KEGG   DRUG: ラモトリギン
エントリ  
D00354                      Drug                                   
一般名   
ラモトリギン (JAN);
Lamotrigine (JAN/USP/INN)
商品名   
米国の商品 
  後発品
LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (Actavis Pharma), LAMOTRIGINE (Advagen Pharma Limited), LAMOTRIGINE (Advanced Rx Pharmacy of Tennessee), LAMOTRIGINE (Ajanta Pharma USA), LAMOTRIGINE (Alembic Pharmaceuticals Limited), LAMOTRIGINE (Alembic Pharmaceuticals Limited), LAMOTRIGINE (Alembic Pharmaceuticals), LAMOTRIGINE (Alembic Pharmaceuticals), LAMOTRIGINE (American Health Packaging), LAMOTRIGINE (American Health Packaging), LAMOTRIGINE (Amneal Pharmaceuticals LLC), LAMOTRIGINE (Amneal Pharmaceuticals of New York LLC), LAMOTRIGINE (Amring Pharmaceuticals), LAMOTRIGINE (Ascend Laboratories), LAMOTRIGINE (Asclemed USA), LAMOTRIGINE (Aurobindo Pharma Limited), LAMOTRIGINE (Aurobindo Pharma Limited), LAMOTRIGINE (AvKARE), LAMOTRIGINE (AvKARE), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Camber Pharmaceuticals), LAMOTRIGINE (Cardinal Health 107), LAMOTRIGINE (Cardinal Health 107), LAMOTRIGINE (Cipla USA), LAMOTRIGINE (DIRECT RX), LAMOTRIGINE (DirectRX), LAMOTRIGINE (Dr. Reddy's Laboratories), LAMOTRIGINE (Dr.Reddy's Laboratories Limited), LAMOTRIGINE (Dr.Reddy's Laboratories Limited), LAMOTRIGINE (Dr.Reddy's Laboratories Limited), LAMOTRIGINE (Glenmark Pharmaceuticals), LAMOTRIGINE (JUBILANT CADISTA PHARMACEUTICALS), LAMOTRIGINE (Lake Erie Medical DBA Quality Care Products LLC), LAMOTRIGINE (Lake Erie Medical DBA Quality Care Products LLC), LAMOTRIGINE (Major Pharmaceuticals), LAMOTRIGINE (NCS HealthCare of KY), LAMOTRIGINE (NorthStar Rx LLC), LAMOTRIGINE (NorthStar Rx LLC), LAMOTRIGINE (Northstar Rx LLC.), LAMOTRIGINE (Northwind Pharmaceuticals), LAMOTRIGINE (Northwind Pharmaceuticals), LAMOTRIGINE (Northwind Pharmaceuticals), LAMOTRIGINE (NuCare Pharmaceuticals), LAMOTRIGINE (NuCare Pharmaceuticals), LAMOTRIGINE (NuCare Pharmaceuticals), LAMOTRIGINE (NuCare Pharmaceuticals), LAMOTRIGINE (NuCare Pharmaceuticals), LAMOTRIGINE (NuCare Pharmaceuticals), LAMOTRIGINE (OWP Pharmaceuticals), LAMOTRIGINE (PD-Rx Pharmaceuticals), LAMOTRIGINE (PD-Rx Pharmaceuticals), LAMOTRIGINE (PD-Rx Pharmaceuticals), LAMOTRIGINE (Par Pharmaceutical), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaeuticals), LAMOTRIGINE (Proficient Rx LP), LAMOTRIGINE (Proficient Rx LP), LAMOTRIGINE (Proficient Rx LP), LAMOTRIGINE (Proficient Rx LP), LAMOTRIGINE (Proficient Rx LP), LAMOTRIGINE (Proficient Rx LP), LAMOTRIGINE (Quallent Pharmaceuticals Health LLC), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (RPK Pharmaceuticals), LAMOTRIGINE (RPK Pharmaceuticals), LAMOTRIGINE (RPK Pharmaceuticals), LAMOTRIGINE (Rising Pharma Holdings), LAMOTRIGINE (ST. MARY'S MEDICAL PARK PHARMACY), LAMOTRIGINE (ScieGen Pharmaceuticals), LAMOTRIGINE (Taro Pharmaceuticals U.S.A.), LAMOTRIGINE (Torrent Pharmaceuticals Limited), LAMOTRIGINE (Torrent Pharmaceuticals Limited), LAMOTRIGINE (Unichem Pharmaceuticals (USA)), LAMOTRIGINE (Zydus Lifesciences Limited), LAMOTRIGINE (Zydus Lifesciences Limited), LAMOTRIGINE (Zydus Pharmaceuticals USA), LAMOTRIGINE (Zydus Pharmaceuticals USA), LAMOTRIGINE ER (Direct_Rx), LAMOTRIGINE EXTENDED RELEASE (Par Pharmaceutical), SUBVENITE (OWP Pharmaceuticals)
組成式   
C9H7Cl2N5
質量    
255.0079
分子量   
256.09
構造式   
クラス   
精神神経系用薬
 DG03199  抗てんかん薬
代謝酵素基質薬
 DG02924  UGT基質薬
  DG03182  UGT1A4基質薬
コード   
薬効分類: 1139 1179
ATCコード: N03AX09
商品: D00354<JP/US>
効能    
双極性障害治療薬, 抗けいれん薬, 抗てんかん薬
  疾患
Lennox-Gastaut症候群 [DS:H01813]
双極性障害における気分エピソードの再発・再燃抑制 [DS:H01653]
ターゲット 
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  パスウェイ
hsa04728  ドーパミン作動性シナプス
代謝    
Enzyme: UGT1A4 [HSA:54657]
相互作用  

構造マップ 
map07033  抗痙攣薬
map07231  ナトリウムチャネル遮断薬
階層分類  
医療用医薬品の薬効分類 [BR:jp08301]
 1  神経系及び感覚器官用医薬品
  11  中枢神経系用薬
   113  抗てんかん剤
    1139  その他の抗てんかん剤
     D00354  ラモトリギン (JAN)
   117  精神神経用剤
    1179  その他の精神神経用剤
     D00354  ラモトリギン (JAN)
医療用医薬品のATC分類 [BR:jp08303]
 N 神経系
  N03 抗てんかん薬
   N03A 抗てんかん薬
    N03AX その他の抗てんかん薬
     N03AX09 ラモトリギン
      D00354  ラモトリギン (JAN) <JP/US>
医療用医薬品のUSP分類 [BR:jp08302]
 抗けいれん薬
  抗けいれん薬, その他
   ラモトリギン
    D00354  ラモトリギン (JAN)
 双極性障害治療薬
  気分安定薬
   ラモトリギン
    D00354  ラモトリギン (JAN)
医薬品グループ [BR:jp08330]
 精神神経系用薬
  DG03199  抗てんかん薬
   D00354  ラモトリギン
 代謝酵素基質薬
  DG02924  UGT基質薬
   DG03182  UGT1A4基質薬
    D00354  ラモトリギン
医薬品クラス [BR:jp08332]
 精神神経系用薬
  DG03199  抗てんかん薬 [商品一覧]
   D00354  ラモトリギン
ターゲットに基づく医薬品分類 [BR:jp08310]
 イオンチャネル
  電位依存性イオンチャネル
   ナトリウムチャネル
    SCN1A
     D00354  ラモトリギン (JAN) <JP/US>
    SCN2A
     D00354  ラモトリギン (JAN) <JP/US>
    SCN3A
     D00354  ラモトリギン (JAN) <JP/US>
    SCN4A
     D00354  ラモトリギン (JAN) <JP/US>
    SCN5A
     D00354  ラモトリギン (JAN) <JP/US>
    SCN8A
     D00354  ラモトリギン (JAN) <JP/US>
    SCN9A
     D00354  ラモトリギン (JAN) <JP/US>
    SCN10A
     D00354  ラモトリギン (JAN) <JP/US>
    SCN11A
     D00354  ラモトリギン (JAN) <JP/US>
日本の新薬 [jp08318.html]
 新有効成分含有医薬品
  D00354
薬物代謝酵素とトランスポーター [jp08309.html]
 薬物代謝酵素
  D00354
リンク   
CAS: 84057-84-1
PubChem: 7847420
PDB-CCD: IYJ[PDBj]
LigandBox: D00354
日化辞: J25.814H
LinkDB    

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