KEGG   ORTHOLOGY: K17753
Entry
K17753                      KO                                     
Symbol
HICDH
Name
isocitrate--homoisocitrate dehydrogenase [EC:1.1.1.286]
Pathway
map00020  Citrate cycle (TCA cycle)
map00300  Lysine biosynthesis
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01210  2-Oxocarboxylic acid metabolism
map01230  Biosynthesis of amino acids
Reaction
R00709  isocitrate:NAD+ oxidoreductase (decarboxylating)
R01934  (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)
R01936  (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)
R04862  (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    K17753  HICDH; isocitrate--homoisocitrate dehydrogenase
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K17753  HICDH; isocitrate--homoisocitrate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.286  isocitrate---homoisocitrate dehydrogenase
     K17753  HICDH; isocitrate--homoisocitrate dehydrogenase
Other DBs
COG: COG0473
GO: 0033708
Genes
PHO: PH1722(PH1722)
PAB: PAB0289(leuB-2)
PYN: PNA2_0331
PYS: Py04_1638
TKO: TK0280
THS: TES1_0505
THV: ADU37_CDS10030
TCH: CHITON_1981
Reference
PMID:15845397
  Authors
Miyazaki K
  Title
Bifunctional isocitrate-homoisocitrate dehydrogenase: a missing link in the evolution of beta-decarboxylating dehydrogenase.
  Journal
Biochem Biophys Res Commun 331:341-6 (2005)
DOI:10.1016/j.bbrc.2005.03.169
  Sequence
[pho:PH1722]
LinkDB

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