| Entry |
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| Symbol |
CFB, AHUS4, ARMD14, BF, BFD, CFAB, CFBD, FB, FBI12, GBG, H2-Bf, PBF2
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| Name |
(RefSeq) complement factor B
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| KO |
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| Organism |
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| Pathway |
| hsa04610 | Complement and coagulation cascades |
| hsa05150 | Staphylococcus aureus infection |
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| Network |
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| Element |
| N01493 | Alternative pathway of complement cascade, C3 convertase formation |
| N01494 | Alternative pathway of complement cascade, C3/5 convertase formation |
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| Disease |
| H00104 | Alternative complement pathway component defects |
| H00821 | Age-related macular degeneration |
| H01434 | Atypical hemolytic uremic syndrome |
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| Drug target |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09150 Organismal Systems
09151 Immune system
04610 Complement and coagulation cascades
629 (CFB)
09160 Human Diseases
09172 Infectious disease: viral
05171 Coronavirus disease - COVID-19
629 (CFB)
09171 Infectious disease: bacterial
05150 Staphylococcus aureus infection
629 (CFB)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:hsa01002]
629 (CFB)
Enzymes [BR:hsa01000]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.21 Serine endopeptidases
3.4.21.47 alternative-complement-pathway C3/C5 convertase
629 (CFB)
Peptidases and inhibitors [BR:hsa01002]
Serine peptidases
Family S1: chymotrypsin family
629 (CFB)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| LinkDB |
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| Position |
6:31946095..31952084
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| AA seq |
764 aa
MGSNLSPQLCLMPFILGLLSGGVTTTPWSLARPQGSCSLEGVEIKGGSFRLLQEGQALEY
VCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPY
YNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQ
YRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTE
TIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKV
ASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQ
AVYSMMSWPDDVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPRE
DYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQSLSLCGM
VWEHRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVS
VGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCT
EGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDA
QYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWG
VVDVCKNQKRQKQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL |
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| NT seq |
2295 nt +upstreamnt +downstreamnt
atggggagcaatctcagcccccaactctgcctgatgccctttatcttgggcctcttgtct
ggaggtgtgaccaccactccatggtctttggcccggccccagggatcctgctctctggag
ggggtagagatcaaaggcggctccttccgacttctccaagagggccaggcactggagtac
gtgtgtccttctggcttctacccgtaccctgtgcagacacgtacctgcagatctacgggg
tcctggagcaccctgaagactcaagaccaaaagactgtcaggaaggcagagtgcagagca
atccactgtccaagaccacacgacttcgagaacggggaatactggccccggtctccctac
tacaatgtgagtgatgagatctctttccactgctatgacggttacactctccggggctct
gccaatcgcacctgccaagtgaatggccgatggagtgggcagacagcgatctgtgacaac
ggagcggggtactgctccaacccgggcatccccattggcacaaggaaggtgggcagccag
taccgccttgaagacagcgtcacctaccactgcagccgggggcttaccctgcgtggctcc
cagcggcgaacgtgtcaggaaggtggctcttggagcgggacggagccttcctgccaagac
tccttcatgtacgacacccctcaagaggtggccgaagctttcctgtcttccctgacagag
accatagaaggagtcgatgctgaggatgggcacggcccaggggaacaacagaagcggaag
atcgtcctggacccttcaggctccatgaacatctacctggtgctagatggatcagacagc
attggggccagcaacttcacaggagccaaaaagtgtctagtcaacttaattgagaaggtg
gcaagttatggtgtgaagccaagatatggtctagtgacatatgccacataccccaaaatt
tgggtcaaagtgtctgaagcagacagcagtaatgcagactgggtcacgaagcagctcaat
gaaatcaattatgaagaccacaagttgaagtcagggactaacaccaagaaggccctccag
gcagtgtacagcatgatgagctggccagatgacgtccctcctgaaggctggaaccgcacc
cgccatgtcatcatcctcatgactgatggattgcacaacatgggcggggacccaattact
gtcattgatgagatccgggacttgctatacattggcaaggatcgcaaaaacccaagggag
gattatctggatgtctatgtgtttggggtcgggcctttggtgaaccaagtgaacatcaat
gctttggcttccaagaaagacaatgagcaacatgtgttcaaagtcaaggatatggaaaac
ctggaagatgttttctaccaaatgatcgatgaaagccagtctctgagtctctgtggcatg
gtttgggaacacaggaagggtaccgattaccacaagcaaccatggcaggccaagatctca
gtcattcgcccttcaaagggacacgagagctgtatgggggctgtggtgtctgagtacttt
gtgctgacagcagcacattgtttcactgtggatgacaaggaacactcaatcaaggtcagc
gtaggaggggagaagcgggacctggagatagaagtagtcctatttcaccccaactacaac
attaatgggaaaaaagaagcaggaattcctgaattttatgactatgacgttgccctgatc
aagctcaagaataagctgaaatatggccagactatcaggcccatttgtctcccctgcacc
gagggaacaactcgagctttgaggcttcctccaactaccacttgccagcaacaaaaggaa
gagctgctccctgcacaggatatcaaagctctgtttgtgtctgaggaggagaaaaagctg
actcggaaggaggtctacatcaagaatggggataagaaaggcagctgtgagagagatgct
caatatgccccaggctatgacaaagtcaaggacatctcagaggtggtcacccctcggttc
ctttgtactggaggagtgagtccctatgctgaccccaatacttgcagaggtgattctggc
ggccccttgatagttcacaagagaagtcgtttcattcaagttggtgtaatcagctgggga
gtagtggatgtctgcaaaaaccagaagcggcaaaagcaggtacctgctcacgcccgagac
tttcacatcaacctctttcaagtgctgccctggctgaaggagaaactccaagatgaggat
ttgggttttctataa |
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