KEGG   DRUG: Golimumab
Entry
D04358                      Drug                                   

Name
Golimumab (USAN/INN);
Golimumab (genetical recombination) (JAN);
Simponi (TN)
Product
Formula
C6530H10068N1752O2026S44
Exact mass
146852.6362
Mol weight
146943.1937
Class
Other
 DG01936  TNF inhibitor
Remark
Therapeutic category: 3999
ATC code: L04AB06
Product: D04358<JP/US>
Efficacy
Anti-inflammatory, Antirheumatic, Anti-TNF-alpha antibody
  Disease
Rheumatoid arthritis [DS:H00630]
Psoriatic arthritis [DS:H01507]
Ankylosing spondylitis [DS:H01674]
Ulcerative colitis [DS:H01466]
Comment
Monoclonal antibody
Target
TNF (TNFA, TNFSF2) [HSA:7124] [KO:K03156]
  Pathway
hsa04010  MAPK signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04210  Apoptosis
hsa04350  TGF-beta signaling pathway
hsa04380  Osteoclast differentiation
hsa04664  Fc epsilon RI signaling pathway
hsa04920  Adipocytokine signaling pathway
hsa05321  Inflammatory bowel disease
hsa05323  Rheumatoid arthritis
Interaction
Structure map
map07050  Antirheumatics - DMARDs and biological agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AB Tumor necrosis factor alpha (TNF-alpha) inhibitors
     L04AB06 Golimumab
      D04358  Golimumab (USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Immunological Agents
  Immunosuppressants
   Tumor Necrosis Factor (TNF) Blockers
    Golimumab
     D04358  Golimumab (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D04358  Golimumab (USAN/INN); Golimumab (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Tumor necrosis factors
    TNF (TNFA, TNFSF2)
     D04358  Golimumab (USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D04358
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D04358
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D04358
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D04358
Other DBs
CAS: 476181-74-5
PubChem: 47206264
LinkDB

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