993  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
102540595  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
116278795  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
116285480  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
102531916  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
102527195  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
102536529  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
102527480  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
116285262  ATP synthase subunit epsilon, mitochondrial [KO:K02135]
809431  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
102545274  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
116280385  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit B1, mitochondrial-like [KO:K02127]
102542870  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
102527040  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
102545086  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
102529615  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
102543382  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
102529373  ATP synthase subunit O, mitochondrial [KO:K02137]
102534637  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
809430  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
102538007  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
102540832  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
102527881  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
102540562  LOW QUALITY PROTEIN: ADP/ATP translocase 2-like [KO:K05863]
102541487  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
102542346  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
102539023  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
102525135  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
102542323  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102536194  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
102526308  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
102525593  PARP1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
102542305  G6PD; glucose-6-phosphate 1-dehydrogenase isoform X3 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
102537785  GSR; glutathione reductase, mitochondrial isoform X2 [KO:K00383] [EC:1.8.1.7]
102526363  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
102529547  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
102538474  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
102531396  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
102538560  PLCB3; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
102529315  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
102529761  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [KO:K05858] [EC:3.1.4.11]
102531845  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
102532894  angiotensin-converting enzyme isoform X2 [KO:K01283] [EC:3.4.15.1]
Compound
C00001  H2O
C00002  ATP
C00005  NADPH
C00006  NADP+
C00022  Pyruvate
C00024  Acetyl-CoA
C00027  Hydrogen peroxide
C00031  D-Glucose
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00051  Glutathione
C00076  Calcium cation
C00085  D-Fructose 6-phosphate
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00118  D-Glyceraldehyde 3-phosphate
C00127  Glutathione disulfide
C00162  Fatty acid
C00165  Diacylglycerol
C00195  N-Acylsphingosine
C00236  3-Phospho-D-glyceroyl phosphate
C00318  L-Carnitine
C00352  D-Glucosamine 6-phosphate
C00369  Starch
C00533  Nitric oxide
C00546  Methylglyoxal
C00704  Superoxide
C00794  D-Sorbitol
C00873  Angiotensin I
C02135  Angiotensin II
C02843  Long-chain acyl-CoA
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06156  alpha-D-Glucosamine 1-phosphate
C16844  Hydroxyl radical
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
C22310  Fructose 3-phosphate
C22311  3-Deoxyglucosone
Reference
PMID:30443826
  Authors
Riehle C, Bauersachs J
  Title
Of mice and men: models and mechanisms of diabetic cardiomyopathy.
  Journal
Basic Res Cardiol 114:2 (2018)
DOI:10.1007/s00395-018-0711-0
Reference
PMID:24462787
  Authors
Huynh K, Bernardo BC, McMullen JR, Ritchie RH
  Title
Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways.
  Journal
Pharmacol Ther 142:375-415 (2014)
DOI:10.1016/j.pharmthera.2014.01.003
Reference
PMID:28231848
  Authors
Lorenzo-Almoros A, Tunon J, Orejas M, Cortes M, Egido J, Lorenzo O
  Title
Diagnostic approaches for diabetic cardiomyopathy.
  Journal
Cardiovasc Diabetol 16:28 (2017)
DOI:10.1186/s12933-017-0506-x
Reference
PMID:32080423
  Authors
Tan Y, Zhang Z, Zheng C, Wintergerst KA, Keller BB, Cai L
  Title
Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence.
  Journal
Nat Rev Cardiol 17:585-607 (2020)
DOI:10.1038/s41569-020-0339-2
Reference
PMID:31212580
  Authors
Zamora M, Villena JA
  Title
Contribution of Impaired Insulin Signaling to the Pathogenesis of Diabetic Cardiomyopathy.
  Journal
Int J Mol Sci 20:E2833 (2019)
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Related
pathway
vpc00010  Glycolysis / Gluconeogenesis
vpc00020  Citrate cycle (TCA cycle)
vpc00190  Oxidative phosphorylation
vpc00520  Amino sugar and nucleotide sugar metabolism
vpc03320  PPAR signaling pathway
vpc04071  Sphingolipid signaling pathway
vpc04150  mTOR signaling pathway
vpc04210  Apoptosis
vpc04260  Cardiac muscle contraction
vpc04350  TGF-beta signaling pathway
vpc04614  Renin-angiotensin system
vpc04910  Insulin signaling pathway
vpc04930  Type II diabetes mellitus
vpc04931  Insulin resistance
vpc04933  AGE-RAGE signaling pathway in diabetic complications
vpc04940  Type I diabetes mellitus
KO pathway
ko05415   
LinkDB

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