KEGG   DRUG: EslicarbazepineHelp
Entry
D09215                      Drug                                   

Name
Eslicarbazepine (USAN/INN)
Formula
C15H14N2O2
Exact mass
254.1055
Mol weight
254.2839
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG02034  Carboxamide antiepileptics
Enzyme inhibitor
 DG01933  CYP2C19 inhibitor
Enzyme inducer
 DG02853  CYP3A inducer
  DG01635  CYP3A4 inducer
 DG01635  CYP3A4 inducer
Remark
ATC code: N03AF04
Chemical structure group: DG00848
Product (DG00848): D09612<US>
Efficacy
Anticonvulsant, Antiepileptic
Comment
Carboxamide derivative
Active metabolite of oxcarbazepine [DR:D00533]
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04728  Dopaminergic synapse
Interaction
CYP inhibition: CYP2C19 [HSA:1557]
CYP induction: CYP3A4 [HSA:1576]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AF Carboxamide derivatives
     N03AF04 Eslicarbazepine
      D09215  Eslicarbazepine (USAN/INN)
USP drug classification [BR:br08302]
 Anticonvulsants
  Sodium Channel Agents
   Eslicarbazepine
    D09215  Eslicarbazepine (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D09215  Eslicarbazepine (USAN/INN)
    SCN2A
     D09215  Eslicarbazepine (USAN/INN)
    SCN3A
     D09215  Eslicarbazepine (USAN/INN)
    SCN4A
     D09215  Eslicarbazepine (USAN/INN)
    SCN5A
     D09215  Eslicarbazepine (USAN/INN)
    SCN8A
     D09215  Eslicarbazepine (USAN/INN)
    SCN9A
     D09215  Eslicarbazepine (USAN/INN)
    SCN10A
     D09215  Eslicarbazepine (USAN/INN)
    SCN11A
     D09215  Eslicarbazepine (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 104746-04-5
PubChem: 96025895
ChEMBL: CHEMBL315985
LigandBox: D09215
LinkDB All DBs
KCF data Show

ATOM        19
            1   C8y C    26.3200  -20.6500
            2   N1y N    27.5800  -20.0200
            3   C8y C    28.8400  -20.6500
            4   C8y C    29.1200  -21.9800
            5   C8y C    26.0400  -22.0500
            6   C1x C    28.2800  -23.1000
            7   C1y C    26.8800  -23.1000
            8   C8x C    25.2700  -19.6700
            9   C8x C    23.9400  -20.1600
            10  C8x C    23.6600  -21.4900
            11  C8x C    24.7100  -22.4700
            12  C8x C    30.5200  -22.3300
            13  C8x C    31.5000  -21.3500
            14  C8x C    31.1500  -20.0200
            15  C8x C    29.7500  -19.6000
            16  C5a C    27.5800  -18.6200
            17  O5a O    26.3900  -17.9200
            18  N1a N    28.7700  -17.9200
            19  O1a O    26.2500  -24.3600
BOND        21
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     1   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    5  11 2
            13    4  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15   3 2
            18    2  16 1
            19   16  17 2
            20   16  18 1
            21    7  19 1 #Down

» Japanese version   » Back

DBGET integrated database retrieval system