KEGG   DRUG: Erythromycin
Entry
D00140                      Drug                                   
Name
Erythromycin (JP18/USP/INN);
Akne-mycin (TN);
Eryc (TN);
Erygel (TN);
Pce (TN);
Staticin (TN);
T-stat (TN)
Product
  Generic
ERY (Bryant Ranch Prepack), ERY (Padagis Israel Pharmaceuticals), ERY-TAB (Arbor Pharmaceuticals), ERY-TAB (PD-Rx Pharmaceuticals), ERY-TAB (PD-Rx Pharmaceuticals), ERY-TAB (PD-Rx Pharmaceuticals), ERYTHROMYCIN (A-S Medication Solutions), ERYTHROMYCIN (A-S Medication Solutions), ERYTHROMYCIN (A-S Medication Solutions), ERYTHROMYCIN (ARMAS PHARMACEUTICALS), ERYTHROMYCIN (Alembic Pharmaceuticals Limited), ERYTHROMYCIN (Alembic Pharmaceuticals), ERYTHROMYCIN (Amneal Pharmaceuticals NY LLC), ERYTHROMYCIN (Amneal Pharmaceuticals NY LLC), ERYTHROMYCIN (Arbor Pharmaceuticals), ERYTHROMYCIN (Arbor Pharmaceuticals), ERYTHROMYCIN (Ascend Laboratories), ERYTHROMYCIN (Asclemed USA), ERYTHROMYCIN (Asclemed USA), ERYTHROMYCIN (Asclemed USA), ERYTHROMYCIN (Bausch & Lomb Incorporated), ERYTHROMYCIN (Bryant Ranch Prepack), ERYTHROMYCIN (Bryant Ranch Prepack), ERYTHROMYCIN (Bryant Ranch Prepack), ERYTHROMYCIN (Bryant Ranch Prepack), ERYTHROMYCIN (Cadila Pharmaceuticals Limited), ERYTHROMYCIN (Cardinal Health 107), ERYTHROMYCIN (Golden State Medical Supply), ERYTHROMYCIN (Golden State Medical Supply), ERYTHROMYCIN (MICRO LABS LIMITED), ERYTHROMYCIN (Mayne Pharma), ERYTHROMYCIN (Modavar Pharmaceuticals LLC), ERYTHROMYCIN (Mylan Pharmaceuticals), ERYTHROMYCIN (Nivagen Pharmaceuticals), ERYTHROMYCIN (NuCare Pharmaceuticals), ERYTHROMYCIN (NuCare Pharmaceuticals), ERYTHROMYCIN (NuCare Pharmaceuticals), ERYTHROMYCIN (NuCare Pharmaceuticals), ERYTHROMYCIN (Orange Pharmaceuticals USA LLC), ERYTHROMYCIN (PD-Rx Pharmaceuticals), ERYTHROMYCIN (PD-Rx Pharmaceuticals), ERYTHROMYCIN (Padagis Israel Pharmaceuticals), ERYTHROMYCIN (Padagis Israel Pharmaceuticals), ERYTHROMYCIN (Padagis US LLC), ERYTHROMYCIN (Preferred Pharmaceuticals), ERYTHROMYCIN (Proficient Rx LP), ERYTHROMYCIN (Proficient Rx LP), ERYTHROMYCIN (Proficient Rx LP), ERYTHROMYCIN (REMEDYREPACK), ERYTHROMYCIN (REMEDYREPACK), ERYTHROMYCIN (RPK Pharmaceuticals), ERYTHROMYCIN (Teva Pharmaceuticals USA), ERYTHROMYCIN (Torrent Pharmaceuticals Limited), ERYTHROMYCIN (Torrent Pharmaceuticals Limited), ERYTHROMYCIN (Wilshire Pharmaceuticals), ERYTHROMYCIN (Wilshire Pharmaceuticals), ERYTHROMYCIN (Zydus Lifesciences Limited), ERYTHROMYCIN (Zydus Lifesciences Limited), ERYTHROMYCIN (Zydus Pharmaceuticals USA), ERYTHROMYCIN (Zydus Pharmaceuticals USA)
Formula
C37H67NO13
Exact mass
733.4612
Mol weight
733.9268
Structure
Simcomp
Sequence
0 Pyk  1 Mtk  2 Mtn  3 Mte  4 Mtk  5 Mtk  6 Mtn
  Type
PK
Source
Saccharopolyspora erythraea [TAX:1836]
Class
Antibacterial
 DG01551  Macrolide antibiotic
  DG01874  14-membered ring macrolide antibiotic
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG02852  CYP3A/CYP3A4 inhibitor
Transporter inhibitor
 DG01622  ABCB1 inhibitor
Remark
Same as: C01912
Therapeutic category: 6141
ATC code: D10AF02 J01FA01 S01AA17
Chemical structure group: DG00436
Product (DG00436): D00140<JP/US> D01361<JP/US> D02009<JP/US> D02184<JP/US>
Product (mixture): D11646<US>
Efficacy
Antibacterial, Protein biosynthesis inhibitor
  Disease
Acne vulgaris [DS:H01445]
Listeriosis [DS:H00332]
Pertussis [DS:H00319]
Diphtheria [DS:H00343]
Amebiasis [DS:H00360]
Syphilis [DS:H00354]
Legionnaires' disease [DS:H00311]
Target
50S ribosomal subunit
  Pathway
ko03010  Ribosome
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551]
Transporter inhibition: ABCB1 [HSA:5243]
Biosynthesis
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
Structure map
map07020  Macrolides and ketolides
Other map
map04976  Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF02 Erythromycin
      D00140  Erythromycin (JP18/USP/INN) <JP/US>
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA01 Erythromycin
      D00140  Erythromycin (JP18/USP/INN) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA17 Erythromycin
      D00140  Erythromycin (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antibacterials
  Macrolides
   Erythromycin
    D00140  Erythromycin (JP18/USP/INN)
 Dermatological Agents
  Topical Anti-infectives
   Antibacterials, dermatological
    Erythromycin
     D00140  Erythromycin (JP18/USP/INN)
 Ophthalmic Agents
  Ophthalmic Anti-Infectives
   Antibacterials, Ophthalmic
    Erythromycin
     D00140  Erythromycin (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   614  Acting mainly on gram-positive bacteria and mycoplasma
    6141  Erythromycins
     D00140  Erythromycin (JP18/USP/INN)
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01874  14-membered ring macrolide antibiotic
    DG00436  Erythromycin
     D00140  Erythromycin
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00436  Erythromycin
    D00140  Erythromycin
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   DG00436  Erythromycin
    D00140  Erythromycin
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   DG00436  Erythromycin
    D00140  Erythromycin
Drug classes [BR:br08332]
 Antibacterial
  DG01551  Macrolide antibiotic
   D00140  Erythromycin
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    D00140  Erythromycin (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00140  Erythromycin
  D00140  Erythromycin enteric-coated tablets
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00140
 Drug transporters
  D00140
Prodrugs [br08324.html]
 D00140
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01874  14-membered ring macrolide antibiotic
    DG00436  Erythromycin
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00436  Erythromycin
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   DG00436  Erythromycin
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   DG00436  Erythromycin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    DG00436  Erythromycin
Other DBs
CAS: 114-07-8
PubChem: 7847208
ChEBI: 42355
PDB-CCD: ERY[PDBj]
LigandBox: D00140
NIKKAJI: J2.892D
LinkDB
KCF data

ATOM        51
            1   C1y C    29.5344  -13.7288
            2   C1z C    29.5344  -12.3594
            3   C1y C    28.3449  -14.4078
            4   O2a O    31.5246  -14.4484
            5   C1x C    28.3449  -11.6747
            6   O1a O    30.5672  -11.3672
            7   C1a C    30.8225  -12.7945
            8   C1y C    28.3449  -15.7772
            9   C1a C    27.3697  -13.3814
            10  C1y C    33.1096  -13.7303
            11  C1y C    28.3449  -10.2995
            12  O2a O    29.0876  -17.1408
            13  C1y C    27.1669  -16.4620
            14  C1y C    34.2830  -14.4247
            15  O2x O    33.1216  -12.3614
            16  C5x C    27.1669   -9.6205
            17  C1a C    29.5344   -9.6205
            18  C1y C    30.6105  -17.5606
            19  C7x C    25.9774  -15.7772
            20  C1a C    27.1669  -17.8312
            21  C1y C    35.4739  -13.7601
            22  O1a O    34.2739  -15.7986
            23  C1y C    34.3175  -11.6941
            24  C1y C    25.9774  -10.2995
            25  O5x O    27.1669   -8.2511
            26  C1x C    30.6105  -18.9243
            27  O2x O    31.8001  -16.8760
            28  O7x O    25.9774  -14.4078
            29  O6a O    24.9155  -16.7288
            30  C1x C    35.4884  -12.3963
            31  N1c N    36.6522  -14.4516
            32  C1a C    34.3373  -10.3274
            33  C1y C    25.9774  -11.6747
            34  C1a C    24.7937   -9.6205
            35  C1z C    31.8001  -19.6148
            36  C1y C    32.9779  -17.5606
            37  C1y C    24.7937  -13.7288
            38  C1z C    24.7937  -12.3594
            39  O1a O    27.1669  -12.3594
            40  C1y C    32.9779  -18.9243
            41  O2a O    31.8001  -20.9437
            42  C1a C    33.2507  -20.6013
            43  C1a C    34.1675  -16.8818
            44  C1b C    23.6099  -14.4078
            45  C1a C    23.5404  -12.9279
            46  O1a O    23.5404  -11.6690
            47  O1a O    34.1675  -19.6148
            48  C1a C    32.9026  -21.9069
            49  C1a C    23.5747  -15.5334
            50  C1a C    37.9042  -13.7409
            51  C1a C    36.7130  -15.8195
BOND        53
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1
            5     2   6 1 #Up
            6     2   7 1 #Down
            7     3   8 1
            8     3   9 1 #Down
            9    10   4 1 #Down
            10    5  11 1
            11    8  12 1 #Down
            12    8  13 1
            13   10  14 1
            14   10  15 1
            15   11  16 1
            16   11  17 1 #Down
            17   18  12 1 #Down
            18   13  19 1
            19   13  20 1 #Up
            20   14  21 1
            21   14  22 1 #Up
            22   15  23 1
            23   16  24 1
            24   16  25 2
            25   18  26 1
            26   18  27 1
            27   19  28 1
            28   19  29 2
            29   21  30 1
            30   21  31 1 #Down
            31   23  32 1 #Down
            32   24  33 1
            33   24  34 1 #Up
            34   26  35 1
            35   27  36 1
            36   28  37 1
            37   33  38 1
            38   33  39 1 #Up
            39   35  40 1
            40   35  41 1 #Down
            41   35  42 1
            42   36  43 1 #Up
            43   37  44 1 #Down
            44   38  45 1 #Down
            45   38  46 1 #Up
            46   40  47 1 #Down
            47   41  48 1
            48   44  49 1
            49   23  30 1
            50   36  40 1
            51   37  38 1
            52   31  50 1
            53   31  51 1

» Japanese version   » Back

KEGG   DRUG: Erythromycin estolate
Entry
D00851                      Drug                                   
Name
Erythromycin estolate (USP);
Erythromycin estorate (JAN);
Ilosone (TN)
Formula
C40H71NO14. C12H26O4S
Exact mass
1055.6426
Mol weight
1056.3875
Structure
Simcomp
Class
Antibacterial
 DG01551  Macrolide antibiotic
  DG01874  14-membered ring macrolide antibiotic
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG02852  CYP3A/CYP3A4 inhibitor
Transporter inhibitor
 DG01622  ABCB1 inhibitor
Remark
Same as: C08031
ATC code: D10AF02 J01FA01 S01AA17
Chemical structure group: DG00436
Product (DG00436): D00140<JP/US> D01361<JP/US> D02009<JP/US> D02184<JP/US>
Efficacy
Antibacterial, Protein biosynthesis inhibitor
Comment
Active form of prodrug: Erythromycin [DR:D00140]
Target
50S ribosomal subunit
  Pathway
ko03010  Ribosome
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551]
Transporter inhibition: ABCB1 [HSA:5243]
Structure map
map07020  Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF02 Erythromycin
      D00851  Erythromycin estolate (USP)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA01 Erythromycin
      D00851  Erythromycin estolate (USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA17 Erythromycin
      D00851  Erythromycin estolate (USP)
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01874  14-membered ring macrolide antibiotic
    DG00436  Erythromycin
     D00851  Erythromycin estolate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00436  Erythromycin
    D00851  Erythromycin estolate
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   DG00436  Erythromycin
    D00851  Erythromycin estolate
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   DG00436  Erythromycin
    D00851  Erythromycin estolate
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    D00851  Erythromycin estolate (USP)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00851
 Drug transporters
  D00851
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01874  14-membered ring macrolide antibiotic
    DG00436  Erythromycin
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00436  Erythromycin
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   DG00436  Erythromycin
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   DG00436  Erythromycin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    DG00436  Erythromycin
Other DBs
CAS: 3521-62-8
PubChem: 7847916
ChEBI: 4846
LigandBox: D00851
NIKKAJI: J383.158B
LinkDB
KCF data

ATOM        72
            1   C1y C     8.6520  -15.8825
            2   C1z C     8.6520  -14.5689
            3   C1y C     7.5110  -16.5339
            4   O2a O    11.1010  -16.9101
            5   C1x C     7.5110  -13.9120
            6   O1a O     9.6429  -13.6171
            7   C1a C     9.8879  -14.9862
            8   C1y C     7.5110  -17.8476
            9   C1a C     6.5756  -15.5493
            10  C1y C    13.0541  -16.0150
            11  C1y C     7.5110  -12.5928
            12  O2a O     8.2235  -19.1557
            13  C1y C     6.3810  -18.5045
            14  C1y C    14.1798  -16.6811
            15  O2x O    13.0658  -14.7018
            16  C5x C     6.3810  -11.9414
            17  C1a C     8.6520  -11.9414
            18  C1y C     9.6844  -19.5584
            19  C7x C     5.2399  -17.8476
            20  C1a C     6.3810  -19.8180
            21  C1y C    15.3897  -16.0436
            22  O7a O    14.2385  -18.8086
            23  C1y C    14.2129  -14.0616
            24  C1y C     5.2399  -12.5928
            25  O5x O     6.3810  -10.6277
            26  C1x C     9.6844  -20.8666
            27  O2x O    10.8257  -18.9017
            28  O7x O     5.2399  -16.5339
            29  O6a O     4.2211  -18.7605
            30  C1x C    15.4060  -14.7352
            31  N1c N    16.4526  -16.7069
            32  C1a C    14.2319  -12.7505
            33  C1y C     5.2399  -13.9120
            34  C1a C     4.1044  -11.9414
            35  C1z C    10.8257  -21.5290
            36  C1y C    11.9555  -19.5584
            37  C1y C     4.1044  -15.8825
            38  C1z C     4.1044  -14.5689
            39  O1a O     6.3810  -14.5689
            40  C1y C    11.9555  -20.8666
            41  O2a O    10.8257  -22.8038
            42  C1a C    12.2172  -22.4754
            43  C1a C    13.0967  -18.9073
            44  C1b C     2.9687  -16.5339
            45  C1a C     2.9020  -15.1142
            46  O1a O     2.9020  -13.9065
            47  O1a O    13.0967  -21.5290
            48  C1a C    11.8832  -23.7278
            49  C1a C     3.0025  -17.6137
            50  C1a C    17.6537  -16.0252
            51  C7a C    15.3913  -19.4848
            52  O6a O    15.3913  -20.8340
            53  C1b C    16.5282  -18.8337
            54  C1a C    17.6754  -19.5017
            55  C1a C    16.4526  -18.0561
            56  C1b C    36.4700  -17.3600
            57  C1b C    35.2576  -18.0600
            58  C1b C    34.0621  -17.3696
            59  C1b C    32.8747  -18.0551
            60  C1b C    31.6835  -17.3671
            61  C1b C    30.4940  -18.0538
            62  C1b C    29.3039  -17.3665
            63  C1b C    28.1138  -18.0535
            64  C1b C    26.9240  -17.3663
            65  C1b C    25.7338  -18.0534
            66  C1b C    24.5440  -17.3662
            67  O2a O    23.3538  -18.0534
            68  C1a C    37.6824  -18.0600
            69  S4a S    21.9812  -18.0478
            70  O1d O    20.5800  -18.0709
            71  O1d O    21.9726  -16.6600
            72  O1d O    21.9900  -19.4600
BOND        73
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1
            5     2   6 1 #Up
            6     2   7 1 #Down
            7     3   8 1
            8     3   9 1 #Down
            9    10   4 1 #Down
            10    5  11 1
            11    8  12 1 #Down
            12    8  13 1
            13   10  14 1
            14   10  15 1
            15   11  16 1
            16   11  17 1 #Down
            17   18  12 1 #Down
            18   13  19 1
            19   13  20 1 #Up
            20   14  21 1
            21   14  22 1 #Up
            22   15  23 1
            23   16  24 1
            24   16  25 2
            25   18  26 1
            26   18  27 1
            27   19  28 1
            28   19  29 2
            29   21  30 1
            30   21  31 1 #Down
            31   23  32 1 #Down
            32   24  33 1
            33   24  34 1 #Up
            34   26  35 1
            35   27  36 1
            36   28  37 1
            37   33  38 1
            38   33  39 1 #Up
            39   35  40 1
            40   35  41 1 #Down
            41   35  42 1
            42   36  43 1 #Up
            43   37  44 1 #Down
            44   38  45 1 #Down
            45   38  46 1 #Up
            46   40  47 1 #Down
            47   41  48 1
            48   44  49 1
            49   23  30 1
            50   36  40 1
            51   37  38 1
            52   31  50 1
            53   22  51 1
            54   51  52 2
            55   51  53 1
            56   53  54 1
            57   31  55 1
            58   56  57 1
            59   57  58 1
            60   58  59 1
            61   59  60 1
            62   60  61 1
            63   61  62 1
            64   62  63 1
            65   63  64 1
            66   64  65 1
            67   65  66 1
            68   66  67 1
            69   56  68 1
            70   67  69 1
            71   69  70 1
            72   69  71 2
            73   69  72 2

» Japanese version   » Back

KEGG   DRUG: Erythromycin ethylsuccinate
Entry
D01361                      Drug                                   
Name
Erythromycin ethylsuccinate (JP18/USP);
E.E.S. (TN);
Eryped (TN);
Erythrocin W (TN)
Product
  Generic
Formula
C43H75NO16
Exact mass
861.5086
Mol weight
862.0527
Structure
Simcomp
Class
Antibacterial
 DG01551  Macrolide antibiotic
  DG01874  14-membered ring macrolide antibiotic
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG02852  CYP3A/CYP3A4 inhibitor
Transporter inhibitor
 DG01622  ABCB1 inhibitor
Remark
Same as: C12796
Therapeutic category: 6141
ATC code: D10AF02 J01FA01 S01AA17
Chemical structure group: DG00436
Product (DG00436): D00140<JP/US> D01361<JP/US> D02009<JP/US> D02184<JP/US>
Efficacy
Antibacterial, Protein biosynthesis inhibitor
  Disease
Listeriosis [DS:H00332]
Pertussis [DS:H00319]
Diphtheria [DS:H00343]
Amebiasis [DS:H00360]
Syphilis [DS:H00354]
Legionnaires' disease [DS:H00311]
Comment
Active form of prodrug: Erythromycin [DR:D00140]
Target
50S ribosomal subunit
  Pathway
ko03010  Ribosome
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551]
Transporter inhibition: ABCB1 [HSA:5243]
Structure map
map07020  Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF02 Erythromycin
      D01361  Erythromycin ethylsuccinate (JP18/USP) <JP/US>
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA01 Erythromycin
      D01361  Erythromycin ethylsuccinate (JP18/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA17 Erythromycin
      D01361  Erythromycin ethylsuccinate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Antibacterials
  Macrolides
   Erythromycin
    D01361  Erythromycin ethylsuccinate (JP18/USP)
 Dermatological Agents
  Topical Anti-infectives
   Antibacterials, dermatological
    Erythromycin
     D01361  Erythromycin ethylsuccinate (JP18/USP)
 Ophthalmic Agents
  Ophthalmic Anti-Infectives
   Antibacterials, Ophthalmic
    Erythromycin
     D01361  Erythromycin ethylsuccinate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   614  Acting mainly on gram-positive bacteria and mycoplasma
    6141  Erythromycins
     D01361  Erythromycin ethylsuccinate (JP18/USP)
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01874  14-membered ring macrolide antibiotic
    DG00436  Erythromycin
     D01361  Erythromycin ethylsuccinate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00436  Erythromycin
    D01361  Erythromycin ethylsuccinate
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   DG00436  Erythromycin
    D01361  Erythromycin ethylsuccinate
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   DG00436  Erythromycin
    D01361  Erythromycin ethylsuccinate
Drug classes [BR:br08332]
 Antibacterial
  DG01551  Macrolide antibiotic
   D01361  Erythromycin ethylsuccinate
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    D01361  Erythromycin ethylsuccinate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01361  Erythromycin ethylsuccinate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01361
 Drug transporters
  D01361
Prodrugs [br08324.html]
 D01361
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01874  14-membered ring macrolide antibiotic
    DG00436  Erythromycin
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00436  Erythromycin
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   DG00436  Erythromycin
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   DG00436  Erythromycin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    DG00436  Erythromycin
Other DBs
CAS: 1264-62-6
PubChem: 7848424
ChEBI: 31555
LigandBox: D01361
NIKKAJI: J217.089B
LinkDB
KCF data

ATOM        60
            1   C1y C    26.6685   -9.4688
            2   C1z C    26.6685   -8.1507
            3   C1y C    25.5236  -10.1224
            4   O2a O    29.1257  -10.4999
            5   C1x C    25.5236   -7.4916
            6   O1a O    27.6627   -7.1957
            7   C1a C    27.9085   -8.5695
            8   C1y C    25.5236  -11.4405
            9   C1a C    24.5850   -9.1345
            10  C1y C    30.3129   -7.8458
            11  C1y C    25.5236   -6.1679
            12  O2a O    26.2385  -12.7531
            13  C1y C    24.3898  -12.0997
            14  C1y C    31.4424   -8.5142
            15  O2x O    30.3246   -6.5282
            16  C5x C    24.3898   -5.5143
            17  C1a C    26.6685   -5.5143
            18  C1y C    27.7044  -13.1571
            19  C7x C    23.2448  -11.4405
            20  C1a C    24.3898  -13.4176
            21  C1y C    32.6564   -7.8745
            22  O7a O    31.5013  -10.6489
            23  C1y C    31.4756   -5.8858
            24  C1y C    23.2448   -6.1679
            25  O5x O    24.3898   -4.1962
            26  C1x C    27.7044  -14.4698
            27  O2x O    28.8495  -12.4982
            28  O7x O    23.2448  -10.1224
            29  O6a O    22.2226  -12.3565
            30  C1x C    32.6027   -6.5617
            31  N1c N    33.7229   -8.5401
            32  C1a C    31.4946   -4.5703
            33  C1y C    23.2448   -7.4916
            34  C1a C    22.1055   -5.5143
            35  C1z C    28.8495  -15.1344
            36  C1y C    29.9831  -13.1571
            37  C1y C    22.1055   -9.4688
            38  C1z C    22.1055   -8.1507
            39  O1a O    24.3898   -8.1507
            40  C1y C    29.9831  -14.4698
            41  O2a O    28.8495  -16.4135
            42  C1a C    30.2457  -16.0840
            43  C1a C    31.1282  -12.5038
            44  C1b C    20.9659  -10.1224
            45  C1a C    20.8990   -8.6979
            46  O1a O    20.8990   -7.4861
            47  O1a O    31.1282  -15.1344
            48  C1a C    29.9106  -17.3407
            49  C1a C    20.9998  -11.2059
            50  C1a C    34.9280   -7.8560
            51  C7a C    32.6580  -11.3274
            52  O6a O    32.6580  -12.6811
            53  C1b C    33.7987  -10.6741
            54  C1b C    34.9498  -11.3443
            55  C1a C    33.7229   -9.8938
            56  C7a C    36.1516  -10.6561
            57  O7a O    37.3309  -11.3426
            58  O6a O    36.0870   -9.2405
            59  C1b C    38.5311  -10.6552
            60  C1a C    39.7112  -11.3421
BOND        62
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1
            5     2   6 1 #Up
            6     2   7 1 #Down
            7     3   8 1
            8     3   9 1 #Down
            9    10   4 1 #Down
            10    5  11 1
            11    8  12 1 #Down
            12    8  13 1
            13   10  14 1
            14   10  15 1
            15   11  16 1
            16   11  17 1 #Down
            17   18  12 1 #Down
            18   13  19 1
            19   13  20 1 #Up
            20   14  21 1
            21   14  22 1 #Up
            22   15  23 1
            23   16  24 1
            24   16  25 2
            25   18  26 1
            26   18  27 1
            27   19  28 1
            28   19  29 2
            29   21  30 1
            30   21  31 1 #Down
            31   23  32 1 #Down
            32   24  33 1
            33   24  34 1 #Up
            34   26  35 1
            35   27  36 1
            36   28  37 1
            37   33  38 1
            38   33  39 1 #Up
            39   35  40 1
            40   35  41 1 #Down
            41   35  42 1
            42   36  43 1 #Up
            43   37  44 1 #Down
            44   38  45 1 #Down
            45   38  46 1 #Up
            46   40  47 1 #Down
            47   41  48 1
            48   44  49 1
            49   23  30 1
            50   36  40 1
            51   37  38 1
            52   31  50 1
            53   22  51 1
            54   51  52 2
            55   51  53 1
            56   53  54 1
            57   31  55 1
            58   54  56 1
            59   56  57 1
            60   56  58 2
            61   57  59 1
            62   59  60 1

» Japanese version   » Back

KEGG   DRUG: Erythromycin lactobionate
Entry
D02009                      Drug                                   
Name
Erythromycin lactobionate (JP18/USP);
Erythrocin (TN)
Product
  Generic
Formula
C37H67NO13. C12H22O12
Exact mass
1091.5724
Mol weight
1092.2227
Structure
Simcomp
Class
Antibacterial
 DG01551  Macrolide antibiotic
  DG01874  14-membered ring macrolide antibiotic
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG02852  CYP3A/CYP3A4 inhibitor
Transporter inhibitor
 DG01622  ABCB1 inhibitor
Remark
Therapeutic category: 6141
ATC code: D10AF02 J01FA01 S01AA17
Chemical structure group: DG00436
Product (DG00436): D00140<JP/US> D01361<JP/US> D02009<JP/US> D02184<JP/US>
Product (mixture): D04099<JP>
Efficacy
Antibacterial, Protein biosynthesis inhibitor
  Disease
Diphtheria [DS:H00343]
Gonorrhea [DS:H00315]
Legionnaires' disease [DS:H00311]
Bacterial endocarditis [DS:H00334]
Target
50S ribosomal subunit
  Pathway
ko03010  Ribosome
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551]
Transporter inhibition: ABCB1 [HSA:5243]
Structure map
map07020  Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF02 Erythromycin
      D02009  Erythromycin lactobionate (JP18/USP) <JP/US>
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA01 Erythromycin
      D02009  Erythromycin lactobionate (JP18/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA17 Erythromycin
      D02009  Erythromycin lactobionate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Antibacterials
  Macrolides
   Erythromycin
    D02009  Erythromycin lactobionate (JP18/USP)
 Dermatological Agents
  Topical Anti-infectives
   Antibacterials, dermatological
    Erythromycin
     D02009  Erythromycin lactobionate (JP18/USP)
 Ophthalmic Agents
  Ophthalmic Anti-Infectives
   Antibacterials, Ophthalmic
    Erythromycin
     D02009  Erythromycin lactobionate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   614  Acting mainly on gram-positive bacteria and mycoplasma
    6141  Erythromycins
     D02009  Erythromycin lactobionate (JP18/USP)
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01874  14-membered ring macrolide antibiotic
    DG00436  Erythromycin
     D02009  Erythromycin lactobionate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00436  Erythromycin
    D02009  Erythromycin lactobionate
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   DG00436  Erythromycin
    D02009  Erythromycin lactobionate
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   DG00436  Erythromycin
    D02009  Erythromycin lactobionate
Drug classes [BR:br08332]
 Antibacterial
  DG01551  Macrolide antibiotic
   D02009  Erythromycin lactobionate
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    D02009  Erythromycin lactobionate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02009  Erythromycin lactobionate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02009
 Drug transporters
  D02009
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01874  14-membered ring macrolide antibiotic
    DG00436  Erythromycin
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00436  Erythromycin
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   DG00436  Erythromycin
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   DG00436  Erythromycin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    DG00436  Erythromycin
Other DBs
CAS: 3847-29-8
PubChem: 7849071
ChEBI: 201377
LigandBox: D02009
NIKKAJI: J383.181G
LinkDB
KCF data

ATOM        75
            1   C1y C    35.9989  -17.5847
            2   C1y C    35.9989  -18.9757
            3   C1y C    37.2044  -19.6713
            4   C1y C    38.3636  -18.9757
            5   O2x O    38.3636  -17.5847
            6   C1y C    37.2044  -16.9355
            7   O2a O    37.2044  -15.5446
            8   C1c C    38.3636  -14.8490
            9   C1c C    39.5692  -15.5446
            10  C1b C    40.7747  -14.8490
            11  O1a O    41.9803  -15.5446
            12  C1c C    38.3636  -12.9015
            13  C1c C    39.5692  -12.2060
            14  O1a O    37.2044  -12.2060
            15  C6a C    40.7747  -12.9015
            16  O1a O    39.5692  -10.8614
            17  O6a O    41.9803  -12.2060
            18  O6a O    40.7747  -14.2925
            19  O1a O    39.5692  -16.9355
            20  C1b C    39.5692  -19.6713
            21  O1a O    40.7747  -18.9757
            22  O1a O    37.2044  -21.0623
            23  O1a O    34.7933  -19.6713
            24  O1a O    34.7933  -16.9355
            25  C1y C    25.9003  -13.1765
            26  C1z C    25.9003  -11.8133
            27  C1y C    24.7162  -13.8524
            28  O2a O    27.8815  -13.8928
            29  C1x C    24.7162  -11.1317
            30  O1a O    26.9284  -10.8256
            31  C1a C    27.1826  -12.2464
            32  C1y C    24.7162  -15.2156
            33  C1a C    23.7455  -12.8307
            34  C1y C    29.4593  -13.1780
            35  C1y C    24.7162   -9.7627
            36  O2a O    25.4556  -16.5730
            37  C1y C    23.5436  -15.8973
            38  C1y C    30.6274  -13.8692
            39  O2x O    29.4713  -11.8153
            40  C5x C    23.5436   -9.0868
            41  C1a C    25.9003   -9.0868
            42  C1y C    26.9716  -16.9909
            43  C7x C    22.3595  -15.2156
            44  C1a C    23.5436  -17.2603
            45  C1y C    31.8829  -13.2076
            46  O1a O    30.6183  -15.2369
            47  C1y C    30.6617  -11.1510
            48  C1y C    22.3595   -9.7627
            49  O5x O    23.5436   -7.7236
            50  C1x C    26.9716  -18.3484
            51  O2x O    28.1558  -16.3094
            52  O7x O    22.3595  -13.8524
            53  O6a O    21.3024  -16.1629
            54  C1x C    31.8273  -11.8500
            55  N1c N    32.9858  -13.8960
            56  C1a C    30.6814   -9.7905
            57  C1y C    22.3595  -11.1317
            58  C1a C    21.1812   -9.0868
            59  C1z C    28.1558  -19.0358
            60  C1y C    29.3282  -16.9909
            61  C1y C    21.1812  -13.1765
            62  C1z C    21.1812  -11.8133
            63  O1a O    23.5436  -11.8133
            64  C1y C    29.3282  -18.3484
            65  O2a O    28.1558  -20.3586
            66  C1a C    29.5998  -20.0178
            67  C1a C    30.5124  -16.3152
            68  C1b C    20.0027  -13.8524
            69  C1a C    19.9335  -12.3792
            70  O1a O    19.9335  -11.1260
            71  O1a O    30.5124  -19.0358
            72  C1a C    29.2532  -21.3175
            73  C1a C    20.0377  -14.9729
            74  C1a C    34.2321  -13.1885
            75  C1a C    32.9764  -15.2577
BOND        77
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     6   7 1 #Down
            8     8   7 1 #Up
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12    8  12 1
            13   12  13 1
            14   12  14 1 #Down
            15   13  15 1
            16   13  16 1 #Up
            17   15  17 1
            18   15  18 2
            19    9  19 1 #Up
            20    4  20 1 #Down
            21   20  21 1
            22    3  22 1 #Down
            23    2  23 1 #Down
            24    1  24 1 #Up
            25   25  26 1
            26   25  27 1
            27   25  28 1 #Down
            28   26  29 1
            29   26  30 1 #Up
            30   26  31 1 #Down
            31   27  32 1
            32   27  33 1 #Down
            33   34  28 1 #Down
            34   29  35 1
            35   32  36 1 #Down
            36   32  37 1
            37   34  38 1
            38   34  39 1
            39   35  40 1
            40   35  41 1 #Down
            41   42  36 1 #Down
            42   37  43 1
            43   37  44 1 #Up
            44   38  45 1
            45   38  46 1 #Up
            46   39  47 1
            47   40  48 1
            48   40  49 2
            49   42  50 1
            50   42  51 1
            51   43  52 1
            52   43  53 2
            53   45  54 1
            54   45  55 1 #Down
            55   47  56 1 #Down
            56   48  57 1
            57   48  58 1 #Up
            58   50  59 1
            59   51  60 1
            60   52  61 1
            61   57  62 1
            62   57  63 1 #Up
            63   59  64 1
            64   59  65 1 #Down
            65   59  66 1
            66   60  67 1 #Up
            67   61  68 1 #Down
            68   62  69 1 #Down
            69   62  70 1 #Up
            70   64  71 1 #Down
            71   65  72 1
            72   68  73 1
            73   47  54 1
            74   60  64 1
            75   61  62 1
            76   55  74 1
            77   55  75 1

» Japanese version   » Back

KEGG   DRUG: Erythromycin stearate
Entry
D02184                      Drug                                   
Name
Erythromycin stearate (JP18/USP);
Bristamycin (TN)
Product
  Generic
Formula
C37H67NO13. C18H36O2
Exact mass
1017.7328
Mol weight
1018.404
Structure
Simcomp
Class
Antibacterial
 DG01551  Macrolide antibiotic
  DG01874  14-membered ring macrolide antibiotic
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG02852  CYP3A/CYP3A4 inhibitor
Transporter inhibitor
 DG01622  ABCB1 inhibitor
Remark
Therapeutic category: 6141
ATC code: D10AF02 J01FA01 S01AA17
Chemical structure group: DG00436
Product (DG00436): D00140<JP/US> D01361<JP/US> D02009<JP/US> D02184<JP/US>
Efficacy
Antibacterial, Protein biosynthesis inhibitor
  Disease
Listeriosis [DS:H00332]
Pertussis [DS:H00319]
Diphtheria [DS:H00343]
Amebiasis [DS:H00360]
Syphilis [DS:H00354]
Legionnaires' disease [DS:H00311]
Target
50S ribosomal subunit
  Pathway
ko03010  Ribosome
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551]
Transporter inhibition: ABCB1 [HSA:5243]
Structure map
map07020  Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF02 Erythromycin
      D02184  Erythromycin stearate (JP18/USP) <JP/US>
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA01 Erythromycin
      D02184  Erythromycin stearate (JP18/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA17 Erythromycin
      D02184  Erythromycin stearate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Antibacterials
  Macrolides
   Erythromycin
    D02184  Erythromycin stearate (JP18/USP)
 Dermatological Agents
  Topical Anti-infectives
   Antibacterials, dermatological
    Erythromycin
     D02184  Erythromycin stearate (JP18/USP)
 Ophthalmic Agents
  Ophthalmic Anti-Infectives
   Antibacterials, Ophthalmic
    Erythromycin
     D02184  Erythromycin stearate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   614  Acting mainly on gram-positive bacteria and mycoplasma
    6141  Erythromycins
     D02184  Erythromycin stearate (JP18/USP)
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01874  14-membered ring macrolide antibiotic
    DG00436  Erythromycin
     D02184  Erythromycin stearate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00436  Erythromycin
    D02184  Erythromycin stearate
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   DG00436  Erythromycin
    D02184  Erythromycin stearate
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   DG00436  Erythromycin
    D02184  Erythromycin stearate
Drug classes [BR:br08332]
 Antibacterial
  DG01551  Macrolide antibiotic
   D02184  Erythromycin stearate
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    D02184  Erythromycin stearate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02184  Erythromycin stearate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02184
 Drug transporters
  D02184
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01874  14-membered ring macrolide antibiotic
    DG00436  Erythromycin
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00436  Erythromycin
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   DG00436  Erythromycin
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   DG00436  Erythromycin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    DG00436  Erythromycin
Other DBs
CAS: 643-22-1
PubChem: 7849244
ChEBI: 34742
LigandBox: D02184
NIKKAJI: J356.134H
LinkDB
KCF data

ATOM        71
            1   C1y C    15.6101  -25.5663
            2   C1z C    15.6101  -24.2032
            3   C1y C    14.4261  -26.2422
            4   O2a O    17.5913  -26.2826
            5   C1x C    14.4261  -23.5216
            6   O1a O    16.6382  -23.2155
            7   C1a C    16.8924  -24.6363
            8   C1y C    14.4261  -27.6054
            9   C1a C    13.4554  -25.2206
            10  C1y C    19.1691  -25.5678
            11  C1y C    14.4261  -22.1526
            12  O2a O    15.1655  -28.9628
            13  C1y C    13.2535  -28.2871
            14  C1y C    20.3372  -26.2590
            15  O2x O    19.1811  -24.2052
            16  C5x C    13.2535  -21.4767
            17  C1a C    15.6101  -21.4767
            18  C1y C    16.6814  -29.3807
            19  C7x C    12.0694  -27.6054
            20  C1a C    13.2535  -29.6501
            21  C1y C    21.5926  -25.5974
            22  O1a O    20.3281  -27.6267
            23  C1y C    20.3715  -23.5409
            24  C1y C    12.0694  -22.1526
            25  O5x O    13.2535  -20.1135
            26  C1x C    16.6814  -30.7381
            27  O2x O    17.8656  -28.6992
            28  O7x O    12.0694  -26.2422
            29  O6a O    11.0123  -28.5527
            30  C1x C    21.5370  -24.2399
            31  N1c N    22.6955  -26.2858
            32  C1a C    20.3912  -22.1804
            33  C1y C    12.0694  -23.5216
            34  C1a C    10.8911  -21.4767
            35  C1z C    17.8656  -31.4255
            36  C1y C    19.0380  -29.3807
            37  C1y C    10.8911  -25.5663
            38  C1z C    10.8911  -24.2032
            39  O1a O    13.2535  -24.2032
            40  C1y C    19.0380  -30.7381
            41  O2a O    17.8656  -32.7483
            42  C1a C    19.3096  -32.4075
            43  C1a C    20.2222  -28.7050
            44  C1b C     9.7127  -26.2422
            45  C1a C     9.6435  -24.7691
            46  O1a O     9.6435  -23.5159
            47  O1a O    20.2222  -31.4255
            48  C1a C    18.9630  -33.7072
            49  C1a C     9.7477  -27.3627
            50  C1a C    23.9418  -25.5783
            51  C1a C    22.6861  -27.6475
            52  C6a C    24.7800  -30.7300
            53  C1b C    25.9700  -31.4300
            54  O6a O    23.5900  -31.4300
            55  C1b C    27.1600  -30.7300
            56  C1b C    28.3500  -31.4300
            57  C1b C    29.5400  -30.7300
            58  C1b C    30.7300  -31.4300
            59  C1b C    31.9200  -30.7300
            60  C1b C    33.1100  -31.4300
            61  C1b C    34.3000  -30.7300
            62  C1b C    35.4900  -31.4300
            63  C1b C    36.6800  -30.7300
            64  C1b C    37.8700  -31.4300
            65  C1b C    39.0600  -30.7300
            66  C1b C    40.2500  -31.4300
            67  C1b C    41.4400  -30.7300
            68  C1b C    42.6300  -31.4300
            69  C1b C    43.8200  -30.7300
            70  C1a C    45.0100  -31.4300
            71  O6a O    24.7800  -29.3300
BOND        72
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1
            5     2   6 1 #Up
            6     2   7 1 #Down
            7     3   8 1
            8     3   9 1 #Down
            9    10   4 1 #Down
            10    5  11 1
            11    8  12 1 #Down
            12    8  13 1
            13   10  14 1
            14   10  15 1
            15   11  16 1
            16   11  17 1 #Down
            17   18  12 1 #Down
            18   13  19 1
            19   13  20 1 #Up
            20   14  21 1
            21   14  22 1 #Up
            22   15  23 1
            23   16  24 1
            24   16  25 2
            25   18  26 1
            26   18  27 1
            27   19  28 1
            28   19  29 2
            29   21  30 1
            30   21  31 1 #Down
            31   23  32 1 #Down
            32   24  33 1
            33   24  34 1 #Up
            34   26  35 1
            35   27  36 1
            36   28  37 1
            37   33  38 1
            38   33  39 1 #Up
            39   35  40 1
            40   35  41 1 #Down
            41   35  42 1
            42   36  43 1 #Up
            43   37  44 1 #Down
            44   38  45 1 #Down
            45   38  46 1 #Up
            46   40  47 1 #Down
            47   41  48 1
            48   44  49 1
            49   23  30 1
            50   36  40 1
            51   37  38 1
            52   31  50 1
            53   31  51 1
            54   52  53 1
            55   52  54 1
            56   53  55 1
            57   55  56 1
            58   56  57 1
            59   57  58 1
            60   58  59 1
            61   59  60 1
            62   60  61 1
            63   61  62 1
            64   62  63 1
            65   63  64 1
            66   64  65 1
            67   65  66 1
            68   66  67 1
            69   67  68 1
            70   68  69 1
            71   69  70 1
            72   52  71 2

» Japanese version   » Back

KEGG   DRUG: Erythromycin acistrate
Entry
D02523                      Drug                                   
Name
Erythromycin acistrate (USAN);
Erasis (TN)
Formula
C39H69NO14. C18H36O2
Exact mass
1059.7433
Mol weight
1060.4407
Structure
Simcomp
Class
Antibacterial
 DG01551  Macrolide antibiotic
  DG01874  14-membered ring macrolide antibiotic
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG02852  CYP3A/CYP3A4 inhibitor
Transporter inhibitor
 DG01622  ABCB1 inhibitor
Remark
ATC code: D10AF02 J01FA01 S01AA17
Chemical structure group: DG00436
Product (DG00436): D00140<JP/US> D01361<JP/US> D02009<JP/US> D02184<JP/US>
Efficacy
Antibacterial, Protein biosynthesis inhibitor
Comment
Active form of prodrug: Erythromycin [DR:D00140]
Target
50S ribosomal subunit
  Pathway
ko03010  Ribosome
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551]
Transporter inhibition: ABCB1 [HSA:5243]
Structure map
map07020  Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF02 Erythromycin
      D02523  Erythromycin acistrate (USAN)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA01 Erythromycin
      D02523  Erythromycin acistrate (USAN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA17 Erythromycin
      D02523  Erythromycin acistrate (USAN)
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01874  14-membered ring macrolide antibiotic
    DG00436  Erythromycin
     D02523  Erythromycin acistrate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00436  Erythromycin
    D02523  Erythromycin acistrate
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   DG00436  Erythromycin
    D02523  Erythromycin acistrate
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   DG00436  Erythromycin
    D02523  Erythromycin acistrate
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    D02523  Erythromycin acistrate (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02523
 Drug transporters
  D02523
Prodrugs [br08324.html]
 D02523
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01874  14-membered ring macrolide antibiotic
    DG00436  Erythromycin
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00436  Erythromycin
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   DG00436  Erythromycin
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   DG00436  Erythromycin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    DG00436  Erythromycin
Other DBs
CAS: 96128-89-1
PubChem: 17396697
LigandBox: D02523
LinkDB
KCF data

ATOM        74
            1   C1y C    14.7668  -16.0137
            2   C1z C    14.7668  -14.6627
            3   C1y C    13.5933  -16.6836
            4   O2a O    16.7304  -16.7236
            5   C1x C    13.5933  -13.9871
            6   O1a O    15.7858  -13.6837
            7   C1a C    16.0377  -15.0919
            8   C1y C    13.5933  -18.0347
            9   C1a C    12.6312  -15.6710
            10  C1y C    13.5933  -12.6303
            11  O2a O    14.3261  -19.3800
            12  C1y C    12.4311  -18.7103
            13  C5x C    12.4311  -11.9604
            14  C1a C    14.7668  -11.9604
            15  C1y C    15.4817  -21.9450
            16  C7x C    11.2575  -18.0347
            17  C1a C    12.4311  -20.0612
            18  C1y C    11.2575  -12.6303
            19  O5x O    12.4311  -10.6093
            20  C1x C    15.4817  -23.2903
            21  O2x O    16.6554  -21.2695
            22  O7x O    11.2575  -16.6836
            23  O6a O    10.2098  -18.9736
            24  C1y C    11.2575  -13.9871
            25  C1a C    10.0897  -11.9604
            26  C1z C    16.6554  -23.9716
            27  C1y C    17.8174  -21.9450
            28  C1y C    10.0897  -16.0137
            29  C1z C    10.0897  -14.6627
            30  O1a O    12.4311  -14.6627
            31  C1y C    17.8174  -23.2903
            32  O2a O    16.6554  -25.2827
            33  C1a C    18.0866  -24.9449
            34  C1b C     8.9217  -16.6836
            35  C1a C     8.8531  -15.2235
            36  O1a O     8.8531  -13.9815
            37  O1a O    18.9911  -23.9716
            38  C1a C    17.7431  -26.2331
            39  C1a C     8.9564  -17.7941
            40  C1a C    19.0133  -21.2569
            41  C1y C    17.7947  -15.8268
            42  C1y C    18.5255  -17.0533
            43  C1y C    19.9130  -17.0606
            44  C1x C    20.6132  -15.8626
            45  C1y C    19.9091  -14.6279
            46  O2x O    18.5215  -14.6205
            47  C1a C    20.6149  -13.4203
            48  O7a O    17.8402  -18.2516
            49  C7a C    17.7907  -19.6049
            50  O6a O    16.5869  -20.2428
            51  C1a C    18.9868  -20.3552
            52  N1c N    20.5878  -18.2437
            53  C1a C    20.5758  -19.6051
            54  C1a C    21.9432  -17.8911
            55  C6a C    24.8960  -23.4904
            56  C1b C    26.0977  -24.1842
            57  O6a O    23.6944  -24.1842
            58  C1b C    27.2826  -23.4999
            59  C1b C    28.4594  -24.1794
            60  C1b C    29.6400  -23.4975
            61  C1b C    30.8190  -24.1781
            62  C1b C    31.9985  -23.4969
            63  C1b C    33.1781  -24.1778
            64  C1b C    34.3573  -23.4967
            65  C1b C    35.5370  -24.1777
            66  C1b C    36.7162  -23.4966
            67  C1b C    37.8958  -24.1777
            68  C1b C    39.0751  -23.4966
            69  C1b C    40.2547  -24.1777
            70  C1b C    41.4340  -23.4966
            71  C1b C    42.6136  -24.1777
            72  C1b C    43.7928  -23.4966
            73  C1a C    44.9725  -24.1777
            74  O6a O    24.8960  -22.1029
BOND        75
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1
            5     2   6 1 #Up
            6     2   7 1 #Down
            7     3   8 1
            8     3   9 1 #Down
            9     5  10 1
            10    8  11 1 #Down
            11    8  12 1
            12   10  13 1
            13   10  14 1 #Down
            14   15  11 1 #Down
            15   12  16 1
            16   12  17 1 #Up
            17   13  18 1
            18   13  19 2
            19   15  20 1
            20   15  21 1
            21   16  22 1
            22   16  23 2
            23   18  24 1
            24   18  25 1 #Up
            25   20  26 1
            26   21  27 1
            27   22  28 1
            28   24  29 1
            29   24  30 1 #Up
            30   26  31 1
            31   26  32 1 #Down
            32   26  33 1
            33   28  34 1 #Down
            34   29  35 1 #Down
            35   29  36 1 #Up
            36   31  37 1 #Down
            37   32  38 1
            38   34  39 1
            39   27  31 1
            40   28  29 1
            41   27  40 1 #Up
            42   41   4 1 #Down
            43   41  42 1
            44   42  43 1
            45   43  44 1
            46   44  45 1
            47   45  46 1
            48   41  46 1
            49   45  47 1 #Down
            50   42  48 1 #Up
            51   48  49 1
            52   49  50 2
            53   49  51 1
            54   43  52 1 #Down
            55   52  53 1
            56   52  54 1
            57   55  56 1
            58   55  57 1
            59   56  58 1
            60   58  59 1
            61   59  60 1
            62   60  61 1
            63   61  62 1
            64   62  63 1
            65   63  64 1
            66   64  65 1
            67   65  66 1
            68   66  67 1
            69   67  68 1
            70   68  69 1
            71   69  70 1
            72   70  71 1
            73   71  72 1
            74   72  73 1
            75   55  74 2

» Japanese version   » Back

KEGG   DRUG: Erythromycin gluceptate
Entry
D02524                      Drug                                   
Name
Erythromycin gluceptate (USP);
Erythromycin glucoheptonate;
Ilotycin gluceptate (TN)
Formula
C37H67NO13. C7H14O8
Exact mass
959.5301
Mol weight
960.108
Structure
Class
Antibacterial
 DG01551  Macrolide antibiotic
  DG01874  14-membered ring macrolide antibiotic
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG02852  CYP3A/CYP3A4 inhibitor
Transporter inhibitor
 DG01622  ABCB1 inhibitor
Remark
ATC code: D10AF02 J01FA01 S01AA17
Chemical structure group: DG00436
Product (DG00436): D00140<JP/US> D01361<JP/US> D02009<JP/US> D02184<JP/US>
Efficacy
Antibacterial, Protein biosynthesis inhibitor
Target
50S ribosomal subunit
  Pathway
ko03010  Ribosome
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551]
Transporter inhibition: ABCB1 [HSA:5243]
Structure map
map07020  Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF02 Erythromycin
      D02524  Erythromycin gluceptate (USP)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA01 Erythromycin
      D02524  Erythromycin gluceptate (USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA17 Erythromycin
      D02524  Erythromycin gluceptate (USP)
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01874  14-membered ring macrolide antibiotic
    DG00436  Erythromycin
     D02524  Erythromycin gluceptate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00436  Erythromycin
    D02524  Erythromycin gluceptate
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   DG00436  Erythromycin
    D02524  Erythromycin gluceptate
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   DG00436  Erythromycin
    D02524  Erythromycin gluceptate
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    D02524  Erythromycin gluceptate (USP)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02524
 Drug transporters
  D02524
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01874  14-membered ring macrolide antibiotic
    DG00436  Erythromycin
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00436  Erythromycin
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   DG00436  Erythromycin
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   DG00436  Erythromycin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    DG00436  Erythromycin
Other DBs
CAS: 23067-13-2
PubChem: 17396698
LigandBox: D02524
NIKKAJI: J244.808D
LinkDB
KCF data

ATOM        66
            1   C1c C    33.7070  -21.6382
            2   C1c C    34.9626  -22.3357
            3   C1c C    32.5213  -22.3357
            4   O1a O    33.7070  -20.2431
            5   C1c C    36.1483  -21.6382
            6   O1a O    34.8928  -23.7308
            7   C1c C    31.2657  -21.6382
            8   O1a O    32.5213  -23.7308
            9   C6a C    37.3342  -22.3357
            10  O1a O    36.1483  -20.2431
            11  C1b C    30.0799  -22.3357
            12  O1a O    31.2657  -20.2431
            13  O6a O    37.3342  -23.7308
            14  O6a O    38.5199  -21.6382
            15  O1a O    28.8940  -21.7080
            16  C1y C    21.3277  -17.1158
            17  C1z C    21.3277  -15.7501
            18  C1y C    20.1414  -17.7929
            19  O2a O    23.3125  -17.8334
            20  C1x C    20.1414  -15.0672
            21  O1a O    22.3577  -14.7606
            22  C1a C    22.6123  -16.1840
            23  C1y C    20.1414  -19.1586
            24  C1a C    19.1690  -16.7693
            25  C1y C    24.8932  -17.1173
            26  C1y C    20.1414  -13.6957
            27  O2a O    20.8822  -20.5184
            28  C1y C    18.9668  -19.8416
            29  C1y C    26.0634  -17.8097
            30  O2x O    24.9052  -15.7521
            31  C5x C    18.9668  -13.0186
            32  C1a C    21.3277  -13.0186
            33  C1y C    22.4009  -20.9371
            34  C7x C    17.7805  -19.1586
            35  C1a C    18.9668  -21.2070
            36  C1y C    27.2511  -17.1469
            37  O1a O    26.0543  -19.1800
            38  C1y C    26.0978  -15.0866
            39  C1y C    17.7805  -13.6957
            40  O5x O    18.9668  -11.6529
            41  C1x C    22.4009  -22.2971
            42  O2x O    23.5873  -20.2543
            43  O7x O    17.7805  -17.7929
            44  O6a O    16.7214  -20.1077
            45  C1x C    27.2655  -15.7868
            46  N1c N    28.4262  -17.8366
            47  C1a C    26.1175  -13.7236
            48  C1y C    17.7805  -15.0672
            49  C1a C    16.6000  -13.0186
            50  C1z C    23.5873  -22.9857
            51  C1y C    24.7619  -20.9371
            52  C1y C    16.6000  -17.1158
            53  C1z C    16.6000  -15.7501
            54  O1a O    18.9668  -15.7501
            55  C1y C    24.7619  -22.2971
            56  O2a O    23.5873  -24.3109
            57  C1a C    25.0340  -23.9695
            58  C1a C    25.9482  -20.2601
            59  C1b C    15.4194  -17.7929
            60  C1a C    15.3500  -16.3170
            61  O1a O    15.3500  -15.0615
            62  O1a O    25.9482  -22.9857
            63  C1a C    24.6867  -25.2716
            64  C1a C    15.4544  -18.9155
            65  C1a C    29.6747  -17.1278
            66  C1a C    28.4167  -19.2008
BOND        67
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1
            5     2   6 1 #Down
            6     3   7 1
            7     3   8 1 #Down
            8     5   9 1
            9     5  10 1 #Up
            10    7  11 1
            11    7  12 1 #Up
            12    9  13 2
            13    9  14 1
            14   11  15 1
            15   16  17 1
            16   16  18 1
            17   16  19 1 #Down
            18   17  20 1
            19   17  21 1 #Up
            20   17  22 1 #Down
            21   18  23 1
            22   18  24 1 #Down
            23   25  19 1 #Down
            24   20  26 1
            25   23  27 1 #Down
            26   23  28 1
            27   25  29 1
            28   25  30 1
            29   26  31 1
            30   26  32 1 #Down
            31   33  27 1 #Down
            32   28  34 1
            33   28  35 1 #Up
            34   29  36 1
            35   29  37 1 #Up
            36   30  38 1
            37   31  39 1
            38   31  40 2
            39   33  41 1
            40   33  42 1
            41   34  43 1
            42   34  44 2
            43   36  45 1
            44   36  46 1 #Down
            45   38  47 1 #Down
            46   39  48 1
            47   39  49 1 #Up
            48   41  50 1
            49   42  51 1
            50   43  52 1
            51   48  53 1
            52   48  54 1 #Up
            53   50  55 1
            54   50  56 1 #Down
            55   50  57 1
            56   51  58 1 #Up
            57   52  59 1 #Down
            58   53  60 1 #Down
            59   53  61 1 #Up
            60   55  62 1 #Down
            61   56  63 1
            62   59  64 1
            63   38  45 1
            64   51  55 1
            65   52  53 1
            66   46  65 1
            67   46  66 1

» Japanese version   » Back

KEGG   DRUG: Erythromycin propionate
Entry
D02525                      Drug                                   
Name
Erythromycin propionate (USAN)
Formula
C40H71NO14
Exact mass
789.4875
Mol weight
789.99
Structure
Simcomp
Class
Antibacterial
 DG01551  Macrolide antibiotic
  DG01874  14-membered ring macrolide antibiotic
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG02852  CYP3A/CYP3A4 inhibitor
Transporter inhibitor
 DG01622  ABCB1 inhibitor
Remark
ATC code: D10AF02 J01FA01 S01AA17
Chemical structure group: DG00436
Product (DG00436): D00140<JP/US> D01361<JP/US> D02009<JP/US> D02184<JP/US>
Efficacy
Antibacterial, Protein biosynthesis inhibitor
Comment
Active form of prodrug: Erythromycin [DR:D00140]
Target
50S ribosomal subunit
  Pathway
ko03010  Ribosome
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551]
Transporter inhibition: ABCB1 [HSA:5243]
Structure map
map07020  Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF02 Erythromycin
      D02525  Erythromycin propionate (USAN)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA01 Erythromycin
      D02525  Erythromycin propionate (USAN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA17 Erythromycin
      D02525  Erythromycin propionate (USAN)
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01874  14-membered ring macrolide antibiotic
    DG00436  Erythromycin
     D02525  Erythromycin propionate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00436  Erythromycin
    D02525  Erythromycin propionate
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   DG00436  Erythromycin
    D02525  Erythromycin propionate
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   DG00436  Erythromycin
    D02525  Erythromycin propionate
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    D02525  Erythromycin propionate (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02525
 Drug transporters
  D02525
Prodrugs [br08324.html]
 D02525
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01874  14-membered ring macrolide antibiotic
    DG00436  Erythromycin
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00436  Erythromycin
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   DG00436  Erythromycin
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   DG00436  Erythromycin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    DG00436  Erythromycin
Other DBs
CAS: 134-36-1
PubChem: 17396699
LigandBox: D02525
NIKKAJI: J5.592A
LinkDB
KCF data

ATOM        55
            1   C1y C    27.5803  -10.5165
            2   C1z C    27.5803   -9.1533
            3   C1y C    26.3962  -11.1924
            4   O2a O    30.1215  -11.5828
            5   C1x C    26.3962   -8.4717
            6   O1a O    28.6084   -8.1656
            7   C1a C    28.8626   -9.5864
            8   C1y C    26.3962  -12.5556
            9   C1a C    25.4255  -10.1707
            10  C1y C    31.3493   -8.8380
            11  C1y C    26.3962   -7.1027
            12  O2a O    27.1356  -13.9130
            13  C1y C    25.2236  -13.2373
            14  C1y C    32.5174   -9.5292
            15  O2x O    31.3613   -7.4753
            16  C5x C    25.2236   -6.4268
            17  C1a C    27.5803   -6.4268
            18  C1y C    28.6516  -14.3309
            19  C7x C    24.0395  -12.5556
            20  C1a C    25.2236  -14.6003
            21  C1y C    33.7729   -8.8676
            22  O7a O    32.5783  -11.7369
            23  C1y C    32.5517   -6.8110
            24  C1y C    24.0395   -7.1027
            25  O5x O    25.2236   -5.0636
            26  C1x C    28.6516  -15.6884
            27  O2x O    29.8358  -13.6494
            28  O7x O    24.0395  -11.1924
            29  O6a O    22.9824  -13.5029
            30  C1x C    33.7173   -7.5100
            31  N1c N    34.8758   -9.5560
            32  C1a C    32.5714   -5.4505
            33  C1y C    24.0395   -8.4717
            34  C1a C    22.8612   -6.4268
            35  C1z C    29.8358  -16.3758
            36  C1y C    31.0082  -14.3309
            37  C1y C    22.8612  -10.5165
            38  C1z C    22.8612   -9.1533
            39  O1a O    25.2236   -9.1533
            40  C1y C    31.0082  -15.6884
            41  O2a O    29.8358  -17.6986
            42  C1a C    31.2798  -17.3578
            43  C1a C    32.1924  -13.6552
            44  C1b C    21.6827  -11.1924
            45  C1a C    21.6135   -9.7192
            46  O1a O    21.6135   -8.4660
            47  O1a O    32.1924  -16.3758
            48  C1a C    30.9332  -18.6575
            49  C1a C    21.7177  -12.3129
            50  C1a C    36.1221   -8.8485
            51  C7a C    33.7745  -12.4386
            52  O6a O    33.7745  -13.8386
            53  C1b C    34.9542  -11.7630
            54  C1a C    36.1447  -12.4561
            55  C1a C    34.8758  -10.9560
BOND        57
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1
            5     2   6 1 #Up
            6     2   7 1 #Down
            7     3   8 1
            8     3   9 1 #Down
            9    10   4 1 #Down
            10    5  11 1
            11    8  12 1 #Down
            12    8  13 1
            13   10  14 1
            14   10  15 1
            15   11  16 1
            16   11  17 1 #Down
            17   18  12 1 #Down
            18   13  19 1
            19   13  20 1 #Up
            20   14  21 1
            21   14  22 1 #Up
            22   15  23 1
            23   16  24 1
            24   16  25 2
            25   18  26 1
            26   18  27 1
            27   19  28 1
            28   19  29 2
            29   21  30 1
            30   21  31 1 #Down
            31   23  32 1 #Down
            32   24  33 1
            33   24  34 1 #Up
            34   26  35 1
            35   27  36 1
            36   28  37 1
            37   33  38 1
            38   33  39 1 #Up
            39   35  40 1
            40   35  41 1 #Down
            41   35  42 1
            42   36  43 1 #Up
            43   37  44 1 #Down
            44   38  45 1 #Down
            45   38  46 1 #Up
            46   40  47 1 #Down
            47   41  48 1
            48   44  49 1
            49   23  30 1
            50   36  40 1
            51   37  38 1
            52   31  50 1
            53   22  51 1
            54   51  52 2
            55   51  53 1
            56   53  54 1
            57   31  55 1

» Japanese version   » Back

KEGG   DRUG: Erythromycin salnacedin
Entry
D04054                      Drug                                   
Name
Erythromycin salnacedin (USAN);
Erythromycin salnacedin dihydrate
Formula
C37H67NO13. C12H13NO5S. 2H2O
Exact mass
1052.5338
Mol weight
1053.2577
Structure
Simcomp
Class
Antibacterial
 DG01551  Macrolide antibiotic
  DG01874  14-membered ring macrolide antibiotic
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG02852  CYP3A/CYP3A4 inhibitor
Transporter inhibitor
 DG01622  ABCB1 inhibitor
Remark
ATC code: D10AF02 J01FA01 S01AA17
Chemical structure group: DG00436
Product (DG00436): D00140<JP/US> D01361<JP/US> D02009<JP/US> D02184<JP/US>
Efficacy
Antibacterial, Protein biosynthesis inhibitor
Target
50S ribosomal subunit
  Pathway
ko03010  Ribosome
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551]
Transporter inhibition: ABCB1 [HSA:5243]
Structure map
map07020  Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF02 Erythromycin
      D04054  Erythromycin salnacedin (USAN)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA01 Erythromycin
      D04054  Erythromycin salnacedin (USAN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA17 Erythromycin
      D04054  Erythromycin salnacedin (USAN)
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01874  14-membered ring macrolide antibiotic
    DG00436  Erythromycin
     D04054  Erythromycin salnacedin
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00436  Erythromycin
    D04054  Erythromycin salnacedin
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   DG00436  Erythromycin
    D04054  Erythromycin salnacedin
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   DG00436  Erythromycin
    D04054  Erythromycin salnacedin
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    D04054  Erythromycin salnacedin (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D04054
 Drug transporters
  D04054
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01874  14-membered ring macrolide antibiotic
    DG00436  Erythromycin
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00436  Erythromycin
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   DG00436  Erythromycin
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   DG00436  Erythromycin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    DG00436  Erythromycin
Other DBs
CAS: 149908-23-6
PubChem: 47206014
LigandBox: D04054
LinkDB
KCF data

ATOM        72
            1   C8x C    31.3154  -18.2114
            2   C8x C    31.3154  -19.6133
            3   C8x C    32.5294  -20.3142
            4   C8x C    33.7436  -19.6133
            5   C8y C    33.7436  -18.2114
            6   C8y C    32.5294  -17.5104
            7   O1a O    32.5294  -16.1087
            8   C5a C    34.9764  -17.4994
            9   S2a S    36.1832  -18.1960
            10  O5a O    34.9761  -16.1086
            11  C1b C    37.3671  -17.5123
            12  C1c C    38.5628  -18.2025
            13  C6a C    39.7523  -17.5156
            14  O6a O    40.9450  -18.2042
            15  O6a O    39.7524  -16.1087
            16  N1b N    38.5630  -19.6130
            17  C5a C    39.7563  -20.3020
            18  O5a O    40.9430  -19.6168
            19  C1a C    39.7566  -21.7158
            20  O0  O    38.1829  -13.4604
            21  C1y C    23.6603  -13.2465
            22  C1z C    23.6603  -11.8833
            23  C1y C    22.4762  -13.9224
            24  O2a O    25.6415  -13.9628
            25  C1x C    22.4762  -11.2017
            26  O1a O    24.6884  -10.8956
            27  C1a C    24.9426  -12.3164
            28  C1y C    22.4762  -15.2856
            29  C1a C    21.5055  -12.9007
            30  C1y C    27.2193  -13.2480
            31  C1y C    22.4762   -9.8327
            32  O2a O    23.2156  -16.6430
            33  C1y C    21.3036  -15.9673
            34  C1y C    28.3874  -13.9392
            35  O2x O    27.2313  -11.8853
            36  C5x C    21.3036   -9.1568
            37  C1a C    23.6603   -9.1568
            38  C1y C    24.7316  -17.0609
            39  C7x C    20.1195  -15.2856
            40  C1a C    21.3036  -17.3303
            41  C1y C    29.5729  -13.2776
            42  O1a O    28.3783  -15.3069
            43  C1y C    28.4217  -11.2210
            44  C1y C    20.1195   -9.8327
            45  O5x O    21.3036   -7.7936
            46  C1x C    24.7316  -18.4184
            47  O2x O    25.9158  -16.3794
            48  O7x O    20.1195  -13.9224
            49  O6a O    19.0624  -16.2329
            50  C1x C    29.5173  -11.9200
            51  N1c N    30.7458  -13.9660
            52  C1a C    28.4414   -9.8605
            53  C1y C    20.1195  -11.2017
            54  C1a C    18.9412   -9.1568
            55  C1z C    25.9158  -19.1058
            56  C1y C    27.0882  -17.0609
            57  C1y C    18.9412  -13.2465
            58  C1z C    18.9412  -11.8833
            59  O1a O    21.3036  -11.8833
            60  C1y C    27.0882  -18.4184
            61  O2a O    25.9158  -20.4286
            62  C1a C    27.3598  -20.0878
            63  C1a C    28.2724  -16.3852
            64  C1b C    17.7627  -13.9224
            65  C1a C    17.6935  -12.4492
            66  O1a O    17.6935  -11.1960
            67  O1a O    28.2724  -19.1058
            68  C1a C    27.0132  -21.3875
            69  C1a C    17.7977  -15.0429
            70  C1a C    31.9921  -13.2585
            71  C1a C    30.7364  -15.3277
            72  O0  O    38.1829  -13.4604
BOND        72
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     5   8 1
            9     8   9 1
            10    8  10 2
            11    9  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   13  15 2
            16   12  16 1 #Up
            17   16  17 1
            18   17  18 2
            19   17  19 1
            20   21  22 1
            21   21  23 1
            22   21  24 1 #Down
            23   22  25 1
            24   22  26 1 #Up
            25   22  27 1 #Down
            26   23  28 1
            27   23  29 1 #Down
            28   30  24 1 #Down
            29   25  31 1
            30   28  32 1 #Down
            31   28  33 1
            32   30  34 1
            33   30  35 1
            34   31  36 1
            35   31  37 1 #Down
            36   38  32 1 #Down
            37   33  39 1
            38   33  40 1 #Up
            39   34  41 1
            40   34  42 1 #Up
            41   35  43 1
            42   36  44 1
            43   36  45 2
            44   38  46 1
            45   38  47 1
            46   39  48 1
            47   39  49 2
            48   41  50 1
            49   41  51 1 #Down
            50   43  52 1 #Down
            51   44  53 1
            52   44  54 1 #Up
            53   46  55 1
            54   47  56 1
            55   48  57 1
            56   53  58 1
            57   53  59 1 #Up
            58   55  60 1
            59   55  61 1 #Down
            60   55  62 1
            61   56  63 1 #Up
            62   57  64 1 #Down
            63   58  65 1 #Down
            64   58  66 1 #Up
            65   60  67 1 #Down
            66   61  68 1
            67   64  69 1
            68   43  50 1
            69   56  60 1
            70   57  58 1
            71   51  70 1
            72   51  71 1
BRACKET     1    35.8400  -14.3500   35.8400  -12.5300
            1    38.9900  -12.5300   38.9900  -14.3500
            1  2
 ORIGINAL  1   20
 REPEAT    1   72

» Japanese version   » Back

KEGG   DRUG: Erythromycin thiocyanate
Entry
D07909                      Drug                                   
Name
Erythromycin thiocyanate;
Erythrocin (TN)
Formula
C37H67NO13. CHNS
Exact mass
792.4442
Mol weight
793.0171
Structure
Simcomp
Class
Antibacterial
 DG01551  Macrolide antibiotic
  DG01874  14-membered ring macrolide antibiotic
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG02852  CYP3A/CYP3A4 inhibitor
Transporter inhibitor
 DG01622  ABCB1 inhibitor
Remark
ATC code: D10AF02 J01FA01 S01AA17
Chemical structure group: DG00436
Product (DG00436): D00140<JP/US> D01361<JP/US> D02009<JP/US> D02184<JP/US>
Efficacy
Antibacterial, Protein biosynthesis inhibitor
Target
50S ribosomal subunit
  Pathway
ko03010  Ribosome
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551]
Transporter inhibition: ABCB1 [HSA:5243]
Structure map
map07020  Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF02 Erythromycin
      D07909  Erythromycin thiocyanate
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA01 Erythromycin
      D07909  Erythromycin thiocyanate
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA17 Erythromycin
      D07909  Erythromycin thiocyanate
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01874  14-membered ring macrolide antibiotic
    DG00436  Erythromycin
     D07909  Erythromycin thiocyanate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00436  Erythromycin
    D07909  Erythromycin thiocyanate
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   DG00436  Erythromycin
    D07909  Erythromycin thiocyanate
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   DG00436  Erythromycin
    D07909  Erythromycin thiocyanate
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    D07909  Erythromycin thiocyanate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07909
 Drug transporters
  D07909
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01874  14-membered ring macrolide antibiotic
    DG00436  Erythromycin
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00436  Erythromycin
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   DG00436  Erythromycin
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   DG00436  Erythromycin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    DG00436  Erythromycin
Other DBs
CAS: 7704-67-8
PubChem: 96024605
LigandBox: D07909
NIKKAJI: J245.554D
LinkDB
KCF data

ATOM        54
            1   C1y C    17.3600  -16.5900
            2   C1z C    17.3600  -15.2600
            3   C1y C    16.1700  -17.2900
            4   O2a O    19.3200  -17.2900
            5   C1x C    16.1700  -14.5600
            6   O1a O    18.4100  -14.2800
            7   C1a C    18.6200  -15.6800
            8   C1y C    16.1700  -18.6200
            9   C1a C    15.1900  -16.2400
            10  C1y C    20.9300  -16.5900
            11  C1y C    16.1700  -13.1600
            12  O2a O    16.9400  -20.0200
            13  C1y C    14.9800  -19.3200
            14  C1y C    22.1200  -17.2900
            15  O2x O    20.9300  -15.2600
            16  C5x C    14.9800  -12.5300
            17  C1a C    17.3600  -12.5300
            18  C1y C    18.4100  -20.4400
            19  C7x C    13.7900  -18.6200
            20  C1a C    14.9800  -20.7200
            21  C1y C    23.2400  -16.6600
            22  O1a O    22.0500  -18.6900
            23  C1y C    22.1200  -14.5600
            24  C1y C    13.7900  -13.1600
            25  O5x O    14.9800  -11.1300
            26  C1x C    18.4100  -21.7700
            27  O2x O    19.6000  -19.7400
            28  O7x O    13.7900  -17.2900
            29  O6a O    12.7400  -19.6000
            30  C1x C    23.3100  -15.2600
            31  N1c N    24.4300  -17.3600
            32  C1a C    22.1200  -13.2300
            33  C1y C    13.7900  -14.5600
            34  C1a C    12.6700  -12.5300
            35  C1z C    19.6000  -22.4700
            36  C1y C    20.7900  -20.4400
            37  C1y C    12.6700  -16.5900
            38  C1z C    12.6700  -15.2600
            39  O1a O    14.9800  -15.2600
            40  C1y C    20.7900  -21.7700
            41  O2a O    19.6000  -23.8000
            42  C1a C    21.0700  -23.4500
            43  C1a C    21.9800  -19.7400
            44  C1b C    11.4800  -17.2900
            45  C1a C    11.4100  -15.8200
            46  O1a O    11.4100  -14.5600
            47  O1a O    21.9800  -22.4700
            48  C1a C    20.7200  -24.7800
            49  C1a C    11.4800  -18.4100
            50  C1a C    25.6900  -16.5900
            51  C1a C    24.4300  -18.6900
            52  C3b C    31.6400  -18.1300
            53  N3a N    33.0400  -18.1300
            54  S1a S    30.2400  -18.1300
BOND        55
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1
            5     2   6 1 #Up
            6     2   7 1 #Down
            7     3   8 1
            8     3   9 1 #Down
            9    10   4 1 #Down
            10    5  11 1
            11    8  12 1 #Down
            12    8  13 1
            13   10  14 1
            14   10  15 1
            15   11  16 1
            16   11  17 1 #Down
            17   18  12 1 #Down
            18   13  19 1
            19   13  20 1 #Up
            20   14  21 1
            21   14  22 1 #Up
            22   15  23 1
            23   16  24 1
            24   16  25 2
            25   18  26 1
            26   18  27 1
            27   19  28 1
            28   19  29 2
            29   21  30 1
            30   21  31 1 #Down
            31   23  32 1 #Down
            32   24  33 1
            33   24  34 1 #Up
            34   26  35 1
            35   27  36 1
            36   28  37 1
            37   33  38 1
            38   33  39 1 #Up
            39   35  40 1
            40   35  41 1 #Down
            41   35  42 1
            42   36  43 1 #Up
            43   37  44 1 #Down
            44   38  45 1 #Down
            45   38  46 1 #Up
            46   40  47 1 #Down
            47   41  48 1
            48   44  49 1
            49   23  30 1
            50   36  40 1
            51   37  38 1
            52   31  50 1
            53   31  51 1
            54   52  53 3
            55   52  54 1

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