| Entry |
|
|---|
| Name |
Panobinostat (USAN/INN);
Farydak (TN) |
|---|
| Formula |
C21H23N3O2
|
|---|
| Exact mass |
349.1790
|
|---|
| Mol weight |
349.43
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antineoplastic
DG03133 Histone deacetylase inhibitor
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
|
|---|
| Remark |
|
|---|
| Efficacy |
Antineoplastic, Histone deacetylase inhibitor |
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
CYP inhibition: CYP2D6 [HSA: 1565]
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01X OTHER ANTINEOPLASTIC AGENTS
L01XH Histone deacetylase (HDAC) inhibitors
L01XH03 Panobinostat
D10319 Panobinostat (USAN/INN)
Drug groups [BR:br08330]
Antineoplastic
DG03133 Histone deacetylase inhibitor
DG01403 Panobinostat
D10319 Panobinostat
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01403 Panobinostat
D10319 Panobinostat
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG01403 Panobinostat
D10319 Panobinostat
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
Histone deacetylase
HDAC
D10319 Panobinostat (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D10319
Drug groups [BR:br08330]
Antineoplastic
DG03133 Histone deacetylase inhibitor
DG01403 Panobinostat
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01403 Panobinostat
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG01403 Panobinostat
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 26
1 C8y C 21.9100 -17.0800
2 C8x C 21.9100 -15.6800
3 C8x C 23.1000 -14.9800
4 C8y C 24.3600 -15.6800
5 C8x C 24.3600 -17.0800
6 C8x C 23.1000 -17.7800
7 C2b C 25.5500 -14.9800
8 C2b C 26.7400 -15.6800
9 C5a C 27.9300 -14.9800
10 N1b N 29.1200 -15.6800
11 O5a O 27.9300 -13.5100
12 O1b O 30.3100 -14.9800
13 C1b C 20.6500 -17.7800
14 N1b N 19.4600 -17.0800
15 C1b C 18.2700 -17.7800
16 C1b C 17.0800 -17.0800
17 C8y C 15.8900 -17.7800
18 C8y C 15.8900 -19.1800
19 N4x N 14.5600 -19.6000
20 C8y C 13.7200 -18.4800
21 C8y C 14.5600 -17.3600
22 C8x C 12.3200 -18.3400
23 C8x C 11.7600 -17.0100
24 C8x C 12.6000 -15.8900
25 C8x C 14.0000 -16.0300
26 C1a C 17.0100 -20.0200
BOND 28
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 2
9 8 9 1
10 9 10 1
11 9 11 2
12 10 12 1
13 1 13 1
14 13 14 1
15 14 15 1
16 15 16 1
17 16 17 1
18 17 18 2
19 18 19 1
20 19 20 1
21 20 21 1
22 17 21 1
23 20 22 2
24 22 23 1
25 23 24 2
26 24 25 1
27 21 25 2
28 18 26 1
|
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