KEGG   DRUG: MexiletineHelp
Entry
D08215                      Drug                                   

Name
Mexiletine (INN)
Formula
C11H17NO
Exact mass
179.131
Mol weight
179.2588
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01651  Class Ib antiarrhythmic agent
Enzyme substrate
 DG01892  CYP1A2 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A substrate
Remark
Same as: C07220
ATC code: C01BB02
Chemical structure group: DG00197
Product (DG00197): D00639<JP/US>
Efficacy
Antiarrhythmic, Sodium channel blocker
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
map07037  Antiarrhythmic drugs
map07231  Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BB Antiarrhythmics, class Ib
     C01BB02 Mexiletine
      D08215  Mexiletine (INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Antiarrhythmics
   Mexiletine
    D08215  Mexiletine (INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D08215  Mexiletine (INN)
    SCN2A
     D08215  Mexiletine (INN)
    SCN3A
     D08215  Mexiletine (INN)
    SCN4A
     D08215  Mexiletine (INN)
    SCN5A
     D08215  Mexiletine (INN)
    SCN8A
     D08215  Mexiletine (INN)
    SCN9A
     D08215  Mexiletine (INN)
    SCN10A
     D08215  Mexiletine (INN)
    SCN11A
     D08215  Mexiletine (INN)
BRITE hierarchy
Other DBs
CAS: 31828-71-4
PubChem: 96024903
ChEBI: 6916
ChEMBL: CHEMBL558
DrugBank: DB00379
LigandBox: D08215
NIKKAJI: J19.958C
LinkDB All DBs
KCF data Show

ATOM        13
            1   C8y C    22.9600  -17.9200
            2   C8y C    21.7000  -18.6200
            3   C8y C    22.9600  -16.5200
            4   O2a O    24.1500  -18.6200
            5   C8x C    20.5100  -17.9200
            6   C1a C    21.7000  -20.0200
            7   C8x C    21.7000  -15.8200
            8   C1a C    24.1500  -15.8200
            9   C1b C    25.3400  -17.9200
            10  C8x C    20.5100  -16.5200
            11  C1c C    26.6000  -18.6200
            12  C1a C    26.6000  -20.0200
            13  N1a N    27.7900  -17.9200
BOND        13
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 2
            10    9  11 1
            11   11  12 1
            12   11  13 1
            13    7  10 1

» Japanese version   » Back

DBGET integrated database retrieval system