KEGG   NETWORK: N00560
Entry
N00560                      Network                                

Name
HSV gD to HVEM-NFKB signaling pathway
Definition
GD -> TNFRSF14 -> TRAF2/5 -> IKK -> NFKBIA -> NFKB => (BIRC2,BIRC3,NFKB1,RELA,CCL2)
  Expanded
K19264 -> 8764 -> (7186,7188) -> (1147+3551+8517) -> 4792 -> (4790+5970) => (329,330,4790,5970,6347)
Class
nt06123 TNF signaling (viruses and bacteria)
nt06150 Cytokine-cytokine receptor interaction (viruses)
nt06168 Herpes simplex virus 1 (HSV-1)
Type
Pathogen
Pathway
hsa05168  Herpes simplex virus 1 infection
hsa04061  Viral protein interaction with cytokine and cytokine receptor
Disease
H00365  Herpes simplex virus infection
Gene
8764  TNFRSF14; TNF receptor superfamily member 14
7186  TRAF2; TNF receptor associated factor 2
7188  TRAF5; TNF receptor associated factor 5
1147  CHUK; conserved helix-loop-helix ubiquitous kinase
3551  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma
4792  NFKBIA; NFKB inhibitor alpha
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
329  BIRC2; baculoviral IAP repeat containing 2
330  BIRC3; baculoviral IAP repeat containing 3
6347  CCL2; C-C motif chemokine ligand 2
Perturbant
K19264 (GD)  gD; Simplexvirus envelope glycoprotein D
Reference
  Authors
Edwards RG, Longnecker R
  Title
Herpesvirus Entry Mediator and Ocular Herpesvirus Infection: More than Meets the Eye.
  Journal
J Virol 91:e00115-17 (2017)
DOI:10.1128/JVI.00115-17
Reference
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
  Authors
Sciortino MT, Medici MA, Marino-Merlo F, Zaccaria D, Giuffre-Cuculletto M, Venuti A, Grelli S, Bramanti P, Mastino A
  Title
Involvement of gD/HVEM interaction in NF-kB-dependent inhibition of apoptosis by HSV-1 gD.
  Journal
Biochem Pharmacol 76:1522-32 (2008)
DOI:10.1016/j.bcp.2008.07.030
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