KEGG   DRUG: Butalbital, acetaminophen, caffeine and codeine phosphate
Entry
D11851            Mixture   Drug                                   
Name
Butalbital, acetaminophen, caffeine and codeine phosphate
Product
  Generic
BUTALBITAL, ACETAMINOPHEN, CAFFEINE AND CODEINE PHOSPHATE (Breckenridge Pharmaceutical), BUTALBITAL, ACETAMINOPHEN, CAFFEINE AND CODEINE PHOSPHATE (Bryant Ranch Prepack), BUTALBITAL, ACETAMINOPHEN, CAFFEINE AND CODEINE PHOSPHATE (Bryant Ranch Prepack), BUTALBITAL, ACETAMINOPHEN, CAFFEINE AND CODEINE PHOSPHATE (Hikma Pharmaceuticals USA), BUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE (Actavis Pharma), BUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE (Actavis Pharma), BUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE (Bryant Ranch Prepack), BUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE (LGM PHARMA SOLUTIONS), FIORICET WITH CODEINE (Actavis Pharma)
Component
Butalbital [DR:D03182], Acetaminophen [DR:D00217], Caffeine [DR:D00528], Codeine phosphate [DR:D02101]
Class
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
 DG02924  UGT substrate
  DG03189  UGT2B4 substrate
  DG03190  UGT2B7 substrate
Remark
Product: D11851<US>
Efficacy
Analgesic
Comment
Caffeine is mainly metabolized by CYP1A2.
Codeine Phosphate is metabolized by UGT2B7, UGT2B4 with some contribution from CYP3A4 and CYP2D6.
Metabolism
Enzyme: CYP1A2 [HSA:1544], UGT2B7 [HSA:7364], UGT2B4 [HSA:7363]; CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]
Interaction
Brite
USP drug classification [BR:br08302]
 Analgesics
  Analgesics Combinations
   Acetaminophen/ Butalbital/ Caffeine/ Codeine Phosphate
    D11851  Butalbital, acetaminophen, caffeine and codeine phosphate
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   D11851  Butalbital, acetaminophen, caffeine and codeine phosphate
  DG01644  CYP2D6 substrate
   D11851  Butalbital, acetaminophen, caffeine and codeine phosphate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D11851  Butalbital, acetaminophen, caffeine and codeine phosphate
  DG02924  UGT substrate
   DG03189  UGT2B4 substrate
    D11851  Butalbital, acetaminophen, caffeine and codeine phosphate
   DG03190  UGT2B7 substrate
    D11851  Butalbital, acetaminophen, caffeine and codeine phosphate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11851
Other DBs
PubChem: 433774526
LinkDB

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