KEGG   DRUG: Conestat alfa
Entry
D10845                      Drug                                   
Name
Conestat alfa (INN);
Ruconest (TN)
Product
RUCONEST (Pharming Healthcare)
Sequence
NPNATSSSSQ DPESLQDRGE GKVATTVISK MLFVEPILEV SSLPTTNSTT NSATKITANT
TDEPTTQPTT EPTTQPTIQP TQPTTQLPTD SPTQPTTGSF CPGPVTLCSD LESHSTEAVL
GDALVDFSLK LYHAFSAMKK VETNMAFSPF SIASLLTQVL LGAGENTKTN LESILSYPKD
FTCVHQALKG FTTKGVTSVS QIFHSPDLAI RDTFVNASRT LYSSSPRVLS NNSDANLELI
NTWVAKNTNN KISRLLDSLP SDTRLVLLNA IYLSAKWKTT FDPKKTRMEP FHFKNSVIKV
PMMNSKKYPV AHFIDQTLKA KVGQLQLSHN LSLVILVPQN LKHRLEDMEQ ALSPSVFKAI
MEKLEMSKFQ PTLLTLPRIK VTTSQDMLSI MEKLEFFDFS YDLNLCGLTE DPDLQVSAMQ
HQTVLELTET GVEAAAASAI SVARTLLVFE VQQPFLFVLW DQQHKFPVFM GRVYDPRA
(Disulfide bridge: 101-406, 108-183)
  Type
Peptide
Remark
ATC code: B06AC04
Product: D10845<US>
Efficacy
C1 esterase inhibitor
  Disease
Hereditary angioedema [DS:H01006]
Comment
Treatment of angioedemas, hereditary
Target
C1R [HSA:715] [KO:K01330]
C1S [HSA:716] [KO:K01331]
KLKB1 [HSA:3818] [KO:K01324]
  Pathway
hsa04610  Complement and coagulation cascades
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B06 OTHER HEMATOLOGICAL AGENTS
   B06A OTHER HEMATOLOGICAL AGENTS
    B06AC Drugs used in hereditary angioedema
     B06AC04 Conestat alfa
      D10845  Conestat alfa (INN) <US>
Target-based classification of drugs [BR:br08310]
 Peptidases and inhibitors
  Serine peptidases
   Chymotrypsin family
    KLKB1
     D10845  Conestat alfa (INN) <US>
    C1R
     D10845  Conestat alfa (INN) <US>
    C1S
     D10845  Conestat alfa (INN) <US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10845
Other DBs
CAS: 80295-38-1
PubChem: 319902645
LinkDB

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