KEGG ORTHOLOGY: K03506

ORTHOLOGY: K03506

Entry

K03506                      KO

Symbol

POLE4

Name

DNA polymerase epsilon subunit 4 [EC:2.7.7.7]

Pathway

map03030

DNA replication

map03410

Base excision repair

map03420

Nucleotide excision repair

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    K03506  POLE4; DNA polymerase epsilon subunit 4
   03410 Base excision repair
    K03506  POLE4; DNA polymerase epsilon subunit 4
   03420 Nucleotide excision repair
    K03506  POLE4; DNA polymerase epsilon subunit 4
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins
    K03506  POLE4; DNA polymerase epsilon subunit 4
   03400 DNA repair and recombination proteins
    K03506  POLE4; DNA polymerase epsilon subunit 4
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.7  DNA-directed DNA polymerase
     K03506  POLE4; DNA polymerase epsilon subunit 4
DNA replication proteins [BR:ko03032]
Eukaryotic type
  DNA Replication Elongation Factors
   DNA polymerase epsilon complex
    K03506  POLE4; DNA polymerase epsilon subunit 4
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Long Patch-BER factors
     DNA polymerase epsilon complex
      K03506  POLE4; DNA polymerase epsilon subunit 4

Other DBs

GO:

0003887

Genes

HSA:	56655(POLE4)

PTR:	459343(POLE4)

PPS:	100982360(POLE4)

GGO:	101126230(POLE4)

PON:	100451783(POLE4)

PPYG:

129030665(POLE4)

NLE:	100593342(POLE4)

HMH:	116483456(POLE4)

SSYN:

129462442(POLE4)

MCC:	710562(POLE4)

MCF:	101867407(POLE4)

MTHB:

126933989

MNI:	105465315(POLE4)

CSAB:

103220011(POLE4)

CATY:

105596877(POLE4)

PANU:

101025211(POLE4)

TGE:	112604725(POLE4)

MLEU:

105544648(POLE4)

RRO:	104674835(POLE4)

RBB:	108531691(POLE4)

TFN:	117062076(POLE4)

PTEH:

111523424(POLE4)

CANG:

105514617(POLE4)

CJC:	100414929(POLE4)

SBQ:	101045109(POLE4)

ANAN:

105717136(POLE4)

CSYR:

103253896(POLE4)

MMUR:

105884566(POLE4)

LCAT:

123637097(POLE4)

PCOQ:

105826858(POLE4)

OGA:	100946214(POLE4)

MMU:	66979(Pole4)

MCAL:

110296495(Pole4)

MPAH:

110316468(Pole4)

RNO:	362385(Pole4)

MCOC:

116099116(Pole4)

ANU:	117715521(Pole4)

ASYL:

127678810(Pole4)

MUN:	110561608(Pole4)

CGE:

103163165

MAUA:

101831245(Pole4)

PROB:

127235485(Pole4)

PLEU:

114694431(Pole4)

MORG:

121438301(Pole4)

MFOT:

126515369

AAMP:

119806892(Pole4)

NGI:	103733850(Pole4)

HGL:	101711731 101721926(Pole4)

CPOC:

100735273(Pole4)

CCAN:

109697835(Pole4)

DORD:

105999564(Pole4)

DSP:	122125160(Pole4)

PLOP:

125356389(Pole4)

NCAR:

124963237

MMMA:

107154240(Pole4)

ITI:	101973826(Pole4)

OCU:

100358589

OPI:	101524740(POLE4)

TUP:	102498485(POLE4)

CFA:	483096(POLE4)

CLUD:

112664265(POLE4)

VVP:	112916699(POLE4)

VLG:	121490379(POLE4)

NPO:	129501184(POLE4)

AML:	100477978(POLE4)

UMR:	103671432(POLE4)

UAH:	113243417(POLE4)

UAR:	123786095(POLE4)

ELK:

111148085

LLV:

125108957

MPUF:

101685647(POLE4)

MNP:	132022501(POLE4)

MLK:	131840348(POLE4)

NVS:	122915031(POLE4)

ORO:	101384323(POLE4)

EJU:	114218845(POLE4)

ZCA:	113938084(POLE4)

MLX:	118001358 118007935(POLE4)

NSU:	110588780(POLE4)

LWW:	102729441(POLE4)

FCA:	101089849(POLE4)

PYU:	121019207(POLE4)

PCOO:

112869136(POLE4)

PBG:	122497069(POLE4)

PVIV:

125161505(POLE4)

LRUF:

124504191

LGF:	123581014(POLE4)

AJU:

113603156

PPAD:

109263408(POLE4)

PUC:

125937149

PLEZ:

122215067(POLE4)

HHV:	120237005(POLE4)

BTA:	613730(POLE4)

BOM:	102275662(POLE4)

BBUB:

102413531(POLE4)

CHX:	102191340(POLE4)

OAS:	101107950(POLE4) 105609801

BTAX:

128056511(POLE4)

CSUM:

138088668(POLE4)

ODA:	120851229(POLE4)

CCAD:

122433677 122441463(POLE4)

MREE:

136163011(POLE4)

OVR:	110139105(POLE4)

MBEZ:

129539719(POLE4)

SSC:	100517646(POLE4)

CFR:	106728730(POLE4)

CBAI:

105067739(POLE4)

CDK:	105085173(POLE4)

BACU:

103006795(POLE4)

BMUS:

118895314 118905613(POLE4)

LVE:	103078646(POLE4)

OOR:	101278492(POLE4)

LALB:

132531086(POLE4)

DLE:	111169119(POLE4)

PCAD:

102983674(POLE4) 102989305

PSIU:

116753950 116764711(POLE4)

NASI:

112390645 112403278(POLE4)

ECB:	100068933(POLE4)

EPZ:	103557198(POLE4)

EAI:	106835131(POLE4)

MYB:	102246982(POLE4)

MYD:	102767991(POLE4)

MMYO:

118668816(POLE4)

MLF:	102423340(POLE4)

MDT:	132213165(POLE4)

MYUM:

139019467(POLE4)

PKL:	118717583(POLE4)

EFUS:

103291507(POLE4)

DRO:	112303061(POLE4)

SHON:

119000114(POLE4)

AJM:	119038420(POLE4)

PDIC:

114499656(POLE4)

PHAS:

123811736(POLE4)

MMF:	118630558(POLE4)

PPAM:

129066893 129086852(POLE4)

HAI:	109371192(POLE4)

RFQ:	117032687(POLE4)

PALE:

102896323(POLE4)

PGIG:

120594450(POLE4)

PVP:	105290721(POLE4)

RAY:	107502943(POLE4)

MJV:	108389978(POLE4)

TOD:	119258584(POLE4)

SARA:

101538543(POLE4)

SFUM:

130024143(POLE4)

SETR:

126024435(POLE4)

TMU:

101342043

ETF:	101651057(POLE4)

DNM:	101420248(POLE4)

MDO:	100032850(POLE4)

GAS:	123234879(POLE4)

SHR:	100931799(POLE4)

AFZ:

127548207

PCW:	110207610(POLE4)

TVP:	118843732(POLE4)

PBRV:

138152145(POLE4)

TACU:

119919638(POLE4)

GGA:	107055326(POLE4)

PCOC:

116236185(POLE4)

MGP:	104914653(POLE4)

CJO:	107325669(POLE4)

TPAI:

128090113(POLE4)

LMUT:

125684952(POLE4)

APLA:

113845596(POLE4)

ACYG:

125184485(POLE4)

CATA:

118258989(POLE4)

AFUL:

116499265(POLE4)

TGU:	100222316(POLE4)

LSR:

110469510

SCAN:

108963061(POLE4)

PMOA:

120496366

OTC:	121345509(POLE4)

PRUF:

121352390(POLE4)

ATRC:

139602372(POLE4)

FAB:	101819262(POLE4)

OMA:	130264373(POLE4)

PHI:	102113459(POLE4)

PMAJ:

107215360(POLE4)

CCAE:

111940209(POLE4)

CCW:

120411443

ACOE:

138099764(POLE4)

ETL:	114070557(POLE4)

ZAB:	102073318(POLE4)

ZLE:	135458711(POLE4)

SVG:	106857963(POLE4)

MMEA:

130579799(POLE4)

HRT:	120763384(POLE4)

SATI:

136371772

CCIC:

134054563(POLE4)

SHAB:

115618142(POLE4)

TALA:

122153636(POLE4)

ACHC:

115349218(POLE4)

AGEN:

126041791

HHAR:

128148293

GCL:

127025716

PPUS:

135192088(POLE4)

CLV:	102096962(POLE4)

RTD:	128900656(POLE4)

CRID:

134526273(POLE4)

AROW:

112967611(POLE4)

NPD:	112943941(POLE4)

DNE:	112986244(POLE4)

ASN:	102379927(POLE4)

AMJ:	102573996(POLE4)

CPOO:

109320540(POLE4)

CMY:	114019409(POLE4)

CCAY:

125627248(POLE4)

DCC:	122457505(POLE4)

CPIC:

112059966(POLE4)

TST:	117868857(POLE4)

MRV:	120391728(POLE4)

ASAO:

132780895(POLE4)

PVT:	110072494(POLE4)

SUND:

121936904(POLE4)

PMUR:

107299622(POLE4)

CTIG:

120299529(POLE4)

PGUT:

117670563(POLE4)

APRI:

131188418(POLE4)

PTEX:

113453506 113453508

NSS:	113427849 113427852

VKO:	123018716(POLE4)

PMUA:

114588315(POLE4)

PRAF:

128405741(POLE4)

ZVI:	118086061(POLE4)

HCG:	128341600(POLE4)

STOW:

125433946(POLE4)

EMC:	129329809(POLE4)

XLA:	779084(pole4.L)

XTR:	549359(pole4)

NPR:	108802028(POLE4)

RTEM:

120911142(POLE4)

BBUF:

120991638(POLE4)

BGAR:

122928635(POLE4)

PWL:	138267881(POLE4)

GSH:	117364509(POLE4)

DRE:	553610(pole4)

SRX:	107747219 107757931

SANH:

107680508 107685140

SGH:	107553534 107597157

CCAR:

109054770 109065206

CAUA:

113055144 113110751

CGIB:

127968476 128022551

LROH:

127172809(pole4)

OMC:	131549274(pole4)

PPRM:

120476415(pole4)

RKG:	130100867(pole4)

MAMB:

125256895(pole4)

CIDE:

127522602

CERY:

137021199(pole4)

MASI:

127427689

TROS:

130570877(pole4)

TDW:	130409923(pole4)

MANU:

129427614(pole4)

PDAB:

135719222(pole4)

IPU:

108271212

IFU:	128613544(pole4)

PHYP:

113533420(pole4)

SMEO:

124391650(pole4)

TFD:	113657934(pole4)

TVC:	132852296(pole4)

CGAR:

128542677(pole4)

NGRA:

132899605(pole4)

TRN:	134331758(pole4)

AMEX:

103045108(pole4)

CMAO:

118819068(pole4)

EEE:	113574467(pole4)

CHAR:

122130195(pole4)

SPIL:

134102218(pole4)

TRU:	101067055(pole4)

TFS:	130529047(pole4)

TNG:	GSTEN00028806G001

LCO:	104930480(pole4)

NCC:	104959649(pole4)

TBEN:

117497776(pole4)

CGOB:

115007205(pole4)

EMAC:

134869821(pole4)

ELY:	117253710(pole4)

EFO:	125895506(pole4)

PLEP:

121941260(pole4)

SLUC:

116055235(pole4)

ECRA:

117950728(pole4)

ESP:	116695141(pole4)

PFLV:

114561564(pole4)

GAT:	120824071(pole4)

PPUG:

119217217(pole4)

AFB:	129095071(pole4)

CLUM:

117729606(pole4)

PSWI:

130194019(pole4)

CANA:

137794656(pole4)

CVE:	137870098(pole4)

MSAM:

119900741(pole4)

SCHU:

122878011(pole4)

CUD:	121512515(pole4)

SPUL:

138607791(pole4)

LMIX:

132962910(pole4)

ALAT:

119029008(pole4)

ASTR:

137598706(pole4)

MZE:	101474498(pole4)

ONL:	100708409(pole4)

OAU:	116309228(pole4)

OLA:	101162035(pole4)

OML:	112150149(pole4)

CSAI:

133457797(pole4)

XMA:	102231701(pole4)

XCO:	114150365(pole4)

XHE:	116725186(pole4)

PRET:

103463523(pole4)

PFOR:

103138455(pole4)

PLAI:

106948681(pole4)

PMEI:

106930037(pole4)

GAF:	122838513(pole4)

PPRL:

129375499(pole4)

CVG:	107087945(pole4)

CTUL:

119780879(pole4)

GMU:	124874103(pole4)

NFU:	107373552(pole4)

KMR:	108230700(pole4)

ALIM:

106521575(pole4)

NWH:	119430659(pole4)

AOCE:

111570625(pole4)

EJA:	138198789(pole4)

BFRE:

138621166(pole4)

MCEP:

125009730(pole4)

CSEM:

103397641(pole4)

POV:	109625883(pole4)

SSEN:

122760872(pole4)

SSOE:

131465156(pole4)

HHIP:

117760692(pole4)

HSP:	118121216(pole4)

PPLT:

128448184(pole4)

SMAU:

118318622(pole4)

LCF:

108881386

SDU:	111232130(pole4)

SLAL:

111654302(pole4)

XGL:	120790934(pole4)

HCQ:	109532274(pole4)

SSCV:

125968160(pole4)

SBIA:

133503547(pole4)

PEE:	133406415(pole4)

BPEC:

110160062(pole4)

ENY:	140353751(pole4)

MALB:

109967476 109967477

BSPL:

114854770(pole4)

SJO:	128361867(pole4)

SSCO:

133984986(pole4)

GMH:	115555086(pole4)

SASA:

100195891(dpoe4) 106613703(DPOE4)

STRU:

115151760 115158173

OTW:	112251792 112252208(pole4)

OMY:	110502819 110524218

OGO:	123998939(pole4)

ONE:	115107383 115109220

OKI:	109889196 109901537

OKE:	118375114(pole4) 118388917

OMM:	135511707 135524584(pole4)

OCLA:

SALP:

SNH:

CCLU:

ELS:	105011481(pole4)

OEP:	134011114(pole4)

SFM:	108921530(pole4)

PKI:	111847616(pole4)

AANG:

118224857(pole4)

AROT:

135252935(pole4)

CCOG:

133127572(pole4)

LOC:	102691164(pole4)

PSPA:

121300540 121301617

ARUT:

117401275 117962711

PSEX:

120537813(pole4)

LCM:	102366845(POLE4)

CMK:	103184515(pole4)

CPLA:

122565283(pole4)

HOC:	132816738 132828884(pole4)

LERI:

129711003(pole4)

PMRN:

116951880(POLE4)

LRJ:	133349979(POLE4)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

DME:	Dmel_CG11301(PolE4)

DER:

6548249

DSE:

6615524

DSI:	Dsimw501_GD11667(Dsim_GD11667)

DYA:	Dyak_GE14182

DSR:

110179841

DPO:

4805204

DPE:

6592636

DMN:	108159702 117192696

DWI:

6638312

DGR:

6559562

DMO:	Dmoj_GI20560

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:

MDE:	101890239 131800959

SCAC:

106080913

LCQ:

111678462

LSQ:

119600101

CVJ:	135959799(PolE4)

GFS:

ECOE:

CLON:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

ACOS:

AAG:

AALB:

109430676 115270186 115270212

ASUA:

134215742

CQU:	CpipJ_CPIJ010897

CPII:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

139101671(Pole4)

TLN:	139811157(Pole4)

HST:

DQU:

CFO:

FEX:

PMEC:

138934005(Pole4)

LHU:	105671464(PolE4)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

VCAN:

CCIN:

DSM:

NPT:	124215978(PolE4)

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

ESIM:

136410025(PolE4)

EFOR:

136340848(PolE4)

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_210109

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:	135071247 135071544

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM117310

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

IEL:

HAMR:

DPX:	DAPPUDRAFT_7359

DMK:

DPZ:

AFRA:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123767967(PolE4)

CQD:

PTRU:

ESN:

PORN:

HAZT:

EAF:

LSM:

TCF:

DSV:

RSAN:

RMP:

VDE:

VJA:

CSCU:

CVS:	136975665(PolE4)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

CEL:	CELE_Y53F4B.3(pole-4)

CBR:

CBG_20898

CRQ:	GCK72_006639

NAI:	NECAME_08727

HRO:	HELRODRAFT_127849

LGI:	LOTGIDRAFT_89209

PCAN:

LSAX:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_046910

SHX:	MS3_00006376

OVI:	T265_06841

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HSY:

RES:

TAD:	TRIADDRAFT_56174

AQU:

100632272

CSAT:

104739381

EUS:	EUTSA_v10008787mg

BRP:

103871543

BNA:	106351207 106400048

BOE:	106292944 106311433

RSZ:

108851116

THJ:

104815749

GHI:	107953224 107954349

GAB:

DZI:

PPER:

PMUM:

PAVI:

LSV:

CCAV:

APRO:

OLU:	OSTLU_19031

CME:	CYME_CMQ472C

SCE:	YBR278W(DPB3) YJL065C(DLS1)

SEUB:

DI49_1301 DI49_2950

SPAO:

SPAR_B03730 SPAR_J01370

AGO:	AGOS_AEL159W

ERC:

Ecym_6281

KLA:	KLLA0_F01859g

KMX:	KLMA_50078(DPB3)

LTH:	KLTH0H10890g

VPO:	Kpol_1027p23

ZRO:	ZYRO0G20878g

CGR:	2886501(GVI51_B03245)

NCS:	NCAS_0A09230(NCAS0A09230) NCAS_0B07510(NCAS0B07510)

NDI:	NDAI_0B04830(NDAI0B04830) NDAI_0G05730(NDAI0G05730)

TPF:	TPHA_0I01210(TPHA0I01210)

TBL:	TBLA_0F01380(TBLA0F01380)

TGB:	HG536_0F01930

TDL:	TDEL_0D01790(TDEL0D01790)

KAF:	KAFR_0A01690(KAFR0A01690) KAFR_0A03690(KAFR0A03690)

KNG:	KNAG_0C01710(KNAG0C01710)

ZMK:	HG535_0C05040

DHA:	DEHA2B06820g

PIC:	PICST_30658(DPB3)

PGU:	PGUG_00764

SPAA:

SPAPADRAFT_58038

LEL:	PVL30_001544(DPB3)

LBG:	92208037(LODBEIA_P28410)

CAL:	CAALFM_C103640CA(HFL1)

CTP:	CTRG_04576

COT:	CORT_0B10040

CDU:	CD36_03400

CTEN:

18250197(PSN45_003100)

CLU:	CLUG_00107

CLUS:

A9F13_20g00319

CAUR:

CJI96_0004481

ASAU:

88174400(PUMCH_003336)

PPA:	PAS_chr2-1_0620

PKZ:	C5L36_0B04960

BBRX:

BRETT_004573

OPA:	HPODL_03599

YLI:	2906463(YALI2_A00643g)

MAW:	19251058(J3458_020501)

MAJ:

MAA_01155

PLJ:	28882858(PLICBS_001116)

MBE:

MBM_00842

GLZ:	GLAREA_07646

PTE:

PTT_15014

BZE:	COCCADRAFT_39584

BSC:	COCSADRAFT_106372

BOR:	COCMIDRAFT_99466

AALT:

CC77DRAFT_119432

CNE:

CNG03660

CNB:

CNBG1090

CNG:	CNAG_03203

CGI:	CGB_G1400W

CDEU:

CNBG_2382

CDEP:

91089417(L203_105208)

KMG:	30167329(I203_103111)

KNE:	92181367(IAR55_004109)

TASA:

A1Q1_05946

CCAC:

CcaHIS019_0306990(CcaverHIS019_0306990)

TVS:	TRAVEDRAFT_122509

DSQ:	DICSQDRAFT_82905

SHS:	STEHIDRAFT_34350 STEHIDRAFT_62834

HIR:	HETIRDRAFT_317563

PSQ:	PUNSTDRAFT_97839

ADL:	AURDEDRAFT_160546

FME:	FOMMEDRAFT_114740

GTR:	GLOTRDRAFT_29077

LBC:	LACBIDRAFT_309028

CCI:	CC1G_02946

ABP:	AGABI1DRAFT113914(AGABI1DRAFT_113914)

ABV:	AGABI2DRAFT193750(AGABI2DRAFT_193750)

MPR:	MPER_11856

MRR:	Moror_2865

E1B28_012589

SCM:	SCHCO_02614728(SCHCODRAFT_02614728)

CPUT:

CONPUDRAFT_55834

SLA:	SERLADRAFT_469731

WSE:	WALSEDRAFT_56082

WIC:	J056_004113

UMA:	UMAG_05207

PFP:	PFL1_03078

SGRA:

MGL:

MRT:

MSYM:

PGR:	PGTG_09116

MLR:	MELLADRAFT_71714

SRE:	PTSG_05820

DDI:	DDB_G0272740

DPP:	DICPUDRAFT_155311

DFA:

DFA_10079

» show all

Reference

PMID:12124389

Authors

Shimizu K, Hashimoto K, Kirchner JM, Nakai W, Nishikawa H, Resnick MA, Sugino A

Title

Fidelity of DNA polymerase epsilon holoenzyme from budding yeast Saccharomyces cerevisiae.

Journal

J Biol Chem 277:37422-9 (2002)
DOI:10.1074/jbc.M204476200

Sequence

[sce:YBR278W]

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