| Entry |
|
|---|
| Name |
Drospirenone (JAN/USP/INN);
Slynd (TN)
|
|---|
| Product |
|
|---|
| Formula |
C24H30O3
|
|---|
| Exact mass |
366.2195
|
|---|
| Mol weight |
366.4932
|
|---|
| Structure |
   |
|---|
| Simcomp |
 |
|---|
| Class |
Cardiovascular agent
DG01885 Potassium-sparing diuretic
DG01676 Aldosterone antagonist
|
|---|
| Remark |
| Product (mixture): | D09741<JP/US> |
|
|---|
| Efficacy |
Contraceptive, Aldosterone antagonist |
|---|
| Comment |
Spironolactone derivative
Progestin
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04914 | Progesterone-mediated oocyte maturation |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
G GENITO URINARY SYSTEM AND SEX HORMONES
G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
G03A HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
G03AC Progestogens
G03AC10 Drospirenone
D03917 Drospirenone (JAN/USP/INN) <US>
USP drug classification [BR:br08302]
Contraceptives
Oral Progestins
Drospirenone
D03917 Drospirenone (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C2 (MR)
D03917 Drospirenone (JAN/USP/INN) <US>
NR3C3 (PGR)
D03917 Drospirenone (JAN/USP/INN) <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D03917
 |
|---|
| Other DBs |
|
|---|
| LinkDB |
 |
|---|
| KCF data |
ATOM 27
1 C1z C 25.7600 -21.4200
2 C1z C 24.5000 -22.1200
3 C1y C 26.8800 -22.1200
4 O7x O 26.8800 -20.6500
5 C1x C 24.6400 -20.6500
6 C1y C 24.5000 -23.4500
7 C1x C 23.3800 -21.4200
8 C1a C 23.8700 -20.5800
9 C1y C 26.8800 -23.4500
10 C7x C 26.4600 -19.3200
11 C1x C 25.0600 -19.3200
12 C1y C 23.3800 -24.1500
13 C1x C 22.1900 -22.1200
14 O6a O 27.2300 -18.2700
15 C1y C 22.1900 -23.4500
16 C1y C 23.3800 -25.5500
17 C1z C 21.0000 -24.1500
18 C1y C 22.1900 -26.1800
19 C2y C 21.0000 -25.4800
20 C1x C 19.8100 -23.4500
21 C1a C 21.0000 -22.7500
22 C2x C 19.8100 -26.1800
23 C1x C 18.6200 -24.1500
24 C5x C 18.6200 -25.4800
25 O5x O 17.4300 -26.1800
26 C1x C 28.0924 -22.8200
27 C1x C 23.3800 -26.9500
BOND 33
1 1 2 1
2 1 3 1
3 1 4 1 #Up
4 1 5 1 #Down
5 2 6 1
6 2 7 1
7 2 8 1 #Up
8 3 9 1
9 4 10 1
10 5 11 1
11 6 12 1
12 7 13 1
13 10 14 2
14 12 15 1
15 12 16 1
16 15 17 1
17 16 18 1
18 17 19 1
19 17 20 1
20 17 21 1 #Up
21 19 22 2
22 20 23 1
23 22 24 1
24 24 25 2
25 6 9 1
26 10 11 1
27 13 15 1
28 18 19 1
29 23 24 1
30 3 26 1 #Up
31 9 26 1 #Up
32 16 27 1 #Up
33 18 27 1 #Up
|
|---|
