KEGG   DRUG: Midazolam
Entry
D00550                      Drug                                   

Name
Midazolam (JAN/USP/INN);
Dormicum (TN);
Buccolam (TN);
Nayzilam (TN)
Product
Formula
C18H13ClFN3
Exact mass
325.0782
Mol weight
325.7673
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01835  Benzodiazepine sedative-hypnotics
 DG01567  GABA-A receptor agonist
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Same as: C07524
Therapeutic category: 1124 1139
ATC code: N05CD08
Chemical structure group: DG00920
Product (DG00920): D00550<JP/US> D00696<US>
Efficacy
Anesthetic (intravenous), Anticonvulsant, Sedative-hypnotic
Comment
Benzodiazepine derivative
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Structure map
map07032  Hypnotics
map07230  GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CD Benzodiazepine derivatives
     N05CD08 Midazolam
      D00550  Midazolam (JAN/USP/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1124  Benzodiazepins
     D00550  Midazolam (JAN/USP/INN)
   113  Antiepileptics
    1139  Others
     D00550  Midazolam (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D00550  Midazolam (JAN/USP/INN) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00550
Other DBs
CAS: 59467-70-8
PubChem: 7847616
ChEBI: 6931
ChEMBL: CHEMBL655
DrugBank: DB00683
PDB-CCD: 08J[PDBj]
LigandBox: D00550
NIKKAJI: J31.859K
LinkDB
KCF data

ATOM        23
            1   C2y C    16.5834  -17.0194
            2   C8y C    15.7413  -15.9098
            3   C8y C    16.0765  -14.5530
            4   N4y N    17.3375  -13.9749
            5   N2x N    17.9892  -17.0446
            6   C8y C    18.5911  -14.5972
            7   C1x C    18.8776  -15.9659
            8   C8x C    15.0694  -13.5846
            9   C8x C    13.7274  -13.9727
            10  C8y C    13.3922  -15.3295
            11  C8x C    14.3993  -16.2976
            12  X   Cl   12.0274  -15.7239
            13  C8y C    15.9489  -18.2691
            14  C8x C    14.5473  -18.2691
            15  C8x C    13.8473  -19.4816
            16  C8x C    14.5473  -20.6940
            17  C8x C    15.9489  -20.6940
            18  C8y C    16.6489  -19.4816
            19  X   F    18.0598  -19.4817
            20  C8x C    19.5704  -13.5973
            21  N5x N    18.9220  -12.3570
            22  C8y C    17.5420  -12.5904
            23  C1a C    16.5611  -11.6294
BOND        26
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13   10  12 1
            14    1  13 1
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   13  18 2
            21   18  19 1
            22    6  20 2
            23   20  21 1
            24   21  22 2
            25    4  22 1
            26   22  23 1

» Japanese version   » Back

KEGG   DRUG: Midazolam hydrochloride
Entry
D00696                      Drug                                   

Name
Midazolam hydrochloride (USAN);
Versed (TN)
Product
  Generic
MIDAZOLAM (General Injectables and Vaccines), MIDAZOLAM (A-S Medication Solutions), MIDAZOLAM (Almaject), MIDAZOLAM (Almaject), MIDAZOLAM (Civica), MIDAZOLAM (General Injectables and Vaccines), MIDAZOLAM (General Injectables and Vaccines), MIDAZOLAM (General Injectables and Vaccines), MIDAZOLAM (General Injectables and Vaccines), MIDAZOLAM (West-Ward Pharmaceuticals Corp.), MIDAZOLAM (West-Ward Pharmaceuticals Corp.), MIDAZOLAM (West-Ward Pharmaceuticals Corp.), MIDAZOLAM (A-S Medication Solutions), MIDAZOLAM HYDROCHLORIDE (A-S Medication Solutions), MIDAZOLAM HYDROCHLORIDE (A-S Medication Solutions), MIDAZOLAM HYDROCHLORIDE (ATLANTIC BIOLOGICALS CORP.), MIDAZOLAM HYDROCHLORIDE (ATLANTIC BIOLOGICALS CORP.), MIDAZOLAM (Akorn), MIDAZOLAM (Alvogen), MIDAZOLAM (Alvogen), MIDAZOLAM HYDROCHLORIDE (American Health Packaging), MIDAZOLAM (Athenex Pharmaceutical Division), MIDAZOLAM (Athenex Pharmaceutical Division), MIDAZOLAM HYDROCHLORIDE (Bryant Ranch Prepack), MIDAZOLAM HYDROCHLORIDE (Cardinal Health), MIDAZOLAM (Fresenius Kabi USA), MIDAZOLAM (Fresenius Kabi USA), MIDAZOLAM (Fresenius Kabi USA), MIDAZOLAM HYDROCHLORIDE (General Injectables & Vaccines), MIDAZOLAM (General Injectables & Vaccines), MIDAZOLAM HYDROCHLORIDE (Gland Pharma Limited), MIDAZOLAM HYDROCHLORIDE (Gland Pharma Limited), MIDAZOLAM HYDROCHLORIDE (Heritage Pharmaceuticals Inc d/b/a as Avet Pharmaceuticals), MIDAZOLAM HYDROCHLORIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), MIDAZOLAM HYDROCHLORIDE (Hospira), MIDAZOLAM HYDROCHLORIDE (Hospira), MIDAZOLAM HYDROCHLORIDE (Hospira), MIDAZOLAM HYDROCHLORIDE (Major Pharmaceuticals), MIDAZOLAM HYDROCHLORIDE (Major Pharmaceuticals), MIDAZOLAM HYDROCHLORIDE (Paddock Laboratories), MIDAZOLAM HYDROCHLORIDE (Precision Dose), MIDAZOLAM HYDROCHLORIDE (Precision Dose), MIDAZOLAM HYDROCHLORIDE (West-Ward Pharmaceuticals Corp.)
Formula
C18H13ClFN3. HCl
Exact mass
361.0549
Mol weight
362.2283
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01835  Benzodiazepine sedative-hypnotics
 DG01567  GABA-A receptor agonist
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
ATC code: N05CD08
Chemical structure group: DG00920
Product (DG00920): D00550<JP/US> D00696<US>
Efficacy
Anesthetic (intravenous), Sedative-hypnotic
Comment
Benzodiazepines
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Structure map
map07032  Hypnotics
map07230  GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CD Benzodiazepine derivatives
     N05CD08 Midazolam
      D00696  Midazolam hydrochloride (USAN) <US>
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D00696  Midazolam hydrochloride (USAN) <US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00696
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00696
Other DBs
CAS: 59467-96-8
PubChem: 7847761
ChEBI: 6932
ChEMBL: CHEMBL1200420
DrugBank: DB00683
LigandBox: D00696
NIKKAJI: J300.613A
LinkDB
KCF data

ATOM        24
            1   X   Cl   37.0651  -16.6762
            2   C2y C    32.2059  -17.5222
            3   C8y C    31.3632  -16.4118
            4   C8y C    31.6986  -15.0540
            5   N4y N    32.9606  -14.4754
            6   N2x N    33.6128  -17.4775
            7   C8y C    34.2151  -15.0982
            8   C1x C    34.5018  -16.4679
            9   C8x C    30.6908  -14.0849
            10  C8x C    29.3478  -14.4732
            11  C8y C    29.0123  -15.8311
            12  C8x C    30.0202  -16.7999
            13  X   Cl   27.6465  -16.2258
            14  C8y C    31.5709  -18.7729
            15  C8x C    30.1683  -18.7729
            16  C8x C    29.4677  -19.9863
            17  C8x C    30.1683  -21.1996
            18  C8x C    31.5709  -21.1996
            19  C8y C    32.2715  -19.9863
            20  X   F    33.6834  -19.9864
            21  C8x C    35.1952  -14.0976
            22  N5x N    34.5463  -12.8563
            23  C8y C    33.1652  -13.0899
            24  C1a C    32.1836  -12.1282
BOND        26
            1     4   5 1
            2     2   6 2
            3     5   7 1
            4     3   4 1
            5     6   8 1
            6     2   3 1
            7     7   8 1
            8     4   9 2
            9     9  10 1
            10   10  11 2
            11   11  12 1
            12    3  12 2
            13   11  13 1
            14    2  14 1
            15   14  15 1
            16   15  16 2
            17   16  17 1
            18   17  18 2
            19   18  19 1
            20   14  19 2
            21   19  20 1
            22    7  21 2
            23   21  22 1
            24   22  23 2
            25    5  23 1
            26   23  24 1

» Japanese version   » Back

KEGG   DRUG: Midazolam maleate
Entry
D05028                      Drug                                   

Name
Midazolam maleate (USAN)
Formula
C18H13ClFN3. C4H4O4
Exact mass
441.0892
Mol weight
441.8395
Structure
Class
Neuropsychiatric agent
 DG01835  Benzodiazepine sedative-hypnotics
 DG01567  GABA-A receptor agonist
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
ATC code: N05CD08
Chemical structure group: DG00920
Product (DG00920): D00550<JP/US> D00696<US>
Efficacy
Anesthetic (intravenous), Sedative-hypnotic
Comment
Benzodiazepines
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Structure map
map07032  Hypnotics
map07230  GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CD Benzodiazepine derivatives
     N05CD08 Midazolam
      D05028  Midazolam maleate (USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D05028  Midazolam maleate (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D05028
Other DBs
CAS: 59467-94-6
PubChem: 47206755
ChEMBL: CHEMBL2106922
DrugBank: DB00683
LigandBox: D05028
NIKKAJI: J276.248J
LinkDB
KCF data

ATOM        31
            1   C2b C    37.5334  -17.1234
            2   C2b C    35.7293  -17.1234
            3   C6a C    35.1048  -18.3029
            4   C6a C    38.2272  -18.3029
            5   O6a O    35.7293  -19.4825
            6   O6a O    37.5334  -19.4825
            7   O6a O    39.6149  -18.3029
            8   O6a O    33.7865  -18.3029
            9   C2y C    28.8459  -18.7122
            10  C8y C    28.0032  -17.6018
            11  C8y C    28.3386  -16.2440
            12  N4y N    29.6006  -15.6654
            13  N2x N    30.2528  -18.6675
            14  C8y C    30.8551  -16.2882
            15  C1x C    31.1418  -17.6579
            16  C8x C    27.3308  -15.2749
            17  C8x C    25.9878  -15.6632
            18  C8y C    25.6523  -17.0211
            19  C8x C    26.6602  -17.9899
            20  X   Cl   24.2865  -17.4158
            21  C8y C    28.2109  -19.9629
            22  C8x C    26.8083  -19.9629
            23  C8x C    26.1077  -21.1763
            24  C8x C    26.8083  -22.3896
            25  C8x C    28.2109  -22.3896
            26  C8y C    28.9115  -21.1763
            27  X   F    30.3234  -21.1764
            28  C8x C    31.8352  -15.2876
            29  N5x N    31.1863  -14.0463
            30  C8y C    29.8052  -14.2799
            31  C1a C    28.8236  -13.3182
BOND        33
            1     1   2 2
            2     2   3 1
            3     1   4 1
            4     3   5 2
            5     4   6 1
            6     4   7 2
            7     3   8 1
            8    11  12 1
            9     9  13 2
            10   12  14 1
            11   10  11 1
            12   13  15 1
            13    9  10 1
            14   14  15 1
            15   11  16 2
            16   16  17 1
            17   17  18 2
            18   18  19 1
            19   10  19 2
            20   18  20 1
            21    9  21 1
            22   21  22 1
            23   22  23 2
            24   23  24 1
            25   24  25 2
            26   25  26 1
            27   21  26 2
            28   26  27 1
            29   14  28 2
            30   28  29 1
            31   29  30 2
            32   12  30 1
            33   30  31 1

» Japanese version   » Back

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