Homo sapiens (human): 2898
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Entry
2898 CDS
T01001
Symbol
GRIK2, EAA4, GLR6, GLUK6, GLUR6, GluK2, MRT6, NEDLAS
Name
(RefSeq) glutamate ionotropic receptor kainate type subunit 2
KO
K05202
glutamate receptor, ionotropic kainate 2
Organism
hsa
Homo sapiens (human)
Pathway
hsa04080
Neuroactive ligand-receptor interaction
hsa04082
Neuroactive ligand signaling
hsa04724
Glutamatergic synapse
Network
nt06544
Neuroactive ligand signaling
Element
N01882
Transport of natrium, KA receptor
Disease
H00768
Autosomal recessive intellectual developmental disorder
H02894
Neurodevelopmental disorder with impaired language and ataxia and with or without seizures
Drug target
Dasolampanel:
D10107
Dasolampanel etibutil:
D10108
Dasolampanel etibutil tosylate:
D10109
Riluzole:
D00775
<JP/US>
Tezampanel:
D06656
Topiramate:
D00537
<JP/US>
Troriluzole (
DG03011
):
D11414
D11415
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09133 Signaling molecules and interaction
04080 Neuroactive ligand-receptor interaction
2898 (GRIK2)
04082 Neuroactive ligand signaling
2898 (GRIK2)
09150 Organismal Systems
09156 Nervous system
04724 Glutamatergic synapse
2898 (GRIK2)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04040 Ion channels [BR:
hsa04040
]
2898 (GRIK2)
Ion channels [BR:
hsa04040
]
Ligand-gated channels
Glutamate (ionotropic)
2898 (GRIK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ANF_receptor
Lig_chan
Lig_chan-Glu_bd
SBP_bac_3
Peripla_BP_6
Motif
Other DBs
NCBI-GeneID:
2898
NCBI-ProteinID:
NP_068775
OMIM:
138244
HGNC:
4580
Ensembl:
ENSG00000164418
UniProt:
Q13002
Q8IY40
A0A8D9PH75
A8K0H7
Structure
PDB
PDBj
LinkDB
All DBs
Position
6:101393708..102070083
Genome browser
AA seq
908 aa
AA seq
DB search
MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFA
VNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQS
ICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDST
GLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILK
QALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMER
LQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFM
SLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGK
PANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEI
RLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISI
LYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSD
VVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLT
VERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKS
NEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITI
AILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVG
EFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRR
LPGKETMA
NT seq
2727 nt
NT seq
+upstream
nt +downstream
nt
atgaagattattttcccgattctaagtaatccagtcttcaggcgcaccgttaaactcctg
ctctgtttactgtggattggatattctcaaggaaccacacatgtattaagatttggtggt
atttttgaatatgtggaatctggcccaatgggagctgaggaacttgcattcagatttgct
gtgaacacaattaacagaaacagaacattgctacccaatactacccttacctatgatacc
cagaagataaacctttatgatagttttgaagcatccaagaaagcctgtgatcagctgtct
cttggggtggctgccatcttcgggccttcacacagctcatcagcaaacgcagtgcagtcc
atctgcaatgctctgggagttccccacatacagacccgctggaagcaccaggtgtcagac
aacaaagattccttctatgtcagtctctacccagacttctcttcactcagccgtgccatt
ttagacctggtgcagtttttcaagtggaaaaccgtcacggttgtgtatgatgacagcact
ggtctcattcgtttgcaagagctcatcaaagctccatcaaggtataatcttcgactcaaa
attcgtcagttacctgctgatacaaaggatgcaaaacccttactaaaagaaatgaaaaga
ggcaaggagtttcatgtaatctttgattgtagccatgaaatggcagcaggcattttaaaa
caggcattagctatgggaatgatgacagaatactatcattatatctttaccactctggac
ctctttgctcttgatgttgagccctaccgatacagtggtgttaacatgacagggttcaga
atattaaatacagaaaatacccaagtctcctccatcattgaaaagtggtcgatggaacga
ttgcaggcacctccgaaacccgattcaggtttgctggatggatttatgacgactgatgct
gctctaatgtatgatgctgtgcatgtggtgtctgtggccgttcaacagtttccccagatg
acagtcagttccttgcagtgtaatcgacataaaccctggcgcttcgggacccgctttatg
agtctaattaaagaggcacattgggaaggcctcacaggcagaataactttcaacaaaacc
aatggcttgagaacagattttgatttggatgtgatcagtctgaaggaagaaggtctagaa
aagattggaacgtgggatccagccagtggcctgaatatgacagaaagtcaaaagggaaag
ccagcgaacatcacagattccttatccaatcgttctttgattgttaccaccattttggaa
gagccttatgtcctttttaagaagtctgacaaacctctctatggtaatgatcgatttgaa
ggctattgcattgatctcctcagagagttatctacaatccttggctttacatatgaaatt
agacttgtggaagatgggaaatatggagcccaggatgatgccaatggacaatggaatgga
atggttcgtgaactaattgatcataaagctgaccttgcagttgctccactggctattacc
tatgttcgagagaaggtcatcgacttttccaagccctttatgacacttggaataagtatt
ttgtaccgcaagcccaatggtacaaacccaggcgtcttctccttcctgaatcctctctcc
cctgatatctggatgtatattctgctggcttacttgggtgtcagttgtgtgctctttgtc
atagccaggtttagtccttatgagtggtataatccacacccttgcaaccctgactcagac
gtggtggaaaacaattttaccttgctaaatagtttctggtttggagttggagctctcatg
cagcaaggttctgagctcatgcccaaagcactgtccaccaggatagtgggaggcatttgg
tggtttttcacacttatcatcatttcttcgtatactgctaacttagccgcctttctgaca
gtggaacgcatggaatcccctattgactctgctgatgatttagctaaacaaaccaagata
gaatatggagcagtagaggatggtgcaaccatgacttttttcaagaaatcaaaaatctcc
acgtatgacaaaatgtgggcctttatgagtagcagaaggcagtcagtgctggtcaaaagt
aatgaagaaggaatccagcgagtcctcacctctgattatgctttcctaatggagtcaaca
accatcgagtttgttacccagcggaactgtaacctgacacagattggcggccttatagac
tctaaaggttatggcgttggcactcccatgggttctccatatcgagacaaaattaccata
gcaattcttcagctgcaagaggaaggcaaactgcatatgatgaaggagaaatggtggagg
ggcaatggttgcccagaagaggagagcaaagaggccagtgccctgggggttcagaatatt
ggtggcatcttcattgttctggcagccggcttggtgctttcagtttttgtggcagtggga
gaatttttatacaaatccaaaaaaaacgctcaattggaaaagaggtccttctgtagtgcc
atggtagaagaattgaggatgtccctgaagtgccagcgtcggttaaaacataagccacag
gccccagttattgtgaaaacagaagaagttatcaacatgcacacatttaacgacagaagg
ttgccaggtaaagaaaccatggcataa
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integrated database retrieval system
