KEGG   DRUG: Methamphetamine hydrochloride
Entry
D02242                      Drug                                   

Name
Methamphetamine hydrochloride (JP17/USP);
Desoxyn (TN)
Product
  Generic
Formula
C10H15N. HCl
Exact mass
185.0971
Mol weight
185.6937
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01970  Agents for ADHD
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Remark
Therapeutic category: 1151
ATC code: N06BA03
Chemical structure group: DG00968
Product (DG00968): D02242<JP/US>
Efficacy
Psychostimulant, Stimulant (central)
  Disease
Attention deficit disorder with hyperactivity [DS:H01895]
Target
SLC6A3 (DAT1) [HSA:6531] [KO:K05036]
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
SLC18A2 (VMAT2) [HSA:6571] [KO:K08155]
SLC18A1 (VMAT1) [HSA:6570] [KO:K08155]
  Pathway
hsa04721  Synaptic vesicle cycle
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
hsa05031  Amphetamine addiction
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Structure map
map07234  Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06B PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
    N06BA Centrally acting sympathomimetics
     N06BA03 Metamfetamine
      D02242  Methamphetamine hydrochloride (JP17/USP) <JP/US>
USP drug classification [BR:br08302]
 Anti-Obesity Agents
  Methamphetamine
   D02242  Methamphetamine hydrochloride (JP17/USP)
 Central Nervous System Agents
  Attention Deficit Hyperactivity Disorder Agents, Amphetamines
   Methamphetamine
    D02242  Methamphetamine hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   115  Stimulants
    1151  Amphetamines
     D02242  Methamphetamine hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D02242  Methamphetamine hydrochloride (JP17/USP) <JP/US>
    SLC6A3 (DAT1)
     D02242  Methamphetamine hydrochloride (JP17/USP) <JP/US>
    SLC6A4 (HTT)
     D02242  Methamphetamine hydrochloride (JP17/USP) <JP/US>
   SLC18
    SLC18A1 (VMAT1)
     D02242  Methamphetamine hydrochloride (JP17/USP) <JP/US>
    SLC18A2 (VMAT2)
     D02242  Methamphetamine hydrochloride (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02242  Methamphetamine hydrochloride
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02242
Other DBs
CAS: 51-57-0
PubChem: 7849301
ChEMBL: CHEMBL1200952
LigandBox: D02242
NIKKAJI: J231.291C
LinkDB
KCF data

ATOM        12
            1   C8y C    15.8200  -15.6100
            2   C1b C    17.0100  -14.9100
            3   C8x C    14.5600  -14.9100
            4   C8x C    15.8200  -17.0100
            5   C1c C    18.2000  -15.6100
            6   C8x C    13.3700  -15.6100
            7   C8x C    14.5600  -17.7100
            8   N1b N    19.4600  -14.9100
            9   C1a C    18.2000  -17.0100
            10  C8x C    13.3700  -17.0100
            11  C1a C    20.6500  -15.6100
            12  X   Cl   23.8700  -16.3800
BOND        11
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 2
            7     5   8 1
            8     5   9 1 #Up
            9     6  10 2
            10    8  11 1
            11    7  10 1

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