Entry
Name
HBV HBx to ERK signaling pathway
Definition
X -> ERK -> AP1 => MMP9
Expanded
K21854 -> (5594,5595) -> (2353,3725) => 4318
Class
Type
Pathogen
Pathway
Disease
H00048 Hepatocellular carcinoma
Gene
5594 MAPK1; mitogen-activated protein kinase 1
5595 MAPK3; mitogen-activated protein kinase 3
2353 FOS; Fos proto-oncogene, AP-1 transcription factor subunit
3725 JUN; Jun proto-oncogene, AP-1 transcription factor subunit
4318 MMP9; matrix metallopeptidase 9
Perturbant
Reference
Authors
Chung TW, Lee YC, Kim CH
Title
Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential.
Journal
Reference
Authors
Panteva M, Korkaya H, Jameel S
Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
Journal
Reference
Authors
Zhang X, Zhang H, Ye L
Title
Effects of hepatitis B virus X protein on the development of liver cancer.
Journal
LinkDB
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