KEGG   DRUG: Anakinra
Entry
D02934                      Drug                                   
Name
Anakinra (USAN/INN);
Kineret (TN)
Product
Formula
C759H1186N208O232S10
Exact mass
17246.4608
Mol weight
17257.47
Sequence
MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG
IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW
FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE
  Type
Peptide
Class
Immunological agent
 DG02019  Interleukin inhibitor
Remark
ATC code: L04AC03
Product: D02934<US>
Efficacy
Anti-inflammatory, Immunosuppressant
  Disease
Active rheumatoid arthritis [DS:H00630]
Cryopyrin-associated periodic syndromes [DS:H00282]
Deficiency of interleukin-1 receptor antagonist [DS:H01275]
Comment
recombinant form of human IL-1 receptor antagonist (rhuIL-1Ra) [HSA:3557] [KO:K05481]
Treatment of inflammatory bowel disease
Target
IL1R (CD121) [HSA:3554 7850] [KO:K04386 K04387]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04750  Inflammatory mediator regulation of TRP channels
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AC Interleukin inhibitors
     L04AC03 Anakinra
      D02934  Anakinra (USAN/INN) <US>
USP drug classification [BR:br08302]
 Immunological Agents
  Immunological Agents, Other
   Interleukin Blockers
    Anakinra
     D02934  Anakinra (USAN/INN)
Drug groups [BR:br08330]
 Immunological agent
  DG02019  Interleukin inhibitor
   D02934  Anakinra
Drug classes [BR:br08332]
 Immunological agent
  DG02019  Interleukin inhibitor
   D02934  Anakinra
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Interleukin receptors
    IL1R (CD121)
     D02934  Anakinra (USAN/INN) <US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D02934
Other DBs
CAS: 143090-92-0
PubChem: 17397091
NIKKAJI: J2.104.924G
LinkDB

» Japanese version   » Back

DBGET integrated database retrieval system