KEGG   PATHWAY: ko03420
Entry
ko03420                     Pathway                                

Name
Nucleotide excision repair
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
ko03420  Nucleotide excision repair
ko03420

Disease
H00076  Cockayne syndrome
H00403  Disorders of nucleotide excision repair
H01428  Xeroderma pigmentosum
H02014  Ataxia-telangiectasia-like syndrome
H02131  UV-sensitive syndrome
H02369  IMAGE-I syndrome
H02370  FILS syndrome
Other DBs
GO: 0006289
Orthology
K03723  transcription-repair coupling factor (superfamily II helicase) [EC:3.6.4.-]
K03701  excinuclease ABC subunit A
K03702  excinuclease ABC subunit B
K03703  excinuclease ABC subunit C
K03657  DNA helicase II / ATP-dependent DNA helicase PcrA [EC:3.6.4.12]
K02335  DNA polymerase I [EC:2.7.7.7]
K01972  DNA ligase (NAD+) [EC:6.5.1.2]
K03868  RING-box protein 1 [EC:2.3.2.32]
K10609  cullin 4
K10610  DNA damage-binding protein 1
K10140  DNA damage-binding protein 2
K10838  xeroderma pigmentosum group C-complementing protein
K10839  UV excision repair protein RAD23
K10840  centrin-2
K10570  DNA excision repair protein ERCC-8
K10841  DNA excision repair protein ERCC-6
K02202  cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
K10842  CDK-activating kinase assembly factor MAT1
K06634  cyclin H
K10843  DNA excision repair protein ERCC-3 [EC:3.6.4.12]
K10844  DNA excision repair protein ERCC-2 [EC:3.6.4.12]
K10845  TFIIH basal transcription factor complex TTD-A subunit
K03141  transcription initiation factor TFIIH subunit 1
K03142  transcription initiation factor TFIIH subunit 2
K03143  transcription initiation factor TFIIH subunit 3
K03144  transcription initiation factor TFIIH subunit 4
K10846  DNA excision repair protein ERCC-5
K10847  DNA-repair protein complementing XP-A cells
K07466  replication factor A1
K10739  replication factor A2
K10740  replication factor A3
K10741  replication factor A4
K10848  DNA excision repair protein ERCC-4 [EC:3.1.-.-]
K10849  DNA excision repair protein ERCC-1
K02327  DNA polymerase delta subunit 1 [EC:2.7.7.7]
K02328  DNA polymerase delta subunit 2
K03504  DNA polymerase delta subunit 3
K03505  DNA polymerase delta subunit 4
K02324  DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
K02325  DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
K02326  DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
K03506  DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
K04802  proliferating cell nuclear antigen
K10754  replication factor C subunit 1
K10755  replication factor C subunit 2/4
K10756  replication factor C subunit 3/5
K10747  DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
Reference
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair] Japanese
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome] Japanese
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8] Japanese
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases] Japanese
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders] Japanese
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
ko03020  RNA polymerase
ko04120  Ubiquitin mediated proteolysis
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