KEGG   DRUG: TheophyllineHelp
Entry
D00371                      Drug                                   

Name
Theophylline (JP17);
Elixophyllin (TN);
Quibron-t (TN);
Theo-24 (TN);
Theodur G (TN);
Theolair (TN);
Uniphyl (TN)
Product
  Generic
THEOPHYLLINE (Alembic Pharmaceuticals), THEOPHYLLINE (Alembic Pharmaceuticals Limited), THEOPHYLLINE (American Health Packaging), THEOPHYLLINE (Bryant Ranch Prepack), THEOPHYLLINE (Bryant Ranch Prepack), THEOPHYLLINE (Bryant Ranch Prepack), THEOPHYLLINE (Bryant Ranch Prepack), THEOPHYLLINE (Carilion Materials Management), THEOPHYLLINE (Carilion Materials Management), THEOPHYLLINE (Carilion Materials Management), THEOPHYLLINE (Glenmark Pharmaceuticals), THEOPHYLLINE (Lannett Company), THEOPHYLLINE (Major Pharmaceuticals), THEOPHYLLINE (Mylan Pharamceuticals), THEOPHYLLINE (Nostrum Laboratories), THEOPHYLLINE(ANHYDROUS) (PACK Pharmaceuticals), THEOPHYLLINE (Pharmaceutical Associates), THEOPHYLLINE (Physicians Total Care), THEOPHYLLINE (Preferred Pharmaceuticals), THEOPHYLLINE (Rhodes Pharmaceuticals L.P.), THEOPHYLLINE (State of Florida DOH Central Pharmacy), THEOPHYLLINE (State of Florida DOH Central Pharmacy), THEOPHYLLINE (Teva Pharmaceuticals USA), THEOPHYLLINE (Tris Pharma), ELIXOPHYLLIN (Atlantic Biologicals Corps), THEO-24 (Avera McKennan Hospital), ELIXOPHYLLIN (Caraco Pharma), THEOPHYLLINE (Cranbury Pharmaceuticals), THEO-24 (Endo Pharmaceuticals), THEOPHYLLINE (Marlex Pharmaceuticals), ELIXOPHYLLIN (Nostrum Laboratories), THEOPHYLLINE (Pharmaceutical Associates), UNIPHYL (Purdue Pharmaceutical Products LP), THEOPHYLLINE EXTENDED RELEASE (NCS HealthCare of KY), THEOPHYLLINE EXTENDED RELEASE (NCS HealthCare of KY)
Formula
C7H8N4O2
Exact mass
180.0647
Mol weight
180.164
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Other
 DG01616  Xanthine derivative
  DG01609  Xanthine-type bronchodilator
Cyp substrate
 DG01892  CYP1A2 substrate
Remark
Same as: C07130
Therapeutic category: 2251
ATC code: R03DA04
Chemical structure group: DG01061
Product (DG01061): D00371<JP/US>
Product (mixture): D10297<US>
Efficacy
Bronchodilator, Phosphodiesterase inhibitor
  Disease
Chronic asthma [DS:H00079]
Comment
Xanthine derivative
Target
  Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
Metabolism
Enzyme: CYP1A2 [HSA:1544]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03D OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
    R03DA Xanthines
     R03DA04 Theophylline
      D00371  Theophylline (JP17) <JP/US>
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Phosphodiesterase Inhibitors, Airways Disease
   Theophylline
    D00371  Theophylline (JP17)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  22  Respiratory organ agents
   225  Bronchodilators
    2251  Xanthines
     D00371  Theophylline (JP17)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for respiratory organs
  26 Antitussives and expectorants
   D00371  Theophylline (JP17)
Risk category of Japanese OTC drugs [BR:br08312]
 First-class OTC drugs
  Inorganic and organic chemicals
   Theophylline
    D00371  Theophylline (JP17)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adenosine
    ADORA1
     D00371  Theophylline (JP17) <JP/US>
    ADORA2B
     D00371  Theophylline (JP17) <JP/US>
 Enzymes
  Hydrolases (EC3)
   Phosphodiesterase
    PDE
     D00371  Theophylline (JP17) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00371  Theophylline
Drug classes of therapeutic agents [br08360.html]
 Respiratory agents
  D00371
BRITE hierarchy
Other DBs
CAS: 58-55-9
PubChem: 7847437
ChEBI: 28177
ChEMBL: CHEMBL190
DrugBank: DB00277
PDB-CCD: TEP[PDBj]
LigandBox: D00371
NIKKAJI: J2.333G
LinkDB All DBs
KCF data Show

ATOM        13
            1   C8y C    24.1848  -17.2082
            2   C8y C    24.1848  -18.6318
            3   C8y C    25.3867  -16.5023
            4   N4x N    22.8837  -16.7764
            5   N4y N    25.3867  -19.3144
            6   N5x N    22.8837  -19.0636
            7   N4y N    26.6061  -17.2374
            8   O5x O    25.3867  -15.1253
            9   C8x C    22.0669  -17.9317
            10  C8y C    26.6061  -18.5794
            11  C1a C    25.3867  -20.7440
            12  C1a C    27.8547  -16.5606
            13  O5x O    27.8547  -19.2794
BOND        14
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     4   9 1
            9     5  10 1
            10    5  11 1
            11    7  12 1
            12   10  13 2
            13    6   9 2
            14    7  10 1

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