Entry
Name
isocitrate---homoisocitrate dehydrogenase;
homoisocitrate---isocitrate dehydrogenase;
PH1722
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
isocitrate(homoisocitrate):NAD+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
(1) isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH [RN:
R00709 ];
(2) (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+ [RN:
R01934 ]
Reaction(KEGG)
Substrate
isocitrate [CPD:
C00311 ];
NAD+ [CPD:
C00003 ];
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate [CPD:
C05662 ]
Product
Comment
Requires Mn2+ and K+ or NH4+ for activity. Unlike EC
1.1.1.41 , isocitrate dehydrogenase (NAD+) and EC
1.1.1.87 , homoisocitrate dehydrogenase, this enzyme, from Pyrococcus horikoshii, can use both isocitrate and homoisocitrate as substrates. The enzyme may play a role in both the lysine and glutamate biosynthesis pathways.
History
EC 1.1.1.286 created 2005
Pathway
ec01110 Biosynthesis of secondary metabolites
ec01120 Microbial metabolism in diverse environments
Orthology
K17753 isocitrate--homoisocitrate dehydrogenase
Genes
Taxonomy
Reference
Authors
Miyazaki K
Title
Bifunctional isocitrate-homoisocitrate dehydrogenase: a missing link in the evolution of beta-decarboxylating dehydrogenase.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 1.1.1.286
LinkDB
All DBs