KEGG   DRUG: Vilazodone hydrochlorideHelp
Entry
D09699                      Drug                                   

Name
Vilazodone hydrochloride (USAN);
Viibryd (TN)
Product
Formula
C26H27N5O2. HCl
Exact mass
477.1932
Mol weight
477.9858
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Metabolizing enzyme substrate
 DG01639  CYP2C19 substrate
 DG01644  CYP2D6 substrate
 DG02913  CYP3A4 substrate
Remark
ATC code: N06AX24
Chemical structure group: DG00964
Product (DG00964): D09699<US>
Efficacy
Antidepressant, Serotonin antagonist and reuptake inhibitor (SARI)
  Disease
Major depressive disorder [DS:H01646]
Target
HTR1A [HSA:3350] [KO:K04153]
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576]; CYP2D6 [HSA:1565], CYP2C19 [HSA:1557]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX24 Vilazodone
      D09699  Vilazodone hydrochloride (USAN) <US>
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Vilazodone
    D09699  Vilazodone hydrochloride (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    HTR1A
     D09699  Vilazodone hydrochloride (USAN) <US>
 Transporters
  Solute carrier family
   SLC6
    SLC6A4 (HTT)
     D09699  Vilazodone hydrochloride (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D09699
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09699
BRITE hierarchy
Other DBs
CAS: 163521-08-2
PubChem: 124490439
ChEBI: 70705
ChEMBL: CHEMBL1615374
LigandBox: D09699
LinkDB All DBs
KCF data Show

ATOM        34
            1   C8x C    26.8800  -23.9400
            2   C8y C    26.8800  -25.3400
            3   C8x C    28.0700  -26.0400
            4   C8y C    29.3300  -25.3400
            5   C8y C    29.3300  -23.9400
            6   C8x C    28.0700  -23.2400
            7   C8x C    30.6600  -25.7600
            8   C8y C    31.4300  -24.6400
            9   O2x O    30.6600  -23.5200
            10  N1y N    25.6900  -26.0400
            11  C1x C    24.5000  -25.3400
            12  C1x C    23.2400  -26.0400
            13  N1y N    23.2400  -27.4400
            14  C1x C    24.4300  -28.1400
            15  C1x C    25.6900  -27.4400
            16  C1b C    22.0500  -28.1400
            17  C1b C    20.8600  -27.4400
            18  C1b C    19.6700  -28.1400
            19  C1b C    18.4800  -27.4400
            20  C8y C    17.2900  -28.1400
            21  C8x C    13.7900  -25.8300
            22  C8x C    13.7900  -27.2300
            23  C8y C    14.9800  -27.9300
            24  C8y C    16.2400  -27.2300
            25  C8x C    16.2400  -25.8300
            26  C8y C    14.9800  -25.1300
            27  N4x N    15.2600  -29.3300
            28  C8x C    16.6600  -29.4700
            29  C5a C    32.8300  -24.6400
            30  N1a N    33.5300  -25.8300
            31  O5a O    33.5300  -23.4500
            32  C3b C    14.9800  -23.7300
            33  N3a N    14.9800  -22.3300
            34  X   Cl   19.9500  -24.9900
BOND        37
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    5   9 1
            11    2  10 1
            12   10  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   10  15 1
            18   13  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   21  22 2
            24   22  23 1
            25   23  24 2
            26   24  25 1
            27   25  26 2
            28   21  26 1
            29   23  27 1
            30   27  28 1
            31   28  20 2
            32   24  20 1
            33    8  29 1
            34   29  30 1
            35   29  31 2
            36   26  32 1
            37   32  33 3

» Japanese version   » Back

DBGET integrated database retrieval system