| Entry |
|
|---|
| Name |
Esmolol hydrochloride (JAN/USP);
Brevibloc (TN) |
|---|
| Product |
|
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| Generic |
ESMOLOL HYDROCHLORIDE (Amneal Pharmaceuticals LLC), ESMOLOL HYDROCHLORIDE (Eugia US LLC), ESMOLOL HYDROCHLORIDE (Fresenius Kabi USA), ESMOLOL HYDROCHLORIDE (Gland Pharma Limited), ESMOLOL HYDROCHLORIDE (HF Acquisition Co LLC), ESMOLOL HYDROCHLORIDE (HF Acquisition Co LLC), ESMOLOL HYDROCHLORIDE (HF Acquisition Co LLC), ESMOLOL HYDROCHLORIDE (Henry Schein), ESMOLOL HYDROCHLORIDE (Henry Schein), ESMOLOL HYDROCHLORIDE (Medical Purchasing Solutions), ESMOLOL HYDROCHLORIDE (Mylan Institutional LLC), ESMOLOL HYDROCHLORIDE (ProPharma Distribution), ESMOLOL HYDROCHLORIDE (REMEDYREPACK), ESMOLOL HYDROCHLORIDE (Sagent Pharmaceuticals), ESMOLOL HYDROCHLORIDE (WG Critical Care), ESMOLOL HYDROCHLORIDE IN SODIUM CHLORIDE (Mylan Institutional LLC) |
|---|
| Formula |
C16H25NO4. HCl
|
|---|
| Exact mass |
331.1550
|
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| Mol weight |
331.83
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01461 beta1-Adrenergic receptor antagonist
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
|
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| Remark |
| Therapeutic category: | 2123 |
| Product (DG00318): | D00644<JP/US> |
|
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| Efficacy |
Antiarrhythmic, beta1-Adrenergic receptor antagonist |
|---|
| Disease |
|
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| Comment |
Propranolol derivative
|
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
|
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| Interaction |
|
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| Structure map |
| map07214 | beta-Adrenergic receptor agonists/antagonists |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C07 BETA BLOCKING AGENTS
C07A BETA BLOCKING AGENTS
C07AB Beta blocking agents, selective
C07AB09 Esmolol
D00644 Esmolol hydrochloride (JAN/USP) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
212 Antiarrhythmic agents
2123 Beta blockers
D00644 Esmolol hydrochloride (JAN/USP)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01461 beta1-Adrenergic receptor antagonist
DG00318 Esmolol
D00644 Esmolol hydrochloride
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
DG00318 Esmolol
D00644 Esmolol hydrochloride
Drug classes [BR:br08332]
Cardiovascular agent
DG01653 Antiarrhythmics
D00644 Esmolol hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRB1
D00644 Esmolol hydrochloride (JAN/USP) <JP/US>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D00644
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01461 beta1-Adrenergic receptor antagonist
DG00318 Esmolol
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
DG00318 Esmolol
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 22
1 X Cl 23.8412 -28.9649
2 C1c C 23.1700 -22.8900
3 C1a C 24.3824 -23.5900
4 N1b N 21.9576 -23.5900
5 C1a C 23.1700 -21.4900
6 C1b C 20.7621 -22.8996
7 C1c C 19.5747 -23.5851
8 C1b C 18.3835 -22.8971
9 O1a O 19.5745 -24.9898
10 O2a O 17.1940 -23.5838
11 C8y C 17.1940 -24.9838
12 C8x C 15.9986 -25.6742
13 C8x C 15.9989 -27.0742
14 C8y C 17.2114 -27.7740
15 C8x C 18.4068 -27.0836
16 C8x C 18.4066 -25.6836
17 C1b C 17.2116 -29.1900
18 C1b C 16.0055 -29.8865
19 C7a C 14.8130 -29.1980
20 O7a O 13.6244 -29.8844
21 O6a O 14.8128 -27.7903
22 C1a C 12.4336 -29.1969
BOND 21
1 2 3 1
2 2 4 1
3 2 5 1
4 4 6 1
5 6 7 1
6 7 8 1
7 7 9 1
8 8 10 1
9 10 11 1
10 11 12 2
11 12 13 1
12 13 14 2
13 14 15 1
14 15 16 2
15 11 16 1
16 14 17 1
17 17 18 1
18 18 19 1
19 19 20 1
20 19 21 2
21 20 22 1
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