KEGG   DRUG: GolimumabHelp
Entry
D04358                      Drug                                   

Name
Golimumab (USAN/INN);
Golimumab (genetical recombination) (JAN);
Simponi (TN)
Product
Formula
C6530H10068N1752O2026S44
Exact mass
146852.6362
Mol weight
146943.1937
Class
Other
 DG01936  TNF inhibitor
Remark
Therapeutic category: 3999
ATC code: L04AB06
Product: D04358<JP/US>
Efficacy
Anti-inflammatory, Antirheumatic, Anti-TNF-alpha antibody
  Disease
Rheumatoid arthritis [DS:H00630]
Psoriatic arthritis [DS:H01507]
Ankylosing spondylitis [DS:H01674]
Ulcerative colitis [DS:H01466]
Comment
Monoclonal antibody
Target
TNF (TNFA, TNFSF2) [HSA:7124] [KO:K03156]
  Pathway
hsa04010  MAPK signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04210  Apoptosis
hsa04350  TGF-beta signaling pathway
hsa04380  Osteoclast differentiation
hsa04664  Fc epsilon RI signaling pathway
hsa04920  Adipocytokine signaling pathway
hsa05321  Inflammatory bowel disease (IBD)
hsa05323  Rheumatoid arthritis
Interaction
Drug interaction
Structure map
map07050  Antirheumatics - DMARDs and biological agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AB Tumor necrosis factor alpha (TNF-alpha) inhibitors
     L04AB06 Golimumab
      D04358  Golimumab (USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Immunological Agents
  Immune Suppressants
   Golimumab
    D04358  Golimumab (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D04358  Golimumab (USAN/INN); Golimumab (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Tumor necrosis factors
    TNF (TNFA, TNFSF2)
     D04358  Golimumab (USAN/INN) <JP/US>
Drug classes of therapeutic agents [br08360.html]
 Antirheumatic and antigout agents
  D04358
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D04358
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D04358
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D04358
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D04358
BRITE hierarchy
Other DBs
CAS: 476181-74-5
PubChem: 47206264
LinkDB All DBs

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