| Entry |
|
|---|
| Name |
dihydropyrimidine dehydrogenase (NAD+);
dihydropyrimidine dehydrogenase;
dihydrothymine dehydrogenase;
pyrimidine reductase;
thymine reductase;
uracil reductase;
dihydrouracil dehydrogenase (NAD+)
|
|---|
| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
|
|---|
| Sysname |
5,6-dihydropyrimidine:NAD+ oxidoreductase
|
|---|
| Reaction(IUBMB) |
(1) 5,6-dihydrouracil + NAD+ = uracil + NADH + H+ [RN: R00977];
(2) 5,6-dihydrothymine + NAD+ = thymine + NADH + H+ [RN: R01414]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
|
|---|
| Product |
|
|---|
| Comment |
An iron-sulfur flavoenzyme. The enzyme was originally discovered in the uracil-fermenting bacterium, Clostridium uracilicum, which utilizes uracil and thymine as nitrogen and carbon sources for growth [1]. Since then the enzyme was found in additional organisms including Alcaligenes eutrophus [2], Pseudomonas strains [3,4] and Escherichia coli [5,6].
|
|---|
| History |
EC 1.3.1.1 created 1961, modified 2011
|
|---|
| Pathway |
| ec00770 | Pantothenate and CoA biosynthesis |
|
|---|
| Orthology |
| K17722 | dihydropyrimidine dehydrogenase (NAD+) subunit PreT |
| K17723 | dihydropyrimidine dehydrogenase (NAD+) subunit PreA |
|
|---|
| Genes |
» show all
|
|---|
| Reference |
|
|---|
| Authors |
CAMPBELL LL Jr. |
|---|
| Title |
Reductive degradation of pyrimidines. III. Purification and properties of dihydrouracil dehydrogenase. |
|---|
| Journal |
J Biol Chem 227:693-700 (1957) |
|---|
| Reference |
|
|---|
| Authors |
Schmitt U, Jahnke K, Rosenbaum K, Cook PF, Schnackerz KD |
|---|
| Title |
Purification and characterization of dihydropyrimidine dehydrogenase from Alcaligenes eutrophus. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Kim S, West TP |
|---|
| Title |
Pyrimidine catabolism in Pseudomonas aeruginosa. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
West TP |
|---|
| Title |
Pyrimidine base catabolism in Pseudomonas putida biotype B. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
West TP |
|---|
| Title |
Isolation and characterization of an Escherichia coli B mutant strain defective in uracil catabolism. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Hidese R, Mihara H, Kurihara T, Esaki N |
|---|
| Title |
Escherichia coli dihydropyrimidine dehydrogenase is a novel NAD-dependent heterotetramer essential for the production of 5,6-dihydrouracil. |
|---|
| Journal |
|
|---|
| Sequence |
|
|---|
| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.3.1.1 |
| ExPASy - ENZYME nomenclature database: | 1.3.1.1 |
| BRENDA, the Enzyme Database: | 1.3.1.1 |
|
|---|
| LinkDB |
|
|---|
