KEGG   DRUG: Vilazodone hydrochloride
Entry
D09699                      Drug                                   
Name
Vilazodone hydrochloride (USAN);
Viibryd (TN)
Product
  Generic
Formula
C26H27N5O2. HCl
Exact mass
477.1932
Mol weight
477.9858
Structure
Simcomp
Class
Metabolizing enzyme substrate
 DG01639  CYP2C19 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
ATC code: N06AX24
Chemical structure group: DG00964
Product (DG00964): D09699<US>
Efficacy
Antidepressant, Serotonin antagonist and reuptake inhibitor (SARI)
  Disease
Major depressive disorder [DS:H01646]
Target
HTR1A [HSA:3350] [KO:K04153]
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576]; CYP2D6 [HSA:1565], CYP2C19 [HSA:1557]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX24 Vilazodone
      D09699  Vilazodone hydrochloride (USAN) <US>
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Vilazodone
    D09699  Vilazodone hydrochloride (USAN)
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01639  CYP2C19 substrate
   DG00964  Vilazodone
    D09699  Vilazodone hydrochloride
  DG01644  CYP2D6 substrate
   DG00964  Vilazodone
    D09699  Vilazodone hydrochloride
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00964  Vilazodone
     D09699  Vilazodone hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    HTR1A
     D09699  Vilazodone hydrochloride (USAN) <US>
 Transporters
  Solute carrier family
   SLC6
    SLC6A4 (HTT)
     D09699  Vilazodone hydrochloride (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D09699
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09699
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D09699
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01639  CYP2C19 substrate
   DG00964  Vilazodone
  DG01644  CYP2D6 substrate
   DG00964  Vilazodone
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00964  Vilazodone
Other DBs
CAS: 163521-08-2
PubChem: 124490439
ChEBI: 70705
LigandBox: D09699
LinkDB
KCF data

ATOM        34
            1   C8x C    26.8800  -23.9400
            2   C8y C    26.8800  -25.3400
            3   C8x C    28.0700  -26.0400
            4   C8y C    29.3300  -25.3400
            5   C8y C    29.3300  -23.9400
            6   C8x C    28.0700  -23.2400
            7   C8x C    30.6600  -25.7600
            8   C8y C    31.4300  -24.6400
            9   O2x O    30.6600  -23.5200
            10  N1y N    25.6900  -26.0400
            11  C1x C    24.5000  -25.3400
            12  C1x C    23.2400  -26.0400
            13  N1y N    23.2400  -27.4400
            14  C1x C    24.4300  -28.1400
            15  C1x C    25.6900  -27.4400
            16  C1b C    22.0500  -28.1400
            17  C1b C    20.8600  -27.4400
            18  C1b C    19.6700  -28.1400
            19  C1b C    18.4800  -27.4400
            20  C8y C    17.2900  -28.1400
            21  C8x C    13.7900  -25.8300
            22  C8x C    13.7900  -27.2300
            23  C8y C    14.9800  -27.9300
            24  C8y C    16.2400  -27.2300
            25  C8x C    16.2400  -25.8300
            26  C8y C    14.9800  -25.1300
            27  N4x N    15.2600  -29.3300
            28  C8x C    16.6600  -29.4700
            29  C5a C    32.8300  -24.6400
            30  N1a N    33.5300  -25.8300
            31  O5a O    33.5300  -23.4500
            32  C3b C    14.9800  -23.7300
            33  N3a N    14.9800  -22.3300
            34  X   Cl   19.9500  -24.9900
BOND        37
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    5   9 1
            11    2  10 1
            12   10  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   10  15 1
            18   13  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   21  22 2
            24   22  23 1
            25   23  24 2
            26   24  25 1
            27   25  26 2
            28   21  26 1
            29   23  27 1
            30   27  28 1
            31   28  20 2
            32   24  20 1
            33    8  29 1
            34   29  30 1
            35   29  31 2
            36   26  32 1
            37   32  33 3

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