KEGG   DRUG: Drospirenone
Entry
D03917                      Drug                                   
Name
Drospirenone (JAN/USP/INN);
Slynd (TN);
Slinda (TN)
Product
SLYND (Exeltis USA)
Formula
C24H30O3
Exact mass
366.2195
Mol weight
366.49
Structure
Simcomp
Class
Cardiovascular agent
 DG03231  Antihypertensive
  DG01676  Aldosterone antagonist
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 2549
ATC code: G03AC10
Product: D03917<JP/US>
Product (mixture): D09741<JP/US> D12047<JP/US> D12130<US> D12497<US>
Efficacy
Contraceptive, Aldosterone antagonist
Comment
Spironolactone derivative
Progestin
Target
NR3C2 (MR) [HSA:4306] [KO:K08555]
NR3C3 (PGR) [HSA:5241] [KO:K08556]
  Pathway
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03A HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
    G03AC Progestogens
     G03AC10 Drospirenone
      D03917  Drospirenone (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Contraceptives
  Oral Progestins
   Drospirenone
    D03917  Drospirenone (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  25  Urogenital and anal organ agents
   254  Contraceptives
    2549  Others
     D03917  Drospirenone (JAN/USP/INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG03231  Antihypertensive
   DG01676  Aldosterone antagonist
    D03917  Drospirenone
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D03917  Drospirenone
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01676  Aldosterone antagonist
   D03917  Drospirenone
  DG03231  Antihypertensive
   D03917  Drospirenone
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C2 (MR)
     D03917  Drospirenone (JAN/USP/INN) <JP/US>
    NR3C3 (PGR)
     D03917  Drospirenone (JAN/USP/INN) <JP/US>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D03917
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D03917
Other DBs
CAS: 67392-87-4
PubChem: 47205906
ChEBI: 50838
LigandBox: D03917
NIKKAJI: J310.243B
LinkDB
KCF data

ATOM        27
            1   C1z C    25.7600  -21.4200
            2   C1z C    24.5000  -22.1200
            3   C1y C    26.8800  -22.1200
            4   O7x O    26.8800  -20.6500
            5   C1x C    24.6400  -20.6500
            6   C1y C    24.5000  -23.4500
            7   C1x C    23.3800  -21.4200
            8   C1a C    23.8700  -20.5800
            9   C1y C    26.8800  -23.4500
            10  C7x C    26.4600  -19.3200
            11  C1x C    25.0600  -19.3200
            12  C1y C    23.3800  -24.1500
            13  C1x C    22.1900  -22.1200
            14  O6a O    27.2300  -18.2700
            15  C1y C    22.1900  -23.4500
            16  C1y C    23.3800  -25.5500
            17  C1z C    21.0000  -24.1500
            18  C1y C    22.1900  -26.1800
            19  C2y C    21.0000  -25.4800
            20  C1x C    19.8100  -23.4500
            21  C1a C    21.0000  -22.7500
            22  C2x C    19.8100  -26.1800
            23  C1x C    18.6200  -24.1500
            24  C5x C    18.6200  -25.4800
            25  O5x O    17.4300  -26.1800
            26  C1x C    28.0924  -22.8200
            27  C1x C    23.3800  -26.9500
BOND        33
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Up
            4     1   5 1 #Down
            5     2   6 1
            6     2   7 1
            7     2   8 1 #Up
            8     3   9 1
            9     4  10 1
            10    5  11 1
            11    6  12 1
            12    7  13 1
            13   10  14 2
            14   12  15 1
            15   12  16 1
            16   15  17 1
            17   16  18 1
            18   17  19 1
            19   17  20 1
            20   17  21 1 #Up
            21   19  22 2
            22   20  23 1
            23   22  24 1
            24   24  25 2
            25    6   9 1
            26   10  11 1
            27   13  15 1
            28   18  19 1
            29   23  24 1
            30    3  26 1 #Up
            31    9  26 1 #Up
            32   16  27 1 #Up
            33   18  27 1 #Up

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