KEGG   PATHWAY: pleo00550
Entry
pleo00550                   Pathway                                

Name
Peptidoglycan biosynthesis - Pleomorphomonas sp. SM30
Description
Peptidoglycan is a macromolecule made of long aminosugar strands cross-linked by short peptides. It forms the cell wall in bacteria surrounding the cytoplasmic membrane. The glycan strands are typically comprised of repeating N-acetylglucosamine (GlcNAc) and N-acetylmuramic acid (MurNAc) disaccharides. Each MurNAc is linked to a peptide of three to five amino acid residues. Disaccharide subunits are first assembled on the cytoplasmic side of the bacterial membrane on a polyisoprenoid anchor (lipid I and II). Polymerization of disaccharide subunits by transglycosylases and cross-linking of glycan strands by transpeptidases occur on the other side of the membrane. Bacterial cell wall biosynthesis inhibitors form a major class of antibiotics.
Class
Metabolism; Glycan biosynthesis and metabolism
Pathway map
pleo00550  Peptidoglycan biosynthesis
pleo00550

Organism
Pleomorphomonas sp. SM30 [GN:pleo]
Gene
OHA_1_03839  murA; UDP-N-acetylglucosamine1-carboxyvinyltransferase [KO:K00790] [EC:2.5.1.7]
OHA_1_04139  murB; UDP-N-acetylenolpyruvoylglucosamine reductase [KO:K00075] [EC:1.3.1.98]
OHA_1_04138  murC; UDP-N-acetylmuramate-L-alanine ligase [KO:K01924] [EC:6.3.2.8]
OHA_1_04135  murD; UDP-N-acetylmuramoylalanine-D-glutamate ligase [KO:K01925] [EC:6.3.2.9]
OHA_1_04142  ddlB; D-alanine-D-alanine ligase B [KO:K01921] [EC:6.3.2.4]
OHA_1_04133  murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-2,6-diaminopimelate ligase [KO:K15792] [EC:6.3.2.13 6.3.2.10]
OHA_1_00124  uppS; ditrans,polycis-undecaprenyl-diphosphate synthase [KO:K00806] [EC:2.5.1.31]
OHA_1_03314  uppP; undecaprenyl-diphosphatase [KO:K06153] [EC:3.6.1.27]
OHA_1_03210  undecaprenyl pyrophosphate phosphatase [KO:K19302] [EC:3.6.1.27]
OHA_1_04134  mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [KO:K01000] [EC:2.7.8.13]
OHA_1_04137  murG; UDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [KO:K02563] [EC:2.4.1.227]
OHA_1_02741  pbpF_2; penicillin-binding protein 1F [KO:K03814] [EC:2.4.1.129]
OHA_1_00545  mrcA; penicillin-binding protein 1A [KO:K05366] [EC:2.4.1.129 3.4.16.4]
OHA_1_03198  pbpG_2; penicillin-binding protein 2D [KO:K05366] [EC:2.4.1.129 3.4.16.4]
OHA_1_01652  pbpG_1; penicillin-binding protein 2D [KO:K05366] [EC:2.4.1.129 3.4.16.4]
OHA_1_00587  pbpF_1; penicillin-binding protein 1F [KO:K05367] [EC:2.4.1.129]
OHA_1_04132  ftsI; peptidoglycan synthase FtsI [KO:K03587] [EC:3.4.16.4]
OHA_1_00829  dacD; D-alanyl-D-alanine carboxypeptidase DacD precursor [KO:K07258] [EC:3.4.16.4]
Compound
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00133  D-Alanine
C00448  trans,trans-Farnesyl diphosphate
C00692  UDP-N-acetylmuramoyl-L-alanyl-D-glutamate
C00993  D-Alanyl-D-alanine
C01050  UDP-N-acetylmuramate
C01212  UDP-N-acetylmuramoyl-L-alanine
C04574  di-trans,poly-cis-Undecaprenyl diphosphate
C04631  UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
C04702  UDPMurNAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)
C04851  MurAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphospho-undecaprenol
C04877  UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate
C04882  UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine
C05892  UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine
C05893  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine
C05894  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-D-alanyl-D-alanine
C05895  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)5-D-alanyl-D-alanine
C05896  Crosslinked peptidoglycan
C05897  Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
C05898  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
C17541  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)-D-alanyl-D-alanine
C17542  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)3-D-alanyl-D-alanine
C17549  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-(L-alanyl-L-alanyl)-D-alanyl-D-alanine
C17550  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-(L-alanyl)-D-alanyl-D-alanine
C17556  di-trans,poly-cis-Undecaprenyl phosphate
C17558  di-trans,poly-cis-Undecaprenol
Reference
  Authors
Bouhss A, Trunkfield AE, Bugg TD, Mengin-Lecreulx D
  Title
The biosynthesis of peptidoglycan lipid-linked intermediates.
  Journal
FEMS Microbiol Rev 32:208-33 (2008)
DOI:10.1111/j.1574-6976.2007.00089.x
Reference
  Authors
Lloyd AJ, Gilbey AM, Blewett AM, De Pascale G, El Zoeiby A, Levesque RC, Catherwood AC, Tomasz A, Bugg TD, Roper DI, Dowson CG
  Title
Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan.
  Journal
J Biol Chem 283:6402-17 (2008)
DOI:10.1074/jbc.M708105200
Reference
  Authors
Barreteau H, Kovac A, Boniface A, Sova M, Gobec S, Blanot D
  Title
Cytoplasmic steps of peptidoglycan biosynthesis.
  Journal
FEMS Microbiol Rev 32:168-207 (2008)
DOI:10.1111/j.1574-6976.2008.00104.x
Reference
  Authors
van Heijenoort J
  Title
Recent advances in the formation of the bacterial peptidoglycan monomer unit.
  Journal
Nat Prod Rep 18:503-19 (2001)
DOI:10.1039/a804532a
Reference
  Authors
van Heijenoort  J
  Title
Formation of the glycan chains in the synthesis of bacterial peptidoglycan.
  Journal
Glycobiology 11:25R-36R (2001)
DOI:10.1093/glycob/11.3.25R
Related
pathway
pleo00520  Amino sugar and nucleotide sugar metabolism
pleo00900  Terpenoid backbone biosynthesis
KO pathway
ko00550   
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