Homo sapiens (human): 5138
Entry
5138 CDS
T01001
Gene name
PDE2A, CGS-PDE, PDE2A1, PED2A4, cGSPDE
Definition
(RefSeq) phosphodiesterase 2A
KO
K18283
cGMP-dependent 3',5'-cyclic phosphodiesterase [EC:
3.1.4.17
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00230
Purine metabolism
hsa01100
Metabolic pathways
hsa04022
cGMP-PKG signaling pathway
hsa04740
Olfactory transduction
hsa04925
Aldosterone synthesis and secretion
hsa05032
Morphine addiction
Drug target
Aminophylline (
DG01062
):
D00227
D05429
D11630
Bemoradan:
D03075
Bucladesine (
DG00230
):
D01238
D07546
Caffeine (
DG00974
):
D00528
D01453
D07603
Choline theophyllinate:
D02017
Diprophylline:
D00691
Doxofylline:
D03898
Enprofylline:
D04006
Flavoxate (
DG00477
):
D00718
D07961
Moxaverine (
DG00045
):
D07089
D08238
Oxagrelate:
D05278
Papaverine (
DG00043
):
D02218
D07425
D07439
Prinoxodan:
D05612
Proxyphylline:
D01771
Theophylline (
DG01061
):
D00371
D01712
D06103
D06104
Theosalicin:
D09822
Tibenelast sodium:
D06132
Trapidil:
D01220
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
5138 (PDE2A)
09130 Environmental Information Processing
09132 Signal transduction
04022 cGMP-PKG signaling pathway
5138 (PDE2A)
09150 Organismal Systems
09152 Endocrine system
04925 Aldosterone synthesis and secretion
5138 (PDE2A)
09157 Sensory system
04740 Olfactory transduction
5138 (PDE2A)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
5138 (PDE2A)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.17 3',5'-cyclic-nucleotide phosphodiesterase
5138 (PDE2A)
SSDB
Motif
Pfam:
PDEase_I
GAF
GAF_2
GAF_3
Other DBs
NCBI-GeneID:
5138
NCBI-ProteinID:
NP_002590
OMIM:
602658
HGNC:
8777
Ensembl:
ENSG00000186642
Vega:
OTTHUMG00000102045
Pharos:
O00408
(Tclin)
UniProt:
O00408
Q8IW54
LinkDB
Structure
PDB:
5U00
6C7E
6EZF
6CYC
3ITU
5TZW
5TZZ
5TZH
6CYB
6C7G
6CYD
5TZA
1Z1L
6C7I
5TZ3
4JIB
5U7D
6B97
6C7D
6C7F
6C7J
5VP1
6B96
5U7J
5TZX
4D08
4HTX
6B98
5U7I
4HTZ
5U7K
6BLF
5XKM
5VP0
5TZC
5U7L
4C1I
3ITM
4D09
3IBJ
Position
11q13.4
AA seq
941 aa
MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDI
SGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCN
GLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAV
EKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDL
DASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVV
EDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTD
EDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITE
ARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPD
AYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAF
SIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNF
ASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMH
AFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYS
SEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDL
QKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAM
GNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSH
KFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE
NT seq
2826 nt
+upstream
nt +downstream
nt
atggggcaggcatgcggccactccatcctctgcaggagccagcagtacccggcagcgcga
ccggctgagccgcggggccagcaggtcttcctcaagccggacgagccgccgccgccgccg
cagccatgcgccgacagcctgcaggacgccttgctgagtctgggctctgtcatcgacatt
tcaggcctgcaacgtgctgtcaaggaggccctgtcagctgtgctcccccgagtggaaact
gtctacacctacctactggatggtgagtcccagctggtgtgtgaggaccccccacatgag
ctgccccaggaggggaaagtccgggaggctatcatctcccagaagcggctgggctgcaat
gggctgggcttctcagacctgccagggaagcccttggccaggctggtggctccactggct
cctgatacccaagtgctggtcatgccgctagcggacaaggaggctggggccgtggcagct
gtcatcttggtgcactgtggccagctgagtgataatgaggaatggagcctgcaggcggtg
gagaagcataccctggtcgccctgcggagggtgcaggtcctgcagcagcgcgggcccagg
gaggctccccgagccgtccagaaccccccggaggggacggcggaagaccagaagggcggg
gcggcgtacaccgaccgcgaccgcaagatcctccaactgtgcggggaactctacgacctg
gatgcctcttccctgcagctcaaagtgctccaatacctgcagcaggagacccgggcatcc
cgctgctgcctcctgctggtgtcggaggacaatctccagctttcttgcaaggtcatcgga
gacaaagtgctcggggaagaggtcagctttcccttgacaggatgcctgggccaggtggtg
gaagacaagaagtccatccagctgaaggacctcacctccgaggatgtacaacagctgcag
agcatgttgggctgtgagctgcaggccatgctctgtgtccctgtcatcagccgggccact
gaccaggtggtggccttggcctgcgccttcaacaagctagaaggagacttgttcaccgac
gaggacgagcatgtgatccagcactgcttccactacaccagcaccgtgctcaccagcacc
ctggccttccagaaggaacagaaactcaagtgtgagtgccaggctcttctccaagtggca
aagaacctcttcacccacctggatgacgtctctgtcctgctccaggagatcatcacggag
gccagaaacctcagcaacgcagagatctgctctgtgttcctgctggatcagaatgagctg
gtggccaaggtgttcgacgggggcgtggtggatgatgagagctatgagatccgcatcccg
gccgatcagggcatcgcgggacacgtggcgaccacgggccagatcctgaacatccctgac
gcatatgcccatccgcttttctaccgcggcgtggacgacagcaccggcttccgcacgcgc
aacatcctctgcttccccatcaagaacgagaaccaggaggtcatcggtgtggccgagctg
gtgaacaagatcaatgggccatggttcagcaagttcgacgaggacctggcgacggccttc
tccatctactgcggcatcagcatcgcccattctctcctatacaaaaaagtgaatgaggct
cagtatcgcagccacctggccaatgagatgatgatgtaccacatgaaggtctccgatgat
gagtataccaaacttctccatgatgggatccagcctgtggctgccattgactccaatttt
gcaagtttcacctatacccctcgttccctgcccgaggatgacacgtccatggccatcctg
agcatgctgcaggacatgaatttcatcaacaactacaaaattgactgcccgaccctggcc
cggttctgtttgatggtgaagaagggctaccgggatcccccctaccacaactggatgcac
gccttttctgtctcccacttctgctacctgctctacaagaacctggagctcaccaactac
ctcgaggacatcgagatctttgccttgtttatttcctgcatgtgtcatgacctggaccac
agaggcacaaacaactctttccaggtggcctcgaaatctgtgctggctgcgctctacagc
tctgagggctccgtcatggagaggcaccactttgctcaggccatcgccatcctcaacacc
cacggctgcaacatctttgatcatttctcccggaaggactatcagcgcatgctggatctg
atgcgggacatcatcttggccacagacctggcccaccatctccgcatcttcaaggacctc
cagaagatggctgaggtgggctacgaccgaaacaacaagcagcaccacagacttctcctc
tgcctcctcatgacctcctgtgacctctctgaccagaccaagggctggaagactacgaga
aagatcgcggagctgatctacaaagaattcttctcccagggagacctggagaaggccatg
ggcaacaggccgatggagatgatggaccgggagaaggcctatatccctgagctgcaaatc
agcttcatggagcacattgcaatgcccatctacaagctgttgcaggacctgttccccaaa
gcggcagagctgtacgagcgcgtggcctccaaccgtgagcactggaccaaggtgtcccac
aagttcaccatccgcggcctcccaagtaacaactcgctggacttcctggatgaggagtac
gaggtgcctgatctggatggcactagggcccccatcaatggctgctgcagccttgatgct
gagtga
DBGET
integrated database retrieval system
