| Entry |
|
|---|
| Name |
Clopidogrel besilate;
Clopidogrel besylate;
Clopidogrel (TN) |
|---|
| Formula |
C16H16ClNO2S. C6H6O3S
|
|---|
| Exact mass |
479.0628
|
|---|
| Mol weight |
479.9968
|
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| Structure |
|
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| Class |
|
|---|
| Remark |
| Product (DG00155): | D00769<JP/US> |
|
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| Efficacy |
Anticoagulant, Platelet aggregation inhibitor, Purinergic receptor P2Y12 antagonist |
|---|
| Comment |
Thienopyridine derivative
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP2C19 [HSA: 1557]; CYP3A4 [HSA: 1576], CYP1A2 [HSA: 1544], CYP2B6 [HSA: 1555]
|
|---|
| Interaction |
CYP inhibition: CYP2C8 [HSA: 1558]
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
B BLOOD AND BLOOD FORMING ORGANS
B01 ANTITHROMBOTIC AGENTS
B01A ANTITHROMBOTIC AGENTS
B01AC Platelet aggregation inhibitors excl. heparin
B01AC04 Clopidogrel
D10824 Clopidogrel besilate
Drug groups [BR:br08330]
Blood modifier agent
DG01950 Antithrombotic agent
DG01712 Antiplatelet agent
DG01808 Thienopyridine
DG00155 Clopidogrel
D10824 Clopidogrel besilate
DG01809 P2Y12 receptor antagonist
DG01808 Thienopyridine
DG00155 Clopidogrel
D10824 Clopidogrel besilate
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00155 Clopidogrel
D10824 Clopidogrel besilate
DG02919 CYP2B6 substrate
DG00155 Clopidogrel
D10824 Clopidogrel besilate
DG01639 CYP2C19 substrate
DG00155 Clopidogrel
D10824 Clopidogrel besilate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00155 Clopidogrel
D10824 Clopidogrel besilate
Metabolizing enzyme inhibitor
DG01641 CYP2C8 inhibitor
DG00155 Clopidogrel
D10824 Clopidogrel besilate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Purine / pyrimidine
P2RY12
D10824 Clopidogrel besilate
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D10824
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D10824
Drug groups [BR:br08330]
Blood modifier agent
DG01950 Antithrombotic agent
DG01712 Antiplatelet agent
DG01808 Thienopyridine
DG00155 Clopidogrel
DG01809 P2Y12 receptor antagonist
DG01808 Thienopyridine
DG00155 Clopidogrel
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00155 Clopidogrel
DG02919 CYP2B6 substrate
DG00155 Clopidogrel
DG01639 CYP2C19 substrate
DG00155 Clopidogrel
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00155 Clopidogrel
Metabolizing enzyme inhibitor
DG01641 CYP2C8 inhibitor
DG00155 Clopidogrel
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 31
1 N1y N 18.7472 -15.8092
2 C1c C 17.5580 -16.5087
3 C1x C 19.9364 -16.5087
4 C1x C 18.7472 -14.4102
5 C8y C 16.3688 -15.8092
6 C7a C 17.5580 -17.9078
7 C8y C 21.1955 -15.8092
8 C1x C 19.9364 -13.7106
9 C8y C 16.3688 -14.4102
10 C8x C 15.1097 -16.5087
11 O7a O 16.3688 -18.6073
12 O6a O 18.7472 -18.6073
13 C8y C 21.1955 -14.4102
14 C8x C 22.5246 -16.2289
15 C8x C 15.1097 -13.7106
16 X Cl 17.5580 -13.7106
17 C8x C 13.9205 -15.8092
18 C1a C 15.1097 -17.9078
19 S2x S 22.5246 -13.9905
20 C8x C 23.3641 -15.1097
21 C8x C 13.9205 -14.4102
22 C8x C 25.4800 -17.2200
23 C8x C 25.4800 -18.6200
24 C8x C 26.6924 -19.3200
25 C8x C 27.9049 -18.6200
26 C8x C 27.9049 -17.2200
27 C8y C 26.6924 -16.5200
28 S4a S 26.6924 -15.1202
29 O1d O 25.2924 -15.1202
30 O1d O 28.0924 -15.1202
31 O1d O 26.6924 -13.7202
BOND 33
1 2 5 1
2 2 6 1 #Down
3 3 7 1
4 4 8 1
5 5 9 1
6 5 10 2
7 6 11 1
8 6 12 2
9 7 13 2
10 7 14 1
11 9 15 2
12 9 16 1
13 10 17 1
14 11 18 1
15 13 19 1
16 14 20 2
17 15 21 1
18 8 13 1
19 17 21 2
20 19 20 1
21 1 2 1
22 1 3 1
23 1 4 1
24 22 23 2
25 23 24 1
26 24 25 2
27 25 26 1
28 26 27 2
29 22 27 1
30 27 28 1
31 28 29 2
32 28 30 2
33 28 31 1
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