KEGG   DRUG: Lamotrigine
Entry
D00354                      Drug                                   
Name
Lamotrigine (JAN/USP/INN);
Lamictal (TN)
Product
LAMICTAL (GlaxoSmithKline LLC), LAMICTAL (GlaxoSmithKline LLC)
  Generic
LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (Actavis Pharma), LAMOTRIGINE (Advagen Pharma Limited), LAMOTRIGINE (Advanced Rx Pharmacy of Tennessee), LAMOTRIGINE (Ajanta Pharma USA), LAMOTRIGINE (Alembic Pharmaceuticals Limited), LAMOTRIGINE (Alembic Pharmaceuticals Limited), LAMOTRIGINE (Alembic Pharmaceuticals Limited), LAMOTRIGINE (Alembic Pharmaceuticals), LAMOTRIGINE (Alembic Pharmaceuticals), LAMOTRIGINE (Alembic Pharmaceuticals), LAMOTRIGINE (American Health Packaging), LAMOTRIGINE (American Health Packaging), LAMOTRIGINE (Amneal Pharmaceuticals LLC), LAMOTRIGINE (Amneal Pharmaceuticals of New York LLC), LAMOTRIGINE (Amneal Pharmaceuticals of New York LLC), LAMOTRIGINE (Ascend Laboratories), LAMOTRIGINE (Asclemed USA), LAMOTRIGINE (Aurobindo Pharma Limited), LAMOTRIGINE (Aurobindo Pharma Limited), LAMOTRIGINE (AvKARE), LAMOTRIGINE (AvKARE), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Camber Pharmaceuticals), LAMOTRIGINE (Cardinal Health 107), LAMOTRIGINE (Cardinal Health 107), LAMOTRIGINE (Cipla USA), LAMOTRIGINE (DIRECT RX), LAMOTRIGINE (Dr. Reddy's Laboratories), LAMOTRIGINE (Dr.Reddy's Laboratories Limited), LAMOTRIGINE (Dr.Reddy's Laboratories Limited), LAMOTRIGINE (Dr.Reddy's Laboratories Limited), LAMOTRIGINE (Endo USA), LAMOTRIGINE (Glenmark Pharmaceuticals), LAMOTRIGINE (JUBILANT CADISTA PHARMACEUTICALS), LAMOTRIGINE (Major Pharmaceuticals), LAMOTRIGINE (NCS HealthCare of KY), LAMOTRIGINE (Nordic Pharma), LAMOTRIGINE (NorthStar Rx LLC), LAMOTRIGINE (Northstar Rx LLC.), LAMOTRIGINE (Northwind Pharmaceuticals), LAMOTRIGINE (Northwind Pharmaceuticals), LAMOTRIGINE (Northwind Pharmaceuticals), LAMOTRIGINE (NuCare Pharmaceuticals), LAMOTRIGINE (NuCare Pharmaceuticals), LAMOTRIGINE (OWP Pharmaceuticals), LAMOTRIGINE (PD-Rx Pharmaceuticals), LAMOTRIGINE (PD-Rx Pharmaceuticals), LAMOTRIGINE (PD-Rx Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaeuticals), LAMOTRIGINE (Proficient Rx LP), LAMOTRIGINE (Proficient Rx LP), LAMOTRIGINE (Proficient Rx LP), LAMOTRIGINE (Proficient Rx LP), LAMOTRIGINE (Proficient Rx LP), LAMOTRIGINE (Proficient Rx LP), LAMOTRIGINE (Quallent Pharmaceuticals Health LLC), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (Rising Pharma Holdings), LAMOTRIGINE (ST. MARY'S MEDICAL PARK PHARMACY), LAMOTRIGINE (ScieGen Pharmaceuticals), LAMOTRIGINE (Taro Pharmaceuticals U.S.A.), LAMOTRIGINE (Torrent Pharmaceuticals Limited), LAMOTRIGINE (Torrent Pharmaceuticals Limited), LAMOTRIGINE (Unichem Pharmaceuticals (USA)), LAMOTRIGINE (Yiling Pharmaceutical), LAMOTRIGINE (Zydus Lifesciences Limited), LAMOTRIGINE (Zydus Lifesciences Limited), LAMOTRIGINE (Zydus Pharmaceuticals USA), LAMOTRIGINE (Zydus Pharmaceuticals USA), LAMOTRIGINE ER (Direct_Rx), LAMOTRIGINE ER (Direct_rx), LAMOTRIGINE EXTENDED RELEASE (Endo USA), SUBVENITE (OWP Pharmaceuticals)
Formula
C9H7Cl2N5
Exact mass
255.0079
Mol weight
256.09
Structure
Class
Neuropsychiatric agent
 DG03199  Antiepileptic agent
Metabolizing enzyme substrate
 DG02924  UGT substrate
  DG03182  UGT1A4 substrate
Remark
Therapeutic category: 1139 1179
ATC code: N03AX09
Product: D00354<JP/US>
Efficacy
Anti-bipolar disorder, Anticonvulsant, Antiepileptic
  Disease
Lennox-Gastaut syndrome [DS:H01813]
Bipolar disorder [DS:H01653]
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: UGT1A4 [HSA:54657]
Interaction
Structure map
map07033  Anticonvulsants
map07231  Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AX Other antiepileptics
     N03AX09 Lamotrigine
      D00354  Lamotrigine (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Anticonvulsants, Other
   Lamotrigine
    D00354  Lamotrigine (JAN/USP/INN)
 Bipolar Agents
  Mood Stabilizers
   Lamotrigine
    D00354  Lamotrigine (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D00354  Lamotrigine (JAN/USP/INN)
   117  Psychotropics
    1179  Others
     D00354  Lamotrigine (JAN/USP/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03199  Antiepileptic agent
   D00354  Lamotrigine
 Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG03182  UGT1A4 substrate
    D00354  Lamotrigine
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG03199  Antiepileptic agent
   D00354  Lamotrigine
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D00354  Lamotrigine (JAN/USP/INN) <JP/US>
    SCN2A
     D00354  Lamotrigine (JAN/USP/INN) <JP/US>
    SCN3A
     D00354  Lamotrigine (JAN/USP/INN) <JP/US>
    SCN4A
     D00354  Lamotrigine (JAN/USP/INN) <JP/US>
    SCN5A
     D00354  Lamotrigine (JAN/USP/INN) <JP/US>
    SCN8A
     D00354  Lamotrigine (JAN/USP/INN) <JP/US>
    SCN9A
     D00354  Lamotrigine (JAN/USP/INN) <JP/US>
    SCN10A
     D00354  Lamotrigine (JAN/USP/INN) <JP/US>
    SCN11A
     D00354  Lamotrigine (JAN/USP/INN) <JP/US>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00354
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00354
Other DBs
CAS: 84057-84-1
PubChem: 7847420
ChEBI: 6367
PDB-CCD: IYJ[PDBj]
LigandBox: D00354
NIKKAJI: J25.814H
LinkDB
KCF data

ATOM        16
            1   C8y C    21.7344  -17.9428
            2   C8y C    20.5227  -17.2321
            3   C8y C    21.7285  -19.3408
            4   N5x N    22.9459  -17.2378
            5   C8y C    20.5286  -15.8341
            6   C8x C    19.3053  -17.9311
            7   N5x N    22.9343  -20.0398
            8   N1a N    20.5111  -20.0281
            9   N5x N    24.1576  -17.9485
            10  C8y C    19.3169  -15.1350
            11  X   Cl   21.7461  -15.1467
            12  C8x C    18.0995  -17.2262
            13  C8y C    24.1517  -19.3465
            14  C8x C    18.0995  -15.8281
            15  X   Cl   19.3228  -13.7313
            16  N1a N    25.3633  -20.0513
BOND        17
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     5  10 1
            10    5  11 1
            11    6  12 2
            12    7  13 2
            13   10  14 2
            14   10  15 1
            15   13  16 1
            16    9  13 1
            17   12  14 1

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