KEGG   DRUG: MetamfetamineHelp
Entry
D08187                      Drug                                   

Name
Metamfetamine (INN);
Methamphetamine
Formula
C10H15N
Exact mass
149.1204
Mol weight
149.2328
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01970  Agents for ADHD
Enzyme substrate
 DG01644  CYP2D6 substrate
Remark
Same as: C07164
ATC code: N06BA03
Chemical structure group: DG00968
Product (DG00968): D02242<JP/US>
Efficacy
Psychostimulant, Stimulant (central)
Target
SLC6A3 (DAT1) [HSA:6531] [KO:K05036]
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
SLC18A2 (VMAT2) [HSA:6571] [KO:K08155]
SLC18A1 (VMAT1) [HSA:6570] [KO:K08155]
  Pathway
hsa04721  Synaptic vesicle cycle
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
hsa05031  Amphetamine addiction
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
map07234  Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06B PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
    N06BA Centrally acting sympathomimetics
     N06BA03 Metamfetamine
      D08187  Metamfetamine (INN)
USP drug classification [BR:br08302]
 Central Nervous System Agents
  Attention Deficit Hyperactivity Disorder Agents, Amphetamines
   Methamphetamine
    D08187  Metamfetamine (INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D08187  Metamfetamine (INN)
    SLC6A3 (DAT1)
     D08187  Metamfetamine (INN)
    SLC6A4 (HTT)
     D08187  Metamfetamine (INN)
   SLC18
    SLC18A1 (VMAT1)
     D08187  Metamfetamine (INN)
    SLC18A2 (VMAT2)
     D08187  Metamfetamine (INN)
BRITE hierarchy
Other DBs
CAS: 537-46-2
PubChem: 96024877
ChEBI: 6809
ChEMBL: CHEMBL1201201
DrugBank: DB01577
PDB-CCD: B40[PDBj]
LigandBox: D08187
NIKKAJI: J6.362B
LinkDB All DBs
KCF data Show

ATOM        11
            1   C8y C    17.4300  -15.4700
            2   C1b C    18.6200  -14.7700
            3   C8x C    16.1700  -14.7700
            4   C8x C    17.4300  -16.8700
            5   C1c C    19.8100  -15.4700
            6   C8x C    14.9800  -15.4700
            7   C8x C    16.1700  -17.5700
            8   N1b N    21.0000  -14.7700
            9   C1a C    19.8100  -16.8700
            10  C8x C    14.9800  -16.8700
            11  C1a C    22.2600  -15.4700
BOND        11
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 2
            7     5   8 1
            8     5   9 1 #Up
            9     6  10 2
            10    8  11 1
            11    7  10 1

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