Homo sapiens (human): 5693
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Entry
5693 CDS
T01001
Symbol
PSMB5, LMPX, MB1
Name
(RefSeq) proteasome 20S subunit beta 5
KO
K02737
20S proteasome subunit beta 5 [EC:
3.4.25.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa03050
Proteasome
hsa05010
Alzheimer disease
hsa05012
Parkinson disease
hsa05014
Amyotrophic lateral sclerosis
hsa05016
Huntington disease
hsa05017
Spinocerebellar ataxia
hsa05020
Prion disease
hsa05022
Pathways of neurodegeneration - multiple diseases
Network
nt06460
Alzheimer disease
nt06461
Huntington disease
nt06463
Parkinson disease
nt06464
Amyotrophic lateral sclerosis
nt06465
Prion disease
nt06466
Pathways of neurodegeneration
Element
N01029
26S proteasome-mediated protein degradation
N01030
Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060
Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061
Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144
Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145
Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146
Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197
Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Drug target
Bortezomib (
DG03219
):
D03150
<JP/US>
D12311
<JP/US>
Carfilzomib:
D08880
<JP/US>
Delanzomib:
D10110
Ixazomib (
DG01269
):
D10130
D10131
<JP/US>
Marizomib:
D09640
Oprozomib:
D10318
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
03050 Proteasome
5693 (PSMB5)
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
5693 (PSMB5)
05012 Parkinson disease
5693 (PSMB5)
05014 Amyotrophic lateral sclerosis
5693 (PSMB5)
05016 Huntington disease
5693 (PSMB5)
05017 Spinocerebellar ataxia
5693 (PSMB5)
05020 Prion disease
5693 (PSMB5)
05022 Pathways of neurodegeneration - multiple diseases
5693 (PSMB5)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
hsa01002
]
5693 (PSMB5)
09182 Protein families: genetic information processing
03051 Proteasome [BR:
hsa03051
]
5693 (PSMB5)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.25 Threonine endopeptidases
3.4.25.1 proteasome endopeptidase complex
5693 (PSMB5)
Peptidases and inhibitors [BR:
hsa01002
]
Threonine peptidases
Family T1: proteasome family
5693 (PSMB5)
Proteasome [BR:
hsa03051
]
Eukaryotic proteasome
Core particles (20S proteasome)
beta type subunits
5693 (PSMB5)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Proteasome
Motif
Other DBs
NCBI-GeneID:
5693
NCBI-ProteinID:
NP_002788
OMIM:
600306
HGNC:
9542
Ensembl:
ENSG00000100804
UniProt:
P28074
Structure
PDB
PDBj
LinkDB
All DBs
Position
14:complement(23025851..23035220)
Genome browser
AA seq
263 aa
AA seq
DB search
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGT
TTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLAR
QCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRI
SGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVRE
DGWIRVSSDNVADLHEKYSGSTP
NT seq
792 nt
NT seq
+upstream
nt +downstream
nt
atggcgcttgccagcgtgttggagagaccgctaccggtgaaccagcgcgggtttttcgga
cttgggggtcgtgcagatctgctggatctaggtccagggagtctcagtgatggtctgagc
ctggccgcgccaggctggggtgtcccagaagagccaggaatcgaaatgcttcatggaaca
accaccctggccttcaagttccgccatggagtcatagttgcagctgactccagggctaca
gcgggtgcttacattgcctcccagacggtgaagaaggtgatagagatcaacccatacctg
ctaggcaccatggctgggggcgcagcggattgcagcttctgggaacggctgttggctcgg
caatgtcgaatctatgagcttcgaaataaggaacgcatctctgtagcagctgcctccaaa
ctgcttgccaacatggtgtatcagtacaaaggcatggggctgtccatgggcaccatgatc
tgtggctgggataagagaggccctggcctctactacgtggacagtgaagggaaccggatt
tcaggggccaccttctctgtaggttctggctctgtgtatgcatatggggtcatggatcgg
ggctattcctatgacctggaagtggagcaggcctatgatctggcccgtcgagccatctac
caagccacctacagagatgcctactcaggaggtgcagtcaacctctaccacgtgcgggag
gatggctggatccgagtctccagtgacaatgtggctgatctacatgagaagtatagtggc
tctaccccctga
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integrated database retrieval system
