KEGG   DRUG: Eslicarbazepine
Entry
D09215                      Drug                                   

Name
Eslicarbazepine (USAN/INN)
Formula
C15H14N2O2
Exact mass
254.1055
Mol weight
254.2839
Structure
Simcomp
Class
Neuropsychiatric agent
 DG03199  Antiepileptic agent
  DG02034  Carboxamide antiepileptic
Metabolizing enzyme inhibitor
 DG01933  CYP2C19 inhibitor
Metabolizing enzyme inducer
 DG02853  CYP3A/CYP3A4 inducer
  DG01635  CYP3A4 inducer
Remark
ATC code: N03AF04
Chemical structure group: DG00848
Product (DG00848): D09612<US>
Efficacy
Anticonvulsant, Antiepileptic
Comment
Carboxamide derivative
Active metabolite of oxcarbazepine [DR:D00533]
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04728  Dopaminergic synapse
Interaction
CYP inhibition: CYP2C19 [HSA:1557]
CYP induction: CYP3A4 [HSA:1576]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AF Carboxamide derivatives
     N03AF04 Eslicarbazepine
      D09215  Eslicarbazepine (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D09215  Eslicarbazepine (USAN/INN)
    SCN2A
     D09215  Eslicarbazepine (USAN/INN)
    SCN3A
     D09215  Eslicarbazepine (USAN/INN)
    SCN4A
     D09215  Eslicarbazepine (USAN/INN)
    SCN5A
     D09215  Eslicarbazepine (USAN/INN)
    SCN8A
     D09215  Eslicarbazepine (USAN/INN)
    SCN9A
     D09215  Eslicarbazepine (USAN/INN)
    SCN10A
     D09215  Eslicarbazepine (USAN/INN)
    SCN11A
     D09215  Eslicarbazepine (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D09215
Other DBs
CAS: 104746-04-5
PubChem: 96025895
ChEBI: 174358
ChEMBL: CHEMBL315985
LigandBox: D09215
LinkDB
KCF data

ATOM        19
            1   C8y C    26.3200  -20.6500
            2   N1y N    27.5800  -20.0200
            3   C8y C    28.8400  -20.6500
            4   C8y C    29.1200  -21.9800
            5   C8y C    26.0400  -22.0500
            6   C1x C    28.2800  -23.1000
            7   C1y C    26.8800  -23.1000
            8   C8x C    25.2700  -19.6700
            9   C8x C    23.9400  -20.1600
            10  C8x C    23.6600  -21.4900
            11  C8x C    24.7100  -22.4700
            12  C8x C    30.5200  -22.3300
            13  C8x C    31.5000  -21.3500
            14  C8x C    31.1500  -20.0200
            15  C8x C    29.7500  -19.6000
            16  C5a C    27.5800  -18.6200
            17  O5a O    26.3900  -17.9200
            18  N1a N    28.7700  -17.9200
            19  O1a O    26.2500  -24.3600
BOND        21
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     1   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    5  11 2
            13    4  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15   3 2
            18    2  16 1
            19   16  17 2
            20   16  18 1
            21    7  19 1 #Down

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