| Entry |
|
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| Name |
Vinorelbine tartrate (USP);
Vinorelbine ditartrate (JAN);
KW 2307;
Navelbine (TN) |
|---|
| Product |
|
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| Generic |
|
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| Formula |
C45H54N4O8. (C4H6O6)2
|
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| Exact mass |
1078.427
|
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| Mol weight |
1079.1059
|
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| Structure |
|
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| Class |
Antineoplastic
DG01965 Antineoplastic, vinca alkaloid
Metabolizing enzyme substrate
DG02913 CYP3A4 substrate
|
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| Remark |
| Therapeutic category: | 4240 |
| Product (DG00692): | D01935<JP/US> |
|
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| Efficacy |
Antineoplastic, Tubulin polymerization inhibitor |
|---|
| Disease |
Non-small cell lung cancer [DS: H00014] |
|---|
| Comment |
Semisynthetic vinblastine derivative
|
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| Target |
|
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| Pathway |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
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| Interaction |
|
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| Structure map |
| map07042 | Antineoplastics - agents from natural products |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01C PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
L01CA Vinca alkaloids and analogues
L01CA04 Vinorelbine
D01935 Vinorelbine tartrate (USP) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
42 Antineoplastics
424 Plant extract preparations
4240 Plant extract preparations
D01935 Vinorelbine tartrate (USP); Vinorelbine ditartrate (JAN)
Target-based classification of drugs [BR:br08310]
Not elsewhere classified
Cellular process
Cytoskeleton
TUBB
D01935 Vinorelbine tartrate (USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01935
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 77
1 O6a O 21.2046 -10.0318
2 C6a C 22.4151 -9.3310
3 C1c C 23.6256 -10.0318
4 C1c C 24.8360 -9.3310
5 C6a C 26.0465 -10.0318
6 O6a O 27.2570 -9.3310
7 O6a O 22.4151 -7.9294
8 O1a O 23.6256 -11.4334
9 O1a O 24.8360 -7.9294
10 O6a O 26.0465 -11.4334
11 C1z C 7.4200 -11.4800
12 C8y C 6.3000 -10.7100
13 C1x C 8.6800 -10.7100
14 C7a C 7.0700 -12.7400
15 C8y C 6.3000 -9.3100
16 N4x N 5.1800 -11.3400
17 C1y C 8.6800 -9.4500
18 O7a O 5.6000 -13.2300
19 O6a O 7.9100 -13.7900
20 C8y C 3.9900 -9.3100
21 C8y C 3.9900 -10.7100
22 C1x C 7.5600 -8.8200
23 C1a C 4.7600 -14.6300
24 C8x C 2.8000 -8.6800
25 C8x C 2.8000 -11.3400
26 N1y N 7.5600 -7.5600
27 C8x C 1.7500 -9.3100
28 C8x C 1.7500 -10.7100
29 C1x C 8.6800 -6.7900
30 C2y C 9.8000 -7.4200
31 C2x C 9.8000 -8.6100
32 C1b C 11.0600 -6.7200
33 C1a C 12.2500 -7.4200
34 C1x C 6.3000 -7.9100
35 C1z C 14.9800 -13.6500
36 C1y C 16.1000 -12.9500
37 C1y C 14.9800 -14.9100
38 C1x C 14.1400 -12.5300
39 C1z C 17.2200 -13.6500
40 N1y N 16.1000 -11.6200
41 C1z C 16.1000 -15.6100
42 N1y N 13.8600 -15.6100
43 C8y C 12.7400 -14.9100
44 C1x C 14.7700 -11.6200
45 C1y C 17.2200 -14.9100
46 C2x C 18.4100 -12.9500
47 C1b C 18.3400 -14.2800
48 C1x C 17.2200 -10.9900
49 C7a C 17.0100 -16.7300
50 O1a O 15.6100 -17.5000
51 C1a C 13.8600 -16.9400
52 O7a O 20.5800 -16.2400
53 C2x C 18.4100 -11.6200
54 C1a C 19.4600 -13.6500
55 O7a O 17.0100 -18.0600
56 O6a O 18.3400 -16.2400
57 C1a C 18.2000 -18.7600
58 C1a C 23.0300 -16.2400
59 C7a C 21.7700 -15.5400
60 O6a O 21.7700 -14.1400
61 C8y C 12.7400 -13.6500
62 C8x C 11.6200 -13.0200
63 C8x C 11.6200 -15.6100
64 C8y C 10.5000 -13.6500
65 C8y C 10.5000 -14.9800
66 O2a O 9.3800 -15.6100
67 C1a C 8.2600 -14.9800
68 O6a O 21.2046 -10.0318
69 C6a C 22.4151 -9.3310
70 C1c C 23.6256 -10.0318
71 C1c C 24.8360 -9.3310
72 C6a C 26.0465 -10.0318
73 O6a O 27.2570 -9.3310
74 O6a O 26.0465 -11.4334
75 O1a O 24.8360 -7.9294
76 O1a O 23.6256 -11.4334
77 O6a O 22.4151 -7.9294
BOND 83
1 11 12 1
2 11 13 1
3 11 14 1 #Up
4 12 15 2
5 12 16 1
6 13 17 1
7 14 18 1
8 14 19 2
9 15 20 1
10 16 21 1
11 17 22 1
12 17 31 1
13 18 23 1
14 20 24 1
15 21 25 1
16 26 22 1
17 24 27 2
18 25 28 2
19 26 29 1
20 20 21 2
21 30 29 1
22 27 28 1
23 30 31 2
24 30 32 1
25 32 33 1
26 15 34 1
27 26 34 1 #Up
28 35 36 1
29 35 37 1
30 35 38 1 #Up
31 36 39 1
32 36 40 1
33 37 41 1
34 37 42 1
35 38 44 1
36 39 45 1
37 39 46 1
38 39 47 1 #Down
39 40 48 1
40 41 49 1 #Down
41 41 50 1 #Up
42 42 51 1
43 45 52 1 #Up
44 46 53 2
45 47 54 1
46 49 55 1
47 40 44 1
48 41 45 1
49 42 43 1
50 48 53 1
51 49 56 2
52 55 57 1
53 58 59 1
54 52 59 1
55 59 60 2
56 61 62 1
57 43 63 1
58 62 64 2
59 63 65 2
60 65 66 1
61 66 67 1
62 64 65 1
63 61 35 1
64 61 43 2
65 11 64 1 #Down
66 1 2 1
67 2 3 1
68 3 4 1
69 4 5 1
70 5 6 1
71 2 7 2
72 3 8 1 #Up
73 4 9 1 #Up
74 5 10 2
75 68 69 1
76 69 70 1
77 70 71 1
78 71 72 1
79 72 73 1
80 69 77 2
81 70 76 1 #Up
82 71 75 1 #Up
83 72 74 2
BRACKET 1 19.8800 -12.1800 19.8800 -7.0000
1 28.7000 -7.0000 28.7000 -12.1800
1 2
ORIGINAL 1 1 2 3 4 5 6 10 9 8 7
REPEAT 1 70 71 72 73 74 75 76 77 78 79
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